Tag: M.W=200-250

Guin, Avishek published the artcileTransition-Metal-Free C2-Functionalization of Pyridines through Aryne Three-Component Coupling, Product Details of C8H4ClF3O, the publication is Chemistry – A European Journal (2021), 27(55), 13864-13869, database is CAplus and MEDLINE.

The direct C2-functionalization of pyridines I (R = H, Me, Cl, pyrrolidin-1-yl, etc.) through a transition-metal-free protocol by using arynes 2-Si(CH₃)₃-3-R¹-4-R²-5-R³-6-R⁴C₆OS(O)₂CF₃ (R¹ = H, Me, OMe; R² = H, Me, F, Cl; R¹R² = -(CH₂)₄-, -CH=CH-CH=CH-; R³ = H, Me, F; R²R³ = -OCH₂O-, -(CH₂)₂-, -CH=CH-CH=CH-; R⁴ = H, Me) multicomponent coupling is demonstrated. The reaction allowed a broad-scope synthesis of C2-substituted pyridine derivatives bearing the -CF₃ group II in good yields with α,α,α-trifluoroacetophenones ArC(O)CF₃ (Ar = Ph, pyren-1-yl, 1-benzothiophen-3-yl, etc.) as the third component. Activated keto esters could also be employed as the third component in this formal 1,2-di(hetero)arylation of ketones. Performing the reaction under dilute conditions inhibited the competing pyridine-aryne polymerization pathway. Nucleophilic attack by the initially generated pyridylidene intermediate on the carbonyl followed by an S_NAr process resembling the Smiles rearrangement affords the desired products.

Chemistry – A European Journal published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kasztelan, Adrian published the artcileHigh-Pressure-Mediated Asymmetric Organocatalytic Hydroxyalkylation of Indoles with Trifluoromethyl Ketones, Synthetic Route of 5860-95-7, the publication is Advanced Synthesis & Catalysis (2016), 358(18), 2962-2969, database is CAplus.

An enantioselective hydroxyalkylation of indoles and 7-azaindole with trifluoromethyl ketones was found to be effectively promoted under high-pressure conditions with a low loading of Cinchona alkaloids (e.g., 1-3 mol% of cinchonidine). Chiral tertiary alcs. containing a trifluoromethyl group were obtained at 9 kbar with good yield and enantioselectivity up to 89%, whereas usually merely traces of products were detected at atm. pressure.

Advanced Synthesis & Catalysis published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Synthetic Route of 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chimenti, Franco published the artcileSynthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides, COA of Formula: C7H4BrClO2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(16), 4922-4926, database is CAplus and MEDLINE.

N-substituted-3-carboxamido-coumarin derivatives, e.g. I, were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clin. strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.

Bioorganic & Medicinal Chemistry Letters published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, COA of Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Djerourou, Abdelhafid published the artcileReactivity of dichlorosilanes with lithium ester enolates: synthesis of 3,3-disubstituted 3-silaglutarates, Name: Dichloro(methyl)(octyl)silane, the publication is Journal of Organometallic Chemistry (1995), 485(1-2), 63-8, database is CAplus.

3,3-Disubstituted 3-silaglutarates were synthesized by reaction of the lithium enolate of Et acetate with dichlorosilanes at -94°. When a Ph group is linked to the silicon atom the reaction in THF gave mainly the silaglutarate. In other cases alkylsilyl ketene acetals were formed in proportions similar to or greater than that of the silaglutarate. The presence of HMPA increased the ratio of C- to O-silylated products and allowed the preparation of 3,3-dialkyl 3-silaglutarates in good yield.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileDesign and Application of a Low-Temperature Continuous Flow Chemistry Platform, Application In Synthesis of 1628684-10-5, the publication is Organic Process Research & Development (2014), 18(10), 1211-1220, database is CAplus.

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Organic Process Research & Development published new progress about 1628684-10-5. 1628684-10-5 belongs to chlorides-buliding-blocks, auxiliary class Boronic Acids,Boronic Acids,Boronic acid and ester, name is (4-Chloro-2-fluoro-6-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Application In Synthesis of 1628684-10-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileReconfiguration of a Continuous Flow Platform for Extended Operation: Application to a Cryogenic Fluorine-Directed ortho-Lithiation Reaction, Quality Control of 944129-07-1, the publication is Organic Process Research & Development (2014), 18(10), 1221-1228, database is CAplus.

A flow platform for preparing various aromatic scaffolds using a low-temperature fluorine-directed ortho-lithiation reaction has been successfully reconfigured to allow large-scale processing over extended reaction periods. During the course of this work several key factors have resulted in the development of new technol. such as stainless steel y-piece fittings capable of hosting a thermocouple at the point of mixing which directly controls the power output of a cryogenic cooling device. These developments have enabled the continuous processing of an industrially relevant product, where adequate mixing, cooling, and exotherm control are important for successful operation. The configuration culminates in a large-scale campaign where the flow platform is utilized to process over 100 g of pure product over 7 h, in a yield of 80% after workup.

Organic Process Research & Development published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Quality Control of 944129-07-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Newby, James A. published the artcileDesign and Application of a Low-Temperature Continuous Flow Chemistry Platform, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, the publication is Organic Process Research & Development (2014), 18(10), 1211-1220, database is CAplus.

A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Organic Process Research & Development published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Name: (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pavlova, A. S. published the artcileSynthesis of combinatorial libraries of amides, sulfonamides and ureas from 2-acylated derivatives of benzo[d]thiazole-2,5-diamine, Synthetic Route of 61551-49-3, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2010), 53(7), 11-15, database is CAplus.

Four 2-(acylamino)-5-aminobenzo[d]thiazoles (acyl = MeCO, EtCO, PhCO, 4-MeC₆H₄CO) were efficiently synthesized in 3 steps by cyclocondensation of 1-chloro-2,4-dinitrobenzene with thiourea followed by acylation of the intermediate 2-amino-5-nitrobenzothiazole and hydrogen reduction of the nitro group on Pd catalyst in DMF. The products were successfully used in the solution-phase parallel synthesis of combinatorial libraries of 5-amide-, 5-sulfonamide- and 5-urea-functionalized 2-(acylamino)benzothiazoles by reactions with carboxylic acids/CDI, sulfonyl chlorides and isocyanates, resp.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Florencia, Heinecke published the artcileThe offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease, Formula: C12H15ClO3, the publication is Molecular and Cellular Endocrinology (2020), 110818, database is CAplus and MEDLINE.

Maternal obesity programs liver derangements similar to those of NAFLD. Our main goal was to evaluate whether these liver anomalies were related to aberrant PPARα function. Obesity was induced in female Albino-Wistar rats by a fatty diet (FD rats). Several parameters related to NAFLD were evaluated in both plasma and livers from fetuses of 21 days of gestation and 140-day-old offspring. FD fetuses and offspring developed increased levels of AST and ALT, signs of inflammation and oxidative and nitrative stress-related damage. FD offspring showed dysregulation of Plin2, CD36, Cyp4A, Aco, Cpt-1, Hadha and Acaa2 mRNA levels, genes involved in lipid metabolism and no catabolic effect of the PPARα agonist clofibrate. These results suggest that the FD offspring is prone to develop fatty liver, a susceptibility that can be linked to PPARα dysfunction, and that this could in turn be related to the liver impairments programmed by maternal obesity.

Molecular and Cellular Endocrinology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rupitha, N. S. published the artcileEvaluation of fibrates for anticancer activity – an insilico approach, Quality Control of 637-07-0, the publication is Journal of Pharmaceutical Sciences and Research (2020), 12(9), 1198-1200, database is CAplus.

Cancer is a major cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out safe anticancer drugs has been major goal for medical scientists. Fibrates class of drugs plays an important role in decreasing the levels of serum cholesterol and triglycerides while increasing the levels of high-d. lipoproteins. Recently, several studies have reveals that fibrates may also have anticancer effects via a variety of pathways involved in apoptosis, cell-cycle arrest, invasion, and migration. Insilico approaches have been applied to evaluate the potential interaction between the target and the fibrate derivatives

Journal of Pharmaceutical Sciences and Research published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Quality Control of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics