Tag: M.W=200-250

Rajasekhar, M. published the artcileSynthesis and antimicrobial activity of novel chalcone analogues bearing 2-furan trifluoromethyl ring, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is chalcone preparation antibacterial activity; apocynin ethyl trifluoro acetoacetate benzaldehyde fluorinated Claisen Schmidt reaction.

Preparation of chalcone I (R = 4-Cl, 2-CF3, 3-CF3, etc.) derivatives from Et 4,4,4-trifluoroacetoacetate and apocynin and their antibacterial activity. All the compounds I were screened in-vitro (at a concentration: 10 μg/disk) for their antibacterial activity against two gram-pos. strains (Staphylococcus aureus and Bacillus subtilis) and two gram-neg. strains (Escherichia coli and Pseudomonas aeruginosa). Results of the antibacterial data revealed that among all the compounds tested, compound I (R = 2-CF3, 3-CF3, 4-CF3, 4-OCF3, 4-OCHF3) showed excellent activity, while compounds I (R = 4-F, 2,4-F2, 3,4-F2, 2,6-F2) displayed good activity against all the tested bacteria.

Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruso, Jayaraman Sembian published the artcileAntimicrobial activities of novel 3-substituted[1,2,4]triazolo[4,3-b]pyridazine derivatives, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is triazolopyridazine preparation antibacterial antifungal.

A novel derivatives of 3-substituted[1,2,4]triazolo[4,3-b]pyridazine I (R1 = 3-BrC6H4, 2-Br-6-ClC6H3, 2,6-Cl2C6H3, etc.) and 7,8,9,10-tetrahydrobenzo[4,5]thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine II (R2 = 3-BrC6H4, 4-Br-C6H4, 2-F3CC6H4, etc.) were prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of Me4NBr and oxone. These derivatives were subjected to preliminary antimicrobial activities against microorganism. All the compounds exhibited good to moderate activity.

Hwahak Sekye published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruso, Jayaraman Sembian published the artcileAntimicrobial activities of novel 3-substituted-[1,2,4]triazolo[4,3-b]pyridazine derivatives, Application In Synthesis of 93118-03-7, the main research area is triazolopyridazine preparation antibacterial antifungal.

A novel derivatives of 3-substituted-[1,2,4]triazolo[4,3-b]pyridazine I [R = 3-C6H4Br, 2,6-C6H3Cl2, 4-C6H4COOH, etc.] and 7,8,9,10-tetrahydrobenzo[4,5]thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine II [R1 = 3-C6H4Br, 2-C6H4CF, cyclopropyl, etc.] were prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of Me4NBr and oxone. The derivatives I and II were subjected to preliminary antimicrobial activities against microorganism. All these compounds I and II exhibit good to moderate activity.

Journal of the Korean Chemical Society published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hossain, Mohammad Anwar published the artcileDesign, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is Pseudomonas aeruginosa virulence synthesis compound; Anti-virulence; Ciprofloxacin; P. aeruginosa; Quorum sensing.

Anti-virulence approaches in the treatment of Pseudomonas aeruginosa (PA)-induced infections have shown clin. potential in multiple in vitro and in vivo studies. However, development of these compounds is limited by several factors, including the lack of mols. capable of penetrating the membrane of gram-neg. organisms. Here, we report the identification of novel structurally diverse compounds that inhibit PqsR and LasR-based signaling and diminish virulence factor production and biofilm growth in two clin. relevant strains of P. aeruginosa. It is the first report where potential anti-virulent agents were evaluated for inhibition of several virulence factors of PA. Finally, co-treatment with these inhibitors significantly reduced the production of virulence factors induced by the presence of sub-inhibitory levels of ciprofloxacin. Further, we have analyzed the drug-likeness profile of designed compounds using quant. estimates of drug-likeness (QED) and confirmed their potential as hit mols. for further development.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chaudhari, Hemchandra K. published the artcileDesign and Synthesis of Novel Oxadiazole and Diphenyl Ether Hydrazone Derivatives of Coumarin as Potential Antibacterial Agents, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is oxadiazole diphenyl ether hydrazone coumarin antibacterial agent.

Coumarins, possesing antimicrobial activity are often used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Mol. hybridization concept was used to design coumarin hybrid mols. Synthesized mols. were evaluated for their in-vitro antibacterial activities. We designed Coumarin derivatives of di-Ph ether and oxadiazole. Most of the compounds showed antimicrobial activity against gram-pos. as well as gram-neg. bacteria. ADME properties of the mols. calculated by Qikprop program. It predicts both phys. appropriate descriptors and drug like properties. Oxadiazole and di-Ph ether hydrazone derivatives of coumarin were designed by mol. hybridization concept. Designed mols. were synthesized and confirmed by spectral data; further synthesized mols. were screened for antimicrobial activity by using the REMA plate method. We analyzed drug like properties with 44 phys. relevant descriptors of coumarin derivatives by Qikprop, out of 28 ligands 14 all coumarin-oxadiazole derivatives structures exhibited allowed values for the properties analyzed and exhibited drug-like characteristics derived from Lipinski’s rule of 5. Biol. screening of coumarin-oxadiazole derivative of nitrophenyl 8g was active against both gram pos. and neg. bacteria. It was seen that electron withdrawing substituent such as nitro group was important for activity. For coumarin -diphenyl hydrazone derivatives, halogens chloro substituent also exhibited significant activity as compare to fluoro substituted compounds The most active hydrazone derivatives were 6c and 6g with chloro and trifluoromethoxy substitution on benzene ring. In part B, fluoro substitution at aromatic ring had no effect on improvement of antibacterial activity. However it showed that electron withdrawing group were more active and exhibited significant improvement in the antibacterial activity. The efficient and instructive SAR study will provide deeper insight into further optimization of coumarin-oxadiazole and coumarin-diphenyl ether derivatives representing to promising leads for further exploration as antibacterial agents.

Current Bioactive Compounds published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kethireddy, Shashikala published the artcileSynthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is Escherichia Staphylococcus Pseudomonas Streptococcus antibacterial tetrahydroimidazo pyrimidine carbohydrazide derivative; 2-Amino pyrimidine; Antibacterial activity; Imidazo[1,2-a]pyrimidine-hydrazones; Norfloxacin.

Background: The intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biol. activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, antipyretic and anti-inflammatory properties. Results: Condensation of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide 7 with aromatic aldehydes a-k in ethanol at reflux led to the generation of hydrazone derivatives 8a-k in 80-92% yield. The synthesis of carbohydrazide 7 was accomplished in six steps from com. available 2-amino pyrimidine. The structures of the synthesized compounds were confirmed by 1H, 13C NMR, Mass and IR spectral data. All the synthesized hydrazone derivatives 8a-k were tested in vitro for their antibacterial activity. Compounds 8d, 8e and 8f exhibited excellent antibacterial activity with zone of inhibition 30-33 mm against E. coli (Gram neg. bacteria) and S. aureus (Gram pos. bacteria). These compounds also exhibited excellent antibacterial activity with zone of inhibition 22-25 mm against P. aeruginosa (Gram neg. bacteria) and S. pyogenes (Gram pos. bacteria). Conclusion: Synthesized and recorded antibacterial activity of some new 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine-hydrazone derivatives

Chemistry Central Journal published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis and cyclooxygenase-2 (COX-2) inhibiting properties of 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is cyclooxygenase inhibitor aryl pyrazole sulfonamide preparation; anti inflammatory agent; inflammation inhibitor; synthetase prostaglandin endoperoxide COX inhibitor benzisothiazole pyrazole preparation.

A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. A structure-activity relationship study within the series are discussed. Compounds prepared for this study included derivatives of 5-[3-(difluoromethyl)-5-[2-fluoro-4-(methylthio)phenyl]-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide and 5-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole dioxide (i.e., cyclic benzenesulfonamide analogs).

Letters in Drug Design & Discovery published new progress about Anti-inflammatory agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thota, Sreekanth published the artcileSynthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru(II) complexes, HPLC of Formula: 61343-99-5, the main research area is preparation ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; DNA interaction ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; cytotoxic activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; anticancer activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; Antiproliferative; Bovine serum albumin; DNA-binding; Ru(II) compounds.

The authors report on the synthesis of novel Ru(II) compounds (Ru-1 to Ru-8: I, II) bearing R-pdc, 4-Cl-pbinh ligands (R = 4-CF3, 4-F, 4-OH pdc = 3-phenyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide, pbinh = phenoxybenzylidene isonicotinyl hydrazides) and their in vitro antitumor activity toward the cell lines murine leukemia L1210, human lymphocyte CEM, human epithelial cervical carcinoma HeLa, BEL-<7402≥ and Molt4/C8. Some of the complexes exhibited more potent antiproliferative activity against cell lines than the standard drug cisplatin. Ruthenium complex Ru-2 displayed potent cytotoxicity with than that of cisplatin. DNA-binding, DNA cleavage and protein binding properties of ruthenium complexes with these ligands are reported. Interactions of these ruthenium complexes with DNA revealed an intercalative mode of binding between them. Synchronous fluorescence spectra proved that the interaction of ruthenium complexes with bovine serum albumin (BSA) resulted in a conformational change of the latter. International Journal of Biological Macromolecules published new progress about Antiproliferative agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liang, Rui published the artcileA Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors, HPLC of Formula: 3032-32-4, the main research area is EZH2 inhibitor anticancer blood brain barrier metabolic stability.

Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting EZH2, the methyltransferase component of PRC2, received U.S. Food and Drug Administration approval following promising clin. responses in cancer patients. However, the current array of EZH2 inhibitors have poor brain penetrance, limiting their use in patients with central nervous system malignancies, a number of which have been shown to be sensitive to EZH2 inhibition. To address this need, we have identified a chem. strategy, based on computational modeling of pyridone-containing EZH2 inhibitor scaffolds, to minimize P-glycoprotein activity, and here we report the first brain-penetrant EZH2 inhibitor, TDI-6118 (compound 5). Addnl., in the course of our attempts to optimize this compound, we discovered TDI-11904 (compound 21), a novel, highly potent, and peripherally active EZH2 inhibitor based on a 7 member ring structure.

ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, HPLC of Formula: 3032-32-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cankarova, Nadezda published the artcileNovel preloaded resins for solid-phase biotinylation of carboxylic acids, Product Details of C7H3ClFNO4, the main research area is carboxylic acid solid phase biotinylation.

Use of solid-phase synthesis for the derivatization of carboxylic acids with biotinylated spacers consisting of ethylenoxy units is described. An aminomethylated resin provided with an acid-labile aldehyde linker is used as the polymer support and three different systems with a reactive amino group are introduced. Acylation of each system was tested with a set of model carboxylic acids and afforded crude products of excellent purity. The preloaded resins are similar to the Biotin-PEG-NovaTagTM resin but offer several advantages including simple elongation of the spacer arm. The protocols described represent a very efficient way of modifying compounds to obtain ligands for affinity chromatog. studies.

Tetrahedron Letters published new progress about Affinity chromatography. 35112-05-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoro-5-nitrobenzoic acid, and the molecular formula is C7H3ClFNO4, Product Details of C7H3ClFNO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics