Tag: M.W=200-250

Hemetsberger, H. published the artcileBehavior of chemically bonded alkylmethyldichlorosilanes to silica gel in reversed-phase high-performance liquid chromatography, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is Chromatographia (1977), 10(12), 726-30, database is CAplus.

Hydrocarbon-bonded stationary phases were prepared by reacting CH₃(CH₂)_nSiMeCl₂, where n = 7, 10, 14, and 17, with silica and were investigated and compared with phases obtained by the reaction of silica with alkyltrichlorosilanes. The reversed-phase chromatog. of halobenzenes with aq MeOH as mobile phase showed a linear relationship between the capacity ratios k‘ and the amount of C in the phases in all cases. The alkylmethyl phases were superior to the alkyl phases; capacity ratios and selectivities were increased and the efficiencies, with one exception, were higher. The improved properties are discussed in relation to residual silanol groups on the stationary phase surface.

Chromatographia published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boodhoo, Nitish published the artcileGlutaminolysis and glycolysis are essential for optimal replication of Marek’s disease virus, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of Virology (2020), 94(4), e01680-19, database is CAplus and MEDLINE.

Marek’s disease virus causes a deadly lymphoproliferative disease in chickens and modulates metabolism of host cells. Metabolic anal. of MDV-infected chicken embryonic fibroblasts identified elevated levels of metabolites involved in glutamine catabolism, such as glutamic acid, alanine, glycine, pyrimidine, and creatine. In addition, our results demonstrate that glutamine uptake is elevated by MDV-infected cells in vitro. Although glutamine, but not glucose, deprivation significantly reduced cell viability in MDV-infected cells, both glutamine and glucose were required for virus replication and spread. In the presence of min. glutamine requirements based on optimal cell viability, virus replication was partially rescued by the addition of the tricarboxylic acid (TCA) cycle intermediate, α-ketoglutarate, suggesting that exogenous glutamine is an essential carbon source for the TCA cycle to generate energy and macromols. required for virus replication. Surprisingly, the inhibition of CPT1a, which is elevated in MDV-infected cells, by chem. (etomoxir) or physiol. (malonyl-CoA) inhibitors, did not reduce MDV replication, indicating that MDV replication does not require fatty acid β-oxidation Taken together, our results demonstrate that MDV infection activates anaplerotic substrate from glucose to glutamine to provide energy and macromols. required for MDV replication, and optimal MDV replication occurs when the cells do not depend on mitochondrial β-oxidation

Journal of Virology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Sung-Chan published the artcileDevelopment of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(53), 6681-6683, database is CAplus and MEDLINE.

The authors report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe, was discovered through a high-content image based screening of 160 members of the chalcone library. The mol. binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.

Chemical Communications (Cambridge, United Kingdom) published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shapkin, N. P. published the artcileSynthesis and study of dipotassium derivatives of oligodiorganylsiloxane-α,ω-diols, Related Products of chlorides-buliding-blocks, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1995), 38(3), 24-9, database is CAplus.

Title salts KO(SiRR’O)_nK (R = Bu, R’ = vinyl; n = 1, 2, 4; R = octyl, R’ = Me, n = 1,3) were prepared by treating hydrolysis products of the corresponding dichlorosilanes with KOH. The polydispersion of these salts approaches 1.1 upon lowering the temperature of the reaction mixture to 50° and cooling it to -12° after the cleavage process is completed. Compositions of the salts thus obtained were confirmed by elemental anal., gel chromatog., IR spectral data, and also by reaction of these salts with Me₃SiCl and TiCl₄.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C6H4BBrF2O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rindhe, S. S. published the artcileSynthesis, antimicrobial and antioxidant activity of some oxindoles, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Indian Journal of Pharmaceutical Sciences (2011), 73(3), 292-296, database is CAplus and MEDLINE.

The present work describes the synthesis and spectral anal. of several (3Z)-[4-[4-(arylsulfonyl)-1-piperazinyl]benzylidene]-1,3-dihydro-2H-indol-2-one derivatives The title compounds were screened in-vitro against six species of microorganisms, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Aspergillus clavatus. Most of the compounds exhibited significant antimicrobial activity. All compounds were also screened in-vitro for the antioxidant activity using DPPH assay. Most of them have shown very significant antioxidant activity. The synthesis of the target compounds was achieved by an amidation (sulfonamidation) of 4-[4-[(2-oxo-3-indolylidene)methylene]phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester with sulfonyl halides. The title compounds thus formed included 1,3-dihydro-3-[(3Z)-[4-[4-[[4-(1-methylethyl)phenyl]sulfonyl]-1-piperazinyl]phenyl]methylene]-2H-indol-2-one (I).

Indian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cartwright, N. J. published the artcileSynthesis of γ-resorcylic acid (2,6-dihydroxybenzoic acid), HPLC of Formula: 36335-47-4, the publication is Journal of the Chemical Society (1952), 3499-502, database is CAplus.

Details are given of the preparation of 2,6-(MeO)₂C₆H₃CO₂H (I) in 14.8% yield from m-C₆H₄(NO₂)₂, 125 g. I and 400 g. AlCl₃ in 3.5 l. C₆H₆, refluxed 2 hrs., give 95-8% 2,6-(HO)₂C₆H₃CO₂H (II), m. 160-3° (decomposition); some decarboxylation occurs in boiling PhMe and, to a smaller extent, in boiling H₂O. 2,6-(HO)₂C₆H₃Ac (III) (133 g.) with Me₂SO₄ and aqueous NaOH gives 127 g. 2,6-(MeO)₂C₆H₃Ac (IV); 100 g. III with MeI and K₂CO₃ in Me₂CO (refluxed 12 hrs.) gives 95 g. IV. Oxidation of IV with Na-OCl at 85° (1.5 hrs.) gives 97% I; if the excess NaOCl is not removed before acidification, there results some 3-chloro-2,6-dimethoxybenzoic acid (V), m. 132°; 2 g. V and AlCl₃ in C₆H₆, refluxed 4 hrs., give 1.65 g. 3-chloro-2,6-dihydroxybenzoic acid, m. 193°, blue color with FeCl₃. 2,6-(HO)₂C₆H₃Me (50 g.) in NaOH, treated with Me₂SO₄ and heated 2 hrs. on the water bath, gives 57 g. 2,6-(MeO)₂C₆H₃Me; oxidation with KMnO₄ (1 hr. at 80°) gives 73% I. The preparation of II in 51% yield from 1.58 g. resorcinol bis(tetrahydro-2-pyranyl) ether and BuLi by the method of Parham and Anderson (C.A. 43, 2203h) is reported.

Journal of the Chemical Society published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, HPLC of Formula: 36335-47-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Koo published the artcileFluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption, Application In Synthesis of 61551-49-3, the publication is Bioorganic & Medicinal Chemistry Letters (1999), 9(17), 2483-2486, database is CAplus and MEDLINE.

LB30057 (I, R = H) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound I (R = H) and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound I (R = F) demonstrated a 3-fold increase in absorption.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Application In Synthesis of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mayer, Bernhard X. published the artcileA 50% n-octylmethyl, 50% diphenyl-polysiloxane as stationary phase with unique selectivity for gas chromatography, Name: Dichloro(methyl)(octyl)silane, the publication is Analyst (Cambridge, United Kingdom) (2003), 128(10), 1238-1242, database is CAplus and MEDLINE.

An n-octylmethyl, diphenyl-polysiloxane called SOP-50-Octyl was prepared by a condensation reaction of bis(dimethylamino) n-octylmethylsilane with diphenylsilanediol. The resulting copolymer was a gum with high mol. weight and was obtained with a yield of 80%. ¹H and ²⁹Si NMR spectroscopy revealed that the copolymer was a 52% octylmethyl, 48% diphenyl-polysiloxane with random microstructure. Small cyclic impurities could be almost quant. removed via a purification step. SOP-50-Octyl was used as stationary phase for the preparation of wall coated open tubular fused silica capillary columns for gas-liquid chromatog. The capillary columns exhibited high separation efficiency and high inertness. The stationary phase offered a unique selectivity due to its unique composition The Rohrschneider-McReynolds constants indicated a low overall polarity in spite of the high Ph content, as the polarity was distinctly decreased by the octyl substituent. Also, the octyl substituent was responsible for a high column bleed, reducing the maximum allowable operating temperature to 280°. The elution temperatures of apolar compounds were increased due to increased interaction of the octyl substituent with the analytes. Some applications with volatile and semi-volatile organic compounds illustrate that SOP-50-Octyl is an excellent choice for confirmational analyses.

Analyst (Cambridge, United Kingdom) published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Yih-Ting published the artcileAcute kidney disease and acute kidney injury biomarkers in coronary care unit patients, Product Details of C12H15ClO3, the publication is BMC Nephrology (2020), 21(1), 207, database is CAplus and MEDLINE.

Background: Acute kidney disease (AKD) describes acute or subacute damage and/or loss of kidney function for a duration of between 7 and 90 days after exposure to an acute kidney injury (AKI) initiating event. This study investigated the predictive ability of AKI biomarkers in predicting AKD in coronary care unit (CCU) patients. Methods: A total of 269 (mean age: 64 years; 202 (75%) men and 67 (25%) women) patients admitted to the CCU of a tertiary care teaching hospital from Nov. 2009 to Sept. 2014 were enrolled. Information considered necessary to evaluate 31 demog., clin. and laboratory variables (including AKI biomarkers) was prospectively recorded on the first day of CCU admission for post hoc anal. as predictors of AKD. Blood and urinary samples of the enrolled patients were tested for neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC) and interleukin-18 (IL-18). Results: The overall hospital mortality rate was 4.8%. Of the 269 patients, 128 (47.6%) had AKD. Multivariate logistic regression anal. revealed that age, Hb, ejection fraction and serum IL-18 were independent predictors of AKD. Cumulative survival rates at 5 years of follow-up after hospital discharge differed significantly (p < 0.001) between subgroups of patients diagnosed with AKD (stage 0A, 0C, 1, 2 and 3). The overall 5-yr survival rate was 81.8% (220/269). Multivariate Cox proportional hazard anal. revealed that urine NGAL, body weight and Hb level were independent risk factors for 5-yr mortality. Conclusions: This investigation confirmed that AKI biomarkers can predict AKD in CCU patients. Age, Hb, ejection fraction and serum IL-18 were independently associated with developing AKD in the CCU patients, and urine NGAL, body weight and Hb level could predict 5-yr survival in these patients.

BMC Nephrology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Product Details of C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Krishna Kanta published the artcileThe development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells, COA of Formula: C7H5Cl2NO2, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(45), 9336-9338, database is CAplus and MEDLINE.

A low-toxicity nucleus staining fluorescent probe, CDb12, was developed for real time mitosis imaging in live cells. CDb12 was identified by unbiased high-throughput imaging-based screening of a new xanthone library (AX). Unlike the conventional Hoechst dye, the low toxicity of CDb12 allows long term monitoring of cell division over more than one cell cycle.

Chemical Communications (Cambridge, United Kingdom) published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, COA of Formula: C7H5Cl2NO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics