Tag: M.W=200-250

Hu, Wen-bin published the artcileSynthesis of microporous silica supported ligand Pt catalyst for hydrosilylation of 1-octene, Category: chlorides-buliding-blocks, the publication is Xiandai Huagong (2007), 27(4), 27-29, database is CAplus.

A novel silica-supported platinum catalyst has been prepared by a simple one-step procedure, using a sol-gel method, and characterized. The solventless hydrosilylation reaction between 1-octene and methyldichlorosilane (I) in an autoclave reactor catalyzed by this catalyst was studied. The catalyst can bring a 99.11% conversion rate of I with 100% β-adduct in regioselectivity at 40°C after 10-h reaction. It has excellent catalyst recyclability relative to Speier’s catalyst under the reaction conditions, after 25 times of reuse the catalyst has no loss in catalytic activity.

Xiandai Huagong published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Janczewski, Marian published the artcileEffect of molecular structure on the optical properties of sulfoxide systems. XLII. β-(1,2,3,4-Tetrahydro-6-naphthylsulfinyl)propionic acids and some their derivatives, Synthetic Route of 61551-49-3, the publication is Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Physica et Chemia (1977), 179-98, database is CAplus.

(±)-I[R = S(O)CH₂CH₂CO₂H] [(±)-II] was prepared and resolved as the cinchonine and cinchonidine salts. The dependence of the mol. rotation of (+)-II on the wavelength obeyed a single term Drude equation which indicated that the ORD exhibited a normal dispersion. The ORD and CD of (+)-II and (+)-III exhibited a pos. Cotton effects and mol. ellipticity which indicated that (+)-II and (+)-III had the same absolute configuration. The solvent effect on the optical rotation of (+)-II and the UV of II, III, and I(R = SO₂CH₂CH₂CO₂H) were discussed.

Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Physica et Chemia published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

McManus, E. C. published the artcileUse of coccidia to study the structure-activity relations of a series of p-aminobenzoic acid antagonists, Computed Properties of 5204-46-6, the publication is Develop. Ind. Microbiol. (1965), 44-7, database is CAplus.

Young coccidiosis-susceptible chicks were fed a standard laboratory ration with graded concentrations of test chemicals added just prior to use. On the 2nd day of the test, the chicks were inoculated orally with 100,000 sporulated oocysts of Eimeria maxima; 6 days later birds were killed and weighed, the small intestine homogenized with water, and the oocysts counted. The min. effective diet concentrations of 28 derivatives of p-aminobenzoic acid (I) were determined together with the percent reduction of oocyst count. Remarkably potent anticoccidial compounds were found in a series of ortho-substituted derivatives of I. Groups with high coccidiostatic activity conferring effects were lower alkoxy, alkylthio, and alkyl amino with approx. similar size and shape. The most active compounds, capable of reducing the oocyst count below 25% were the ο-ethoxy derivative, its esters, and N-acyl derivatives, and the ο-chloro, ο-methoxy, ο-isopropoxy, ο-ethyl, and ο-thioethyl derivatives of I. Me 4-acetamido-2-ethoxybenzoate (ethopabate) (II) reduced the oocyst count to nil. The methyl, chloro, nitro, and methoxy derivatives conferred anticoccidial activity when substituted in the ortho position, but not in meta position. Disubstituted derivatives were inactive. The in vivo anticoccidial activity of II and sulfaquinoxaline (III) was overcome completely by simultaneous administration of I. Both II and III potentiated the anticoccidial activity of pyrimethamine. Cross resistance occurred between II and III for many strains of coccidia. The dose-response curves of II and III were parallel, and their anticoccidial activities were additive. II was about 150-fold more potent than III for control of certain strains of E. maxima and Ε. brunetti, and less potent for Ε. tenella. Both II and III were assumed to inhibit biosynthesis of folic acid-type compounds at different steps in the sequence of reactions for synthesis of tetrahydrofolic acid.

Develop. Ind. Microbiol. published new progress about 5204-46-6. 5204-46-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Amine,Benzene, name is 4-Amino-2,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Computed Properties of 5204-46-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cremlyn, Richard J. published the artcileThe chemistry of sulfonylcoumarin derivatives, Category: chlorides-buliding-blocks, the publication is Journal of the Chemical Society of Pakistan (1988), 10(1), 97-104, database is CAplus.

6-(Chlorosulfonyl)coumarin was amidated to give amides I (R¹ = H, alkyl; R² = H, alkyl, PhCH₂, tolyl; or NR¹R² = morpholino). Similarly, hydrazones II [R³ = Me, H; R⁴ = Me, Ph, ClC₆H₄, O₂NC₆H₄; or R³R⁴ = (CH₂)₄] were prepared from the sulfonyl chloride via the resp. hydrazide. Some I and II showed fungicidal activity.

Journal of the Chemical Society of Pakistan published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Evans, Nicola published the artcileIn vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Toxicology and Applied Pharmacology (2022), 116136, database is CAplus and MEDLINE.

Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, addnl. work is needed to characterize PFAS activity on PPAR gamma (PPARγ) and other nuclear receptors. We utilized in vitro assays with either human or rat PPARα or PPARγ ligand binding domains to evaluate 16 PFAS (HFPO-DA, HFPO-DA-AS, NBP2, PFMOAA, PFHxA, PFOA, PFNA, PFDA, PFOS, PFBS, PFHxS, PFOSA, EtPFOSA, and 4:2, 6:2 and 8:2 FTOH), 3 endogenous fatty acids (oleic, linoleic, and octanoic), and 3 pharmaceuticals (WY14643, clofibrate, and the metabolite clofibric acid). We also tested chems. for human estrogen receptor (hER) transcriptional activation. Nearly all compounds activated both PPARα and PPARγ in both human and rat ligand binding domain assays, except for the FTOH compounds and PFOSA. Receptor activation and relative potencies were evaluated based on effect concentration 20% (EC20), top percent of max fold induction (pmaxtop), and area under the curve (AUC). HFPO-DA and HFPO-DA-AS were the most potent (lowest EC20, highest pmaxtop and AUC) of all PFAS in rat and human PPARα assays, being slightly less potent than oleic and linoleic acid, while NBP2 was the most potent in rat and human PPARγ assays. Only PFHxS, 8:2 and 6:2 FTOH exhibited hER agonism >20% pmax. In vitro measures of human and rat PPARαand PPARγ activity did not correlate with oral doses or serum concentrations of PFAS that induced increases in male rat liver weight from the National Toxicol. Program 28-d toxicity studies. Data indicate that both PPARα and PPARγ activation may be mol. initiating events that contribute to the in vivo effects observed for many PFAS.

Toxicology and Applied Pharmacology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Curtis, Michael P. published the artcileThe discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle, Quality Control of 864725-22-4, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5011-5014, database is CAplus and MEDLINE.

Hematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since current treatments such as organophosphates and pyrethroids suffer from field resistance. Isoxazoline oxime ethers represent a new class of γ-aminobutyric acid (GABA) receptor channel blockers which show good activity (LD⁹⁰ = 1.0 μg/mL) against horn flies in an in vitro feed assay and have demonstrated efficacy (>90% reduction at 1.0 mg/kg) as a topical treatment in a field study.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Zhaomeng published the artcileFluoroform: an Efficient Precursor for the Trifluoromethylation of Aromatic Esters by Sodium Diisopropylamide with Trialkylamines, HPLC of Formula: 5860-95-7, the publication is European Journal of Organic Chemistry (2019), 2019(29), 4658-4661, database is CAplus.

The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluoromethylation reactions. It is believed to be incompatible with Na⁺ cation due to the strong Na-F bond. However, herein we demonstrate that it could be prepared for the first time. Trialkylamines can be used as cation chelating agents to stabilize the isolated ^–CF₃ ion to realize trifluoromethylation reaction. With this strategy, trifluoromethyl aromatic ketones could be effectively synthesized from fluoroform and aromatic esters with diisopropyl aminosodium (NaDA) and trialkylamines.

European Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Xianfeng published the artcileDesign and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate, the publication is Journal of Medicinal Chemistry (2015), 58(6), 2809-2820, database is CAplus and MEDLINE.

Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities. There is growing interest in identifying HDAC6-selective inhibitors as chem. biol. tools and ultimately as new therapeutic agents. Herein we report the design, synthesis, and phenotypic screening of a novel class of 3-aminopyrrolidinone-based hydroxamic acids as HDAC6 inhibitors. In particular, the α-methyl-substituted enantiomer I (3-S) showed significant in-cell tubulin acetylation (Tub-Ac) with an EC₅₀ of 0.30 μM but limited impact on p21 levels at various concentrations In enzyme inhibition assays, I demonstrated high selectivity for HDAC6 with an IC₅₀ of 0.017 μM and selectivity indexes of 10 against HDAC8 and over 4000 against HDAC1-3 isoforms. Moreover, I has suitable drug metabolism and pharmacokinetics properties compared with other hydroxamic acid-based HDAC inhibitors, warranting further biol. studies and development as a selective HDAC6 inhibitor.

Journal of Medicinal Chemistry published new progress about 117738-74-6. 117738-74-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Ester, name is Methyl 4-bromo-3-chlorobenzoate, and the molecular formula is C8H6BrClO2, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shen, Kun published the artcileDesign and synthesis of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2014), 34(10), 1441-1445, database is CAplus.

The compounds of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin were designed, and new drugs for the treatment of neuropathic pain were found. The nNOS-PSD-95 interrupts and gabapentin, pregabalin were connected to form amide. The analgesic effects of target compounds were evaluated by neuropathic pain model. All target compounds showed different degree analgesic effects in neuropathic pain, the analgesic effect of twin drug of nNOS-PSD-95 interrupts and gabapentin, pregabalin twin drug in neuropathic pain was stronger than that of single target drugs. Twin drug with nNOSPSD-95 interrupts and gabapentin, pregabalin may get a better analgesic effect than that of single target drugs in neuropathic pain.

Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H8INO, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wan, Tianfeng published the artcileCovalent organic nanospheres modified magnetic nanoparticles for extraction of blood lipid regulators in water samples, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of Separation Science (2021), 44(11), 2301-2309, database is CAplus and MEDLINE.

Covalent organic nanospheres are new kind of nanospherical polymer with large sp. surface area, uniform morphol., and excellent chem. and thermal stability. This material can be fabricated by a facile and rapid room temperature solution-phase strategy. In this work, magnetic nanoparticles were attached to the surface of covalent organic nanospheres, and the obtained composites were used for the extraction of blood lipid regulators such as clofibrate and fenofibrate. These composites were characterized with Fourier-transformed IR spectroscopy, XPS, and transmission electron microscopy. Several parameters that might affect the extraction efficiency including acetonitrile content, pH value, extraction time, and sample volume were investigated. Under optimum conditions, the proposed anal. method showed high extraction efficiency toward clofibrate and fenofibrate with enrichment factors between 60 and 83. This method exhibited outstanding anal. performance with wide linear range and excellent reproducibility and had low limits of detection in the range of 0.02-0.03 ng/mL. This method was also applied to the detection of clofibrate and fenofibrate in lake water samples, and good recoveries in the range of 92.6-112.6% was obtained.

Journal of Separation Science published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C15H14Cl2S2, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics