Tag: M.W=200-250

Odlyha, M. published the artcileDSC study of chemically modified porous silica powders, Category: chlorides-buliding-blocks, the publication is Thermochimica Acta (1988), 457-61, database is CAplus.

DSC was used to characterize silica samples following their reaction with n-octylmethyldichlorosilane by using the fluidized bed technique. The observed thermal effects varied with the progressive increase in octylsilyl groups bonded to the silica surface in a regular manner.

Thermochimica Acta published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Siddiqui, Farid A. published the artcilePDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity, Formula: C9H5ClO4S, the publication is ACS Omega (2020), 5(1), 832-842, database is CAplus and MEDLINE.

The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and therefore activity. However, the unloading mechanism also leads to the undesired ejection of PDE6D inhibitors. To counteract ejection, others have recently optimized inhibitors for picomolar affinities; however, cell penetration generally seems to remain an issue. To increase resilience against ejection, we engineered a “chem. spring” into prenyl-binding pocket inhibitors of PDE6D. Furthermore, cell penetration was improved by attaching a cell-penetration group, allowing us to arrive at micromolar in cellulo potencies in the first generation. Our model compounds, Deltaflexin-1 and -2, selectively disrupt K-Ras, but not H-Ras membrane organization. This selectivity profile is reflected in the antiproliferative activity on colorectal and breast cancer cells, as well as the ability to block stemness traits of lung and breast cancer cells. While our current model compounds still have a low in vitro potency, we expect that our modular and simple inhibitor redesign could significantly advance the development of pharmacol. more potent compounds against PDE6D and related targets, such as UNC119 in the future.

ACS Omega published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C6H13NO2, Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tonzola, Christopher J. published the artcileNew silicon-containing polyquinolines: Synthesis, characterization, and electroluminescence, Synthetic Route of 14799-93-0, the publication is Macromolecular Chemistry and Physics (2005), 206(13), 1271-1279, database is CAplus.

This study reports the synthesis, characterization, and electroluminescent device application of three new silicon-containing polyquinolines: poly(2,2′-(bis(p-phenyl)-diphenylsilane)-6,6′-bis(4-Ph quinoline)), poly(2,2′-(bis(p-phenyl)octylmethylsilane)-6,6′-bis(4-Ph quinoline)), and poly(2,2′-(bis(p-phenyl)diphenylsilane)-6,6′-bis(4-hexylquinoline)). The polymers with alkyl side chains were soluble in organic solvents. The new polymers showed robust thermal properties with glass transitions of 161°-339°. Cyclic voltammetry of the polymers revealed quasireversible reductions with onsets of -1.55 to -1.71 V (vs SCE) and corresponding electron affinities of 2.69-2.85 eV. Organic light-emitting devices using new polyquinolines as emissive materials showed blue (CIE coordinates = 0.21, 0.20) or blue-green (0.23, 0.36) electroluminescence with a moderate brightness (≈140 cd·m^-2) and efficiency (0.04%). The results demonstrate that silicon-containing polyquinolines are promising n-type wide band-gap semiconductors for organic electronics.

Macromolecular Chemistry and Physics published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C14H26O2, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Bary, H. published the artcileReactions with coumarin. II, COA of Formula: C9H5ClO4S, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1995), 47(1), 43-8, database is CAplus.

Coumarin-6-sulfonyl chloride reacted with o-, m-, p-phenylenediamine to give the sulfonamides I (R = 2-, 3-, 4-H₂NC₆H₄). Phenylisocyanate or phenylisothiocyanate reacted with I yielding the urea derivatives Condensation of I with acetaldehyde or acetophenone gave the imines. The sulfonic acid esters were formed through condensation of coumarin-6-sulfonyl chloride with phenolic derivatives

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd El-Bary, H. published the artcileReactions with coumarin. II, SDS of cas: 10543-42-7, the publication is Afinidad (1994), 51(452), 311-14, database is CAplus.

Coumarin-6-sulfonyl chloride (I) reacted with o-, m-, and p-phenylenediamines to give the sulfonamides. Ph isocyanate or Ph isothiocyanate reacted with the sulfonamides yielding urea derivatives Condensation of the sulfonamides with acetaldehyde or acetophenone gave imines. Sulfonic acid esters were formed through condensation of I with phenolic derivatives

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Naggar, A. M. published the artcileSynthesis and antimicrobial activity of some new N-coumarin-6-sulfonyl amino acid and dipeptide derivatives, SDS of cas: 10543-42-7, the publication is Afinidad (1987), 44(411), 431-3, database is CAplus.

Title amino acids I [X = β-Ala, Val, DL-Val, Leu, p-NHC₆H₄CO (p-Aba), m-NHC₆H₄CO (m-Aba), Tyr, etc.] were prepared by sulfonylating the appropriate amino acid with sulfonyl chloride II. I were esterified with MeOH via SOCl₂ to give the corresponding Me esters. Dipeptides III (X-X¹ = β-Ala-DL-Ser, β-Ala-Leu, Pro-Phe, Phe-Val, etc.) were prepared by coupling the appropriate I with H-X¹-OMe.HCl by DCC in THF containing Et₃N. I (X = β-Ala, p-Aba, m-Aba) and the Me esters of I (X = Leu, Pro) were active against a number of microorganisms.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdel Bary, Hamed M. published the artcileReaction with coumarin. IV, Synthetic Route of 10543-42-7, the publication is Afinidad (1995), 52(459), 344-6, database is CAplus.

Coumarin-6-sulfonyl chloride (I) reacts with 4-aminobenzenesulfonamide or 2-amino-1,3,4-thiadiazole-5-sulfonamide at the sulfonamido amino group, leaving the amino group attached to the ring unreacted. Reaction of I with 4-aminoacetophenone, or with o-, m-, or p-phenylenediamine, gives corresponding mono- and bis-sulfonamides II or III, resp. II reacts with hydrazine hydrate or phenylhydrazine to yield hydrazones. Ortho-III is cyclized with aldehydes to give benzimidazole derivatives

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sabt, Ahmed published the artcileNovel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies, Application of Coumarin-6-sulfonyl chloride, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2018), 33(1), 1095-1107, database is CAplus and MEDLINE.

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a-d, 11a-d, 13a, b, and 15a-c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocellular carcinoma), MCF-7 (breast cancer), and Caco-2 (colon cancer). HepG2 cells were the most sensitive cells to the influence of the target coumarins. Compounds and emerged as the most active members against HepG2 cells (IC₅₀ = 3.48 ± 0.28 and 5.03 ± 0.39 μM, resp.). Compounds and were able to induce apoptosis in HepG2 cells, as assured by the upregulation of the Bax and downregulation of the Bcl-2, besides boosting caspase-3 levels. Besides, compound induced a significant increase in the percentage of cells at Pre-G1 by 6.4-folds, with concurrent significant arrest in the G2-M phase by 5.4-folds compared to control. Also, displayed significant increase in the percentage of annexin V-FITC pos. apoptotic cells from 1.75-13.76%. Moreover, QSAR models were established to explore the structural requirements controlling the anti-proliferative activities.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Oyagbemi, Ademola A. published the artcileClofibrate, a PPAR-α agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anti-calbindin signaling pathways, Category: chlorides-buliding-blocks, the publication is Environmental Toxicology (2020), 35(2), 242-253, database is CAplus and MEDLINE.

Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiol. findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and motor disorders. The neuroprotective effect of clofibrate, a peroxisome proliferator-activated receptor alpha agonist, was investigated in the present study. Forty male Wistar rats were used for this study and randomly grouped into 10 rats per group as control, sodium fluoride (NaF) alone (300 ppm), NaF plus clofibrate (250 mg/kg), and NaF plus lisinopril (10 mg/kg), resp., for 7 days. NaF was administered in drinking water while clofibrate and lisinopril were administered by oral gavage. Markers of neuronal inflammation and oxidative stress, acetylcholinesterase activity, and neurobehavioral (hanging wire and open field) tests were performed. Immunohistochem. was performed on brain tissues, and they were probed with glial fibrillary acidic protein, ionized calcium-binding adaptor mol. 1, and cerebellar Ca²⁺-binding protein calbindin-D28k. The results showed that NaF significantly increased of oxidative stress and neuroinflammation and inhibited AChE activity. Immunostaining showed reactive astrocytes, microgliosis, loss of dendritic spines, and arborization in Purkinje cells in rats administered only NaF. Neurobehavioral results showed that cotreatment of NaF with clofibrate improved muscular strength and locomotion, reduced anxiety, and significantly reduced astrocytic count. Overall, cotreatment of NaF with either clofibrate or lisinopril showed neuroprotective effects by mitigating neuronal inflammation and oxidative and motor incoordination. Hence, clofibrate could be seen as a novel drug candidate against neurodegeneration and motor disorders.

Environmental Toxicology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Oyagbemi, Ademola Adetokunbo published the artcileClofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity, Related Products of chlorides-buliding-blocks, the publication is Biological Trace Element Research (2022), 200(3), 1220-1236, database is CAplus and MEDLINE.

Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized for prevention of dental caries and tartar formation, and may be added to mouthwash, mouth rinse, and toothpastes. This study is aimed at mitigating fluoride-induced hypertension and nephrotoxicity with clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist. For this study, forty male Wistar rats were used and randomly grouped into ten rats per group, control, sodium fluoride (NaF; 300 ppm) only, NaF plus clofibrate (250 mg/kg) and NaF plus lisinopril (10 mg/kg), resp., for 7 days. The administration of NaF was by drinking water ad libitum, while clofibrate and lisinopril were administered by oral gavage. Administration of NaF induced hypertension, and was accompanied with exaggerated oxidative stress; depletion of antioxidant defense system; reduced nitric oxide production; increased systolic, diastolic and mean arterial pressure; activation of angiotensin-converting enzyme activity and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); and testicular apoptosis. Treatment of rats with clofibrate reduced oxidative stress, improved antioxidant status, lowered high blood pressure through the inhibition of angiotensin-converting enzyme activity, mineralocorticoid receptor over-activation, and abrogated testicular apoptosis. Taken together, clofibrate could offer exceptional therapeutic benefit in mitigating toxicity associated with sodium fluoride.

Biological Trace Element Research published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics