Tag: M.W=200-250

Liang, Junqing published the artcileA bench-stable reagent for C-4 selective deuteriodifluoromethylation of azines, Formula: C12H15ClO3, the publication is Chinese Chemical Letters (2022), 33(11), 4817-4821, database is CAplus.

A bench-stable reagent, deuteriodifluoromethyl phosphine (DDFP) from cheap deuterium source for selectivity deuteriodifluoromethylation of azines with a high deuterium incorporation yield was reported. The late-stage modification of complex mols. further confirmed the potential of this reagent for practical applications. This reagent would be expected to find applications in synthesis of isotope-labeled mols. of interests for drug-discovery and related ilucidation of mechanism of action.

Chinese Chemical Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Feng, Yan published the artcilePreparation and Capacity-Fading Investigation of Polymer-Derived Silicon Carbonitride Anode for Lithium-Ion Battery, COA of Formula: C9H20Cl2Si, the publication is ACS Omega (2017), 2(11), 8075-8085, database is CAplus and MEDLINE.

Polymer-derived silicon carbonitride (SiCN) materials have been synthesized via pyrolyzing from five poly(silylcarbondiimide)s with different contents of carbon (labeled as 1-5#). The morphol. and structure measurements show the SiCN materials are the mixtures of nanocrystals of SiC, Si3N4, and graphite. The SiCN materials have been used as anodes for lithium ion batteries (LIBs). Among the five polymer-derived SiCN materials, the 5#SiCN derived from dichloromethylvinylsilane and di-n-octyldichlorosilane, has the best cycle stability and high-rate performance at the low cut-off voltage of 0.01-1.0 V. In lithium-ion half-cells, the specific delithiation capacity of that 5#SiCN anode still remains at 826.7 mAh g-1 after 100 charge/discharge cycles; it can even deliver the capacity above 550 mAh g-1 at high current densities of 1.6 and 2 A g-1. In lithium-ion full cells, the 5#SiCN anode works well with NCM com. cathode. The outstanding electrochem. performance of 5#SiCN anode is attributed to two factors: (1) the formation of stable and compact SEI layer on the anode surface anode, which protects the electrode cracking during the charge/discharge cycling; (2) a large amount of carbon component the less Si3N4 phase in the 5#SiCN structure, which provides electrochem. reactive and conductive environment in the SiCN structure, benefits the lithiation/delithiation process. In addition, we explore the reason for the capacity fading of these SiCN anodes.

ACS Omega published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, COA of Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corriu, R. J. P. published the artcileThe palladium-catalyzed cross-coupling polymerization of diethynylmethyl (n-octyl)silane with dihaloarenes, Synthetic Route of 14799-93-0, the publication is European Polymer Journal (1993), 29(12), 1563-9, database is CAplus.

Polymers of structure -[-CCSi(MeOctⁿ)CC-Z-]-_n(Z = 1,4-benzene, 4,4′-biphenyl, 9,10-anthracene, 2,7-fluorene, 2,5 and 2,6-pyridine, 6,6′-bipyridine, 2,5-thiophene, 2,6-p-dimethylaminonitrobenzene, 2,6-p-nitroaniline, 2,7-fluoren-9-one, p-tetrafluorobenzene, 2,6-p-nitrophenol or 2,6-p-cyanophenol) were prepared by reaction of diethynylmethyl(n-octyl)silane with the appropriate hetero(aromatic) dibromide or diiodide in the presence of (PPh₃)₂PdCl₂ and CuI. The polymer where Z = 6,6′-bipyridine reacted with copper(II) trifluoromethanesulfonate to give a copper(II)-containing polymer, reduction of which with hydrazine afforded the Cu(I)-containing polymer. The effect of change in reaction conditions on the cross-coupling polymerization was investigated. High mol. weights are favored by use of: (a) the diiodo- rather than the dibromoarene, (b) an equimolar mixture of the reactants or excess diethynylsilane, and in most cases (c) toluene cosolvent. The mol. weight passes through a maximum as the total catalyst concentration is increased, or as the individual Cu and Pd catalyst concentrations are sep. raised. The presence of tetraethylammonium chloride or high concentrations of triphenylphosphine reduces the mol. weight

European Polymer Journal published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brain, E. G. published the artcileDerivatives of 6-aminopenicillanic acid. IV. Analogs of 2,6-dimethoxyphenylpenicillin in the naphthalene and quinoline series, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Journal of the Chemical Society (1963), 491-7, database is CAplus.

cf. CA 57, 12458c. A number of sterically hindered alkoxynaphthoic and -quinolinecaxboxylic acids have been synthesized. Reaction of the acid chlorides with 6-aminopenicillanic acid gave substituted naphthyl- and quinolylpenicillins which resisted inactivation by penicillinase.

Journal of the Chemical Society published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qiu, Lin published the artcileSynthesis and in vitro evaluation of new TRPV4 ligands and biodistribution study of an ¹¹C-labeled radiotracer in rodents, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(22), 127573, database is CAplus and MEDLINE.

Nine new compounds targeting the transient receptor potential vanilloid-4 (TRPV4) were synthesized and their biol. activities toward TRPV4 were determined using freshly isolated mouse skin macrophages through live cell Ca²⁺ imaging assay. Three compounds 4b, 4c, and 4i exhibited higher percentages of in vitro activation of TRPV4 as 48.1%, 59.3% and 33.5%, which are comparable to 56.4% activation response of the reported TRPV4 agonist GSK1016790A (3). The compound 4i was chosen for ¹¹C-radiosynthesis using its phenol precursor 4g to reacted with [¹¹C]methyl iodide. The radiosynthesis was achieved with good radiochem. yield (16 ± 5%), high chem. and radiochem. purity (>95%), and high molar activity (16-21 GBq/μmol, decay corrected to the end of bombardment, EOB n ≥ 4). Furthermore, the initial ex vivo biodistribution study in rats showed that [¹¹C]4i had higher uptake in kidney, liver and small intestine compared to other tissues with rapid washout.

Bioorganic & Medicinal Chemistry Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Romero, F. Anthony published the artcilePotent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2007), 50(5), 1058-1068, database is CAplus and MEDLINE.

A study of the structure-activity relationships (SAR) of 2f (I, OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position of the oxazole. Examination of a series of substituted benzene derivatives (12-14) revealed that the optimal position for substitution was the meta-position with selected members approaching or exceeding the potency of 2f. Concurrent with these studies, the effect of substitution on the pyridine ring of 2f was also examined A series of small, nonaromatic C5-substituents was also explored and revealed that the K_i follows a well-defined correlation with the Hammett σ_p constant (ρ = 3.01, R² = 0.91) in which electron-withdrawing substituents enhance potency, leading to inhibitors with K_is as low as 400 pM (20n). Proteomic-wide screening of the inhibitors revealed that most are exquisitely selective for FAAH over all other mammalian proteases, reversing the 100-fold preference of 20a (C5 substituent = H) for the enzyme TGH.

Journal of Medicinal Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shen, Hui published the artcileSynthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides via palladium-catalyzed intramolecular cyclization, Name: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Organic & Biomolecular Chemistry (2022), 20(17), 3589-3597, database is CAplus and MEDLINE.

A palladium-catalyzed intramol. cyclization of α-bromo-propionanilides was developed, delivering a series of 3-substituted 2-oxindoles in high yields. The method features easy to prepare starting materials, broad substrate scope and excellent functional group tolerance. A detailed mechanistic investigation was performed.

Organic & Biomolecular Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C10H10O2, Name: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, R. published the artcileOptimization of polystyrene resin-supported Pt catalysts in room temperature, solvent-less, 1-octene hydrosilylation using methyldichlorosilane, Category: chlorides-buliding-blocks, the publication is Combinatorial Chemistry and High Throughput Screening (2002), 5(3), 201-209, database is CAplus and MEDLINE.

Six precursor resins with systematic variation of porous parameters were prepared by suspension polymerization using specific compositions of divinylbenzene, styrene vinylbenzyl chloride (VBC) and 2-ethylhexan-1-ol (a porogen) and the surface areas from N₂ sorption and BET anal. were ∼2-170 m²·g^-1. The VBC content in each case was 38 mol% and these groups were aminated using the sodium salt of trimethylethylenediamine and Pt was introduced onto each resin at three different loadings (∼0.03, ∼ 0.2 and ∼ 0.4 mmol·g^-1) by appropriate manipulation of K₂PtCl₄. The matrix of 18 resin-supported Pt complexes was then assessed for catalytic activity in the room temperature, solvent-less, hydrosilylation of 1-octene using methyldichlorosilane such that alkene:silane:Pt ratio was fixed as 2:1:1×10^-3. Though all the catalysts showed activity lower than that of homogeneous Speier’s catalyst, most were sufficiently active to be potentially valuable heterogeneous catalysts in the laboratory, and indeed the plant. The most lightly loaded resins proved to be the least active and the remainders were recycled 5 times, and the best performers, the most highly loaded species, a further 5 times making 10 consecutive uses in all. A strong dependence on the porous structure of the resins was demonstrated with the activity rising systemically with the surface area. The two highest surface area highest loaded species displayed good activity even when used for the tenth time. The level of concurrent alkene isomerization observed was low throughout (<1%) making these heterogeneous species selective and highly active. Overall the derived catalysts are excellent candidates for use in the research laboratory, and with further development could also be valuable in continuous processes.

Combinatorial Chemistry and High Throughput Screening published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, R. published the artcilePolymethacrylate and polystyrene-based resin-supported Pt catalysts in room temperature, solvent-less, oct-1-ene hydrosilylations using trichlorosilane and methyldichlorosilane, Product Details of C9H20Cl2Si, the publication is Journal of Molecular Catalysis A: Chemical (2001), 177(1), 49-69, database is CAplus.

A first group of methacrylate-based resins have been prepared with different amine ligands each co-ordinating Pt(II). Evaluation of each of these as room temperature catalysts in the solvent-less hydrosilylation of oct-1-ene by trichlorosilane has identified a supported ethylenediamine-derived ligand as providing the most active and stable Pt catalyst. A second group of methacrylate-based resins and third group of styrene-based resins have also been prepared with a variety of morphologies. Each of these was chem. modified to introduce the same ethylenediamine-derived ligand and subsequently Pt(II) coordinated to each of these. Both groups of resin catalysts were evaluated for activity, selectivity, Pt leaching and recyclability in the hydrosilylation of oct-1-ene by trichlorosilane and methyldichlorosilane. Specific samples of resin catalysts have been recycled up to 11 times in successive batch reactions. The styrene-based resins have been shown to be more active than the methacrylate-based ones, almost certainly because as a group they are more hydrophobic. Gel-type morphologies in the support are totally unsuitable and appear to provide severe mass transport limitations. The various macroporous resin based species are very attractive catalysts and the most likely optimum design criteria are discussed.

Journal of Molecular Catalysis A: Chemical published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wawrzynczak, Agata published the artcileHydrosilylation of n-alkenes and allyl chloride over platinum supported on styrene-divinylbenzene copolymer, Safety of Dichloro(methyl)(octyl)silane, the publication is Catalysis Today (2011), 169(1), 69-74, database is CAplus.

Catalytic performance of styrene-divinylbenzene copolymer-supported platinum catalyst of high crosslinking degree and high surface area was studied in reactions of hydrosilylation of allyl chloride, 1-octene and 1-butene. The catalyst has shown considerably greater stability of catalytic activity than classical active carbon-supported catalyst. In experiments on repeated use of catalysts, the decrease in catalytic activity for hydrosilylation of liquid double bond-containing compounds proceeding in the presence of the copolymer-supported and carbon-supported platinum was considerably smaller in the case of the former catalyst. Bimetallic Pt-Cu catalyst on polymeric support appeared to be considerably less active than monometallic catalyst.

Catalysis Today published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C10H20O2, Safety of Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics