Tag: M.W=200-250

Arcoleo, A. published the artcileReaction of 2-acetyltetralone with some esters of benzoic acid, Name: Ethyl 2,5-dichlorobenzoate, the main research area is acetyltetralone condensation benzoate; naphthopyranone phenyl.

Reaction of 2-acetylteralone (I) with RC6H4CO2Me (II, R = H, 4-Cl, 4-Me3C, 2-MeO, 2-EtO, 2-PrO) gave the corresponding triketones III, however reaction of I with II (R = 2-Cl) and 2,5-Cl2C6H3CO2Me gave III [R = 2-Cl, 2-MeO) and III (R = 2,5-Cl2, 2,5-(MeO)Cl] resp. Treating III with H2SO4 gave naphthopyranones IV.

Journal of Heterocyclic Chemistry published new progress about acetyltetralone condensation benzoate; naphthopyranone phenyl. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Name: Ethyl 2,5-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yeager, Gary W. published the artcileA convenient method for the preparation of 4-aryloxyphenols, Synthetic Route of 61343-99-5, the main research area is arylphenol; phenol aryl.

The treatment of p-RC6H4OH (R = H, Cl, Br, CMe3, OMe, OPh, CO2Et) with p-FC6H4COR1 (I; R1 = H, Me) in the presence of K2CO3 gave di-Ph ethers II. The Baeyer-Villiger oxidation of II followed by acid hydrolysis gave 4-aryloxyphenols III. Bisphenols IV (X = p-C6H4, 4,4′-C6H4OC6H4, 4,4′-biphenylene) were prepared similarly from HOXOH and I.

Synthesis published new progress about arylphenol; phenol aryl. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kas’yan, A. O. published the artcileNew N-(arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes. Synthesis, 1H and 13C NMR spectra, and chemical reactions, Formula: C7H6ClFO2S, the main research area is arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation.

N-(Arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes (I) were obtained by reaction of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes with arylsulfonyl chlorides. The contribution of the stereochem. features of the sulfonamides to the spectral structure of the endo- and exo-isomers of I was evaluated with the use of 1H and 13C NMR spectral data, including those of two-dimensional COSY and NOESY spectra. Phase-transfer catalysis alkylation and acylation of I was carried out. The reactions of endo- and exo-5-[N-benzyl-N-(3,4-dichlorophenylsulfonyl)aminomethyl]bicyclo[2.2.1]hept-2-enes with peroxyphthalic acid yielded epoxides; the orientation of substituents in the cage norbornene fragment does not affect the direction of this process.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Formula: C7H6ClFO2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Umio, Suminori published the artcileTotal synthesis of pyrrolnitrin. VI. Synthesis of nitrochloro-2-aminoacetophenones and 1-aryl-1,3-butanediones, Quality Control of 23082-45-3, the main research area is pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl.

Synthetic methods nitro-chloro-2-aminoacetophenones XYC6H3COCH(NH2)R (I) (X = 2-NO2, 3-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl; and R = H, Me), and 1-(nitrochlorophenyl)-1,3-butanediones XYC6H3COCH2COCH2R (II) (X = 2-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl, 5-Cl), starting materials for the synthesis of pyrrolnitrin (III) and related compounds, were investigated. Never rearrangement was suitable for the preparation of I. Cleavage of Et 2-(nitro-chlorobenzoyl) acetoacetate and a 2,4-pentanedione derivative led to II.

Chemical & Pharmaceutical Bulletin published new progress about pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, Quality Control of 23082-45-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Barfield, Michael published the artcileBond-order dependence of orthobenzylic coupling constants involving a methyl group [4J(MeC-CH)], Application of Pyrene-2-carboxylic acid, the main research area is spin coupling bond order relation; NMR bond order relation; methyl aromatic NMR bond order relation; orthobenzylic coupling bond order relation.

A relation between exptl. measured orthobenzylic coupling constants (Job) in a series of methyl-substituted aromatic hydrocarbons was examined by using extensive, accurate data and a variety of criteria for the π-bond orders of the C1-C2 bonds. The best linear correlations of Job were found with squares of the SCF MO bond orders and with the Pauling (VB) bond orders, as would be expected from the theor. expressions for coupling constants within the average-energy approximation In fact, the standard deviation in the correlation of the Job with the Pauling bond order is almost within the exptl. error of the measurements (0.06 Hz). Thus, Job emerge as an exptl. criterion for examining π-bond orders in conjugated systems.

Journal of the American Chemical Society published new progress about Bond order. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El-Gendy, Z. published the artcileBiologically active thiazolidinone. Part-II. Synthesis and fungitoxicities of isolated and fused thiazolidinones derived from thiosemicarbazones, Recommanded Product: 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is thiazolidinone preparation fungicide; structure activity thiazolidinone fungicide; thiosemicarbazone fungicidal activity conversion thiazolidinone.

The preparation and fungicidal activity of thiazolidinones, e.g., I, and of the precursor thiosemicarbazones, e.g., 3,4-(HO)2C6H3CH:NNC(S)NH2 (II), are reported. Thus, cyclocondensation of II with ClCH2CO2H gave I which cyclocondensed with HSCH2CO2H to give (oxothiazolidinylamino)thiazolidinone III. III was the most active compound prepared The structure activity relationship is discussed.

Journal of the Indian Chemical Society published new progress about Fungicides. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Recommanded Product: 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hansen, Poul Erik published the artcileInfrared spectra of pyrene derivatives. Relation to the substitution pattern, Recommanded Product: Pyrene-2-carboxylic acid, the main research area is IR pyrene substituent effect.

The IR of one-hundred and thirty-seven pyrene derivatives with 21 different types of substitution patterns are examined and a set of empirical rules based on band positions and intensities are formulated which allow most types of pyrene derivatives to be structurally assigned. The examination of 1-, 1,3-, 1,6-, 1,8- and 1,3,6,8-substituted pyrenes are used to reassign the 680 cm-1 band to an Au species.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about IR spectra. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Recommanded Product: Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Berg, Arne published the artcileMetalation of pyrene, Application of Pyrene-2-carboxylic acid, the main research area is .

By the action of excess BuLi in Et2O, pyrene (I) is not only metalated, as evidenced by pyrenecarboxylic acid formation on carbonation of the reaction mixture, but is also attacked in the 1, 3, and 4 positions in the ratio of 2:1:0.2. In a typical experiment, 85% I is converted to pyrene-1-carboxylic acid (II), m. 275-6° (PhCl) [Me ester, m. 107-8° (MeOH)], 3-isomer, m. 273° (AcOH-PhCl) [Me ester, m. 83-4° (MeOH)] and 4-isomer, m. 327-8° (AcOH-PhCl) [Me ester, m. 139° (MEOH)]. II with LiAlH4 in Et2O refluxed 5 hrs. gave 1-pyrenylcarbinol (III), m. 155-5.5°. The chloride of III treated with LiAlH4 in boiling Et2O and the product chromatographed from 1:1 C6H6-C6H14 on alumina gave 1-methylpyrene, m. 147.5-8.0° (EtOH) [picrate, m. 228-9° (C6H6)].

Acta Chemica Scandinavica published new progress about Metalation. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Georgiadis, Taxiarchis M. published the artcileSolid-phase synthesis of an oxalic acid amide library, Related Products of chlorides-buliding-blocks, the main research area is oxalic acid amide library solid phase synthesis; Wang resin bound oxaloyl chloride amidation; arylamine amidation resin bound oxaloyl chloride.

Monoamides of oxalic acid are of interest as bioisosteric replacements for phosphate groups in the design of enzyme inhibitors. The use of oxalic acid as a linker to the Wang resin in the synthesis of individual or libraries of phosphate biosteres is demonstrated. The highly reactive resin-bound acid chloride reacts with arylamines to yield resin-bound N-aryloxamic acids (oxanilic acids). This methodol. is especially useful for the rapid synthesis of 2-(oxalylamino)benzoic acids, because it can be utilized for library synthesis and eliminates the intermediate purification step necessary in solution-phase reactions. The products are cleaved off the resin with trifluoroacetic acid in dichloromethane in good yields.

Journal of Combinatorial Chemistry published new progress about Amidation. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Krupkova, Sona published the artcileSolid-Phase Synthesis of 3-Hydroxy-6-Nitroquinolin-4(1H)-ones with Two Diversity Positions, Product Details of C7H3ClFNO4, the main research area is anthranilic acid chloro resin bound amination esterification cyclization rearrangement; quinolinone hydroxy nitro amino aryl preparation solid phase.

The efficient solid-phase synthesis of 3-hydroxy-2,7-disubstituted-6-nitroquinolin-4(1H)-ones I [R1R2 = (CH2)5, (CH2)2O(CH2)2, R3 = 4-H2N-3,5-Cl2, 4-O2N; etc.] using Rink amide resin was described. The synthesis started from immobilized 4-chloro-5-nitroanthranilic acid, which after nucleophilic replacement of the chlorine atom with various amines R1R2NH and subsequent esterification with bromoacetophenones, afforded substituted phenacyl anthranilates. Their cyclization by heating in sulfuric acid or trifluoroacetic acid gave the corresponding hydroxyquinolinones in excellent purity.

Journal of Combinatorial Chemistry published new progress about Amination. 35112-05-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoro-5-nitrobenzoic acid, and the molecular formula is C7H3ClFNO4, Product Details of C7H3ClFNO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics