Tag: M.W=200-250

Xu, Xiao published the artcileVisible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines, SDS of cas: 5860-95-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(78), 11017-11020, database is CAplus and MEDLINE.

Using an umpolung strategy, herein the first intermol. reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Bronsted acid catalyst upon visible-light irradiation is reported. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcs. with tri-/difluoromethyl groups in moderate to excellent yields. The com. available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C30H24BrCuN2P, SDS of cas: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Amagase, Yoko published the artcilePeroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver., Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is The Journal of toxicological sciences (2020), 45(8), 475-492, database is MEDLINE.

By analysis of the data from the Toxicogenomics Database (TG-GATEs), histidine decarboxylase gene (Hdc) was identified as largely and commonly upregulated by three fibrates, clofibrate, fenofibrate, and WY-14,643, which are known to induce hepatocellular hypertrophy and proliferation via stimulation of peroxisome proliferator-activated receptor α (PPARα) in rodents. As histamine has been reported to be involved in the proliferation of liver cells, the present study was conducted to focus on Hdc. Among other genes related to histidine and histamine, the expression of the gene of histamine ammonia lyase (Hal) was exclusively mobilized by the three fibrates. The expression of Hdc, which was usually very low in the liver, was increased with the repeated administration of fibrates, and concomitantly, the constitutive expression of Hal was suppressed. An interpretation is that the formation of urocanic acid from histidine under the normal condition switches to the formation of histamine. The mobilization of gene expression of Hdc and Hal by PPARα agonists could not be reproduced in primary cultured hepatocytes. The Hdc mRNA appeared to be translated to a protein which is processed differently from brain but similarly to gastric mucosa. Surprisingly, the fibrates caused hepatic hypertrophy but no induction of Hdc mRNA at all in mice. These results revealed that the changes in the histidine catabolism by PPARα agonists might be partially, but not directly, involved in the hepatocyte proliferation in rats, and there is a large genetic distance even between rat and mouse.

The Journal of toxicological sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Amagase, Yoko published the artcilePeroxisome proliferator-activated receptor a agonist-induced histidine decarboxylase gene expression in the rat and mouse liver, Related Products of chlorides-buliding-blocks, the publication is Journal of Toxicological Sciences (2020), 45(8), 475-492, database is CAplus.

By anal. of the data from the Toxicogenomics Database (TG-GATEs), histidine decarboxylase gene (Hdc) was identified as largely and commonly upregulated by three fibrates, clofibrate, fenofibrate, and WY-14,643, which are known to induce hepatocellular hypertrophy and proliferation via stimulation of peroxisome proliferator-activated receptor α (PPARα) in rodents. As histamine has been reported to be involved in the proliferation of liver cells, the present study was conducted to focus on Hdc. Among other genes related to histidine and histamine, the expression of the gene of histamine ammonia lyase (Hal) was exclusively mobilized by the three fibrates. The expression of Hdc, which was usually very low in the liver, was increased with the repeated administration of fibrates, and concomitantly, the constitutive expression of Hal was suppressed. An interpretation is that the formation of urocanic acid from histidine under the normal condition switches to the formation of histamine. The mobilization of gene expression of Hdc and Hal by PPARαagonists could not be reproduced in primary cultured hepatocytes. The Hdc mRNA appeared to be translated to a protein which is processed differently from brain but similarly to gastric mucosa. Surprisingly, the fibrates caused hepatic hypertrophy but no induction of Hdc mRNA at all in mice. These results revealed that the changes in the histidine catabolism by PPARα agonists might be partially, but not directly, involved in the hepatocyte proliferation in rats, and there is a large genetic distance even between rat and mouse.

Journal of Toxicological Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shimojima, Atsushi published the artcileSynthesis of Silylated Derivatives of a Layered Polysilicate Kanemite with Mono-, Di-, and Trichloro(alkyl)silanes, Product Details of C9H20Cl2Si, the publication is Chemistry of Materials (2001), 13(10), 3603-3609, database is CAplus.

Interlayer modification of a layered polysilicate kanemite was performed by silylation with mono-, di-, and trichloro(alkyl)silanes. The introduction of silyl groups into the interlayer region was confirmed by XRD, IR, ¹³C NMR, and ²⁹Si NMR. The layered structures of the silylated products were confirmed by swelling behavior upon adsorption of n-alkyl alcs. The amounts of attached alkylsilyl groups varied with the number of functional groups as well as the alkyl chain length in the silylating agents. The products modified with alkyltrichlorosilanes exhibited various interlayer structures due to the different arrangements and/or conformations of the alkyl chains, depending on the chain lengths. The BET surface areas were relatively large (up to ∼480 m² g^-1) when short-chain alkyltrichlorosilanes were used, and decreased substantially to nonporous structures with increasing chain length. In addition to the inherent six-membered rings in the single layered silicate sheets of kanemite, new five- and six-membered rings were formed onto the silicate frameworks when dichloro- and trichlorosilanes were used for silylation. This leads to a new method for constructing novel organosilicate nanomaterials utilizing layered silicates.

Chemistry of Materials published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C10H19NO3, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Steingruber, H. Sebastian published the artcileConvenient One-Pot Synthesis of 9H-Carbazoles by Microwave Irradiation Employing a Green Palladium-Based Nanocatalyst, HPLC of Formula: 117738-74-6, the publication is Synthesis (2021), 53(21), 4048-4058, database is CAplus.

An efficient palladium-catalyzed tandem reaction for the one-pot synthesis of 9H-carbazoles under microwave irradiation was developed. This approach involves a sequential Buchwald-Hartwig amination and a direct arylation from affordable and inexpensive anilines and 1,2-dihaloarenes. For the development of this purpose, a novel and magnetically recoverable palladium nanocatalyst-supported on a green biochar under ligand-free conditions was used. Compared to other existing palladium-based protocols, the present synthetic methodol. shows a drastic reduction in reaction times and excellent compatibility with different functional groups allowing to obtain a small library of 9H-carbazoles in high yields and with good regioselectivity. This procedure represents the first example in the direct synthesis of carbazoles using a heterogeneous palladium nanocatalyst from com. precursors. To examine the application of this protocol, a direct and scalable synthesis of the bioactive carbazole alkaloid clausenalene from com. available starting materials was described.

Synthesis published new progress about 117738-74-6. 117738-74-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Ester, name is Methyl 4-bromo-3-chlorobenzoate, and the molecular formula is C4H3Cl2N3, HPLC of Formula: 117738-74-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Guang-Wu published the artcileCatalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc-to-Titanium Transmetalation, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2011), 50(15), 3538-3542, S3538/1-S3538/84, database is CAplus and MEDLINE.

Trifluoromethyl ketones were alkynylated stereoselectively in presence of cinchona alkaloid ligands, titanium tetraisopropoxide, dimethylzinc, and barium fluoride. The barium fluoride proved to be essential for asym. induction. The mechanism of zinc-to-titanium transmetalation is discussed.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C5H8N2O, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mszar, Nicholas W. published the artcileElectronically Activated Organoboron Catalysts for Enantioselective Propargyl Addition to Trifluoromethyl Ketones, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Angewandte Chemie, International Edition (2017), 56(30), 8736-8741, database is CAplus and MEDLINE.

A broadly applicable, practical, scalable, efficient and highly α- and enantioselective method for addition of a silyl-protected propargyl moiety to trifluoromethyl ketones was developed. Reactions, promoted by 2.0 mol % of a catalyst that is derived in situ from a readily accessible aminophenol compound at ambient temperature, were complete after only 15 min at room temperature The desired tertiary alcs. were isolated in up to 97% yield and 98.5:1.5 enantiomeric ratio. Alkyl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trifluoromethyl ketones can be used. Utility is highlighted by application to a transformation that is relevant to enantioselective synthesis of BI 653048, a compound active against rheumatoid arthritis.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al-Kindy, S. M. Z. published the artcileCoumarin-6-sulfonyl chloride: a novel label in fluorometry and phosphorimetry. Part 1. Synthesis and luminescence properties, HPLC of Formula: 10543-42-7, the publication is Analytica Chimica Acta (1989), 227(1), 145-53, database is CAplus.

Coumarin-6-sulfonyl chloride was synthesized from coumarin in a single step and characterized. It was used to label amines, amino acids and phenols in mild conditions. The products of such reactions show intense fluorescence in alk. solutions as a result of a photolytic ring-opening reaction. The derivatives are also phosphorescent a 77 K without ring opening.

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, HPLC of Formula: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Al-Kindy, S. M. Z. published the artcileCoumarin-6-sulfonyl chloride: a novel label in fluorometry and phosphorimetry. Part 2. Chromatographic applications, Computed Properties of 10543-42-7, the publication is Analytica Chimica Acta (1989), 227(1), 155-63, database is CAplus.

Coumarin-6-sulfonyl chloride is suitable for precolumn labeling in the ion-pair chromatog. of amino acids. Amino acid mixtures can also be separated, after derivatization, by thin-layer chromatog. using phosphorimetric detection at 77 K. Both approaches allow nanogram amounts of analytes to be determined

Analytica Chimica Acta published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Computed Properties of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pero, Joseph E. published the artcileDesign and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model, Product Details of C7H3Cl2NO2S, the publication is Journal of Medicinal Chemistry (2018), 61(24), 11209-11220, database is CAplus and MEDLINE.

Pulmonary edema is a common ailment of heart failure patients and has remained an unmet medical need due to dose-limiting side effects associated with current treatments. Preclin. studies in rodents have suggested that inhibition of transient receptor potential vanilloid-4 (TRPV4) cation channels may offer an alternative-and potentially superior-therapy. Efforts directed toward small-mol. antagonists of the TRPV4 receptor have led to the discovery of a novel sulfone pyrrolidine sulfonamide chemotype exemplified by lead compound 6. Design elements toward the optimization of TRPV4 activity, selectivity, and pharmacokinetic properties are described. Activity of leading exemplars 19 and 27 in an in vivo model suggestive of therapeutic potential is highlighted herein.

Journal of Medicinal Chemistry published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Product Details of C7H3Cl2NO2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics