Tag: M.W=200-250

Beck, Keith Russell published the artcileSelective exchange of alkyl and chloro groups attached to silicon, COA of Formula: C9H20Cl2Si, the publication is Journal of Organometallic Chemistry (1970), 21(2), P35-P37, database is CAplus.

A method is described for the cleaving of a C-Si bond in which an alkyl group is cleaved from a Si atom and replaced by a Cl atom derived from hSiCl3. Thus, RSiMe3 (R = octyl), HSiCl3, and H2PtCl6.6H2O were heated 8 hr in a sealed tube at 151° to give 92% RSiClMe2. Similarly prepared were Me3SiCl, ClMe2Si(CH2)6SiMe2Cl, PhCH2-CH2SiMe2Cl, RSiEt2Cl, PhSiMe2Cl, ClMe2SiOSiMe2Cl, RSiMe-Cl2, and Me2SiCl2.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, COA of Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tran, Duc N. published the artcileFlow chemistry as a discovery tool to access sp²-sp³ cross-coupling reactions via diazo compounds, HPLC of Formula: 944129-07-1, the publication is Chemical Science (2015), 6(2), 1120-1125, database is CAplus and MEDLINE.

The work took advantage of an important feature of flow chem., whereby the generation of a transient species (or reactive intermediate) was followed by a transfer step into another chem. environment, before the intermediate was reacted with a coupling partner. This concept was successfully applied to achieve a room temperature sp²-sp³ cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO₂ as the oxidant.

Chemical Science published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C8H13N5O, HPLC of Formula: 944129-07-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baumgartner, Yann published the artcileOne-Pot Alkene Hydroboration/Palladium-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling, Category: chlorides-buliding-blocks, the publication is ACS Catalysis (2020), 10(18), 10508-10515, database is CAplus.

Chain-walking is a powerful approach toward the functionalization of C-H bonds remote to a functional group. Whereas various Pd-catalyzed migratory cross-couplings have been developed in the past years, the design of an efficient migratory version of the popular Suzuki-Miyaura cross-coupling has remained elusive. The current article reports a one-pot procedure consisting of alkene hydroboration and migratory Suzuki-Miyaura coupling of the resulting alkylboronic acid intermediate. A high regioselectivity for the benzylic position of the initial alkene was achieved by using P(t-Bu)₂Me as the ligand and an ortho-substituted aryl electrophile. Regioconvergence from alkene positional and geometrical isomers and long-range migration were demonstrated. Mechanistic investigations indicated that the migration occurs through a partially reversible, nondissociative mechanism.

ACS Catalysis published new progress about 117738-74-6. 117738-74-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Ester, name is Methyl 4-bromo-3-chlorobenzoate, and the molecular formula is C8H6BrClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fox, Brian M. published the artcileA Selective Prostaglandin E₂ Receptor Subtype 2 (EP2) Antagonist Increases the Macrophage-Mediated Clearance of Amyloid-Beta Plaques, Product Details of C7H4BrClO2, the publication is Journal of Medicinal Chemistry (2015), 58(13), 5256-5273, database is CAplus and MEDLINE.

A high-throughput screen resulted in the discovery of benzoxazepine I, an EP2 antagonist possessing low microsomal stability and potent CYP3A4 inhibition. Modular optimization of lead compound I resulted in the discovery of benzoxazepine II, a mol. with single-digit nM binding affinity for the EP2 receptor and significantly improved microsomal stability. It was devoid of CYP inhibition and was ∼4000-fold selective against the other EP receptors. Compound II was shown to have good PK properties in CD-1 mice and high CNS permeability in C57Bl/6s mice and Sprague-Dawley rats. In an ex vivo assay, it demonstrated the ability to increase the macrophage-mediated clearance of amyloid-beta plaques from brain slices in a dose-dependent manner.

Journal of Medicinal Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Product Details of C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Islam, A. M. published the artcileSynthesis and biological activity of coumarin sulfonamides and related compounds, Name: Coumarin-6-sulfonyl chloride, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1982), 21B(5), 487-9, database is CAplus.

The coumarins I [R = BuNH, PhCH₂NH, 2-furylmethylamino, (un)substituted anilino, (un)substituted phenoxy; R¹ = R² = H; X = O] were prepared by treating 6-coumarinylsulfonyl chloride with RH. Some I (R¹ = R² = H) were converted to I (R¹ = R² = Br, R¹ = H, R² = NO₂, R = R¹ = H, X = S, NOH). Some I had bactericidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Name: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Yisong published the artcileHydrosilylation of alkenes catalyzed by rhodium with polyethylene glycol-based ionic liquids as ligands, Product Details of C9H20Cl2Si, the publication is Journal of Organometallic Chemistry (2014), 59-63, database is CAplus.

A series of polyethylene glycol-functionalized imidazolium ionic liquids has been prepared and characterized. These ionic liquids have been successfully applied in the hydrosilylation of alkenes catalyzed by rhodium complexes. The effects of the length of the polyether chain, the amount of ionic liquid, and the reaction temperature on the catalytic performance of hydrosilylation have been investigated. Furthermore, the catalytic system has been tested for the hydrosilylation of different alkenes with triethoxysilane. The new catalytic system exhibits both excellent catalytic activity and selectivity under low-temperature conditions. The catalyst system could be recycled five times with slightly deactivation.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C14H28O5S, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Xiaoling published the artcileHydrosilylation of alkenes catalyzed by Fe powder, Application In Synthesis of 14799-93-0, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2019), 194(1-2), 1-4, database is CAplus.

A novel iron-catalyzed hydrosilylation of alkenes process under solvent-free conditions has been reported. The influence of the amount of Fe catalyst, reaction temperature and various alkenes and silanes on the hydrosilylation were investigated. High yields of adduct were obtained in the hydrosilylation of octene with MeCl₂H, Me₂ClSiH and Ph₂SiH₂ by using 10 mol% iron powder as a signal catalyst.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C5H11NO2S, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Santra, Sourav Kumar published the artcilePd^II/CuBr₂ catalysed keto α-C_sp3-H benzoxylation of N,N-dialkylamides directed by o-hydroxy groups, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(24), 4501-4504, database is CAplus and MEDLINE.

A hydroxy group directed keto α-C_sp3-H benzoyloxylation of amides, including N,N-dialkylamides and cyclic amides, has been accomplished involving ortho-hydroxy substrates possessing either an aldehydic or a keto Me (-COCH₃) group with a Pd(II)/CuBr₂ catalytic combination. The carboxy group obtained via the in situ oxidation of -CHO or -COCH₃ groups of ortho-hydroxy substrates then undergoes a cross-dehydrogenative coupling (CDC) with amides to furnish an α-benzoyloxylation product with concurrent aromatic ring bromination.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Churcher, Ian published the artcileA new series of potent benzodiazepine γ-secretase inhibitors, Application of 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(2), 179-183, database is CAplus and MEDLINE.

A new series of benzodiazepine-containing γ-secretase inhibitors, e.g. I, with potential use in the treatment of Alzheimer’s disease is disclosed. Structure-activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly potent inhibitors are described.

Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Application of 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huntress, Ernest H. published the artcileIdentification of organic compounds. IV. Chlorosulfonic acid as a reagent for identification of alkylbenzenes, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Journal of the American Chemical Society (1941), 3446-8, database is CAplus.

cf. C. A. 34, 2804.4. The use of ClSO₃H has been extended to 37 aromatic hydrocarbons. The process of part I (C. A. 34, 2803.9) was used except that 5 mL. of ClSO₃H was used and the reaction product was stirred 45 min. before pouring it onto ice; the chloride was converted by solid (NH₄)₂CO₃ to the amide. The structures of the amides of the monoalkylated benzenes were established by KMnO₄ oxidation of the side chain and indicated that the chlorosulfonylation occurred in the p-position to the side chain. For the polyalkylated benzenes the structures were inferred from previous work. The derivative of C₆H₆, the derivative of the benzenesulfonamide, the m. p. and yield are given. C₆H₆, PhSO₂NH₂, 150-50.5° 23%; Me, 4-Me, 135.5-6°, 36-44%; Et, 4-Et, 109-10° 73-95%; 1,2-Me₂, 3,4-Me₂, 143-4°, 67%; 1,3-Me₂, 2,4-Me₂, 136.5-7° 78%; 1,4-Me₃, 2,5-Me₂, 145.5-6°, 84%; Pr, 4-Pr, 107-8°, 65-95%; iso-Pr, 4-iso-Pr, 104.5-5.5°, 82-8%; 1,2,4-Me₃, 2,4,5-Me₃, 175-6°, 52%; 1,3,5-Me₃, 2,4,6-Me₃, 141.5-2.5°, 57%; Bu, 4-Bu, 94.5-5°, 80%; sec-Bu, 4-sec-Bu, 81-2.5°, 63-72%; tert-Bu, 4-tert-Bu, 136-7°, 100%; iso-Bu, 4-iso-Bu, 84-5°, 82%; 1,4-Me(iso-Pr), 2,5-Me(iso-Pr), 114.5-15.5°, 84-7%; 1,3-Et₂, 2,4-Et₂(?), 98-9°, 57-8%; 1,3,4-Me₂Et, 2,4,5-Me₂Et(?), 147-8°, 80-5%; 1,2,3,4-Me₄, 2,3,4,5-Me₄, 183.5-4°, 85%; 1,2,3,5-Me₄, 2,3,4,6-Me₄, 141.5-2°, 82%; 1,2,4,5-Me₄, 2,3,5,6-Me₄, 153-4°, Am, 4-Am, 85.5-6.5°, 80-100%; tert-Am, 4-tert-Am, 83-4°, 89-90%; 1,3,4-Me₂Pr, 2,4,5-Me₂Pr(?), 90-3°, 79-82%; 1,3,4-Me₂(iso-Pr), 2,4,5-Me₂(iso-Pr)(?), 155.5-6°, 68%; 1,3,5,2-Me₃Et, 2,4,6,3-Me₃Et, 131-2°, 64-71%; Me₅, Me₅, 182-3° 90-2%; hexyl, 4-hexyl, 85-5.5°, 81%; 1,3,4-Me₂(tert-Bu), gives an amide m. 128-30° (81%); 1,3,5-Me₂(tert-Bu), 2,4,6-Me₂(tert-Bu)(?), 132-3°, 86%; 1,3,5-Et₃, 2,4,6-Et₃, 118-18.5°, 94%; 1,4-di-tert-Bu, 2,5-di-tert-Bu, 135.5-6.5°, -; nonyl, 4-nonyl, 94.5-5° 54-67%; hendecyl, 4-hendecyl, 95.7-6.2°, ; cyclohexyl, 4-cyclohexyl, 160-60.5°, 85-7%; 1,2,4,5-tetra(iso-Pr), 2,3,5,6-tetra-iso-Pr, 154.5-5° 60-85%. The following 1-benzenesulfonyl chlorides were isolated: 4-Me, 64-6°, 61-5%; 3,4-Me₂, 52°, 74-86%; 2,4,6-Me₃, 50-3°, 65-72%; 4-tert-Bu, 80-2°, 100%; 2,3,4,5-Me₄, 72-3°, 95%; 2,3,5,6-Me₄, 98-9°, 100%; Me₅ 77-8.5°, 98%; 2,4,6-Me₂(tert-Bu), 65-7°, 97%; 4-cyclohexyl, 51-2.5°; 2,3,5,6-tetra(iso-Pr), 141.5-42°, 77-86%. The amount of sulfone formation was considerable (27%) only in the case of C₆H₆; PhMe gives 1-10%, PhEt 1-6%, iso-PrPh 2-3%, but the other hydrocarbons gave no evidence of corresponding products. Hydrindene gives 65-70% of the 5-sulfonamide, m. 132.5-3.5°; 1,2,3,4-tetrahydronaphthalene gives 75% of 5,6,7,8-tetrahydro-2-naphthalenesulfonamide, m. 134.5-5°; the sulfonyl chloride m. 58-8.5°.

Journal of the American Chemical Society published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics