Tag: M.W=200-250

Archibald, John L. published the artcileDesign of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl substituted dihydropyridines, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is pyridine heteroaryl preparation antithrombotic antihypertensive; antithrombotic antihypertensive heteroaryldihydropyridine.

An approach to the design of potential combined antithrombotic-antihypertensive agents is described. A series of 1,4-dihydropyridines bearing a 1H-imidazol-1-yl or pyrid-3-yl substituted side chain in the 2-position, e.g. I (R, R1 = Me, Et; R2 = 3-pyridyl, 1-imidazolyl, R3 = 2, 3-NO2, X = CH2, CH2O) were synthesized and tested for antihypertensive activity in spontaneously hypertensive rats and for inhibition of TXA2 synthetase in rabbit platelets, in vitro. I (R = Et, R1 = Me, R2 = 1-imidazolyl, R3 = 3-NO2, X = CH2) (II) was shown to be similar in potency to nitrendipine as an antihypertensive agent. II inhibited TXA2 synthetase in rabbit and human platelets in vitro and reduced plasma TXB2 levels in rats at antihypertensive dose levels. The reductions in thromboxane production observed in vivo and in vitro were accompanied by enhanced levels of 6-KPGF1α, reflecting diversion of the arachidonic acid cascade towards prostacyclin synthesis.

Journal of Medicinal Chemistry published new progress about Anticoagulants. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Penglie published the artcileDiscovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor, SDS of cas: 23082-45-3, the main research area is betrixaban factor Xa inhibitor.

Systematic SAR studies of in vitro factor Xa inhibitory activity around N-[(5-chloropyridin-2-yl)-2-(4-N,N-dimethylcarbamimidoyl)benzamido]benzamide were performed by modifying each of the three Ph rings. A class of highly potent, selective, efficacious and orally bioavailable direct factor Xa inhibitors was discovered. These compounds were screened in hERG binding assays to examine the effects of substitution groups on the hERG channel affinity. From the leading compounds, betrixaban (PRT054021) has been selected as the clin. candidate for development.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, SDS of cas: 23082-45-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jakobsen, P. published the artcileInhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel specific 2-aryl substituted 4H-3,1-benzoxazin-4-ones, Application of 2-Amino-3,6-dichlorobenzoic acid, the main research area is benzoxazinone preparation structure anticoagulant.

The synthesis of a series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones and their evaluation as specific inhibitors of the Tissue Factor (TF)/Factor VIIa (FVIIa)-induced pathway of coagulation is reported. Inhibitory activities (IC50 values) in the range 0.17 to °40 μM on the activation of Factor X (FX) by the TF/FVIIa complex were found for compounds having one or two electroneg. substituents such as F, Cl and NO2 in the 2-aryl substituent. Different substitutions both electron-attracting and donating groups were allowed in the 5, 6, 7 and 8 positions. Several of the compounds showed a selectivity ratio towards FX and thrombin of °50, thus being the first small mols. described as potential drugs for oral antithrombotic treatment without side effects such as bleeding which is observed especially with thrombin inhibitors. The best substituent pattern being the 2-aryl group substituted with: 2-F; 2,6-F2; or 2-FX; 6-Cl; together with electroneg. substitution in the 5, 6, 7, or 8 positions. 2-Heteroaryl substituents like thienyl and furanyl were of low activity while some 2-(2-chloro-3-pyridyl) derivatives had inhibitory activity <10 μM and a good selectivity. Bioorganic & Medicinal Chemistry published new progress about Anticoagulants. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Application of 2-Amino-3,6-dichlorobenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Clarke, Earl published the artcileDesign and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist, Category: chlorides-buliding-blocks, the main research area is chloroethoxyisopropoxybenzamidomethylbenzoate preparation bioavailability retinoate receptor alpha agonist.

A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 and AGN 193836 was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid (5), which has good selectivity over the RARβ, and RARγ receptors. Anal. of the medicinal chem. parameters of the 3,5-substituents of derivatives of template (5) enabled the authors to design a class of drug-like mols. with lower intrinsic clearance and higher oral bioavailability which led to the novel RARα agonist 4-(3-chloro-4-ethoxy-5-isopropoxybenzamido)-2-methylbenzoic acid (56) that has high RARα potency and excellent selectivity vs. RARβ (2 orders of magnitude) and RARγ (4 orders of magnitude) at both the human and mouse RAR receptors with improved drug-like properties. This RARα specific agonist (56) has high oral bioavailability (>80%) in both mice and dogs with a good PK profile and was shown to be inactive in cytotoxicity and genotoxicity screens.

Bioorganic & Medicinal Chemistry published new progress about Binding energy. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shimada, Kinji published the artcileOrganic compounds in kraft bleaching spent liquors. V. Photodegradation of red-pine chlorinated oxylignin, Formula: C8H7ClO4, the main research area is UV light degradation chlorinated oxylignin; dechlorination chlorinated oxylignin photodegradation; demethoxylation chlorinated oxylignin photodegradation; photodegradation chlorinated lignin model compound.

The degradation of chlorinated oxylignin (I) in NaOH solution with UV light in the presence of O increased with increasing pH and resulted in the formation of low-mol.-weight compounds with accompanying dechlorination, demethoxylation, and cleavage of the aromatic rings and in the reduction of COD of I solutions Upon UV irradiation in the presence of N, no reduction of COD and cleavage of aromatic rings were observed, but Cl and methoxy groups were removed, the color of the I solution became dark, and the I was polymerized slightly. In the methoxy group-containing chlorinated model compounds for lignin, the cleavage of C-Cl bonds in the presence of N promoted a demethoxylation reaction.

Mokuzai Gakkaishi published new progress about Dechlorination. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Formula: C8H7ClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pews, R. Garth published the artcileSynthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines, Recommanded Product: 2,4-Dichloro-6-(trifluoromethyl)aniline, the main research area is haloaniline regioselective reductive dehalogenation; aniline substituted.

A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines were prepared via the selective para dehalogenation. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the formate hydrogen donor, Pd catalyst, solvent, and temperature on the efficiency and selectivity of the dehalogenation are discussed. Thus, 3-methyl-2,4,6-trichlorodiacetanilide (I) was hydrogenated over Pd/C in MeCN containing HCO2Na and the resulting diacetanilide hydrolyzed in aqueous HCl-AcOH to give 90% 3,2,6-Me(Cl)2C6H2NH2.

Tetrahedron published new progress about Regiochemistry. 62593-17-3 belongs to class chlorides-buliding-blocks, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, and the molecular formula is C7H4Cl2F3N, Recommanded Product: 2,4-Dichloro-6-(trifluoromethyl)aniline.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carrasco, Marta P. published the artcileProbing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites, Computed Properties of 61343-99-5, the main research area is azaaurone msbar antimalarial Plasmodium; antiprotozoal agents; azaaurones; erythrocytic stage; liver stage; malaria.

The potential of azaaurones as dual-stage antimalarial agents was investigated by assessing the effect of a small library of azaaurones on the inhibition of liver and intraerythrocytic lifecycle stages of the malaria parasite. The whole series was screened against the blood stage of a chloroquine-resistant Plasmodium falciparum strain and the liver stage of P. berghei, yielding compounds with dual-stage activity and sub-micromolar potency against erythrocytic parasites. Studies with genetically modified parasites, using a phenotypic assay based on the P. falciparum Dd2-ScDHODH line, which expresses yeast dihydroorotate dehydrogenase (DHODH), showed that one of the azaaurone derivatives has the potential to inhibit the parasite mitochondrial electron-transport chain. The global urgency in finding new therapies for malaria, especially against the underexplored liver stage, associated with chem. tractability of azaaurones, warrants further development of this chemotype. Overall, these results emphasize the azaaurone chemotype as a promising scaffold for dual-stage antimalarials.

ChemMedChem published new progress about Antimalarials. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elslager, Edward F. published the artcileAntimalarial drugs. 34. Synthesis of 5,5′-[[3-(dimethylamino)propyl]imino]bis[3-(trichloromethyl)-1,2,4-thiadiazole] and related thiadiazoles as antimalarial agents, Related Products of chlorides-buliding-blocks, the main research area is antimalarial thiadiazole derivative.

The condensation of 5-chloro-3-(trichloromethyl)-1,2,4-thiadiazole with N,N-dimethyl-1,3-propanediamine gave 5-[[3-(dimethylamino)propyl]-amino]-3-(trichloromethyl)-1,2,4-thiadiazole and 5,5′-[[3-(dimethylamino)propyl]imino]bis[3-(trichloromethyl)-1,2,-4-thiadiazole] (I), together with 5,5′-[(3-methyl[3-(trichloromethyl)-1,2,4-thiadiazole-5-yl]amino]propyl)imino]bis[3-(trichloromethyl)-1,2,4-thiadiazole] which was formed by a displacement of the distal methyl group of I. The antimalarial activity of I prompted the preparation of 5-amino-3-(trichloromethyl, methyl, and 3,4-dichlorophenyl)-1,2,-4-thiadiazoles and 5,5′-[[(dialkylamino)alkyl]imino]bis[3-(trichloromethyl, methyl, and 3,4-dichlorophenyl)-1,2,4-thiadiazoles] from an amine and the requisite 5-chloro-3-substituted-1,2,4-thiadiazoles, which were prepared from the appropriate amidine and trichloromethylsulfenyl chloride. 5-[3-[(Diethylamino)methyl]-p-anisidino]-3-(trichloromethyl)-1,2,-4-thiadiazole was active against a chloroquine-resistant line of Plasmodium berghei in the mouse. Structure-activity relations against P. berghei in mice and P. gallinaceum in chicks are discussed.

Journal of Heterocyclic Chemistry published new progress about Antimalarials. 50292-25-6 belongs to class chlorides-buliding-blocks, name is 3,4-Dichlorobenzene-1-carboximidamide hydrochloride, and the molecular formula is C7H7Cl3N2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Neilson, Douglas G. published the artcilePreparation of optically active 3-aryl-1,4-dioxaspiro[4.5]decanes and their 2-oxo derivatives; Cotton effects associated with these compounds, HPLC of Formula: 32345-60-1, the main research area is dioxaspirodecanes ORD; phenyl dioxaspirodecanes ORD; Cotton effect dioxaspirodecanes; mandelates dioxaspirodecanes; dioxolanes ORD; spiro dioxolanes ORD.

Optically active mandelic acids, ArCH(OH)CO2H (I), were prepared including I (Ar = 3,4-(methylenedioxy)phenyl, m-MeO-C6H4, and ο-BrC6H4), which had not been resolved previously. I reacted with cyclohexanone to give 3-aryl-1,4-dioxaspiro[4.5]-decan-2-ones (II). The signs of the Cotton effects agreed with those predicted by the lactone sector rule. LiAlH4 reduction of I gave glycols ArCH(OH)CH2OH, which reacted with cyclohexanone to give 2-aryl-1,4-dioxaspiro[4.5]decanes (III). III provided a skeletal background which showed up more clearly the Cotton effects associated with the lactone keto group. Changes in ORD characteristics of PhCH(OH)CH2OH on successive methylation of the OH groups were recorded.

Journal of the Chemical Society [Section] C: Organic published new progress about Cotton effect. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, HPLC of Formula: 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

McClure, Kelly J. published the artcileNovel non-benzimidazole chk2 kinase inhibitors, Formula: C13H9ClO2, the main research area is chk2 kinase inhibitor SAR benzimidazole analog preparation.

In a recent paper we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound I, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitors and allow for refinement of the binding model of these compounds to the chk2 kinase is described.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrogen bond. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Formula: C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics