Tag: M.W=200-250

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Category: chlorides-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C3H6O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C21H37BO, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Yong published the artcileSynthesis of 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl) benzene, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Huaxue Shiji (2017), 39(11), 1237-1240, 1243, database is CAplus.

In this work, 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone was synthesized by reaction of Et trifluoroacetate with the Grignard reagent, which was obtained by reaction of 3,5-dichlorobromobenzene, magnesium and diisobutyl aluminum hydride. 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone was then reacted with methyltriphenylphosphonium iodide in the presence of potassium t-butoxide to give the desired product 1,3-dichloro-5-(3, 3, 3-trifluoroprop-1-en-2-yl) benzene. Above two compounds were confirmed by IR, MS, UV, ¹HNMR and ¹³CNMR. The synthetic route has the advantages of simple operation, mild reaction condition, cheap and easy access to raw materials, green environmental protection and low cost.

Huaxue Shiji published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C33H22N4, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dalvi, Prashant B. published the artcileRhodium-Catalyzed Regioselective Synthesis of Isocoumarins through Benzothiadiazine-Fused Frameworks, Formula: C7H3Cl2NO2S, the publication is Organic Letters (2016), 18(15), 3706-3709, database is CAplus and MEDLINE.

An unprecedented two-step, one-pot synthesis of benzimidazothiadiazine 5,5-dioxides is presented. Reaction condition based regioselectivity has been achieved where fused benzimidazo[1,2-b][1,2,4]thiadiazines are exclusively formed under thermal conditions, whereas benzimidazo[2,1-c][1,2,4]thiadiazines were created only under microwave irradiation The salient features of this protocol include a regioselective sulfonylation of 2-aminobenzimidazole with o-halo sulfonyl chlorides followed by N-C bond formation. The acid forms of these fused regioisomers have been used to introduce novel guanidine-containing isocoumarin frameworks.

Organic Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Formula: C7H3Cl2NO2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Jingjing published the artcileDBN-Mediated Addition Reaction of α-(Trifluoromethyl)styrenes with Diazoles, Triazoles, Tetrazoles, and Primary, Secondary, and Secondary Cyclic Amines, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Organic Letters (2022), 24(12), 2299-2304, database is CAplus and MEDLINE.

A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various β-trifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.

Organic Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Laiming published the artcilePreparation and evaluation of a novel and high efficient boronic acid-substituted silica supported Pt catalyst, Formula: C9H20Cl2Si, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2019), 322-330, database is CAplus.

A smart design of transition metal nanocatalyst can efficiently improve its catalytic activity and use value. In this work, platinum (Pt) was successfully anchored to silica gel with phenylboronic acid group first time and formed nanoparticles (0.5-5 nm) which afforded a highly active supported catalyst for the hydrosilylation of olefins. The turnover number and regioselectivity in the reaction of methyldichlorosilane and 1-octene using 0.00000004 mol of the immobilized Pt catalyst approached 1,321,317 and 99% over 12 h. The corresponding hydrosilylation products in excellent yields and regioselectivities were obtained when we employed a broad range of terminal aliphatic olefins and methyldichlorosilane as substrates. The fully immobilized Pt nanoparticles could be recycled at least 10 runs without any obvious loss in catalytic activity.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shao, Dongyun published the artcilePreparation of polycarboxylic acid-functionalized silica supported Pt catalysts and their applications in alkene hydrosilylation, Recommanded Product: Dichloro(methyl)(octyl)silane, the publication is RSC Advances (2018), 8(36), 20379-20393, database is CAplus and MEDLINE.

A series of novel immobilized platinum catalysts was prepared by loading Pt onto silica particles modified with polycarboxylic acid groups such as diethylenetriaminepentaacetic acid (DTPA), nitrilotriacetic acid (NTA) and succinic acid (SA). The three modified heterogeneous Pt catalysts were characterized using IR spectroscopy (IR), transmission electron microscopy (TEM), XPS, energy dispersive X-ray spectroscopy (EDS) and at. absorption spectroscopy (AAS). The residual H₂PtCl₆ solutions were characterized using UV spectroscopy (UV). The polycarboxylic acid-functionalized silica supported Pt catalysts were used to catalyze alkene hydrosilylation and 1-hexene was chosen as a model alkene. The data indicated that the catalytic performance was strongly dependent on the properties of the polycarboxylic acid group bonded to the silica particles. Among them, DTPA-functionalized silica supported Pt (SiO₂-DTPA-Pt) showed the best catalytic activity and reusability. Furthermore, some hydrosilylation reactions between other linear alkenes (1-heptene, 1-octene, 1-decene, 1-do-decene, 1-tetra-decene, 1-hexa-decene, 1-octa-decene, styrene or cis-hex-2-ene), or ring type alkenes (norbornene) with methyldichlorosilane could be catalyzed in the presence of these three Pt catalysts. Their high activities were more than 90%, and their selectivities were more than 99%, which were apparently better than homogeneous Pt catalysts. In addition, reactions with cyclohexene were also successfully catalyzed by the Pt catalysts. These results indicate that the polycarboxylic acid-functionalized silica gel supported Pt catalysts have potential value in industrial hydrosilylation reactions.

RSC Advances published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C16H20N2, Recommanded Product: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Meng, Haoyu published the artcileUsing a high-throughput zebrafish embryo screening approach to support environmental hazard ranking for cardiovascular agents, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Science of the Total Environment (2020), 134703, database is CAplus and MEDLINE.

Cardiovascular agents are among the most frequently prescribed pharmaceuticals worldwide. They are widely detected in aquatic ecosystems, while their ecotoxicol. implications are rarely explored. Here, by the use of a new developed high-throughput zebrafish embryo screening approach, we systematically assessed the cardiovascular disruptive effects of 32 commonly used cardiovascular agents at environmental relevant concentrations and above (0.04, 0.2 and 1 μM). Multiple endpoints, including cardiac output, heart rate and blood flow, were quantified via customized video anal. approaches. Among the 32 agents, simvastatin and lovastatin exhibited the strongest toxicities to fish embryos, and the LDs were observed at 0.2 μM and 1 μM. Beta-blockers such as atenolol and metoprolol significantly decreased heart rates by up to 15% and 12% and increased blood flows by up to 14% and 14%, resp., at concentrations as low as 0.04 μM. Several hypertension/hyperlipidemia medications such as pravastatin and enalapril led to significant inhibition of heart rates (up to 14% and 16% decreases, resp.) as well as slightly decreases of the cardiac outputs and blood flows. In addition, a tentative risk assessment clearly demonstrated that some compounds such as atenolol, metoprolol and bezafibrate pose considerable risks to aquatic organisms at environmental or slightly higher than surface water concentrations Our results provided novel insights into understanding of the potential risks of cardiovascular agents and contributed to their environmental hazard ranking.

Science of the Total Environment published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dong, Lefeng published the artcileCopper-catalyzed radical trifluoroethylthiolation of arylboronic acids with PhSO₂SCH₂CF₃, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Tetrahedron Letters (2022), 153293, database is CAplus.

Herein, a copper-catalyzed trifluoroethylthiolation reaction of S-(2,2,2-trifluoroethyl)benzenesulfonothioate and phenylboronic acids at room temperature was reported. The reaction achieved the insertion of trifluoroethylthio moiety to efficiently obtain various substituted aryl 2,2,2-trifluoroethyl thioethers RSCH₂CF₃ [R = 3-OMeC₆H₄, 4-BrC₆H₄, 4-PhC₆H₄, etc.] in good yields. Mechanistic investigation indicated the trifluoroethylthiolation radical was involved in the catalytic circle. Moreover, trifluoroethylthiolated clofibrate was synthesized in a particular fashion.

Tetrahedron Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Safety of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Song published the artcileDMSO-catalysed late-stage chlorination of (hetero)arenes, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Nature Catalysis (2020), 3(2), 107-115, database is CAplus.

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications.

Nature Catalysis published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C19H14O2, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics