Tag: M.W=200-250

Desai, Ranjit C. published the artcile5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents, Category: chlorides-buliding-blocks, the main research area is thiazolidinedione derivative preparation structure activity peroxisome proliferator receptor antidiabetic.

A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARα/γ agonists was identified. A number of highly potent and orally bioavailable analogs were synthesized. Efficacy study results of some of these analogs in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evans, Karen A. published the artcileAmino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors, Synthetic Route of 3032-32-4, the main research area is amino acid anthranilamide preparation glycogen phosphorylase inhibitor SAR.

A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described. A solid-phase synthesis using Wang resin was also developed which provided efficient access to a variety of analogs, and resulted in the identification of key structure-activity relationships, and the discovery of the potent exemplar I (IC50 = 80 nM). The SAR scope, synthetic strategy, and in vitro results for this series are presented herein.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 3032-32-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reed, Nilgun Isik published the artcileExploring N-Arylsulfonyl-L-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is arylsulfonylproline scaffold preparation alphavbeta1 integrin inhibitor structure activity antifibrotic; RGF mimetic preparation alphavbeta1 integrin inhibitor structure activity antifibrotic; Fibrosis; TGFβ; integrin antagonist; phenylsulfonylproline; αvβ1 integrin.

One small mol. inhibitor of αvβ1 integrin, RGD mimetic c8, shows antifibrotic effects in multiple in vivo mouse models. Here the authors synthesized c8 analogs and systematically investigate their structure-activity relationships (SAR) in αvβ1 integrin inhibition. N-Phenylsulfonyl-L-homoproline analogs of c8 maintained excellent potency against αvβ1 integrin while retaining good selectivity over other RGD integrins. In addition, 2-aminopyridine or cyclic guanidine analogs were shown to be equally potent to c8. A rigid Ph linker increased the potency compared to c8, but the selectivity over other RGD integrins diminished. These results can provide further insights on design of αvβ1 integrin inhibitors as antifibrotics.

ACS Medicinal Chemistry Letters published new progress about Antifibrotic agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klavetter, Floyd L. published the artcilePhotoluminescence and electroluminescence of transparent polyphenylene derivatives, Formula: C9H8Cl2O2, the main research area is photoluminescence electroluminescence polyphenylene derivative LED device.

Blue and violet luminescence is reported of a series of polyphenylene (PPP) derivatives containing “”waxy”” side chains. While the luminescence is red-shifted by the electron-donating amino group directly bonded to the PPP chain, the length of the side-chain in these PPP derivatives does not seem to significantly shift the photoluminescence. Investigation is underway into the effect of side-chain polarity upon electroluminescence in LED devices.

Polymeric Materials Science and Engineering published new progress about Electroluminescence. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Formula: C9H8Cl2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mao, Qi published the artcileIdentification of Novel 1-O-Substituted Aporphine Analogues as Potent 5-HT2C Receptor Agonists, Synthetic Route of 32345-60-1, the main research area is serotonin 5HT2C receptor 5HT2B receptor 5HT2A receptor agonist aporphine; 5-HT2A receptor; 5-HT2B receptor; 5-HT2C receptor; Serotonin; agonist; aporphine.

The 5-HT2C receptor has emerged as a promising target in the treatment of a variety of central nervous system disorders. We have first identified aporphines as a new class of 5-HT2C receptor agonists. Structure-activity relationship results indicate that the aporphine core may be required for 5-HT2C receptor activity, and substitutions at its C1 position are important for 5-HT2C receptor activity. Our efforts to optimize our hit 15781 lead to the identification of the highly potent and selective 5-HT2C agonist 18b (MQ02-439) with an EC50 value of 104 nM and weak antagonism at the 5-HT2A and 5-HT2B receptors. The findings may serve as good starting points for the development of more potent and selective 5-HT2C agonists as valuable pharmacol. tools or potential drug candidates.

ACS Chemical Neuroscience published new progress about 5-HT2A antagonists. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bittel, Amy M. published the artcileVaried Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy, SDS of cas: 61343-99-5, the main research area is boron dipyrromethene aromatic aldehyde fluorophore stokes shift multicolor microscopy.

Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technol. While com. fluorophores cover spectral space from the UV to the near IR region and are optimized for conventional bandpass based fluorescence microscopy, they are not ideal for highly multiplexed fluorescence microscopy as they tend to have short Stokes shifts, restricting the number of fluorophores that can be detected in a single sample to four to five. Herein, we synthesized a library of 95 novel boron-dipyrromethene (BODIPY)-based fluorophores and screened their photophys., optical and spectral properties for their utility in multicolor microscopy. A subset of our BODIPY-based fluorophores yielded varied length Stokes shifts probes, which were used to create a five-color image using a single excitation with confocal laser scanning microscopy for the first time. Combining these novel fluorophores with conventional fluorophores could facilitate imaging in up to nine to ten colors using linear unmixing based microscopy approaches.

Scientific Reports published new progress about Biological imaging. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Toya, Michihisa published the artcileSynthesis and properties of helically-folded poly(arylenediethynylene)s, Product Details of C17H10O2, the main research area is polyarylenediethynylene helical foldamer naphthalene pyrene pyridine polymerization photophys property.

Aryl-based helical foldamers with diacetylene linkers are not only capable of providing phys. large diameter cavities, but can also showcase a variety of properties, such as structural transformation, that the corresponding foldamers with simple acetylene linkers cannot achieve. Here, the authors have developed helical foldamers based on poly(arylene diethynylene)s (poly-ArDEs), in which each aryl group is connected by diacetylene linkers. The poly-ArDEs with naphthalene, pyrene and pyridine as a central aryl group each expressed unique properties. The foldamers incorporating naphthalene and pyrene stabilized the helical folding in a variety of solvents. In addition, the concentration-dependent emission by the pyrene polymer was completely different from that of the monomer due to its folded three-dimensional structure. The pyridine-based polymer showed unexpected solvent dependence and stimuli responsiveness, suggesting possible applications in sensing. These properties were elucidated in detail by UV-Vis absorption, fluorescence, and CD spectra, mol. dynamics calculations, and titration experiments

Polymer Chemistry published new progress about Circular dichroism. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Product Details of C17H10O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hara, Nobuyuki published the artcileInter- and intramolecular excimer circularly polarised luminescence of planar chiral paracyclophane-pyrene luminophores, Computed Properties of 36428-96-3, the main research area is paracyclophane pyrene luminophore intramol excimer.

Two types of planar chiral [2,2]paracyclophane-pyrene luminophores (1 and 2) with different binding positions of the fluorescent pyrene units were synthesized. (R)/(S)-1 with 1-pyrene units exhibited green intermol. excimer circularly polarised luminescence (CPL) at 530 nm in the KBr-pellet, but exhibited no CPL signal in dilute CHCl3 solution In contrast, (R)/(S)-2 with 2-pyrene units exhibited a blue intramol. excimer CPL at 450 nm in CHCl3 solution This is the first example of using the binding position of pyrene and the external environment to tune the type (inter- or intramol.) and chiroptical sign of excimer CPL.

RSC Advances published new progress about Circular dichroism. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Computed Properties of 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kirk, T. Kent published the artcileOxygenation of 4-alkoxyl groups in alkoxybenzoic acids by Polyporus dichrous, Application of 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is alkoxybenzoate oxidation Polyporus; lignin degradation Polyporus.

The degradation of several alkyl ethers of vanillic acid, 3-ethoxy-4-hydroxybenzoic acid, and of syringic acid by the lignin-decomposing fungus P. dichrous included 4-dealkylation, hydroxylation of the 4-alkoxyl groups, and reduction of carboxyl groups. The dealkylations and hydroxylations indicate that the fungus has a relatively nonspecific mechanism for oxygenating various 4-alkoxyl groups of alkoxybenzoic acids; no evidence for oxygenation of 3-alkoxyl groups was obtained. Hydroxylation products were generally degraded further, probably via dealkylation. The vanillic acid and 3-ethoxy-4-hydroxybenzoic acid formed by dealkylations were readily metabolized. Although the isopropyl ether of syringic acid was hydroxylated to 2-(4-carboxyl-2,6-dimethoxyphenoxy)propan-1-ol, neither this compound nor the parent isopropyl ether was dealkylated; syringic acid itself was only slowly and incompletely metabolized. The relation of these results to lignin degradation is discussed.

Applied Microbiology published new progress about Polyporus dichrous. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Application of 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kar, Tapas published the artcileSite Preferences of Carboyxl Groups on the Periphery of Graphene and Their Characteristic IR Spectra, Application In Synthesis of 36428-96-3, the main research area is site preference carboyxl group periphery graphene IR spectrum.

Energetics of carboxyl groups at the periphery of a graphene sheet are studied using d. functional theory (B3LYP) with a 6-31G* basis set, augmented with diffuse functions on O. Corner sites are energetically preferred followed by zigzag edges, and armchair edges are least stable. The energy and geometry of each is attributed to a competition between π-conjugation and steric repulsion factors. Vibrational analyses reveal certain features that are characteristic of each site location, which may help in the assignment of exptl. spectra of graphene and other polycyclic aromatic hydrocarbons. For example, zigzag sites typically lead to an intense C=O stretching band that occurs below 1700 cm-1, quite uncommon for the carboxyl group.

Journal of Physical Chemistry C published new progress about Ab initio methods. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application In Synthesis of 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics