Tag: M.W=200-250

Arienti, Kristen L. published the artcileCheckpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is checkpoint kinase inhibitor radioprotective arylbenzimidazole structure activity relationship.

The discovery of a series of novel, potent, and highly selective inhibitors of the DNA damage control kinase chk2 is disclosed. Here we report the first SAR study around inhibitors of this kinase. High-throughput screening of purified human chk2 led to the identification of a novel series of 2-arylbenzimidazole inhibitors of the kinase. Optimization was facilitated using homol. models of chk2 and docking of inhibitors, leading to the highly potent 2-arylbenzimidazole 2h (IC50 15 nM). Compound 2h is an ATP-competitive inhibitor of chk2 that dose dependently protects human CD4+ and CD8+ T-cells from apoptosis due to ionizing radiation. This work suggests that a selective small mol. inhibitor of chk2 could be a useful adjuvant to radiotherapy, increasing the therapeutic window of such treatment.

Journal of Medicinal Chemistry published new progress about Apoptosis. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shimada, Kinji published the artcileOrganic compounds in kraft bleaching spent liquors. IV. Toxicity bioassay of organic compounds from beech kraft bleach effluents, COA of Formula: C8H7ClO4, the main research area is bleaching effluent toxicity activated sludge; chloroorg compound toxicity activated sludge; phenolic compound toxicity activated sludge; pulp bleaching effluent toxicity.

The toxicity of organic matter fractionated from the title bleaching effluents of C, E, and D stages to activated sludge decreased in the order of C > E > D. The Et2O-soluble fraction of bleaching effluent was more toxic in pH range 4-6 than in pH range 7-9. The chlorinated low-mol.-weight compounds present in the effluent were primarily responsible for the toxicity. Some of the chlorinated low-mol.-weight compounds were synthesized and tested for toxicity. The results indicated greater toxicity in the acidic region than in the alk. one, and important contribution to toxicity of organically bonded Cl and phenolic OH group.

Mokuzai Gakkaishi published new progress about Bleaching. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, COA of Formula: C8H7ClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Lisheng published the artcileEffect of lignin structure on adsorbable organic halogens formation in chlorine dioxide bleaching, Recommanded Product: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is lignin structure chlorine dioxide bleaching; adsorbable organic halogens; bleaching; chlorine dioxide; lignin model compounds.

Adsorbable organic halogens (AOX) are formed in pulp bleaching as a result of the reaction of residual lignin with chlorine dioxide. The natural structure of lignin is very complex and it tends to be damaged by various extraction methods. All the factors can affect the study about the mechanism of AOX formation in the reaction of lignin with chlorine dioxide. Lignin model compounds, with certain structures, can be used to study the role of different lignin structures on AOX formation. The effect of lignin structure on AOX formation was determined by reacting phenolic and non-phenolic lignin model compound with a chlorine dioxide solution Vanillyl alc. (VA) and veratryl alc. (VE) were selected for the phenolic and non-phenolic lignin model compound, resp. The pattern consumption of lignin model compounds suggests that both VA and VE began reacting with chlorine dioxide within 10 min and then gradually steadied. The volume of AOX produced by VE was significantly higher than that produced by VA for a given initial lignin model compound concentration In a solution containing a combination of VA and VE in chlorine dioxide, VE was the dominant producer of AOX. This result indicates that the non-phenolic lignin structure was more easily chlorinated, while the phenolic lignin structure was mainly oxidized. In addition, AOX content produced in the combined experiments exceeded the total content of the two sep. experiments It suggested that the combination of phenolic and non-phenolic lignin structure can promote AOX formation.

Royal Society Open Science published new progress about Bleaching. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Recommanded Product: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takaishi, Kazuto published the artcileEvolving Fluorophores into Circularly Polarized Luminophores with a Chiral Naphthalene Tetramer: Proposal of Excimer Chirality Rule for Circularly Polarized Luminescence, Application of Pyrene-2-carboxylic acid, the main research area is fluorophore polycyclic aromatic circularly polarized luminescence excimer chirality.

A versatile method for converting various fluorescent polycyclic aromatic hydrocarbons into circularly polarized luminescence (CPL) excimer dyes with high glum and ΦFL values is reported. This method involves the functionalization of a chiral quaternaphthyl with six fluorophores via ester linkages in the last step of the synthesis. The usefulness of this approach was demonstrated for 1-, 2-, and 4-pyrenyl, 2- and 3-perylenyl, and 2-anthryl dyes. Most of them are the first or rare examples of CPL dyes. In the ground state, the fluorophores are tightly arranged by cumulative steric and electronic effects. In the excited state, the fluorophores form a twist excimer that maintains the ground-state conformations. The local chiral excimer directly affected the CPL properties. The systematic study on the signs of the CPLs allowed us to find a rule called the excimer chirality rule: right- and left-handed excimers exhibit (+)- and (-)-CPL, resp.

Journal of the American Chemical Society published new progress about Chirality. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vendrell, Marc published the artcileSolid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is solid phase synthesis BODIPY dye development Ig fluorescent sensor.

The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chem. Herein the authors report the first solid-phase synthesis of a BODIPY library in high purities. The authors screened the library against a set of proteins, identified an Ig fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments

Chemical Communications (Cambridge, United Kingdom) published new progress about Affinity. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Xiaoguang published the artcileDevelopment of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss, Category: chlorides-buliding-blocks, the main research area is mitochondrial pyruvate carrier inhibitors hair loss inhibition.

Herein, we report the synthesis and evaluation of novel analogs of UK-5099 both in vitro and in vivo for the development of mitochondrial pyruvate carrier (MPC) inhibitors to treat hair loss. A comprehensive understanding of the structure-activity relationship was obtained by varying four positions of the hit compound, namely, the alkyl group on the N1 position, substituents on the indole core, various aromatic and heteroaromatic core structures, and various Michael acceptors. The major discovery was that the inhibitors with a 3,5-bis(trifluoromethyl)benzyl group at the N1 position were shown to have much better activity than JXL001 (UK-5099) to increase cellular lactate production Addnl., analog JXL069, possessing a 7-azaindole heterocycle, was also shown to have significant MPC inhibition activity, which further increases the chem. space for drug design. Finally, more than 10 analogs were tested on shaved mice by topical treatment and promoted obvious hair growth on mice.

Journal of Medicinal Chemistry published new progress about Alopecia. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crawford, R. L. published the artcileDegradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment. Significance to lignin degradation and effect of chloro substituents, Safety of 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is methyl benzoate demethylation Nocardia; lignin degradation actinomycete benzoate derivative; anisate vanillate demethylation Nocardia.

N. corallina A81 from a lignin-rich environment demethylated p-anisic acid to p-hydroxybenzoic acid and isovanillic acid. It dimethylated veratric acid to a mixture of vanillic and isovanillic acids, which were both demethylated to protocatechuic acid which undergoes ring cleavage to muconic acid. An o-chloro substituent on the benzene ring hinders both demethylation and ring opening. o-Hydroxylation of p-methoxybenzoic acid to isovanillic acid was unaffected by a Cl ortho to the Me group. Though N. corallina was able to use various aromatic compounds that are structurally related to lignin, no structural changes in isolated lignin were detected.

Applied Microbiology published new progress about Nocardia. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Safety of 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nycholat, Corwin M. published the artcileA sulfonamide sialoside analogue for targeting Siglec-8 and -F on immune cells, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is sulfonamide sialoside analog Siglec8 ligand immune cell targeting.

The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor signaling. Human Siglec-8, for instance, has been identified as a therapeutic target for the treatment of eosinophil and mast cell disorders. A promising strategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Siglec ligands. A key challenge for this approach is the identification of a high affinity ligand for the target Siglec. Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogs was screened to identify potential lead compounds The best ligand, 9-N-(2-naphthyl-sulfonyl)-Neu5Acα2-3-[6-O-sulfo]-Galβ1-4GlcNAc (6′-O-sulfo NSANeu5Ac) combined the lead 2-naphthyl sulfonyl C-9 substituent with the preferred sulfated scaffold. The ligand 6′-O-sulfo NSANeu5Ac was conjugated to lipids for display on liposomes to evaluate targeted delivery to cells. Targeted liposomes showed strong in vitro binding/uptake and selectivity to cells expressing Siglec-8 or -F and, when administered to mice, exhibit in vivo targeting to Siglec-F+ eosinophils.

Journal of the American Chemical Society published new progress about B cell. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Qi published the artcileA fluorescent light-up probe as an inhibitor of intracellular β-tryptase, SDS of cas: 36428-96-3, the main research area is fluorescence light inhibitor animal cell tryptase.

A pyrene-functionalized peptidic inhibitor 1 binds to and inhibits β-tryptase in a non-competitive and reversible manner even in cells. Upon protein binding a fluorescence increase of the two pyrene fluorophores is observed which allows using 1 as a fluorescent light-up probe for this enzyme.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cell. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, SDS of cas: 36428-96-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fujimura, Kazumi published the artcileOptical resolution of some mandelic derivatives on a chemically bonded cyclodextrin stationary phase, Synthetic Route of 32345-60-1, the main research area is alkyl mandelate resolution liquid chromatog; cyclodextrin carbamate stationary phase chromatog; hydrogen bond cyclodextrin liquid chromatog; substituent effect resolution liquid chromatog; HPLC optical isomer carboxylic ester.

The preparation and use of a new type of cyclodextrin-carbamate-bonded stationary phase are described. HPLC resolution of racemic mandelates and their analogswas achieved by using this phase. The chiral recognition was explained in terms of a 3-point attachment model. In addition to the inclusion of the aromatic ring of the sample into the cavity of cyclodextrin, enantioselective interaction occurs at 2 other points; H bonding of the 2 polar substituents on the asym. C atom with secondary hydroxyl groups on the rim of the wider opening face of the cyclodextrin mol. The effect of the type and position of substituents and other factors responsible for the resolution is discussed.

Journal of Liquid Chromatography published new progress about HPLC. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics