Tag: M.W=200-250

Du, Huang-Chi published the artcileSynthesis of 5-substituted tetrazoles via DNA-conjugated nitrile, Synthetic Route of 254749-11-6, the publication is Organic & Biomolecular Chemistry (2020), 18(45), 9221-9226, database is CAplus and MEDLINE.

A zinc bromide-catalyzed synthesis of 5-substituted tetrazoles via DNA-conjugated nitriles using sodium azide has been developed. The protocol offered moderate to excellent yields of tetrazoles with a broad range of substrates, including a variety of functionalized aromatic, heterocyclic, and aliphatic nitriles. In addition, the electronic effect within the substrate scope was evaluated. DNA fidelity was assessed by ligation efficiency and amplifiability anal. The ability to generate tetrazoles expands the diversity of heterocycles in the preparation of DNA-encoded chem. libraries.

Organic & Biomolecular Chemistry published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Synthetic Route of 254749-11-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pena-Mendez, E. M. published the artcileMetal organic framework composite, nano-Fe₃O₄@Fe-(benzene-1,3,5-tricarboxylic acid), for solid phase extraction of blood lipid regulators from water, Related Products of chlorides-buliding-blocks, the publication is Talanta (2020), 120275, database is CAplus and MEDLINE.

The magnetic metal-organic framework Fe₃O₄@(Fe-(benzene-1,3,5-tricarboxylic acid) (MMOF) was prepared, characterized and studied as a magnetic sorbent for the dispersive solid-phase extraction (DSPE) of several widely used blood lipid regulators (i.e., bezafibrate, clofibric acid, clofibrate, gemfibrozil and fenofibrate) from water samples. Characterization of the synthesized Fe₃O₄@Fe-BTC magnetic nanomaterial was performed by Fourier transform IR spectroscopy, powder X-ray diffractometry, thermogravimetric anal., SEM and transmission electron microscopy. The magnetic nanocomposite was found to be chem. stable and to possess a large surface area (803.62 m²/g) and pore volume (0.59 cm³/g). The concentrations of fibrates in different water samples were determined using HPLC-UV-Vis and confirmed by UPLC-MS/MS. Parameters affecting the extraction efficiency of magnetic-DSPE were studied and optimized. The maxima absorption capacities (Q_max) were determined to be (in mg/g) 197.0 for bezafibrate, 620.3 for clofibric acid, 537.6 for clofibrate, 288.7 gemfibrozil and 223.2 for fenofibrate. Validations of the optimized magnetic DSPE method for analyses at two fibrate concentrations in spiked water samples produced relative recovery values ≤ 70% for clofibrate and within the range of 80-100% for bezafibrate, clofibric acid, gemfibrozil and fenofibrate. LODs ranging from 4μg/L for fenofibrate to 99μg/L for gemfibrozil were obtained. The validated methodol. produced recovery values ranging from 70 to 112% (relative standard deviations < 7%).

Talanta published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fadeev, Alexander Y. published the artcileSelf-Assembly Is Not the Only Reaction Possible between Alkyltrichlorosilanes and Surfaces: Monomolecular and Oligomeric Covalently Attached Layers of Dichloro- and Trichloroalkylsilanes on Silicon, Application of Dichloro(methyl)(octyl)silane, the publication is Langmuir (2000), 16(18), 7268-7274, database is CAplus.

Si-supported alkylsiloxane layers were prepared by reaction of alkylmethyldichlorosilanes and alkyltrichlorosilanes with Si wafers under two conditions: (1) in the vapor phase and (2) in toluene in the presence of ethyldiisopropylamine. Covalent attachment of di- and trichlorosilanes to the surface of Si/Si oxide through Si_S-O-Si bonds occurs for the amine-catalyzed reactions. This sets apart this reaction from the self-assembly process that occurs in the reaction between certain trichlorosilanes and hydrated SiO₂ with no amine present. The thickness of the layers formed from dichloro- and trichlorosilanes (as assessed by ellipsometry) is on the order of the single mol. sizes and increases gradually with alkyl chain length. The thickness values are considerably smaller (by a factor of ∼0.75) than the length of the fully stretched alkyl chain, which argues for disordered structures of the monolayers. Dynamic advancing and receding contact angles for H₂O, methylene iodide, and hexadecane argue for interaction between the probe fluids and accessible silanol groups (Si-OH) on the surface. H₂O contact angles increase with alkyl chain length and level at θ_A/θ_R ≃103°/∼90° for relatively long alkyl chains (approx. C₆ and longer), indicating that these surfaces project disordered Me and methylene groups toward the probe fluid. N-Hexadecane and methylene iodide contact angles show more complex behavior, which is discussed. The vapor-phase reaction of di- and trichlorosilanes with Si wafers yields surfaces that depend dramatically on the alkyl chain of the silane. Alkylsilanes with short and medium chains form polymeric grafted layers with thicknesses ranging from a few nanometers for dichlorosilanes up to tens of nanometers for trichlorosilanes. The authors suggest a mechanism that involves polycondensation of chlorosilanes into 3-dimensional alkylsiloxanes in the presence of adsorbed H₂O. Dynamic advancing and receding contact angles of H₂O, methylene iodide, and hexadecane on these surfaces are consistently higher than for surfaces prepared in the liquid phase. Alkylsilanes with long alkyl moieties yield approx. monomol. layers that exhibit wettabilities similar to those for surfaces prepared in the liquid phase.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Application of Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cuyegkeng, Maria Assunta published the artcileChromatographic separation of enantiomers and barriers to enantiomerization of axially chiral aromatic carboxamides, Synthetic Route of 36335-47-4, the publication is Chemische Berichte (1987), 120(5), 803-9, database is CAplus.

The enantiomers (M) and (P) of a series of similar aromatic carboxamides were for the first time examined anal. and enriched preparatively by liquid chromatog. on triacetylcellulose. Enantiomeric purities (7-99%), sp. rotations, and barriers to rotation about the C(sp²)-C(sp²) bond (87-120 kJ/mol) were determined These energies were discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.

Chemische Berichte published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Synthetic Route of 36335-47-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lochmuller, C. H. published the artcileAn examination of chemically modified silica surfaces using fluorescence spectroscopy, Quality Control of 14799-93-0, the publication is Analytica Chimica Acta (1981), 130(1), 31-43, database is CAplus.

Aminated microparticulate silica gel was derivatized with the fluorescent tag, dansyl chloride, to produce a chem.-modified silica surface that could be examined by fluorescence spectroscopy; also a dansylated silica was further derivatized with various alkyl functionalities. The labeled silicas were introduced into solvents and solvent mixtures of different polarities and the emission spectra obtained were compared with the spectra of a model compound, n-propyldansylamide, in the same solvents. Residual amine groups, as well as unreacted silanol groups, produce a polar surface environment reflected in the emission maximum of the spectrum of the modified silica. The degree of residual surface polarity also appears to be a function of the aminopropylsilane reagents used.

Analytica Chimica Acta published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Quality Control of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abd-El-Hafez, O. M. published the artcileSynthesis of some new coumarin derivatives with evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Egyptian Journal of Pharmaceutical Sciences (1994), 35(1-6), 113-26, database is CAplus.

6-Aminocoumarin (I) was condensed with some aromatic aldehydes to give the Schiff’s bases II (R = N:CHR², R¹ = H, R² = C₆H₄OMe-4, C₆H₄Cl-2, C₆H₄Cl-4, C₆H₄NO₂-4, C₆H₄NMe₂, 2-thienyl, X = O). I was also reacted with some halo-compounds to give coumarin-6-amino derivatives II (R = NHR³, R¹ = H, R³ = COCH₂Cl, CH₂CHO, COPh, X = O). 6-Nitrocoumarin-3-sulfonyl chloride II (R = NO₂, R¹ = SO₂R⁴, R⁴ = Cl, X = O) and thiocoumarin-6-sulfonyl chloride II (R = SO₂R⁴, R⁴ = Cl, R¹ = H, X = S) were reacted with some amines to give 6-nitrocoumarin-3-sulfonamide derivatives II (R = NO₂, R¹ = SO₂R⁴, R⁴ = NHNH₂, NMe₂, pyrrolidino, 2-pyridinyl, morpholino, etc., X = O) and thiocoumarin-6-sulfonamide derivatives II (R = SO₂R⁴, R¹ = H, R⁴ = piperidino, pyrrolidino, morpholino), resp. On the other hand, thiocoumarin II (R = R¹ = H, X = S) was reacted with primary amines to give benzopyran-2-imino derivatives II (X = NR⁵, R⁵ = NH₂, Me, NHPh, CH₂Ph, 2-pyridinyl, Ph). The antimicrobial activity of the prepared compounds was also investigated.

Egyptian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shalaby, A. M. published the artcileSynthesis of some coumarin-6-sulfono-N-amino acids and evaluation of their antimicrobial activity, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Bulletin of the National Research Centre (Egypt) (1994), 19(2), 97-106, database is CAplus.

The reaction of 6-coumarinsulfonyl chloride with amino acid esters gave N-[(coumarinyl)sulfonyl]glycine derivatives that were converted to the corresponding N-[(coumarinyl)sulfonyl]glycine hydrazides I (R = alkyl, benzyl, etc.). The antimicrobial activity of N-[(coumarinyl)sulfonyl]glycine hydrazide s and preparation of N-[(coumarinyl)sulfonyl]dipeptides was reported.

Bulletin of the National Research Centre (Egypt) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C16H12O, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shultz, Michael D. published the artcileStructure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases, Application of 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(17), 7049-7059, database is CAplus and MEDLINE.

Tankyrases 1 and 2 are members of the poly(ADP-ribose) polymerase (PARP) family of enzymes that modulate Wnt pathway signaling. While amide- and lactam-based nicotinamide mimetics that inhibit tankyrase activity, such as XAV939, are well-known, the discovery and evaluation of a novel nicotinamide isostere that demonstrates selectivity over other PARP family members is reprted. The utilization of lipophilic efficiency-based structure-efficiency relationships (SER) to rapidly drive the evaluation of this series is demonstrated. These efforts led to a series of selective, cell-active compounds with solubility, physicochem., and in vitro properties suitable for further optimization.

Journal of Medicinal Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C15H19BO2, Application of 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Zhuang published the artcileTungstate-Catalyzed Biomimetic Oxidative Halogenation of (Hetero)Arene under Mild Condition, Computed Properties of 36335-47-4, the publication is iScience (2020), 23(5), 101072, database is CAplus and MEDLINE.

A biomimetic approach for halogenation (Br, Cl, I) of (hetero)arene catalyzed by tungstate under mild pH in a cost-efficient and environment- and operation-friendly manner was reported. Broad substrates diverse functional group tolerance and good chemo- and regioselectivities were observed, even in late-stage halogenation of complex mols. Moreover, this approach was scaled up to over 100 g without time-consuming and costly column purification Several drugs and key precursors for drugs bearing aryl halides (Br, Cl, I) was conveniently prepared based on this approach.

iScience published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Computed Properties of 36335-47-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Yi published the artcileNickel-Catalyzed Reductive Coupling for Transforming Unactivated Aryl Electrophiles into β-Fluoroethylarenes, Application In Synthesis of 637-07-0, the publication is Chemistry – An Asian Journal (2020), 15(1), 156-162, database is CAplus and MEDLINE.

We report herein a facile synthetic method for converting unactivated (hetero)aryl electrophiles into β-fluoroethylated (hetero)arenes via nickel-catalyzed reductive cross-couplings. This coupling reaction features the involvement of FCH₂CH₂ radical intermediate rather than β-fluoroethyl manganese species which provides effective solutions to the problematic β-fluoride side eliminations. The practical value of this protocol is further demonstrated by the late-stage modification of several complex ArCl or ArOH-derived bioactive mols.

Chemistry – An Asian Journal published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C21H18N4OS, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics