Tag: M.W=200-250

Derhamine, Sary Abou published the artcileNickel-Catalyzed Mono-Selective α-Arylation of Acetone with Aryl Chlorides and Phenol Derivatives, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Angewandte Chemie, International Edition (2020), 59(43), 18948-18953, database is CAplus and MEDLINE.

The challenging nickel-catalyzed mono-α-arylation of acetone with aryl chlorides, pivalates, and carbamates was achieved for the first time. A nickel/Josiphos-based catalytic system is shown to feature unique catalytic behavior, allowing the highly selective formation of the desired mono-α-arylated acetone. The developed methodol. was applied to a variety of (hetero)aryl chlorides including biol. relevant derivatives The methodol. was extended to the unprecedented coupling of acetone with phenol derivatives Mechanistic studies allowed the isolation and characterization of key Ni⁰ and Ni^II catalytic intermediates. The Josiphos ligand is shown to play a key role in the stabilization of Ni^II intermediates to allow a Ni⁰/Ni^II catalytic pathway. Mechanistic understanding was then leveraged to improve the protocol using an air-stable Ni^II pre-catalyst.

Angewandte Chemie, International Edition published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Burkhard, C. A. published the artcileAlkylation of hydrochlorosilanes, HPLC of Formula: 14799-93-0, the publication is Journal of the American Chemical Society (1947), 2687-9, database is CAplus.

HSiCl₃ adds with ease to olefinic double bonds in the presence of peroxides or ultraviolet light; the reaction appears to proceed exclusively by the addition of the SiH bond. In general, 0.5 or 0.75 mole olefin was used with 1 mole of the chlorosilane and 0.013-0.026 mole of peroxide (30% Ac₂O₂ in o-C₆H₄(CO₂Me)₂ used unless otherwise indicated); this mixture was heated 4-24 hrs. at 70-100°. 1-Pentene and HSiCl₃ give 73% AmSiCl₃, b. 166-9°, and MeHSiCl₂ gives 37% pentylmethyldichlorosilane, b. 164-8°. 2-Pentene and MeHSiCl₂ give 71% 2-pentylmethyldichlorosilane, b₁₀₀ 100°. Cyclohexene and HSiCl₃ give 64% cyclohexyltrichlorosilane, b. 199°; iso-C₄H₈ and HSiCl₃ (tert-Bu perbenzoate as catalyst) give iso-BuSiCl₃, b. 136°. CH₂:CHSiCl₃ (I) and HSiCl₃ give 19% (CH₂SiCl₃)₂, b. 199°; this results in 3% yield from C₂H₂ (Bz₂O₂ as catalyst), I being postulated as an intermediate. CH₂:CHCH₂SiCl₃ and HSiCl₃ give 83% 1,3-bis(trichlorosilyl)propane, b₂₀ 111°. HSiCl₃ (135 g.) and 78 g. uninhibited PhCH:CH₂, heated 4 hrs. at 100°, give 70 g. of a glassy solid; alc.-NaOH gives no H, indicating that Si-C bonds had been formed.

Journal of the American Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Merchant, Jaysukhlal R. published the artcileSynthesis of sulfones with antitubercular activity, Application of Coumarin-6-sulfonyl chloride, the publication is Chemistry & Industry (London, United Kingdom) (1982), 955, database is CAplus.

6-Coumarylsulfonyl chlorides underwent Friedel-Crafts reaction with aromatic compounds to give 6-coumaryl aryl sulfones in 30-40% yield. E.g., treatment of sulfonyl chloride I (R = Cl) with PhEt for 4 h at 100° in the presence of AlCl₃ gave I (R = C₆H₄Et-p) (II). The sulfones were generally active against Mycobacterium tuberculosis.

Chemistry & Industry (London, United Kingdom) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tony, D. Eswar published the artcileA comparative research between pharmacological and nonpharmacological profile of anti-hyperlipidemic activity on rodents, HPLC of Formula: 637-07-0, the publication is Journal of Drug Delivery and Therapeutics (2021), 11(5), 65-70, database is CAplus.

The condition of hyperlipidemia is found to be a great establisher for all the neg. health consequences which may lead to cardiac complications. Continuous usage of medication alone is not permanent remedy but also need phys. exercise. The same situation was established in animals to assess the performance of pharmacol. and nonpharmacol. profile by standardized screening using In-vivo methods. The highcholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-d. lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-d. lipoprotein cholesterol (HDL-C) was significantly decreased for the treatment groups intended for phys. exercise. This article enables the importance of health benefited by phys. performance by depicting the biochem. parameters.

Journal of Drug Delivery and Therapeutics published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C14H26O2, HPLC of Formula: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rupprecht, Herbert published the artcileRegulation of drug release from micro- and mesoporous silicic acids. Part II. Effect of subsequent coating on release of drugs adsorbed on silicon dioxide, Product Details of C9H20Cl2Si, the publication is Pharmazeutische Zeitung (1980), 125(31), 1482-5, database is CAplus.

Codeine [76-57-3] desorption from SiO₂ was decreased by coatings of silicone oil, n-octylmethyldichlorosilane [14799-93-0], or polyphenylethoxysiloxane. These coatings decreased the effect of pH on drug delivery.

Pharmazeutische Zeitung published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Smirnov, E. A. published the artcileStructure and color of salicylideneaniline derivatives containing substituents in the aldehyde component, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Doklady Akademii Nauk SSSR (1968), 179(2), 358-61, database is CAplus.

The tabulated I were prepared by heating the substituted salicylaldehyde with PhNH2 in PrOH and crystallized from the solvent shown. 3,5,2-BrCl(HO)C6H2CHO, m. 102.5-3.5° (CCl4), and its 5,3,2-isomer, m. 86° (CCl4), were prepared by halogenation of the corresponding 5-substituted salicylaldehyde in AcOH. The colors listed in the table were shown by the powd. compound on white paper. The absorption spectra of these powders were also obtained. [TABLE OMITTED] The introduction of halogen or NO2 shifts the absorption of the I (R3 = H) (II) into the visible region and increases it, whereas the substituents have little effect on the absorption spectra of I (R3 = Me). Evidently, the substituents promote structure IIb. In HCONMe2 solution unsubstituted or monohalogenated II have λmax. at 272 and 339 mμ, but disubstituted II show λmax. in the visible region, with II (R1 = NO2, R2 = Br; R1 = H, R2 = NO2; or R1 = NO2, R2 = H) showing 2 such maximum

Doklady Akademii Nauk SSSR published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H5Br2F, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Duesel, Simon Josef Siegfried published the artcileOxidative Photochlorination of Electron-Rich Arenes via in situ Bromination, Application In Synthesis of 637-07-0, the publication is European Journal of Organic Chemistry (2020), 2020(10), 1491-1495, database is CAplus.

Electron-rich arenes are oxidatively photochlorinated in the presence of catalytic amounts of bromide ions, visible light, and 4CzIPN as organic photoredox catalyst. The substrates are brominated in situ in a first photoredox-catalyzed oxidation step, followed by a photocatalyzed ipso-chlorination, yielding the target compounds in high ortho/para regioselectivity. Dioxygen serves as a green and convenient terminal oxidant. The use of aqueous hydrochloric acid as the chloride source reduces the amount of saline byproducts.

European Journal of Organic Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Platonov, Dmitry N. published the artcileIonic Cyclopropenium-Derived Triplatinum Cluster Complex [(Ph₃C₃)₂Pt₃(MeCN)₄]²⁺(BF₄^–)₂: Synthesis, Structure, and Perspectives for Use as a Catalyst for Hydrosilylation Reactions, Formula: C9H20Cl2Si, the publication is Organometallics (2021), 40(23), 3876-3885, database is CAplus.

This study presents a methodol. for the synthesis of the ionic cyclopropenium-derived triplatinum cluster complex [(Ph₃C₃)₂Pt₃(MeCN)₄]²⁺(BF₄^–)₂ and its analog with the replacement of one of the BF₄^– anions with a Cl^– anion, which represents a chain coordination polymer in crystalline form. The structures of the complexes were studied by several physicochem. methods, primarily x-ray diffraction using synchrotron radiation and ¹⁹⁵Pt NMR spectroscopy in solution with measurement and anal. of the ¹⁹⁵Pt-¹⁹⁵Pt and ¹³C-¹⁹⁵Pt spin-spin coupling constants A high catalytic activity of the synthesized Pt₃ complex was observed in hydrosilylation reactions. The catalytic efficiency of the complex is comparable to that of Karstedt’s catalyst and in some cases even higher.

Organometallics published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sergeev, Pavel G. published the artcileConstruction of 6-Aminopyridazine Derivatives by the Reaction of Malononitrile with Dichloro-Substituted Diazadienes, Recommanded Product: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, the publication is European Journal of Organic Chemistry (2020), 2020(31), 4964-4971, database is CAplus.

The reactions of 4,4-dichloro-1,2-diazabuta-1,3-dienes with malononitrile resulted in an efficient approach to highly functionalized 6-aminopyridazine derivatives isolated in up to 98%. The process was found to provide straightforward access to the interesting type of nitrogen-containing heterocycles with an exocyclic double bond. Furthermore, the possibility of subsequent functionalization of the obtained compounds via intramol. cyclization was demonstrated. As a result, condensed azaheterocycles can be prepared very efficiently in one-pot and tandem versions. Finally, the influence of structural features of all synthesized compounds on their absorption characteristics in the UV/Vis-range is also investigated.

European Journal of Organic Chemistry published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C15H20N2O2, Recommanded Product: 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mandour, A. H. published the artcileSynthesis of N-(Coumarinsulfonyl)thiohydantoin and -hydantoin derivatives, Product Details of C9H5ClO4S, the publication is Afinidad (2000), 57(489), 344-348, database is CAplus.

Acylation of glycine with 6-coumarinylsulfonyl chloride or (6-nitro-3-coumarinyl)sulfonyl chloride gave N-[(coumarinyl)sulfonyl]glycine derivatives Treatment of the latter compounds with ammonium thiocyanate and acetic anhydride afforded N-[(coumarinyl)sulfonyl]-3-thiohydantoins. The key intermediates thus prepared were 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2-thioxo-4-imidazolidinone and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2-thioxo-4-imidazolidinone. Hydrolysis of these intermediates using aqueous chloroacetic acid gave N-[(coumarinyl)sulfonyl]hydantoins. Thus, the above (thioxo)imidazolidinones were transformed into the resp. diones, 1-[(2-oxo-2H-1-benzopyran-6-yl)sulfonyl]-2,4-imidazolidinedione and 1-[(6-nitro-2-oxo-2H-1-benzopyran-3-yl)sulfonyl]-2,4-imidazolidinedione. Condensation of N-[(coumarinyl)sulfonyl]-3-thiohydantoins and N-[(coumarinyl)sulfonyl]-3-hydantoins with (arylidene)malononitrile in piperidine gave the corresponding pyrano[2,3-d]imidazolidines. Also, the condensation of the above intermediates with aromatic aldehyde led to the formation of 5(arylidene)thiohydantoins and 5-(arylidene)hydantoins. The condensation of the latter compounds with malononitrile was also carried out.

Afinidad published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics