Tag: M.W=200-250

Rubtsov, M. V. published the artcileDerivatives of sulfanilamide. IV, Application of Coumarin-6-sulfonyl chloride, the publication is Zhurnal Obshchei Khimii (1944), 857-64, database is CAplus.

6-Methoxy-2-chloroquinoline (25 g.) in 50 g. PhOH was heated to 135° and treated with dry NH₃, cooled, treated with Me₂CO, filtered and treated with EtOH-HCl, and the separated HCl salt neutralized to yield 6-methoxy-2-phenoxyquinoline, b₃ 183°, m. 46°. 6-Methoxy-2-chloroquinoline (17 g.) and 40 g. AcNH₂ were heated to 180° for 4 h. and 200° for 2 h. with treatment with gaseous NH₃; no reaction occurred; after addition of 1.7 g. CuCl and continuation of the reaction for 12 h. at 200° there was obtained 6.7 g. 6-methoxy-2-aminoquinoline, m. 175° (from water); 4 g. of this and 5.4 g. p-AcNHC₆H₄SO₂Cl (I) in pyridine gave after 3 h. at 90-100° 2-(p-acetamidophenylsulfonamido)-6-methoxyquinoline, m. 245-6° (from 50% AcOH), which was hydrolyzed by 10% NaOH to 2-sulfanilamido-6-methoxyquinoline, m. 214.5° (from 50% AcOH). 4-Amino-6-methoxyquinoline (4 g.) and 5.4 g. I gave, as above, 2.4 g. 4-(p-acetamidophenylsulfonamido)-6-methoxyquinoline, m. 292° (from water), which was hydrolyzed by 10% NaOH to 4-sulfanilamido-6-methoxyquinoline, m. 274° (from 50% AcOH). 6-Aminoquinoline (7.2 g.) and 11.7 g. I gave 6-(p-acetamidophenylsulfonamido)quinoline, m. 282°, which was hydrolyzed by 17% HCl to 6-sulfanilamidoquinoline, m. 209-10° (from 50% EtOH). Coumarin (10 g.), added with cooling to 40 g. ClSO₃H, heated to 100° for 4 h., cooled, and poured on ice yielded 10 g. 6-coumarinsulfonyl chloride, m. 116° (from (CH₂Cl)₂); treatment with 15% NH₄OH at 35° gave 6-sulfamylcoumarin, m. 185° (from water), while substitution of sulfanilamide for NH₄OH gave N-(p-sulfamylphenyl)-6-coumarin sulfonamide, m. 219° (from 50% EtOH), and the use of p-H₂NC₆H₄CO₂H gave p-carboxy-6-coumarinsulfonanilide, m. 241° (from 65% AcOH). Coumarinsulfonyl chloride and p-AcNHC₆H₄NH₂ gave p-acetamido-6-coumarinsulfonanilide, m. 280° (from 75% AcOH), which was hydrolyzed by 10% NaOH to p-amino-6-coumarinsulfonanilide, m. 209° (from 50% EtOH). 6-Aminocoumarin (2.9 g.) with 2.4 g. I in Me₂CO gave 3.5 g. 6-(p-acetamidophenylsulfonamido)coumarin, m. 230° (from 75% AcOH), which was hydrolyzed with 10% NaOH to 6-sulfanilamidocoumarin, m. 191° (from 50% EtOH). Only the last compound showed promising activity against streptococci, pneumococci, and staphylococci.

Zhurnal Obshchei Khimii published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Kedong published the artcileArylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination, Quality Control of 10543-42-7, the publication is Chemical Science (2021), 12(4), 1363-1367, database is CAplus and MEDLINE.

PdII/CuI co-catalyze an arylation reaction of gem-difluoroalkenes using arylsulfonyl chlorides to deliver α,α-difluorobenzyl products. The reaction proceeded through a β,β-difluoroalkyl-Pd intermediate that typically underwent unimol. β-F elimination to deliver monofluorinated alkene products in a net C-F functionalization reaction. However to avoid β-F elimination, the β,β-difluoroalkyl-Pd intermediate were offered, an alternate low-energy route involving β-H elimination to ultimately deliver difluorinated products in a net arylation/isomerization sequence. Overall, this reaction enabled exploration of new reactivities of unstable fluorinated alkyl-metal species, while also providing new opportunities for transforming readily available fluorinated alkenes into more elaborate substructures.

Chemical Science published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C12H9N3O4, Quality Control of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Harrill, Joshua A. published the artcileHigh-throughput transcriptomics platform for screening environmental chemicals, HPLC of Formula: 637-07-0, the publication is Toxicological Sciences (2021), 181(1), 68-89, database is CAplus and MEDLINE.

New approach methodologies (NAMs) that efficiently provide information about chem. hazard without using whole animals are needed to accelerate the pace of chem. risk assessments. Technol. advancements in gene expression assays have made in vitro high-throughput transcriptomics (HTTr) a feasible option for NAMs-based hazard characterization of environmental chems. In this study, we evaluated the Templated Oligo with Sequencing Readout (TempO-Seq) assay for HTTr concentration-response screening of a small set of chems. in the human-derived MCF7 cell model. Our exptl. design included a variety of reference samples and reference chem. treatments in order to objectively evaluate TempO-Seq assay performance. To facilitate anal. of these data, we developed a robust and scalable bioinformatics pipeline using open-source tools. We also developed a novel gene expression signature-based concentration-response modeling approach and compared the results to a previously implemented workflow for concentration-response anal. of transcriptomics data using BMDExpress. Anal. of reference samples and reference chem. treatments demonstrated highly reproducible differential gene expression signatures. In addition, we found that aggregating signals from individual genes into gene signatures prior to concentration-response modeling yielded in vitro transcriptional biol. pathway altering concentrations (BPACs) that were closely aligned with previous ToxCast high-throughput screening assays. Often these identified signatures were associated with the known mol. target of the chems. in our test set as the most sensitive components of the overall transcriptional response. This work has resulted in a novel and scalable in vitro HTTr workflow that is suitable for high-throughput hazard evaluation of environmental chems.

Toxicological Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, HPLC of Formula: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chuntao published the artcileReactions of Organosilanes with Silica Surfaces in Carbon Dioxide, Formula: C9H20Cl2Si, the publication is Langmuir (2001), 17(3), 757-761, database is CAplus.

Silylation reactions using liquid and supercritical CO₂ as the solvent were performed on both single surface (silicon wafers) and nanoporous (silica gel) silica samples. The alkylsilyl monolayers formed on single surfaces were characterized by wettability, ellipsometry, and XPS. Modified nanoporous silica samples were analyzed by chem. anal. A range of different silanes including monochloro-, dichloro-, trichloro-, and dimethylamino-silanes was examined The results indicate that dense carbon dioxide is a good solvent for silylation reactions, comparable or better than most solvents. Compared with the optimum conditions for silylation at solid-liquid interfaces, reactions in carbon dioxide are faster, although maximum bonding densities are slightly lower.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ismail, I. Imam published the artcileReactions with coumarin. III, Product Details of C9H5ClO4S, the publication is Afinidad (1995), 52(456), 133-6, database is CAplus.

Various coumarin-6-sulfonic acid esters are prepared through reaction of coumarin-6-sulfonyl chloride (I) with some phenolic compounds The reaction of 2-formylphenyl coumarin-6-sulfonate with primary amines led to the Schiff’s bases. Aceturic or hippuric acid reacts with 4-formylphenyl coumarin-6-sulfonate to give oxazolone derivatives I reacts with some sulfonamides yielding coumarin-6-sulfonamide derivatives Coumarin-6-sulfonylurea derivatives were also prepared

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al-Kindy, S. M. Z. published the artcileUV-visible absorption and fluorescence characteristics of the luminescent label coumarin-6-sulfonyl chloride in homogeneous and micellar solutions, Application of Coumarin-6-sulfonyl chloride, the publication is Analytica Chimica Acta (1994), 285(3), 329-33, database is CAplus.

This paper describes the study of the UV-visual absorption, fluorescence emission, and fluorescence excitation spectra of coumarin-6-sulfonyl chloride (C-6SCl) in various organic solvents and buffer solutions The spectral behavior in aqueous micellar systems of anionic and cationic surfactants was studied. The spectral properties of the compound together with the determined pK values in the ground and excited state are discussed in relation to its electronic structure. The results reflect the importance of the medium effect on the anal. application of C-6SCl as a potential luminescent label for derivatization of amino and phenolic groups.

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raja, K. Kanmani published the artcileSynthesis, spectral, electrochemical and catalytic properties of Cu(II), Ni(II) and Co(II) complexes containing N,O donors, Computed Properties of 19652-33-6, the publication is Journal of Molecular Catalysis A: Chemical (2009), 303(1-2), 52-59, database is CAplus.

Metal(II) chelates of Schiff bases derived from the condensation of multi-substituted aniline with salicylaldehyde derivatives were prepared Product structures were determined by NMR, IR, EPR, magnetic and cyclic voltammetry measurements. The complexes are of the type M(X-DPMP)₂ [(M = Cu(II), Ni(II) or Co(II)), DPMP = 2-[[(2,6-diisopropylphenyl)imino]methyl]phenol, X = Br, Cl, I, BrCl]. These Schiff bases behave as monobasic bidentate ligands in their complexes. The spectral data indicate that the ligand coordinates through a phenolic oxygen and the azomethine nitrogen atoms. The observed A _|| values in the Cu(II) complexes indicate a tetrahedrally distorted square planar structure. The cyclic voltammetric redox potential of copper(II) and nickel(II) complexes suggest the existence of irreversible pairs in acetonitrile. Cu(Br-DPMP)₂ was found to be an efficient catalyst for the cyanosilylation of aldehydes under mild conditions.

Journal of Molecular Catalysis A: Chemical published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ismail, Imam published the artcileReactions with coumarin. V., SDS of cas: 10543-42-7, the publication is Afinidad (2000), 57(487), 217-221, database is CAplus.

Several coumarin-6-sulfonamides (I; R = H, Me; substituent attached ortho, meta, or para) were prepared by reaction of coumarin-6-sulfonyl chloride with different aromatic amino compounds Imidazole derivatives were formed by reaction of I (R = Me) with ethylenediamine. Reaction of I (R = Me) with hydrazine hydrate afforded acid hydrazides. An oxadiazole was synthesized by reaction of a hydrazide with BzCl to give a diacylhydrazine, which cyclized to the oxadiazole derivative by heating with POCl₃. A thiadiazole derivative was synthesized by reaction of a hydrazide with Ph isothiocyanate, followed by treatment with POCl₃. Reaction of I (R = Me) with excess hydrazine hydrate (1:5 mol) proceeded with α-pyrone ring fission to give the corresponding cinnamoyl hydrazide derivatives Condensation of one of these with furfural gave the hydrazone, which cyclized to the oxadiazole on treatment with acetic anhydride.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Aleem, A. H. Abd published the artcileReactions with coumarin, Related Products of chlorides-buliding-blocks, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1994), 46(3), 17-23, database is CAplus.

Some reactions of coumarin-6-sulfonyl chloride (I) with hydrazines or acid hydrazides were investigated. E.g., reaction of I with hydrazine hydrate gave the hydrazino derivative, which reacted with aldehydes or ketones to yield hydrazones.

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ismail, I. Imam published the artcileReactions with coumarin. VI, Application In Synthesis of 10543-42-7, the publication is Afinidad (2002), 59(498), 151-154, database is CAplus.

The present investigation is designed to study the reaction of some active methylene compounds with coumarin-6-sulfonyl hydrazones, I (X = O, S). The following active methylene compounds were used: malononitrile, Et cyanoacetate, di-Et malonate and 2,4-pentanedione. It was found that, the active methylene compound is added to the double bond of the hydrazone to give an adduct, which cyclized directly to pyrazole or pyrazoline-5-one derivatives, e.g. II.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application In Synthesis of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics