Tag: M.W=200-250

Kulathooran, S. published the artcileSynthesis and biological evaluation of some new chalcones using anhydrous potassium carbonate as an efficient basic catalyst by conventional and microwave assisted techniques, Quality Control of 93118-03-7, the main research area is chalcone furanyl preparation green chem antibacterial antifungal activity SAR; aryl aldehyde furan Claisen Schmidt reaction microwave irradiation diastereoselective.

Series of novel 3-(substituted aryl)-1-(5-methylfuran-2-yl)prop-2-en-1-one derivatives I [R = 3-furanyl, 2-F-3-MeOC6H3, 3-Cl-2-FC6H3, etc.] were synthesized from com. available 2-acetyl-5-methylfuran and various substituted aromatic aldehydes in presence of anhydrous potassium carbonate in ethanol solution and by microwave irradiation method with good yield compared to conventional method. Anhydrous potassium carbonate was utilized as safe, inexpensive and efficient basic catalyst for synthesis of chalcones. The structures of the all synthesized compounds were established on the basis of IR, Mass, 1H NMR and 13C NMR. The antimicrobial activities of these derivatives were evaluated by quantifying the minimal inhibitory concentration (MIC) against various microbial strains such as Escherichia coli [ATCC-9637], Staphylococcus aureus [ATCC-25923], Klebsiella pneumonia [ATCC-13883], Candida albicans [ATCC-28366], Rhizopus arrhizus [ATCC-11145] and Aspegillus niger [ATCC-26036]. Among the tested compounds, compound I [R = 5-Me-3-indolyl] exhibited strong microbial activity against most of the microbial strains except A. niger.

International Journal of Pharmaceutical Sciences and Research published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dascalu, Anca-Elena published the artcileDesign, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is hydrazine hydrazone pyrrolidinone preparation antifungal toxicity SAR; Antifungal agents; Biological screening; Hydrazine; Hydrazone; Pyrrolidin-2-one.

Twenty-eight 5-pyrrolidine-2-ones decorated by hydrazine or acyl hydrazones groups have been designed, synthesized and evaluated as antifungal agents on a panel of twelve fungal strains and three non albicans candida yeasts species which have demonstrated reduced susceptibility to commonly used antifungal drugs. Half of the target compounds exhibited good to high antifungal activities on at least one strain with MIC50 lower than the control antifungal agent – hymexazol or ketoconazole. 5-Arylhydrazino-pyrrolidin-2-ones were found active and the -NH-NH- linker proved to be essential to maintain the antifungal potential. Compound I is a broad-spectrum antifungal, active on 60% of the tested strains. Replacing the hydrazine linker by an acylhydrazone one narrowed the spectrum of activity but pyroglutamylaryl hydrazones, mainly aromatic ones, exhibited good activity, adequate “”fungicide-like”” properties and were devoted of cytotoxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about Diastereoselective synthesis. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kharas, G. B. published the artcileNovel copolymers of styrene. 4. halophenoxy ring-substituted 2-cyano-3-phenyl-2-propenamides, Computed Properties of 61343-99-5, the main research area is halophenoxycyanophenylpropenamide styrene copolymer preparation thermal property.

Novel electrophilic trisubstituted ethylenes, halophenoxy ring substituted 2-cyano-3-phenyl-2-propenamides, RC6H4CH=C(CN)CONH2, where R is 4-(4-bromophenoxy), 2-(4-chlorophenoxy), 3-(4-chlorophenoxy), 4-(3-chlorophenoxy), 4-(4-chlorophenoxy), and 4-(4-fluorophenoxy) were prepared and copolymerized with styrene. The monomers were synthesized by potassium hydroxide catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and cyanoacetamide, and characterized by CHN elemental anal., IR, 1H- and 13C-NMR. Novel copolymers of the ethylenes and styrene were prepared at equimolar monomer feed composition by solution in the presence of a radical initiator, AIBN at 70°C. The compositions of the copolymers were calculated from nitrogen anal., and the structures were analyzed by IR, 1H- and 13C-NMR, GPC, DSC, and TGA. Thus, the order of relative reactivity (1/r1) was 4-(4-ClC6H4O) (2.01) > 4-(4-FC6H4O) (0.89) > 4-(4-BrC6H4O) (0.73) > 3-(4-ClC6H4O) (0.65) > 2-(4-ClC6H4O) (0.24) > 4-(3-ClC6H4O) (0.22). High Tg of the copolymers in comparison with that of polystyrene indicated a substantial decrease in chain mobility of the copolymer due to the high dipolar character of the trisubstituted ethylene monomer unit. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500°C range with residue (10.4-15.0 wt%), which then decomposed in the 500-800°C range.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Glass transition temperature. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kharas, Gregory B. published the artcileNovel copolymers of styrene. 8. Phenoxy ring-substituted butyl 2-cyano-3-phenyl-2-propenoates, SDS of cas: 61343-99-5, the main research area is phenoxy substituted butyl cyano phenyl propenoate styrene copolymer preparation.

Novel trisubstituted ethylenes, phenoxy ring-substituted Bu 2-cyano-3-phenyl-2-propenoates, RPhCH = C(CN)CO2C4H9 (where R is 2-(4-chlorophenoxy), 3-(4-chlorophenoxy), 4-(3-chlorophenoxy), 4-(4-chlorophenoxy), 4-(4-fluorophenoxy), 2-(3-methoxyphenoxy), 2-(4-methoxyphenoxy), 3-(4-methoxyphenoxy), 4-(4-methoxyphenoxy), 3-(4-methylphenoxy)) were prepared and copolymerized with styrene. The monomers were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and Bu cyanoacetate, and characterized by CHN anal., IR, 1H and 13C-NMR. All the ethylenes were copolymerized with styrene (M1) in solution with radical initiation (ABCN) at 70°C. The compositions of the copolymers were calculated from nitrogen anal. and the structures were analyzed by IR, 1H and 13C-NMR. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500°C range with residue (3.1-6.5% wt), which then decomposed in the 500-800°C range.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Glass transition temperature. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saha, Debasmita published the artcileRapid Access to New Thiazepinyl and Oxazepinyl Phosphonates through a Green Pudovik Reaction, COA of Formula: C8H4ClF3O, the main research area is thiazepinyl oxazepinyl phosphonate preparation green Pudovik reaction; dibenzothiaoxazepin dibenzoxazepine imine cyclic alpha amino phosphonate preparation; crystal mol structure dibenzothiazepinyl phosphonate.

A simple, facile, and efficient microwave-assisted synthetic protocol for the preparation of novel dibenzothiazepinyl and dibenzoxazepinyl phosphonates has been reported. The present Pudovik approach works without a catalyst or solvent to furnish cyclic α-amino phosphonates by using dibenzothia- and dibenzoxazepines as imine substrates. This method has a greener edge and is amenable to large-scale production

Asian Journal of Organic Chemistry published new progress about Addition reaction (Pudovik). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Seth, Kapileswar published the artcile2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation, Synthetic Route of 480438-56-0, the main research area is arylphenylbenzoxazole preparation cyclooxygenase2 inhibitor; antiinflammatory arylphenylbenzoxazole preparation; benzoxazole arylphenyl preparation cyclooxygenase2 inhibitor; 2-(2-Arylphenyl)benzoxazoles; 3D QSAR; cyclooxygenase-2 selective; in vivo potency; novel anti-inflammatory scaffold.

The 2-(2-arylphenyl)benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl)benzoxazoles I [R = (un)substituted Ph] have been synthesized by Suzuki reaction of 2-(2-bromophenyl)benzoxazole. The compounds II, III, and IV selectively inhibited COX-2 with selectivity index of III much better than that of the COX-2 selective NSAID celecoxib. The in vivo anti-inflammatory potency of II and III is comparable to that of celecoxib and the nonselective NSAID diclofenac at two different doses, and IV showed better potency compared to these clin. used NSAIDs.

ACS Medicinal Chemistry Letters published new progress about Cyclooxygenase 2 inhibitors. 480438-56-0 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Synthetic Route of 480438-56-0.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chance, Leon H. published the artcile2,4-Diaminotrihalopropyltriazines derived from γ-trihalobutyronitriles, Category: chlorides-buliding-blocks, the main research area is trichlorobutyronitrile; butyronitrile trihalo; triazinediamine trihalopropyl; butyrate trihalo cyclization biguanide; biguanidine cyclization trihalobutyrate.

Cl3CCH2CH2CN and Br3CCH2CH2CN were prepared in improved yields by modification of reported methods by reacting the appropriate haloform with H2C:CHCN. Cl3CCH2CH2CO2Me, Cl3CCH2CH2CO2Et, Br3CCH2CH2CO2Me and Br3CCH2CH2CO2Et were prepared from the corresponding nitriles. 2,4-Diamino-6-(3,3,3-trichloro-1-propyl)-1,3,5-triazine and 2,4-diamino-6-(3,3,3-tribromo-1-propyl)-1,3,5-triazine were prepared by the reaction of the corresponding methyl or ethyl trihalobutyrates with biguanide. The tetramethylol derivatives of the triazines, viz., 2,4-bis[di(hydroxymethyl)amino]-6-(3,3,3-trichloro-1-propyl)-1,3,5-triazine and 2,4-bis[di(hydroxymethyl)amino]-6-(3,3,3-tribromo-1-propyl)-1,3,5-triazine, were prepared by the reaction of the triazines with alk. aqueous formaldehyde.

Journal of Chemical and Engineering Data published new progress about Cyclocondensation reaction. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lloyd-Jones, Guy C. published the artcileEnantioselective homoallyl-cyclopropanation of dibenzylideneacetone by modified allylindium halide reagents-rapid access to enantioenriched 1-styryl-norcarene, Recommanded Product: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, the main research area is asym synthesis styryl norcarene homoallyl cyclopropanation ring closing metathesis; enantioselective cyclopropanation allylindium halide dibenzylideneacetone modifier.

Dibenzylideneacetone reacts with in situ-generated allylindium halide reagents to yield 2-(3”-butenyl)-1,1-bis[(E)-2′-phenylethenyl]cyclopropane I via a homoallyl-cyclopropanation reaction. A range of enantiomerically enriched ligands have been tested as stoichiometric asym. modifiers for this process. Enantiopure compounds such as cinchona alkaloids, ephedra, aminoalcs. and tartaric acid derivatives, which have proven of utility as asym. modifiers for the indium-mediated allylation of aldehydes and ketones, were very inefficient in the homoallyl-cyclopropanation. However, mandelic acid derivatives, in particular mandelates, were found to be of significant potential. The absolute stereochem. of the cyclopropane I has been determined by degradation to 1,1-dicarboxymethyl-2-butylcyclopropane, converging with an independent enantioselective synthesis starting from hexene. Under optimized conditions by using allylindium iodide reagents and working-up with aqueous Na2SO3 to avoid iodine-mediated polymerization, I can be generated in 86% yield and 94/6 er enantiopurity with (S)-Me mandelate as modifier. The cyclopropane product I undergoes RCM to afford 1-styrylnorcarene II without loss of enantiopurity.

Tetrahedron published new progress about Cyclopropanation catalysts. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Recommanded Product: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Murakami, Takaya published the artcilePorphyrin-dye sensitized solar cell utilizing nitroxide radical mediator, Application In Synthesis of 36428-96-3, the main research area is nitroxide radical mediator porphyrin dye sensitized solar cell.

The application of nitroxide radical mediator and porphyrin dye to dye-sensitized solar cell (DSSC) was reported. A typical porphyrin 5,10,15,20-tetra(4-carboxyphenyl)porphyrin-Zn(II) (ZnTCCP) was utilized as a dye sensitizer and 1-pyrene carbonate as light-harvesting antenna dye. DSSC using the nitroxide radical 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and ZnTCCP with deoxychoal acid gave maximum properties. The DSSC which was common absorption of ZnTCCP and pyrene was decrease of photovoltaic performance. Such decrease gave less absorption of ZnTCCP due to excess pyrene dye.

Journal of Photopolymer Science and Technology published new progress about Dye-sensitized solar cells. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application In Synthesis of 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Telvekar, Vikas N. published the artcileNovel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents, Related Products of chlorides-buliding-blocks, the main research area is aryloxy benzylidene hydrazinyl benzothiazole preparation antitubercular.

A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using mol. hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 μg/mL) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0 μg/mL. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl) benzothiazole showed MIC of 1.5 μg/mL. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs. Bioorganic & Medicinal Chemistry Letters published new progress about Mycobacterium tuberculosis. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics