Tag: M.W=200-250

Munteanu, Charissa published the artcilePd- and Ni-Based Systems for the Catalytic Borylation of Aryl (Pseudo)halides with B₂(OH)₄, COA of Formula: C12H15ClO3, the publication is Journal of Organic Chemistry (2020), 85(16), 10334-10349, database is CAplus and MEDLINE.

Despite recent advancements in metal-catalyzed borylations of aryl (pseudo)halides, there is a continuing need to develop robust methods to access both early-stage and late-stage organoboron intermediates amendable for further functionalization. In particular, the development of general catalytic systems that operate under mild reaction conditions across a broad range of electrophilic partners remains elusive. Herein, it is reported the development and application of three catalytic systems (two Pd-based and one Ni-based) for the direct borylation of aryl (pseudo)halides using tetrahydroxydiboron (B₂(OH)₄). For the Pd-based catalyst systems, it was identified general reaction conditions that allow for the sequestration of halide ions through simple precipitation that results in catalyst loadings as low as 0.01 mol % (100 ppm) and reaction temperatures as low as room temperature It is also described a complementary Ni-based catalyst system that employs simple unligated Ni(II) salts as an inexpensive alternative to the Pd-based systems for the borylation of aryl (pseudo)halides. Extrapolation of all three systems to a one-pot tandem borylation/Suzuki-Miyaura cross-coupling is also demonstrated on advanced intermediates and drug substances.

Journal of Organic Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, COA of Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramesh, Perla published the artcileRecyclable Aliphatic Nitrile-Template Enabled Remote meta-C-H Functionalization at Room Temperature, Synthetic Route of 51656-68-9, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

This article describes the development of a new aliphatic nitrile-template-directed remote meta-selective C-H olefin functionalization reaction of arenes. Remarkably, unlike the previous reports, this process was feasible at room temperature and enabled the formation of products with excellent regio-selectivity. The present protocol encompasses a broad spectrum of substituted dihydrocinnamic acids and olefins, producing meta-C-H olefinated products (up to 96% yield). In addition, the efficacy of the present method was showcased by the synthesis of various drug analogs (e.g., cholesterol, estrone, ibuprofen, and naproxen). Significantly, the robustness of meta-olefination was also demonstrated by gram-scale synthesis. The new nitrile-based meta-directing template, in particular, could be easily synthesized in two steps and recycled under mild conditions. A, B, and C represent the Intrinsic Reaction Curves (IRCs) for the meta-C-H activation, Alkene Insertion, and β-Hydride elimination, resp., along with the corresponding transition states. CYL view software was used for showing transition state structures.

Journal of Organic Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Synthetic Route of 51656-68-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Timmers, Peer H. A. published the artcileImproved drinking water quality after adding advanced oxidation for organic micropollutant removal to pretreatment of river water undergoing dune infiltration near The Hague, Netherlands, SDS of cas: 637-07-0, the publication is Journal of Hazardous Materials (2022), 128346, database is CAplus and MEDLINE.

Introduction of AOP decreased the number and concentration of OMP that were introduced during MARR, which decreased the risk of neg. impacts on ecol. and groundwater. The many uncertainties, such as seasonal and annual fluctuations of the intake water and in the infltration ponds, made it diffcult to determine if factors were directly affected by the AOP introduction. However, AOP did increase the amount of easily biol. degradable compounds, but these were diluted with non-AOP treated infltration water and degraded during transport to the dunes, making the effects on MARR negligible. Several OMP that were not removed during AOP, were removed during MARR. The overall OMP concentrations in resulting drinking water therefore decreased after introduction of AOP, without showing a measurable neg. effect on other water quality parameters.

Journal of Hazardous Materials published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C16H12N2O2, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gourdet, Benoit published the artcileRhodium-catalyzed carbometalation of ynamides with organoboron reagents, Product Details of C9H12BClO3, the publication is Tetrahedron (2010), 66(32), 6026-6031, database is CAplus.

In the presence of catalytic [Rh(cod)(MeCN)₂]BF₄, ynamides undergo carbometalation with boronic acids, arylboronic esters, and triarylboroxines. These reactions enable the regio- and stereocontrolled synthesis of multisubstituted enamides. E.g., reaction of 3-(2-phenylethynyl)oxazolidin-2-one with 4-chlorophenylboronic acid gave 65% 3-[(E)-2-(4-chlorophenyl)-2-phenylvinyl]oxazolidin-2-one (I).

Tetrahedron published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Product Details of C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rehak, Vladimir published the artcileComparison of linear and branched nonpolar chemically bonded stationary phases in high-performance liquid chromatography, Application In Synthesis of 14799-93-0, the publication is Journal of Chromatography (1980), 191(1), 71-9, database is CAplus.

Nonpolar chem. bonded stationary phases with branched or unbranched structure were synthesized, and their sp. surface areas, pore size distributions, and C contents were estimated Based on these data the number of silane mols. bonded to unit surface area of the original silica gel was calculated for each phase. Retentions of selected solute groups were measured in 4 mobile phases of various elution strength, prepared from MeOH-H₂O mixtures at various ratios. Dependence of k‘ on the length of the “bristle”, on the size and structure of the solute mol., and the elution strength of the mobile phase were plotted. Results are compared for pairs of phases having different structures but either the same total number of C atoms in the bonded mol. or the same length of the “bristle”. The synthesis of several halosilanes used for preparation of the bonded phases is described.

Journal of Chromatography published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hanessian, Stephen published the artcileDesign, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P₂/P₃ core motifs, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1972-1976, database is CAplus and MEDLINE.

Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives, e.g., I·HCl, were designed and synthesized having diverse functionality at the P₁ and P₃ sites. Potent in vitro activity against thrombin, with excellent selectivity over trypsin was found for selected analogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileInfluence of temperature and mobile phase composition on retention properties of oligomeric bonded phases in reversed-phase liquid chromatography (RPLC), Safety of Dichloro(methyl)(octyl)silane, the publication is Chromatographia (1997), 44(3/4), 135-144, database is CAplus.

The effect of temperature and mobile phase composition (methanol-water) on the retention behavior of an oligomeric series of n-octylsilyl bonded phases in reversed-phase liquid chromatog. was investigated. Plots of In k against 1/T (van’t Hoff plot) and the enthalpy of transfer (ΔH°) yields linear relationships under the conditions studied. The ΔH° values of the aromatic hydrocarbons and n-alkyl benzoates are higher than those of the polar compounds due to their higher level of interaction with the stationary phase. A linear plot of ΔH° vs. ΔS° suggest that the retention process, which is essentially controlled by non-specific (dispersive) interactions between the solutes and the bonded ligands, is identical for all cases evaluated. The existence of similar retention mechanisms is confirmed by the constant value of the enthalpy-entropy compensation temperature of the columns for a given class of compounds As expected, decreasing the methanol content (% volume/volume) of the mobile phase results in increased eluate retention times. The methylene and Ph selectivities are found to be independent of the carbon content of the stationary phases and varied only with the eluent composition In addition to their high stability under aggressive mobile phase conditions as previously reported, the results of this study generally showed that the solute retention process on oligomeric phases are similar to those exhibited by the conventional reversed phases.

Chromatographia published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Safety of Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileSyntheses of stationary phases for reversed-phase HPLC: comparison of the fluidized bed technique with the organic solvent process, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Journal of Chromatographic Science (1994), 32(3), 86-92, database is CAplus.

Chem. bonded stationary phases were prepared by fluidized bed and conventional organic solvent (toluene) bonding processes, resp., using mono-, di-, and trifunctional n-octylchlorosilanes. Solid-state ¹³C CPMAS NMR spectroscopic studies show that the surface structure of the fluidized bed packings consists only of the expected silane skeleton. In addition to the silane signals, the organic solvent packings give unexpected -OMe absorbance at ∼50 ppm, which arises from a possible side reaction between the methanol washings and the residual chlorine atoms. Chromatog. studies show that the fluidized bed packings possess higher plate numbers and superior retention characteristics for hydrocarbon solutes. This is probably caused by their higher carbon load and homogeneous distribution of the alkyl ligands on the silica surface as a result of better accessibility of the silane mols. to the surface silanol groups. In comparison with the organic solvent process, the fluidized bed technique produces a more reproducible packing regardless of the functionality of the silanizing agent.

Journal of Chromatographic Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcilePreparation, structure, and chromatographic properties of different silica-based octylsilyl bonded phases, Product Details of C9H20Cl2Si, the publication is Journal of Chromatographic Science (1990), 28(4), 186-93, database is CAplus.

The preparation, using the fluidized bed technique, of a series of silica-based octylsilyl bonded phases with or without silica deactivation prior to silanization with mono-, di- or trifunctional chlorosilane is described. The surface structures of the bonded phases are determined by ²⁹Si and ¹³C cross-polarization and magic angle spinning NMR. Furthermore, the retention behavior of the phases is investigated with polar and nonpolar solutes, and data are correlated in terms of the bonding procedure and the functionality of the silanizing agent. Mass loading experiments for a single solute on selected packings give a maximum load of about 140.0 and 70.0 μg/g of packing for large and small particles, resp., irresp. of the silanizing agent.

Journal of Chromatographic Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharma, Shivani published the artcileA review on characteristics and analytical methods of pitavastatin: a potent statin drug, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(5), 1761-1772, database is CAplus.

A review. The distinctive solutions are utilized within the treatment of hyperlipidemia join the fibric corrosive subordinates such as clofibrate, fenofibrate; bile corrosive sequestrants e.g. colestipol; cholesterol retention inhibitors e.g. ezetimibe; HMG CoA reductase inhibitors e.g. lovastatin, rosuvastatin, simvastatin and pitavastatin. Pitavastatin is novel medicate utilized within the treatment of hyperlipidemia. It must be given in single or in mixture with distinctive antihyperlipidemic specialists. Pitavastatin may be a exceptionally strong specialist called HMG CoA reductase inhibitors, or ”quot;statins.” Pitavastatin lower the levels of low-d. lipoprotein, or LDL and triglycerides within the blood, whereas expanding levels of high-d. lipoprotein, or HDL. An colossal number of techniques counting Tall Execution Fluid chromatog. (HPLC), UV-Visible spectroscopy are utilized for the assurance pitavastatin. There are different explanatory strategies utilized for sedate examination and these strategies have been approved agreeing to ICH rules (Q1A R2). Hence, this procedure can be securely utilized for standard pitavastatin quality control tests.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C14H10O4, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics