Tag: M.W=200-250

Barry, A. J. published the artcileReaction of olefins and chlorohydrosilanes, Product Details of C9H20Cl2Si, the publication is Journal of the American Chemical Society (1947), 2916, database is CAplus.

Organic Si compounds have been prepared by heating an unsaturated organic compound and R_xSiCl_y under pressure at temperatures from 160° (slow reaction) to 400° (rapid reaction). Thus 406 g. HSiCl₃ and 756 g. octadecene, heated to 300° during 2.5 hrs., give 94% octadecyltrichlorosilane, b_2-3 185-99°. PrMeSiCl₂, b₇₄₇ 123-4°, results in 72% yield on heating 345 g. MeSiHCl₂ and 128 g. C₃H₆ 12 hrs. at 300°. The following new compounds were thus prepared: sec-butyltrichlorosilane, b₇₃₆ 145-6°; (2-methylpentyl)trichlorosilane, b₅₀ 98°; 3-(2,2,4-trimethylpentyl)trichlorosilane (from diisobutylene), b₂₀ 94-6°; hexadecyltrichlorosilane, b_7.5 194-6°; butenyltrichlorosilane, b₄₀ 64°; trichlorosilyl(trichlorosilylethyl)cyclohexane, b₆ 161°; hexenyltrichlorosilane, b₅₀ 103-40°; bis(trichlorosilyl)hexane, b₁₀ 148-53°; propyltribromosilane, b₇₅₆ 183°; ethylmethyldichlorosilane, b₇₄₄ 100°; butylmethyldichlorosilane, b₇₄₄ 147.5-8°; hexylmethyldichlorosilane, b₇₄₃ 192°; methyloctyldichlorosilane, b₂₀ 100-16°; methyloctadecyldichlorosilane, b₆ 200-10°; cyclohexylmethyldichlorosilane, b₇₄₅ 204°; phenylpropyldichlorosilane, b_44-7 140-4°; diethylpropylchlorosilane, b₇₄₂ 164-6°; methylphenylpropylchlorosilane, b₃₀ 124-6°; diphenylpropylchlorosilane, b₁₀ 174-6°.

Journal of the American Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Padhya, A. C. published the artcileAntimicrobial properties of azomethines of salicylaldehyde derivatives, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Indian Journal of Microbiology (1974), 14(2), 91-3, database is CAplus.

Many azomethine derivatives of 5-chloro-, 5-bromo-, 3-bromo-5-chloro-, and 5-bromo-3-chlorosalicylaldehyde were prepared and tested for their antibacterial and antifungal activities. The azomethine derivatives of 5-chlorosalicylaldehyde showed no antibacterial activity, but were active against all tested fungi except Nocardia asteroides. The azomethine derivatives of 5-bromosalicylaldehyde had no antibacterial activity, and species variable antifungal activity. The azomethine derivatives of 5-bromo-3-chloro- and 3-chloro-5-bromosalicylaldehyde were poor antifungal agents, compared with the 5-chloro or 5-bromosalicylaldehyde derivatives, probably due to the blocking of the phenolic group by substituents on both sides. However, they were better antibacterial agents than the 5-monosubstituted salicylaldehyde derivatives, most being active against S. aureus at 6.25-12.5 μg/ml.

Indian Journal of Microbiology published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajan, Srinivasan R. published the artcileR-Isomers of Arg-Gly-Asp (RGD) mimics as potent α_vβ₃ inhibitors, SDS of cas: 19652-33-6, the publication is Bioorganic & Medicinal Chemistry (2007), 15(11), 3783-3800, database is CAplus and MEDLINE.

The integrin α_vβ₃, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. The authors recently disclosed the discovery of a tripeptide Arg-Gly-Asp (RGD) mimic, which has been shown to be a potent inhibitor of the integrin α_vβ₃ and has excellent anti-angiogenic properties including its suppression of tumor growth in animal models. In other investigations involving RGD mimics, only compounds containing the S-isomers of the β-amino acids have been shown to be potent. The authors were surprised to find the potencies of analogs containing enantiomerically pure S-isomers of β-amino acids which were only marginally better than the corresponding racemic mixtures Thus, the authors synthesized RGD mimics containing R-isomers of β-amino acids and found them to be relatively potent inhibitors of α_vβ₃. One of the compounds, peptidomimetic I, was examined in tumor models in mice and has been shown to significantly reduce the rate of growth and the size of tumors.

Bioorganic & Medicinal Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, SDS of cas: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lenstra, Danny C. published the artcileStructure-Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7, Synthetic Route of 61551-49-3, the publication is ChemMedChem (2018), 13(14), 1405-1413, database is CAplus and MEDLINE.

SETD7 is a histone H3K4 lysine methyltransferase involved in human gene regulation. Aberrant expression of SETD7 has been associated with various diseases, including cancer. Therefore, SETD7 is considered a good target for the development of new epigenetic drugs. To date, few selective small-mol. inhibitors have been reported that target SETD7, the most potent being (R)-PFI-2. Herein we report structure-activity relationship studies on (R)-PFI-2 and its analogs. A library of 29 structural analogs of (R)-PFI-2 was synthesized and evaluated for inhibition of recombinantly expressed human SETD7. The key interactions were found to be a salt bridge and a hydrogen bond formed between (R)-PFI-2’s NH₂⁺ group and SETD7’s Asp256 and His252 residue, resp.

ChemMedChem published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yue, Wen-Jun published the artcileSite-Selective Defluorinative sp³ C-H Alkylation of Secondary Amides, Synthetic Route of 864725-22-4, the publication is Journal of the American Chemical Society (2021), 143(17), 6395-6400, database is CAplus and MEDLINE.

A site-selective defluorinative sp³ C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp³ sites was disclosed. This protocol was distinguished by its mild conditions, wide scope and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

Journal of the American Chemical Society published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C12H10F2Si, Synthetic Route of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fantacuzzi, Marialuigia published the artcileSynthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors, SDS of cas: 254749-11-6, the publication is European Journal of Medicinal Chemistry (2020), 111815, database is CAplus and MEDLINE.

In order to identify new aromatase enzyme inhibitors, thirty aryl sulfonamide derivatives containing an indole nucleus have been synthesized. The enzyme inhibition assay showed that four compounds inhibit aromatase in the sub-micromolar range. Loading concentrations of these four compounds were afterwards tested for cell viability and cytotoxicity on MCF7 human breast cancer cells, revealing a time- and dose-dependent decrease of active metabolizing cells over the time of the culture (0-72 h), starting from a concentration of 100μM. Likewise LDH released raised up to 40% at early time of exposures (24 h). Finally, the docking study showed that the best active compounds efficiently bound in the active site of the aromatase; high values of HBD and low levels of HBA are the principal requirement evidenced by the QSAR model.

European Journal of Medicinal Chemistry published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, SDS of cas: 254749-11-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Russo Spena, Concetta published the artcileLiposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer, Formula: C9H8Cl2O2, the publication is Journal of Controlled Release (2018), 1-10, database is CAplus and MEDLINE.

Pin1, a prolyl isomerase that sustains tumor progression, is overexpressed in different types of malignancies. Functional inactivation of Pin1 restrains tumor growth and leaves normal cells unaffected making it an ideal pharmaceutical target. Although many studies on Pin1 have focused on malignancies that are influenced by sex hormones, studies in ovarian cancer have lagged behind. Here, we show that Pin1 is an important therapeutic target in high-grade serous epithelial ovarian cancer. Knock down of Pin1 in ovarian cancer cell lines induces apoptosis and restrains tumor growth in a syngeneic mouse model. Since specific and non-covalent Pin1 inhibitors are still limited, the first liposomal formulation of a Pin1 inhibitor was designed. The drug was efficiently encapsulated in modified cyclodextrins and remotely loaded into pegylated liposomes. This liposomal formulation accumulates preferentially in the tumor and has a desirable pharmacokinetic profile. The liposomal inhibitor was able to alter Pin1 cancer driving-pathways trough the induction of proteasome-dependent degradation of Pin1 and was found to be effective in curbing ovarian tumor growth in vivo.

Journal of Controlled Release published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Formula: C9H8Cl2O2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grob, Jonathan E. published the artcileOne-Pot C-N/C-C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization, Recommanded Product: 4-Chloro-2-ethoxycarbonylphenylboronic acid, the publication is Organic Letters (2012), 14(21), 5578-5581, database is CAplus and MEDLINE.

Iterative cross-coupling is a highly efficient and versatile strategy for modular construction in organic synthesis, though this has historically been demonstrated solely in the context of C-C bond formation. A C-N cross-coupling of haloarene methyliminodiacetic acid (MIDA) boronates with a wide range of aromatic and aliphatic amines is reported. Successful cross-coupling of aliphatic amines was realized only through protective enolization of the MIDA group. This reaction paradigm was subsequently utilized to achieve a one-pot C-N/C-C cross-coupling sequence.

Organic Letters published new progress about 850568-61-5. 850568-61-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is 4-Chloro-2-ethoxycarbonylphenylboronic acid, and the molecular formula is C9H10BClO4, Recommanded Product: 4-Chloro-2-ethoxycarbonylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Childress, Scott J. published the artcileElectronegative substitutions in local anesthetics of the benzoic acid ester type, Computed Properties of 5204-46-6, the publication is Journal of the American Chemical Society (1954), 3988-91, database is CAplus.

A series of substituted BzOH esters of various alkanolamines has been prepared and tested pharmacologically. Esters of the tertiary amino alcs. were prepared either by the condensation of the corresponding dialkylaminoalkyl chloride with the Na salt of the acid (method A) or by the condensation of the acid chloride with the amino alc. in the presence of excess base (method B). The esters of secondary amines were prepared by refluxing the HCl salt of the secondary amino alc. with the acid chloride (method C). The nitro esters were reduced to the amino esters by treating the HCl salts with Fe powder in H₂O or aqueous EtOH (method D). The topical and intradermal anesthetic activities of the resulting esters were measured on guinea pig wheal and rabbit cornea, resp.; comparisons were made with cocaine or procaine, to each of which the value 1 was assigned; the acute toxicities were determined in albino mice. Me₃CNH₂ (37 g.), 22 g. ethylene oxide, and 2 cc. MeOH refrigerated 3 days and the mixture fractionated gave 6.5 g. Me₃CNH(CH₂)₂OH, b. 176-7°; picrate, m. 159-60° (from H₂O). 2,4-Cl(H₂N)C₆H₃CO₂H (34.3 g.), 30 g. BuBr, and 13.2 g. KOH in 250 cc. 75% EtOH refluxed overnight, the mixture treated with 13.2 g. KOH and 30 g. BuBr, refluxed 8 hrs., concentrated in vacuo, made basic with KOH, extracted with Et₂O, and acidified, the solid precipitate (20 g.) extracted with 3 l. boiling H₂O, the solution let stand, the procedure repeated with the mother liquor, and the resulting crystals recrystallized 3 times from 95% EtOH yielded 7.5 g. 2,4-Cl(BuNH)C₆H₃CO₂H (I), white crystals, m. 112-14°; the residue from the H₂O extraction recrystallized twice from absolute EtOH gave 2,4-Cl(Bu₂N)C₆H₃CO₂H, white crystals, m. 127-9°. 2,6,4-Cl₂(O₂N)C₆H₂Me (12 g.) in 50 cc. pyridine and 40 cc. H₂O, the mixture heated to the b.p., treated at intervals with six 4.3-g. portions KMnO₄, and filtered, the filtrate concentrated in vacuo to 1/4 its original volume and treated with concentrated HCl, the precipitate dissolved in aqueous NaOH to remove 6 g. unreacted material, the solution acidified, and the yellow crystalline precipitate (2 g.) repeatedly recrystallized from H₂O and dried gave 2,6,4-Cl₂(O₂N)C₆H₂CO₂H (II), white crystals, m. 172-4° with sintering at 157°. II (7 g.) refluxed 4 hrs. with 25 g. SOCl₂, and the resulting crude acid chloride treated with EtOH gave a poor yield of the Et ester, but yielded some anhydride of II, yellow needles, m. 190-1.5° (from EtOH). II (1.9 g.) and 1.5 g. 5% Pd-C added to 60 cc. MeOH, the mixture treated with stirring during 5 min. with 1 g. N₂H₄ in 5 cc. MeOH, let stand over the weekend, filtered, concentrated to 10 cc., poured into 25 cc. H₂O, and acidified, and the precipitate recrystallized twice from H₂O yielded 0.4 g. 2,6,4-Cl₂(H₂N)C₆H₂CO₂H (III), cream-colored crystals, m. 178-9° (decomposition). The following alkyl ester of ο-ClC₆H₄CO₂H HCl salts [alkyl group, m.p., method of preparation, local anesthetic activity compared to cocaine (topical) and procaine (intradermal), and the subcutaneous and the intravenous LD₅₀ in mg./kg. given] were prepared: Et₂N(CH₂)₂, 127-8° (from 95% EtOH), A, 0, 0.4, >1000, 120; Me₂CHCH₂NH(CH₂)₂, 141-2° (from EtOH-Et₂O), C, 0, 1.5, >1000, 75; EtMeCHNH(CH₂)₂, 181-3° (95% EtOH), C, 0, 1.2, >1000, 91; β-cyclohexylaminoethyl, 203-5° (from 50% EtOH), C, 0.3, 1,2, >1000, 98; β-cyclohexylaminoisopropyl, 174-5°, C, 1.7, 1.1, 250, 36. The following ester HCl salts of 3,4-Cl₂C₆H₄CO₂H (same data given): Et₂N(CH₂)₂, 178.5-80° (from EtOAc-EtOH), B, 0, 0.6, 840, 84; EtMeCHNH(CH₂)₂, 180-2° (from 95% EtOH), C, 0.3, 0.8, 510, 120. The following ester HCl salts of 2,4-Cl(O₂N)C₆H₃CO₂H (m.p. and method given): Et₂NCHMeCH₂, 150.5-2.5°, B; Et₂NCH₂CHMe, 145-8° (from EtOH-Et₂O), B; Et₂N(CH₂)₃, 125-6° (from EtOH-Et₂O), B; Me₂CHNH(CH₂)₂, 188-9°, C; BuNH(CH₂)₂, 162-3.5°, C; Me₂CHCH₂NH(CH₂)₂, 172-4°, C; EtMeCHNH(CH₂)₂, 160-1°, C; Me₃CNH(CH₂)₂, 190-2°, C; Et₂CHNH(CH₂)₂, 162-4°, C; BuNH(CH₂)₃, 140-1°, C; EtMeCHNH(CH₂)₃, 160-3°, C; β-cyclohexylaminoethyl, 177-8°, C; 2-cyclohexylamino-1-propyl, 179-80.5°, C; 1-cyclohexyl-2-propyl, 171-2.5°, C; β-cyclohexylaminoisopropyl, 182.5-84°, C; 2-cyclohexylamino-1-phenylethyl, 196-8°, C. 2,4-Br(O₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe.HCl, 157-8°, C. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂, 137-9° (from EtOH-Et₂O), B (all nitro esters, except where otherwise stated, were recrystallized from EtOH). The following alkyl ester HCl salts of 2,4-Cl(H₂N)C₆H₃CO₂H (all by method D) (alkyl group, m.p., activity, and toxicity given): Et₂NCHMeCH₂, 156.5-7.5° (from EtOH-EtOAc), 1.1, 2.2, 240, 44; Et₂NCH₂CHMe, 156-7°, 1.3, 3.1, 220, 55; Et₂N(CH₂)₃, 198.5-9.5°, 2.9, 2.5, 205, 50; Me₂CHNH(CH₂)₂(HCO₂H salt), 163-5°, 0.9, 1.0, 900, 84; BuNH(CH₂)₂, 161-3°, 0.9, 6.0, 320, 47; Me₂CHCH₂NH(CH₂)₂, 215-17°, 1.3, 4.4, 260, 50; EtMeCHNH(CH₂)₂, 195.5-97°, 2.6, 4.1, 570, 45; (HCO₂H salt), 152-2.5°, 2.3, 4.9, 670, 46) [0.5(CH₂CO₂H)₂ salt], 192-4°, -, 4.9, -, -]; Me₂CHNH(CH₂)₂, 270° (decomposition), 1.0, 1.0, 750, 63; Et₂CHNH(CH₂)₂(HCO₂H salt), 145-6.5°, 1.9, 1.3, 740, 37; BuNH(CH₂)₃, 168-70°, 1.8, 3.1, 140, 23; EtMeCH(CH₂)₃, 208-9.5°, 2.7, 1.4, 220, 29; β-cyclohexylaminoethyl, 224.5-26°, 2.4, 3.1, 280, 29; 2-cyclohexylaminopropyl (HCO₂H salt), 162.5-64°, 3.0, 2.1, 330, 24; β-cyclohexylamino-2-propyl, 159-61°, 3.4, 3.1, 57, 17; 3-cyclohexylaminoisopropyl, 188.5-9.5°, 2.2, 3.4, 120, 17; 2-cyclohexylamino-1-phenylethyl, 239-41° (decomposition), -, -, -, -; 2,4-Br(H₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe, 202-4°, 2.5, 2.7, 450, 43. The following ester HCl salts of 4,2-H₂N(O₂N)C₆H₃CO₂H by method A (same data given): Et₂N(CH₂)₂, 177-9°, 0.2, 1.4, 850, 130; Et₂NCHMeCH₂, 182-5°, 0, 1.5, 800, 71; Et₂N(CH₂)₃, 221-3°, 0.5, 1.0, 430, 49. The following ester salts of I (same data given) by method A: Me₂N(CH₂)₂ HCl salt monohydrate, 84-6° (from EtOH-EtOAc), 0.1, 1.9, 1000, 72; Me₂N(CH₂)₂ di-HCl salt, 167-70° (decomposition), -, -, -, -; Et₂N(CH₂)₂ di-HCl salt, 151-4°, -, -, -, – (all previous ester salts were recrystallized from EtOH, except where otherwise indicated). The Et₂N(CH₂)₂ ester HCl salts of the following acids (m.p., method, activity, and toxicity given): 2,5-Cl(O₂N)C₆H₃CO₂H, 197-8° (from EtOH), B, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 152.5-4.5° (from iso-PrOH), D, 0, 0.6, >1200, 110; 3,4-Cl(H₂N)C₆H₃CO₂H, 148-50° (from EtOH-EtOAc), A, 1.2, 0.7, >450, 45; II, 170-1° (from EtOH), A, -, -, -, -; III, 154-5.5° (from EtOH-EtOAc), D, 2.8, 3.5, 130, 31; 3,5,4-Cl₂(H₂N)C₆H₂CO₂H, 237-8° (from EtOH), A, 0.7, 2.0, 290, 44. The EtMeCHNH(CH₂)₂ ester HCl salts of the following acids (same data given): 2,5-Cl(O₂N)C₆H₃CO₂H, 158.5-9.5° (from EtOH), C, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 121-3° (from iso-PrOH), D, 0, 2.0, >1200, 75; 3,4-Cl(O₂N)C₆H₃CO₂H, 174-5° (from EtOH), C, -, -, -, -; 3,4-Cl(H₂N)C₆H₃CO₂H HCO₂H salt, 108-9° (from EtOH-EtOAc), D, 0.8, 1.5, 490, 45; 4,3-Cl(O₂N)C₆H₃CO₂H, 185-7° (from EtOH), C, -, -, -, -; 4,3-Cl(H₂N)C₆H₃CO₂H, 179-80.5°, D, 0.3, 2.0, 570, 68. The amino alc. in the preparation of IV neutralized incompletely gave N-[2-(2-chloro-4-nitrobenzoxy)-1-propyl]-N-cyclohexyl-2-chloro-4-nitrobenzamide) cream-colored solid, m. 156.5-58° (from CHCl₃-Et₂O) as a by-product. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂ (0.6 g.) in 20 cc. EtOH and 1 cc. 3N NH₄OH treated at room temperature 0.5 hr. with H₂S, the mixture filtered, and the filtrate concentrated gave 0.2 g. 4,2-HONH(O₂N)C₆H₃CO₂(CH₂)₂NEt₂, m. 170-2° (from EtOH) having topical activity 0, intradermal activity 0.5, subcutaneous LD₅₀ 790, and intravenous LD₅₀ 55.

Journal of the American Chemical Society published new progress about 5204-46-6. 5204-46-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Amine,Benzene, name is 4-Amino-2,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Computed Properties of 5204-46-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lahm, George P. published the artcile4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 3001-3006, database is CAplus and MEDLINE.

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biol. activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides e. g., I.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics