Tag: M.W=200-250

Song, Qingbao published the artcileCatalytic asymmetric Henry reaction using copper(II) chiral tridentate Schiff-base complexes and their polymer-supported complexes, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Comptes Rendus Chimie (2015), 18(2), 215-222, database is CAplus.

A series of chiral tridentate Schiff-base ligands and their polymer-supported ligands were conveniently prepared and introduced as copper(II) chiral complexes for the asym. Henry reaction. The structures of these ligands have been characterized by IR, ¹H NMR, ¹³C NMR and MS. The exptl. results showed that the corresponding β-nitro alcs. were obtained in moderate to high yields (up to 98%) with up to 98% ee under mild conditions. The complex catalyst forming from copper(II) polymer-supported ligands could be recycled by a simple filtration and reused 6 times at least with similar good catalytic effect (about 94% yield and 90% ee).

Comptes Rendus Chimie published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C14H31NO2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Abbady, A. M. published the artcileγ-Ray initiated reactions. II. The addition of silicon hydrides to alkenes, HPLC of Formula: 14799-93-0, the publication is Journal of the American Chemical Society (1958), 1737-9, database is CAplus.

The appropriate alkene 1 equivalent) and silicon hydride (3 equivalents) (in the case of the fluoroalkenes the ratio was 1: 4) in a Pyrex tube purged 15 min. with N, sealed, and irradiated with the γ-radiation from 3.0 kilocurie Co₆₀ at a rate of 810,000 r.e.p./hr., the unreacted hydride and alkene evaporated, and the residue fractionated gave the corresponding adduct. In this manner were prepared adducts from SiHCl₃ (I) (alkene used, g. weight, adduct, irradiation time, % yield, b.p./mm., and n²⁵_D, of adduct given): 1-octene, 15, C₈H₁₇SiCl₃, 40, 99, 112°/15, 1.4453; Me₂C:CH₂ 20.5, iso-BuSiCl₃, 70, 95, 141°/760, 1.4346; (MeCH:)₂ (II), 12.7, EtCHMeSiCl₃65, 95, 57-8°/34, 1.4403; MeCH:CHMe₂ (III), 14, C₅H₁₁SiCl₃ (IV), 63, 94, 44-5°/8, 1.4489; cyclohexene, 30, C₆H₁₁SiCl₃, 57, 98, 81°/10, 1.4773; styrene, 30, 6 g. viscous glassy material, 20, -, -, -. Similarly were prepared adducts from MeSiHCl₂ (V) (same data given): 1-octene, 11.2, C₈H₁₇SiMeCl₂, 62, 55, 117-18°/21, 1.4422 (and 1.5 g. viscous residue); cyclohexene, 12.3, C₆H₁₁SiMeCl₂, 62, 45, 83°/15, 1.4711; CH₂:CHCH₂OAc (VI), 20, AcO(CH₂)₃SiMeCl₂, 85, 47, 121°/30, 1.4437 (and 14 g. viscous residue). Similarly were prepared new adducts from I (same data given): cyclopentene (VII), 13.6, C₅H₉SiCl₃, 39, 96, 70-1°/19, 1.4688; 1-methylcyclohexene, 6.7, MeC₆H₁₀S-MeCl₂ (VIII), 61, 92, 82-3°/8, 1.4805; CH₂:CHCH₂Cl (IX), 15.3, Cl(CH₂)₃SiCl₃, 62, 40, 58-60°/8, 1.4646 [and 34% H(CH₂CHClCH₂)₂SiO₂)₂SiCl₃, 80-110°/1.4, 1.4871, and 3.5 g. residue]; VI, 20, AcO(CH₂)₃SiCl₃, 61, 22, 101-2°/34 1.4380 [and 71% H (AcOCH₂:CHCH₂)₂SiCl₃, b₂₄ 120°, 1.4474, and 8 g. residue]; CH₂:CHCH₂CN, 16, NC(CH₂)₃SiCl₃ (X), 61, 8, 93-4°/8, 1.4654 (and 13 g. residue); cis-CHCl:CHCl, 19.4, CH₂ClCHClSiCl₃, 68, 27, 63-4°/13, 1.4762 [and 12% CH₂Cl(CHCl)₃SiCl₃, b₁₃ 103-5°, 1.4996]; PhMeC:CH₂, 17.7 g., 0.9 g. viscous oil, 39, -, 115-20°/0.4, -; C₂F₅CH:CH₂, 10.2 g., C₂F₅(CH₂)₂SiCl₃, 66, 40, 120°/760, 1.3705 (and 1.4 g. residue); C₂F₅CMe:CH₂ (XI), 19, C₂F₅CHMeCH₂SiCl₃, 65, 9, 64-5°/28, 1.3812; C₃F₇CH:CH₂ (XII), 16, C₃F₇(CH₂)₂SiCl₃, 61, 52, 62-4°/49, 1.3626 (and 0.9 g. residue); C₃F₇CMe:CH₂ (XIII), 28, C₃F₇CMeCH₂SiCl₃, 65, 11, 53-4°/24, 1.3722. X treated with MeMgI gave 62.5% NC(CH₂)₃SiMe₃, b₂₅ 91-2°, n²⁵_D 1.4254, which was hydrolyzed to Me₃Si(CH₂)₃CONH₂, flakes, m. 65-7° (petr. ether). Similarly were prepared new adducts from V (same data given): II, 12.7, EtMeCHSiMeCl₂, 65, 57, 45°/20, 1.4343; III, 14, C₅H₁₁SiMeCl₂, 63, 30, 49-50°/11, 1.4433; VII, 13.6, C₅H₉SiMeCl₂ (XIV), 62, 20, 75°/23, 1.4627 (and 0.9 g. residue); IX, 15.3, Cl(CH₂)₃SiMeCl₂, 65, 4, 68-70°/15, 1.4585 [and 11% H(CH₂ClCHCH₂)₂SiMeCl₂, b₂ 105-10°, n²⁵_D 1.4820, and 3.9 g. residue]; XI, 20, C₂F₅CHMeCH₂SiMeCl₂, 87, 1.7, 65°/52, 1.3884; XII, 13.5, C₃F₇(CH₂)₂SiMeCl₂ (XV), 111, 23, 54-5°/33, 1.3707; XIII, 15, C₃F₇ CHMeCH₂SiMeCl₂, 85, 6.4, 65°/26, 1.3748. The appropriate chlorosilane derivative in Et₂O added dropwise with stirring and cooling to a slight excess of MeMgI in Et₂O, refluxed about 17 hrs., and distilled to remove the Et₂O, the residue heated 5 hrs. on the steam bath, the Et₂O distillate again added to the residual mixture, the mixture hydrolyzed with H₂O, the precipitate dissolved with 10% H₂SO₄, the aqueous layer extracted with Et₂O, and the combined Et₂O layer and extract washed, dried, and distilled gave the corresponding tetra-alkylsilane (compound, b.p./mm., n²⁵_D, % yield, and starting material given): C₅H₁₁SiMe₃, 50°/37, 1.4191, 61, IV; MeC₆H₁₀SiMe₃, 85°/40, 1.4519, 54, VIII; C₂F₅(CH₂)₂SiMe₃, 100-1°/760, 1.3000, 56, C₂F₅(CH₂)₂SiCl₃; C₃F₇(CH₂)₂SIMe₃, 36°/30, 1.3390, 50, C₃F₇(CH₂)₂SiCl₃. The appropriate alkylchlorosilane (about 3-4 g.) in cold Et₂O treated dropwise with stirring with 100 cc. iced H₂O and shaken 5 min., the aqueous layer extracted with Et₂O, the combined Et₂O layer and extract washed with NH₃ and H₂O, dried, and distilled, and the residue dried at 100° in vacuo gave the corresponding tetraalkylsiloxane; in this manner were prepared: [C₅H₁₁SiMeO]_x, n²⁵_D 1.4478; (C₅H₉SiMeO)_x, n²⁵_D 1.4747; [C₃F₇(CH₂)₂SiMeO]_x, b₁ 110-40°, n²⁵_D 1.3592, 71.5% yield; [C₃F₇(CH₂)SiO_1.5]_x, n²⁵_D 1.3530, 98% yield.

Journal of the American Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Douglas, James J. published the artcileA Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist, Computed Properties of 254749-11-6, the publication is Angewandte Chemie, International Edition (2015), 54(49), 14898-14902, database is CAplus and MEDLINE.

In the presence of Ru(bpy)₃Cl₂ (bpy = 2,2′-bipyridine), 2-bromo-2,2-difluoroethyl arylsulfonates (and a styrenesulfonate) such as bromodifluoroethoxysulfonylthiophenecarboxylate I underwent chemoselective photochem. Smiles rearrangements mediated by Bu₃ and HCO₂H in DMSO to yield β-aryl-β,β-difluoroethanols such as II in 24-94% yields; a pyridinesulfonate and a chloropyrazolesulfonate were ineffective substrates in the photochem. Smiles rearrangement. Using the method, I was converted to the ORL-1 receptor antagonist III•HCl in five steps; the photochem. step could be conducted on 15 g scale using 0.01 mol% of the ruthenium catalyst, and the overall route compares favorably to the current synthetic sequence for III. The bromodifluoroethyl esters were prepared in two steps from Et bromodifluoroacetate via reduction to 2-bromo-2,2-difluoroethanol which was prepared on 40 g scale. 2-Bromo-2,2-difluoroethanol is volatile and a lachrymator and should be handled in a hood, and the photochem. Smiles rearrangements generate toxic SO₂ gas as a byproduct.

Angewandte Chemie, International Edition published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Computed Properties of 254749-11-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suliman, Fakhr Eldin O. published the artcileMicrofluidic precolumn derivatization of environmental phenols with coumarin-6-sulfonyl chloride and HPLC separation, Product Details of C9H5ClO4S, the publication is Journal of Chromatographic Science (2015), 53(8), 1379-1385, database is CAplus and MEDLINE.

A simple, fast, sensitive and versatile method for the anal. of phenols in water is proposed using microfluidic precolumn derivatization with the fluorogenic label coumarin-6-sulfonyl chloride (C6SCl) and HPLC separation on monolithic columns. Phenols react with C6SCl within 3.0 min in the microreactor at ambient temperature to produce phenol-coumarin sulfonamides derivatives which were separated in reversed phase high-performance liquid chromatog. followed by postcolumn ring-opening and fluorescence detection at λexc = 360 nm and λem = 460 nm. The optimum conditions for the derivatization, separation and ring-opening reaction have been established. The calibration curves were linear for the studied phenols in the range of 0.75-12.5 mg L-1. The application of the method to environmental samples was demonstrated by analyzing tap and fountain water samples spiked with the phenolic compounds

Journal of Chromatographic Science published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C18H12ClNO, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yashmin, Sabina published the artcileDMSO-assisted environmentally benign synthesis of benzo[c]-chromeno[4,3,2-gh]phenanthridines by remote oxidative hetero cross-coupling cyclization and aromatization reaction, SDS of cas: 19652-33-6, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(39), 5853-5856, database is CAplus and MEDLINE.

An unprecedented metal-free and catalyst-free synthesis of benzo[c]chromeno[4,3,2-gh]phenanthridine derivatives such as I and II, a class of 1,6-diheterophenalenoid heterocycle, was reported for the first time. The oxidative cross-coupling reaction for the remote cyclization is achieved through the in situ generated o-quinone methide intermediate followed by an electrocyclic ring closure reaction. The aromatization of the cyclohexane ring is achieved by sequential H shift, hydroxylation, and elimination reaction. DMSO-assisted concomitant cyclization and aromatization reactions are also disclosed for the first time.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C12H14IN, SDS of cas: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al-Kindy, Salma M. Z. published the artcileHIGH-PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF ANILINES WITH FLUORESCENT DETECTION AND PRE-COLUMN DERIVATIZATION, HPLC of Formula: 10543-42-7, the publication is Instrumentation Science & Technology (2013), 41(1), 48-59, database is CAplus.

A simple, sensitive, and rapid reverse-phase high-performance liquid chromatog. (RP-HPLC) method for the determination of anilines in water is proposed. The use of 2,7-diethylamino-2-oxo-2H-chromen-3-yl-benzothiazole-6-sulfonylchloride (coumarin 6-SO₂Cl) as a fluorigenic-labeling reagent was investigated. The label reacted with aniline within 30 min under mild conditions (ambient temperature, pH 9.0) to give sulfonamides that were separated by RP-HPLC employing fluorescence detection with an excitation wavelength of 470 nm and an emission wavelength of 520 nm. The optimum conditions for fluorescence, derivatization, and chromatog. separation were established. The calibration curves were linear for the range 0-800 ppb. The proposed method was applied for the determination of anilines in spiked drinking water samples and irrigation water samples with recoveries of 90.0-103.9% and relative standard deviations of 1.2-4.7%, resp. This method showed good accuracy and repeatability that can be used for the quantification of aniline in real samples.

Instrumentation Science & Technology published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suliman, Fakhr Eldin O. published the artcileAnalysis of phenols in water by high-performance liquid chromatography using coumarin-6-sulfonyl chloride as a fluorogenic precolumn label, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Journal of Chromatography A (2006), 1101(1-2), 179-184, database is CAplus and MEDLINE.

A simple, sensitive and rapid reversed-phase HPLC (RP-HPLC) method is proposed for the anal. of some environmentally important phenols in H₂O. The use of coumarin-6-sulfonyl chloride (C6SCl) as a fluorescence-labeling reagent was studied. The compound reacts with phenols within 20 min under mild conditions (ambient temperature, pH 9.0) to give sulfonates that can be separated by RP-HPLC employing fluorescence detection at λ _ex = 360 and λ _em = 460 nm. The optimum conditions for fluorescence, derivatization and chromatog. separation were established and detection limits in the range 0.1-0.9 μg L^-1 were obtained for the studied compounds The calibration curves were linear for the range 6-200 μg L^-1 for phenol, 3-200 μg L^-1 for 2-chlorophenol, 4-chlorophenol and 2,3,5-trichlorophenol and for the range of 3-100 μg L^-1 for 2,3-dichlorophenol and 3,5-dichlorophenol. The practical applicability of the method to environmental samples was demonstrated by analyzing drinking and industrial H₂O samples spiked with the phenolic compounds

Journal of Chromatography A published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C10H7IN2, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bedair, A. H. published the artcileBiologically active sulfonamides derived from α-pyrones, Formula: C9H5ClO4S, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1987), 26B(1), 91-4, database is CAplus.

Amidation of 3-carbethoxycoumarin (I) and p-H₂NC₆H₄SO₂NHR [e.g., R = H, o-, m-, and p-tolyl, CH₂Ph, C(NH₂):NH] gave R¹CONHC₆H₄SO₂NHR-p (II) (same R; R¹ = coumarin-3-yl). Treatment of I with p-H₂NNHSO₂C₆H₄NHAc gave R¹CONHNHSO₂C₆H₄R² III (same R¹; R² = NHAc-p), which was converted to III (R² = N:CHPh-p) with PhCHO after hydrolysis. Substitution reaction of 6-coumarinsulfonyl chloride (= R³SO₂Cl) with p– or o-HOC₆H₄CHO gave R³SO₃C₆H₄CHO-p (IV) or –o, resp. IV was converted to Schiff bases V (R⁴ = o-NO₂, p-Me) with R⁴C₆H₄NH₂ (same R⁴). Similar reactions occurred starting with 3-carbethoxy-5,6-benzocoumarin. II (R = H, o-tolyl), IV, and V showed bactericidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Maghraby, A. A. published the artcileSynthesis of coumarin sulfonamides, sulfonates, and related compounds, Related Products of chlorides-buliding-blocks, the publication is Egyptian Journal of Chemistry (1985), 27(4), 459-69, database is CAplus.

Condensation of coumarin-6-sulfonyl chloride I (R = SO₂Cl) with H₂NCH₂CH₂NH₂ gave sulfonamide I [R = SO₂NH(CH₂)₂NH₂], which reacted with aromatic amines to give the corresponding Schiff bases I [R = SO₂NH(CH₂)₂N:CHR¹ (R¹ = Ph, substituted Ph)]. Various coumarin-3,6-disulfonamides II [R = SO₂NHR¹ (R¹ = Ph, substituted Ph)], diarylsulfonates II [R = SO₃R¹ (R¹ = substituted Ph)], and coumarin-6-sulfonamides I [R = SO₂NHR¹ (R¹ = Bu, CH₂Ph, 2-furyl, piperidyl)] were prepared starting from coumarin-3,6-disulfonyl chloride (II, R = SO₂Cl).

Egyptian Journal of Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mandour, A. H. published the artcileSynthesis, antimicrobial and antiaflatoxigenic activities of new coumarin derivatives, Computed Properties of 10543-42-7, the publication is Egyptian Journal of Pharmaceutical Sciences (1995), 36(1-6), 71-85, database is CAplus.

Coumarin-6-sulfonyl chloride reacted with m-or p- aminoacetophenone to give sulfonamide derivatives, which in turn were condensed with semicarbazide hydrochloride to give semicarbazone derivatives Also some sulfonamides reacted with thiosemicarbazide to give thiosemicarbazone derivatives Oxidative cyclization of semicarbazones or thiosemicarbazones using thionylchloride led to the formation of 4-substituted-1,2,3-thiadiazoles using selenium dioxide led to the formation of 4-substituted-1,2,3- selenadiazoles . Also, 4-[6-nitrocoumarin-3- sulfonamido-N-(m or p-phenylene)] -1,2,3-thiadiazoles and -1,2,3-selenadiazoles. The antimicrobial and antiaflatoxigenic activities of thiadiazoles and selenadiazoles were also investigated.

Egyptian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Computed Properties of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics