Tag: M.W=200-250

Morrill, Charlotte; Gillespie, James E.; Phipps, Robert J. published the artcile< An Aminative Rearrangement of O-(Arenesulfonyl)hydroxylamines: Facile Access to ortho-Sulfonyl Anilines>, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride, the main research area is ortho sulfonyl aniline regioselective preparation; arenesulfonyl hydroxylamine ortho aminative rearrangement ferrous sulfate catalyst; Arene Amination; Ion-Pairing; Non-Covalent Interactions; Radical Reactions; Regioselectivity.

The discovery of an aromatic rearrangement reaction of O-(arenesulfonyl)hydroxylamines which lead directly to ortho-aminoarylsulfonic acids and ortho-aminobenzenemethanesulfonic acids through formation of a new C-N bond with excellent levels of regiocontrol for the ortho position(s) over all others was reported. The rearrangement was proceeding through an intermol. mechanism and proposed that the regiocontrol observed was the result of attractive non-covalent interactions occurring during the C-N bond-forming step. Importantly, this method was complementary to classical aniline sulfonation in terms of the variously substituted regioisomers that could be obtained and it was also applicable to O-(benzylsulfonyl) hydroxylamines.

Angewandte Chemie, International Edition published new progress about Amination catalysts. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Name: 3-Chloro-4-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Monastyrskyi, Andrii; Nilchan, Napon; Quereda, Victor; Noguchi, Yoshihiko; Ruiz, Claudia; Grant, Wayne; Cameron, Michael; Duckett, Derek; Roush, William published the artcile< Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer>, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine, the main research area is casein kinase 1delta 1epsilon inhibitor antitumor breast purine preparation; Breast cancer; Casein kinase 1 delta and epsilon; Inhibitor; Kinase; Structure-activity relationship.

Casein kinase 1δ/ε have been identified as promising therapeutic target for oncol. application, including breast and brain cancer. Here, the authors described the authors’ continued efforts in optimization of a lead series of purine scaffold inhibitors that led to identification of two new CK1δ/ε inhibitors 17 (N-((4,5-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3,5-difluorophenyl)-2-morpholino-9H-purin-6-amine) and 28 (N-((4,5-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-(4-methylpiperazin-1-yl)-9-(pyridin-4-yl)-9H-purin-6-amine) displaying low nanomolar values in antiproliferative assays against the human MDA-MB-231 triple neg. breast cancer cell line and have phys., in vitro and in vivo pharmacokinetic properties suitable for use in proof of principle animal xenograft studies against human cancers.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Recommanded Product: 2,6-Dichloro-9-methyl-9H-purine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Sheng-Ren; Ke, Yi-Yu; Yeh, Teng-Kuang; Lin, Shu-Yu; Ou, Li-Chin; Chen, Shu-Chun; Chang, Wan-Ting; Chang, Hsiao-Fu; Wu, Zih-Huei; Hsieh, Chih-Chien; Law, Ping-Yee; Loh, Horace H.; Shih, Chuan; Lai, Yiu-Kay; Yeh, Shiu-Hwa; Ueng, Shau-Hua published the artcile< Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists>, SDS of cas: 162046-61-9, the main research area is analgesic pain tetrahydroisoquinolinylmethylbenzamide opioid receptor agonist pharmacokinetics; Anti-nociceptive effects; Blood-brain barrier; Penetration; Structure-activity relationship; Tail-flick test; κ-opioid receptor agonist; μ-opioid receptor agonist.

μ-Opioid receptor (MOR) agonists are analgesics used clin. for the treatment of moderate to severe pain, but their use is associated with severe adverse effects such as respiratory depression, constipation, tolerance, dependence, and rewarding effects. In this study, the authors identified I as a novel opioid receptor agonist by high-throughput screening. Structural modifications made to I to improve potency and blood-brain-barrier (BBB) penetration resulted in compounds II and III. Compound II was a potent MOR/KOR (κ-opioid receptor) agonist, and compound III was a potent MOR and medium KOR agonist. Both II and III demonstrated a significant antinociceptive effect in a tail-flick test performed in wild type (WT) B6 mice. The ED50 value of III was 1.059 mg/kg, and the brain concentrations of II and III were 7424 and 11696 ng/g, resp. Accordingly, compounds II and III are proposed for lead optimization and in vivo disease-related pain studies.

European Journal of Medicinal Chemistry published new progress about Analgesics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, SDS of cas: 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lorenz, Daniel A.; Kaur, Tanpreet; Kerk, Samuel A.; Gallagher, Erin E.; Sandoval, Jorge; Garner, Amanda L. published the artcile< Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction>, Electric Literature of 42413-03-6, the main research area is catalytic enzyme linked click chem assay catELCCA.

Dysregulation of microRNA (miRNA) expression has been linked to many human diseases; however, because of the challenges associated with RNA-targeted drug discovery, addnl. approaches are needed for probing miRNA biol. The emerging regulatory role of miRNA-binding proteins in miRNA maturation presents such an alternative strategy. Exploiting our laboratory’s click chem.-based high-throughput screening (HTS) technol., catalytic enzyme-linked click chem. assay or cat-ELCCA, we have designed a modular method by which to discover new chem. tools for manipulating pre-miRNA-miRNA-binding protein interactions. Using the pre-let-7d-Lin28 interaction as proof-of-concept, the results presented demonstrate how HTS using cat-ELCCA can enable the discovery of small mols. targeting RNA-protein interactions.

ACS Medicinal Chemistry Letters published new progress about Bioassay. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Electric Literature of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nycholat, Corwin M.; Duan, Shiteng; Knuplez, Eva; Worth, Charli; Elich, Mila; Yao, Anzhi; O’Sullivan, Jeremy; McBride, Ryan; Wei, Yadong; Fernandes, Steve M.; Zhu, Zhou; Schnaar, Ronald L.; Bochner, Bruce S.; Paulson, James C. published the artcile< A sulfonamide sialoside analogue for targeting Siglec-8 and -F on immune cells>, Reference of 42413-03-6, the main research area is sulfonamide sialoside analog Siglec8 ligand immune cell targeting.

The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor signaling. Human Siglec-8, for instance, has been identified as a therapeutic target for the treatment of eosinophil and mast cell disorders. A promising strategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Siglec ligands. A key challenge for this approach is the identification of a high affinity ligand for the target Siglec. Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogs was screened to identify potential lead compounds The best ligand, 9-N-(2-naphthyl-sulfonyl)-Neu5Acα2-3-[6-O-sulfo]-Galβ1-4GlcNAc (6′-O-sulfo NSANeu5Ac) combined the lead 2-naphthyl sulfonyl C-9 substituent with the preferred sulfated scaffold. The ligand 6′-O-sulfo NSANeu5Ac was conjugated to lipids for display on liposomes to evaluate targeted delivery to cells. Targeted liposomes showed strong in vitro binding/uptake and selectivity to cells expressing Siglec-8 or -F and, when administered to mice, exhibit in vivo targeting to Siglec-F+ eosinophils.

Journal of the American Chemical Society published new progress about B cell. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Reference of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bourzikat, Otmane; El Abbouchi, Abdelmoula; Ghammaz, Hamza; El Brahmi, Nabil; El Fahime, Elmostfa; Paris, Arnaud; Daniellou, Richard; Suzenet, Franck; Guillaumet, Gerald; El Kazzouli, Said published the artcile< Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-b]pyridazine Derivatives Bearing Sulfonamides>, Reference of 22952-32-5, the main research area is arylsulfonyl tetrahydroimidazopyridazine preparation anticancer human mol docking SAR; sulfonyl chloride phenyl tetrahydroimidazopyridazine sulfonylation; 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazine; anticancer activity; human cancer cell lines; sulfonamides.

New 2-phenyl-5-(arylsulfonyl)-7,8-dihydro-6H-imidazo[1,2-b]pyridazines I [R = 4-MeC6H4, 4-F3CC6H4, 1-naphthyl, etc.] were synthesized via sulfonylation of 2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-b]pyridazine using sulfonyl chlorides. The structures of these derivatives I were elucidated by 1H NMR, 13C NMR, IR and high-resolution mass spectrometry for further characterization and were further evaluated for their anticancer activities. The anticancer activities of compounds I were evaluated against five human cancer cell lines, including A-549, Hs-683, MCF-7, SK-MEL-28 and B16-F10 cell lines with 5-fluorouracil and etoposide as reference drugs. Among the tested compounds, I [R = 5-Cl-2-OMeC6H3, 4-F3CC6H4] exhibited excellent activities in the same range of the pos. controls, 5-fluorouracil and etoposide, against MCF-7 and SK-MEL-28 cancer cell lines, with IC50 values ranging from 1 to 10 μM. The mol. docking studies of compounds, I [R = 5-Cl-2-OMeC6H3, 4-F3CC6H4] showed a strong binding with some kinases, which were linked to MCF-7 and SK-MEL-28 cancer cell lines.

Molecules published new progress about Antitumor agents. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Reference of 22952-32-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deprez-Poulain, Rebecca; Hennuyer, Nathalie; Bosc, Damien; Liang, Wenguang G.; Enee, Emmanuelle; Marechal, Xavier; Charton, Julie; Totobenazara, Jane; Berte, Gonzague; Jahklal, Jouda; Verdelet, Tristan; Dumont, Julie; Dassonneville, Sandrine; Woitrain, Eloise; Gauriot, Marion; Paquet, Charlotte; Duplan, Isabelle; Hermant, Paul; Cantrelle, Francois- Xavier; Sevin, Emmanuel; Culot, Maxime; Landry, Valerie; Herledan, Adrien; Piveteau, Catherine; Lippens, Guy; Leroux, Florence; Tang, Wei-Jen; van Endert, Peter; Staels, Bart; Deprez, Benoit published the artcile< Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice>, Quality Control of 351003-34-4, the main research area is insulin degrading enzyme glucose intolerance catalysis.

Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer’s disease and type-2 diabetes. As the major insulin-degrading protease, IDE is a candidate drug target in diabetes. Here we have used kinetic target-guided synthesis to design the first catalytic site inhibitor of IDE suitable for in vivo studies (BDM44768). Crystallog. and small angle X-ray scattering analyses show that it locks IDE in a closed conformation. Among a panel of metalloproteases, BDM44768 selectively inhibits IDE. Acute treatment of mice with BDM44768 increases insulin signalling and surprisingly impairs glucose tolerance in an IDE-dependent manner. These results confirm that IDE is involved in pathways that modulate short-term glucose homeostasis, but casts doubt on the general usefulness of the inhibition of IDE catalytic activity to treat diabetes.

Nature Communications published new progress about Alzheimer disease. 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, Quality Control of 351003-34-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yangyang; Li, Yuqiang; Peng, Long; Wu, Dong; Zhu, Lei; Yin, Guoyin published the artcile< Nickel-catalyzed migratory alkyl-alkyl cross-coupling reaction>, Formula: C8H8BrCl, the main research area is alkyl halide migratory cross coupling bond formation nickel catalyst.

A migratory cross-coupling strategy, which can overcome this obstacle to access the desired cross-coupling products ArCH(R)(CH2)nCR1R2R3 (Ar = Ph, 4-fluorophenyl, indol-3-yl, etc.; R = cyclopentyl, cyclohexyl, cycloheptyl, N-benzyl-piperidin-4-yl, 2-methyl-propan-1-yl; R1 = H, D; R2 = H, D; R3 = H; n = 0-3, 5), 1-cyclopentyl-indan, 1-cycloheptyl-indan, (1-cyclopentyl-3-methyl-pentyl)benzene was described. Accordingly, a selective migratory cross-coupling of two alkyl electrophiles (RBr, ArCH(R)(CH2)nCR1R2R3 (R3 = Br or Cl), 2-bromoindan, (5-bromo-1-cyclopentyl-3-methyl-pentyl)benzene) has been accomplished by nickel catalysis. Remarkably, this alkyl-alkyl cross-coupling reaction provides a platform to prepare 2°-2° carbon-carbon bonds from 1° and 2° carbon coupling partners. Preliminary mechanistic studies suggest that chain-walking occurs at both alkyl halides in this reaction, thus a catalytic cycle with the key step involving two alkylnickel(II) species is proposed for this transformation.

Chemical Science published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Formula: C8H8BrCl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R. published the artcile< Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4>, Related Products of 42413-03-6, the main research area is homopiperazinylsulfonamide preparation structure activity relationship pharmacokinetics mGlu4 modulator; pos allosteric modulator mGlu4 homopiperazinylsulfonamide preparation amidation sulfonamidation; sulfonyl chloride amine reactant homopiperazinylsulfonamide preparation.

Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of pos. allosteric modulators for mGlu4, a G-protein coupled receptor. This series is comprised of a homopiperazine central core, e.g. I and II. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of pos. allosteric modulators of mGlu4 provide critical research tools to further probe the mGlu4-mediated effects in Parkinson’s disease.

ACS Combinatorial Science published new progress about Amidation. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Related Products of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lukesh, John C.; Carney, Daniel W.; Dong, Huijun; Cross, R. Matthew; Shukla, Vyom; Duncan, Katharine K.; Yang, Shouliang; Brody, Daniel M.; Brutsch, Manuela M.; Radakovic, Aleksandar; Boger, Dale L. published the artcile< Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance>, Application In Synthesis of 162046-61-9, the main research area is vinblastine amide preparation antitumor.

A series of 180 vinblastine 20′ amides were prepared in three steps from com. available starting materials, systematically exploring a typically inaccessible site in the mol. enlisting a powerful functionalization strategy. Clear structure-activity relationships and a structural model were developed in the studies which provided many such 20′ amides that exhibit substantial and some even remarkable enhancements in potency, many that exhibit further improvements in activity against a Pgp overexpressing resistant cancer cell line, and an important subset of the vinblastine analogs that display little or no differential in activity against a matched pair of vinblastine sensitive and resistant (Pgp overexpressing) cell lines. The improvements in potency directly correlated with target tubulin binding affinity, and the reduction in differential functional activity against the sensitive and Pgp overexpressing resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Application In Synthesis of 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics