Tag: M.W=200-250

Nageswara Rao, Ramisetti published the artcileRP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: Method development and validation, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, the main research area is carisbamate impurity degradation product separation HPLC mass spectrometry.

A stability indicating reversed phase HPLC method was developed and validated for determination of process related impurities and forced degradants of carisbamate (CRS) in bulk drugs. Carisbamate when subjected to acid/base hydrolysis, H2O2 oxidation, photolysis and thermal stress significant degradation was observed during acid/base hydrolysis and the degradants were isolated and characterized by ESI-MS, 1H and 13C NMR. MS/MS and 2D-NMR (COSY and HSQC) studies revealed the possible isomerization of CRS under stress conditions. The optimum separation was accomplished on Agilent XDB C18 column (150 mm × 4.6 mm; 5 μm) using 0.02 M KH2PO4 (pH = 3.5) and CH3CN as a mobile phase in a gradient elution mode at a flow rate of 1.0 mL/min. The eluents were monitored by PDA detector at 211 nm and quantitation limits were obtained in the range of 0.1-0.3 μg/mL for CRS, degradants and other impurities. The LC method was validated with respect to accuracy, precision, linearity, robustness and limits of detection and quantification as per ICH guidelines.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Acid hydrolysis. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, Malavalli published the artcileSynthesis and Pharmacological Evaluation of Novel 1′-[2-(Difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-diones and Their Derivatives, Related Products of chlorides-buliding-blocks, the main research area is difluoromethoxyphenylmethyl spiro azabicyclooctane imidazolidine preparation anticonvulsant; Anticonvulsant; Isocyanate; Maximal electroshock; ScPTZ; Spirohydantoins.

A series of novel 1′-[2-(difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione substituted hydantoins was synthesized using an appropriate synthetic route and characterized by elemental anal. and spectral data. The novel mols. were screened for anticonvulsant activity in mice by maximal electroshock (MES) and s.c. pentylenetetrazol (ScPTZ)-induced seizure tests. The neurotoxicity was assessed using the rotarod method. Several compounds exhibited anticonvulsant activity in an MES seizure model and in a ScPTZ model, with lower neurotoxicity. Some title compounds showed lower central nervous system depression compared to phenytoin. The synthesis of the target compounds was achieved by a reaction of [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione with arenesulfonyl chlorides or aryl isocyanates. The title compounds thus formed included [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione sulfonamide analogs , such as a 4-fluoro-2-methylbenzenesulfonamide analog (I) and [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione amide analogs.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, Laxmi published the artcileAnticonvulsant and neurotoxicity evaluation of some novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides, Application In Synthesis of 61343-99-5, the main research area is cyclohexyl amine reaction carbon sulfide hydrazine; thiosemicarbazide cyclohexyl preparation condensation aryl aldehyde; isatin condensation cyclohexyl thiosemicarbazide; arylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; indolonylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; thiosemicarbazone preparation anticonvulsant neurotoxicity activity.

A series of novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and s.c. metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. The compounds cyclohexyl-[4-(4-chlorophenoxy)-benzylidene]thiosemicarbazide and cyclohexyl-[2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazide emerged as the most promising one with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in rotorod method.

Asian Journal of Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application In Synthesis of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, Laxmi published the artcileDesign, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is phenyl benzylidene hydrazinecarbothioamide preparation; epilepsy anticonvulsant neurotoxicity structure activity docking pharmacokinetic study.

Thirty six new N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothioamides were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models i.e. MES, scMET and 6 Hz model. The most active compound was 2-[4-(4-chlorophenoxy)benzylidene]-N-(4-fluorophenyl)hydrazinecarbothioamide, I, which showed 100% protection at 0.5 h in the 6 Hz test. Compound 2-[4-(4-bromophenoxy) benzylidene]-N-(4-bromophenyl) hydrazinecarbothioamide, II, was found to be active in both the MES and 6 Hz test. A computational study was carried out from calculation of a pharmacophore pattern and the prediction of pharmacokinetic properties. Titled compounds have also exhibited good binding properties with epilepsy mol. targets such as glutamate, GABA (A) delta and GABA (A) alpha-1 receptors, in the Lamarckian genetic algorithm based on flexible docking studies.

European Journal of Medicinal Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, Praveen published the artcileComputational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N′-[substituted]-acetohydrazides, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is anticonvulsant drug psychomotor seizure test; 2-(1; 3-benzodioxol-5-yloxy)-N’-[substituted]-acetohydrazides; 6 Hz psychomotor seizure test; computational study; docking; neurotoxicity.; synthesis.

About 50 million epileptic cases worldwide and 12 million in India are reported. Currently, available drugs yield adequate control of seizure in 60-70% of patients and show many toxic effects. These actualities provoked the search for novel, more efficacious and safer anticonvulsants. The concatenation of 2-(1,3-benzodioxol-5-yloxy)-N′-[substituted]-acetohydrazides SA 1- 10 was designed by mol. hybridization, optimized by computational study and synthesized with the objective of obtaining a prototype of potent anticonvulsant mols. especially active against partial seizures. Computational study was performed to calculate the pharmacophoric design, projection of the pharmacokinetic parameters and docking scores of the titled compounds with mol. targets of epilepsy. The anticonvulsant activity was ascertained by 6 Hz psychomotor seizure test. Minimal motor impairment showing neurotoxicity was assessed using the Rotarod test. Titled compounds possessed the indispensable elements of pharmacophore and displayed good binding affinity with mol. targets of epilepsy, such as GABA (A) alpha-1 & delta receptor, glutamate receptor, Na+/H+ exchanger and GABA- aminotransferase in docking studies. The most potent compound of the concatenation was 2-(1,3-benzodioxol-5-yloxy)-N′-[4-(4- chlorophenoxy)benzylidene]-acetohydrazide SA 4, showing 100% protection at four different time points with ED50 value 146.8 mg/kg at a TPE of 1 h in mice. The protection shown in 6 Hz test is implicated as the compound′s ability to control partial seizures. Thus, the titled compounds can be considered as potential prototype candidates for antiepileptic therapy against partial seizures.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, M. published the artcileSynthesis and structure-activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is diazaspirodecanedione amino fluorophenoxyethyl preparation anticonvulsant.

A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives was synthesized and their pharmacol. activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds I [R = 4-MeC6H4NHCO, 3-MeC6H4NHCO, 2-CF3C6H4NHCO] showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having an amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.

Medicinal Chemistry Research published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, Laxmi published the artcileDesign & synthesis of N’-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents, SDS of cas: 61343-99-5, the main research area is pyridine carbohydrazide derivative preparation anticonvulsant activity neurotoxicity; pharmacophore pharmacokinetic docking pyridinecarbohydrazide.

A series of N’-[substituted] pyridine-4-carbohydrazides were designed and synthesized keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity of the titled compounds was established after i.p. administration in three seizure models, which include MES, scMET and 6 Hz model. The most active compound of the series was N’-[4-(4-fluorophenoxy)benzylidene]pyridine-4-carbohydrazide (I), which showed a MES ED50 value of 128.3 mg/kg and 6 Hz ED50 value of 53.3 mg/kg in mice. The median toxic dose (TD50) was 343.6 mg/kg, providing compound I with a protection index of 2.67 in the MES test and 6.44 in 6 Hz test. A computational study was also carried out, including calculation of pharmacophore pattern, prediction of pharmacokinetic properties and docking studies.

European Journal of Medicinal Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, Praveen published the artcileAnticonvulsant and neurotoxicity evaluation of some novel 3-{[substituted]-amino}-2-phenyl-3H-quinazolin-4-one, Application of 4-(4-Chlorophenoxy)benzaldehyde, the main research area is anticonvulsant neurotoxicity aminophenylquinazolinone preparation structure activity.

Various 3-{[substituted]-amino}-2-phenyl-3H-quinazolin-4-one were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and s.c. metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the Rotorod method. The 3-{[4-(4-Fluoro-phenoxy)-benzylidene]-amino}-2-phenyl-3H-quinazolin-4-one 7b and 3-{[4-(4-Chloro-3-methyl-phenoxy)-benzylidene]-amino}-2-phenyl-3H-quinazolin-4-one 7e emerged as the most promising compounds with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in Rotorod method.

International Journal of Pharmacology and Biological Sciences published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application of 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kohlmann, Anna published the artcileFragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors, Formula: C7H6ClNO4, the main research area is preparation lactate dehydrogenase A inhibitor cancer.

Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative phosphorylation to generate ATP, a phenomenon known as the Warburg effect. The inhibition of LDH-A by small mols. is therefore of interest for potential cancer treatments. We describe the identification and optimization of LDH-A inhibitors by fragment-based drug discovery. We applied ligand based NMR screening to identify low affinity fragments binding to LDH-A. The dissociation constants (Kd) and enzyme inhibition (IC50) of fragment hits were measured by surface plasmon resonance (SPR) and enzyme assays, resp. The binding modes of selected fragments were investigated by X-ray crystallog. Fragment growing and linking, followed by chem. optimization, resulted in nanomolar LDH-A inhibitors that demonstrated stoichiometric binding to LDH-A. Selected mols. inhibited lactate production in cells, suggesting target-specific inhibition in cancer cell lines.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 100959-51-1 belongs to class chlorides-buliding-blocks, name is 2-Chloro-5-methoxy-4-nitrophenol, and the molecular formula is C7H6ClNO4, Formula: C7H6ClNO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nam, Nguyen-Hai published the artcileSynthesis, bioevaluation and docking study of 5-substituted phenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents, Quality Control of 89978-31-4, the main research area is thiadiazole hydroxamic acid preparation histone deacetylase inhibitor antitumor; 5-phenyl-1,3,4-thiadiazole; cytotoxicity; heterocycle; histone deacetylase (HDAC) inhibitors.

Since the first histone deacetylase (HDAC) inhibitor (Zolinza, widely known as suberoylanilide hydroxamic acid; SAHA) was approved by the Food and Drug Administration for the treatment of T-cell lymphoma in 2006, the search for newer HDAC inhibitors has attracted a great deal of interest of medicinal chemists worldwide. As a continuity of the ongoing research in this area, the authors designed and synthesized a series of thiadiazole-based hydroxamic acids I [R = H, 2-Cl, 4-Me, etc.] as analogs of SAHA and evaluated their biol. activities. A number of compounds in this series, e.g. I [R = H], I [R = 2-Cl], I [R = 4-MeO], were found to possess potent anticancer cytotoxicity and HDAC inhibition effects. These compounds were generally two- to five-fold more potent in terms of cytotoxicity compared to SAHA against five cancer cell lines tested. Docking studies revealed that these hydroxamic acid displayed higher affinities than SAHA toward HDAC8.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Quality Control of 89978-31-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics