Tag: M.W=200-250

Bernardo, Paul H. published the artcileSynthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid, the publication is Pure and Applied Chemistry (2011), 83(3), 723-731, database is CAplus.

Symposium report presented at the 18th International Conference on Organic Synthesis (ICOS) Bergen, Norway 1-6 August, 2010. A small library of pyridine-based rhodanine analogs of BH-3I-1 [i.e., 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-3-thiazolidineacetic acid] was designed, the synthesis of the target compound was achieved using amino acids as starting materials and the products thus obtained were screened against B-cell lymphoma (extra large, Bcl-XL, antiapoptotic protein, inhibitor of apoptosis proteins) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-(carboxy)fluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-mol. inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors.

Pure and Applied Chemistry published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Recommanded Product: 3-Chloro-4-isopropoxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Moldavskaya, N. A. published the artcileHydrosilylation of olefins in the presence of phosphoryl complexes of nickel(II), Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Zhurnal Obshchei Khimii (1981), 51(7), 1621-4, database is CAplus.

Hydrosilylating CH₂:CHR (R = hexyl, pentyl) with Cl₂HSiMe gave mixtures of RCH₂CH₂SiMeCl₂ and RCH₂CH₂SiMeHCl in the presence of NiL₂X₂ (L = substituted phosphine oxide, substituted phosphine, X = Br, NO₃, Cl) at 120° for 10 h at concentrations alkene:Cl₂HSiMe:nickel complex of 1:1:10^-3 mol. Catalyst effectiveness was: Ph₃PO < R¹Ph₂PO (R¹ = alkyl) < R¹₂PhPO < R¹₃PO.

Zhurnal Obshchei Khimii published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vazquez, Alexei published the artcileIdentification of putative calorie restriction mimetics using mammalian gene expression profiles, COA of Formula: C12H15ClO3, the publication is Open Biology (2020), 10(9), 200158, database is CAplus and MEDLINE.

Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacol. approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here, I expand in the pharmacol. direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat, I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures.

Open Biology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C25H47NO8, COA of Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Klevay, Leslie M. published the artcileCholesterotropic and cuprotropic chemicals, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of the Science of Food and Agriculture (2020), 100(10), 4057, database is CAplus and MEDLINE.

A review. A dozen or so chems. modify both cholesterol and copper metabolism Ascorbic acid and cadmium, etc., inhibit copper metabolism and raise cholesterol. Calcium and clofibrate, etc., enhance copper and lower cholesterol. Perhaps the doses of dietary cholesterol and fructose in this experiment were too severe to permit fenofibrate to lower cholesterol in a manner similar to clofibrate. 2020 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Aleem, Abd El-Aleem Hassan published the artcileReactions with coumarin-3,6-disulfonyl chloride, Application of Coumarin-6-sulfonyl chloride, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1995), 47(1), 49-54, database is CAplus.

The reaction between coumarin-3,6-disulfonyl chloride (I) and amino compounds is investigated. The acid chloride reacts with aliphatic amines such as Et amine, ethanolamine, ethylenediamine or benzylamine to give the corresponding coumarin-6-sulfonamide derivatives While its reaction with secondary amines, aromatic amines or acid hydrazide gives the corresponding coumarin-3,6-disulfonamides. The reaction with hydrazine hydrate gives coumarin-6-sulfonylhydrazide or coumarin-3,6-disulfonylhydrazide, depends on the reaction conditions.

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarin sulfonamides, Safety of Coumarin-6-sulfonyl chloride, the publication is Afinidad (1998), 55(473), 67-71, database is CAplus.

Coumarin-6-sulfonyl chloride was animated with different secondary amines to give the sulfonamides. Treatment of these with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides which were converted to hydrazones by reaction with various aldehydes. The hydrazones were cyclized using acetic anhydride to yield oxadiazolines. Reaction of the hydrazides with 4-toluoyl chloride afforded the corresponding N-toluoyl derivatives which cyclized with POCl₃ to the corresponding 1,3,4-oxadiazole derivatives Thiosemicarbazide derivatives were obtained by treatment of the hydrazides with PhNCS. Cyclization of the thiosemicarbazides using POCl₃ afforded the corresponding 1,3,4-thiadiazoles.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Safety of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel-Bary, Hamed M. published the artcileReactions with coumarin: synthesis and reactions of coumarinsulfonamides, COA of Formula: C9H5ClO4S, the publication is Mansoura Science Bulletin, A: Chemistry (1997), 24(1), 161-170, database is CAplus.

Coumarin-6-sulfonyl chloride was amidated with different secondary amines to give coumarin-6-sulfonamides. The latter with hydrazine under controlled conditions effected ring-opening of the lactone ring to afford the corresponding o-hydroxycinnamoyl hydrazides. Hydrazones were obtained by condensation of the latter with aldehydes. Some reactions of the hydrazones or hydrazides were examined

Mansoura Science Bulletin, A: Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akusoba, E. U. published the artcile6-Coumarinsulfonyl chloride (6CSCL): a fluorescent label for protein molecules, SDS of cas: 10543-42-7, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1985), 320(2), 182-3, database is CAplus.

Albumin and γ-globulin were labeled with 6CSCL, purified by gel chromatog. on Sephadex G 25, and the fluorescence and other properties of the labeled proteins were studied. The fluorescence intensity of labeled albumin decreased slightly with increasing temperature and increased sharply with increasing pH. An increase in dielec. constants of solvents was accompanied by a bathochromic shift in fluorescence maximum for labeled γ-globulin. Freeze-dried conjugate lost no fluorescence intensity after refrigeration for 2 wk. 6CSCL resembles dansyl chloride in its reactions and is a promising cheap and stable label for proteins and amino acids.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chambers, Henry F. published the artcileRifabutin to the rescue?, Product Details of C12H15ClO3, the publication is Journal of Infectious Diseases (2020), 222(9), 1422-1424, database is CAplus and MEDLINE.

A review. Rifampin as the most interesting new antibiotic, specifically noting its in vitro activity against methicillin-resistant staphylococci and its good oral bioavailability. Administration of rifampin in combination with another active agent was found to prevent emergence of resistance. The activity of rifampin against bacteria within biofilms is a strong rationale for current recommendations for its use in combination therapy to treat device-related staphylococcal infections, eg, prosthetic joint infections, spinal implant infections, prosthetic-valve endocarditis, cerebrospinal fluid shunt infections. A partial list includes anticonvulsants, antiarrhythmics, antiestrogens, antipsychotics, oral anti- coagulants, antifungals, antibacterials, antiretrovirals, barbiturates, β-blockers, benzodiazepines and related drugs, calcium channel blockers, corticosteroids, cardiac glycosides preparations, clofibrate, oral contraceptives, estrogens, oral hypo- glycemic agents, immunosuppressive agents, levothyroxine, losartan, narcotic analgesics, methadone, progestins, selective 5-HT3 receptor antagonists, statins, theophylline, thiazolidinediones, and tri- cyclic antidepressants. Rifamycins (eg, rifampin, rifabutin, rifapentine, and refalazil) all have the same mechanism of action. A randomized controlled trial is warranted to define the efficacy and advantages of rifabutin compared with rifampin in combination therapy for device-related infections, so that clinicians will not have to rely on personal experience, anecdotal reports, and data from observational studies, as was the case for decades with rifampin.

Journal of Infectious Diseases published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Product Details of C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chibowski, Emil J. published the artcileSurface free energy and wettability of silyl layers on silicon determined from contact angle hysteresis, COA of Formula: C9H20Cl2Si, the publication is Advances in Colloid and Interface Science (2005), 113(2-3), 121-131, database is CAplus and MEDLINE.

Using the literature data [A.Y. Fadeev and T.J. McCarthy, Langmuir 15(1999) 3759; A.Y. Fadeev and T.J. McCarthy, Langmuir 16(2000) 7268] of the advancing and receding contact angles for H₂O, diiodomethane and hexadecane measured on various hydrophobic silyl layers (mostly monolayers) produced on Si wafers the apparent surface free energies γ^tot_s were calculated by applying new model of the contact angle hysteresis interpretation. For the same silyl layer, the calculated γ^tot_s values to some degree depended on the probe liquid used. Therefore, thus calculated the surface free energies should be considered as apparent ones. Also, also the values of the dispersion component γ_s^d of these layers depend on the probe liquid used, but to a less degree. This must be due to the strength of the force field originating from the probe liquid and the spacing between the interacting mols. The relations between γ^tot_s and γ^d_s are discussed from the equations derived. It may be postulated that applying proposed model of the contact angle hysteresis and calculating the apparent total surface free energies and the dispersion contributions better insight into wetting properties of the silyled Si surface can be achieved.

Advances in Colloid and Interface Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, COA of Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics