Tag: M.W=200-250

Oechsner, Regina M. published the artcileAcetate Facilitated Nickel Catalyzed Coupling of Aryl Chlorides and Alkyl Thiols, HPLC of Formula: 637-07-0, the publication is ACS Catalysis (2022), 12(4), 2233-2243, database is CAplus.

A mild, fast, and convenient catalytic system for the coupling of aryl chlorides RCl (R = Ph, pyridin-3-yl, benzodioxol-5-yl, etc.) with primary, secondary, as well as previously challenging tertiary alkyl thiols R¹SH (R¹ = heptyl, cyclohexyl, adamantan-1-yl, etc.) uses an air-stable nickel(II) precatalyst in combination with the low-cost base potassium acetate at room temperature The catalytic system tolerates a variety of functional groups and enables the generation of thioethers for a wide range of substrates, including pharmaceutical compounds RSR¹ in excellent yields. Chemoselective functionalization of disubstituted substrates was demonstrated. Kinetic and NMR studies, as well as DFT computations support a Ni(0)/Ni(II) catalytic cycle and identify the oxidative addition product as the resting state. Acetate coordination and subsequent acetate facilitated the formation of a thiolate complex via internal deprotonation and play a key role in the catalytic cycle.

ACS Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, HPLC of Formula: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chamberlain, K. published the artcileStudies on plant growth-regulating substances. LV. The plant growth-promoting properties of some β-aryl-propionic acids, SDS of cas: 51656-68-9, the publication is Annals of Applied Biology (1978), 90(1), 115-19, database is CAplus.

Of 17β-arylpropionic acids prepared and tested for their plant growth-regulating activity in wheat coleoptile, pea segment, and pea curvature tests, the following compounds were among the most active: β-(4-fluorophenyl) [459-31-4], β-(2,4-dichlorophenyl) [55144-92-8], and β-(2,6-dichlorophenyl)propionic acid [51656-68-9]. Of 4 other compounds of the general formula I (X = CH₂, O, NH, or S) which were also tested in this study, 2,4-D (I; X = O) [94-75-7] was generally the most active.

Annals of Applied Biology published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, SDS of cas: 51656-68-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aukland, Miles H. published the artcileMetal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Nature Catalysis (2020), 3(2), 163-169, database is CAplus.

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance.

Nature Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Caiyan published the artcileNon-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines, Synthetic Route of 10543-42-7, the publication is Organic & Biomolecular Chemistry (2019), 17(20), 5009-5013, database is CAplus and MEDLINE.

A simple and general method for the synthesis of phenothiazinyl sulfones I [R = n-Bu, Ph, Bn, etc.; R¹ = cyclopropyl, 4-MeC₆H₄, 2-naphthyl, etc.; R² = H, SMe, Cl; R³ = H, Cl] was developed via copper-catalyzed regioselective C-H sulfonylation of phenothiazines with sulfonyl chlorides. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles.

Organic & Biomolecular Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, Robert published the artcileHigh surface area polystyrene resin-supported Pt catalysts in room temperature solventless octene hydrosilylation using methyldichlorosilane, Formula: C9H20Cl2Si, the publication is Journal of the Chemical Society, Perkin Transactions 1 (2002), 1523-1534, database is CAplus.

Eight macroporous styrene-divinylbenzene-vinylbenzyl chloride resins have been synthesized by suspension polymerization The first four employed toluene as the porogen and the second four Bu acetate, at a level of 1 : 1 volume/volume relative to the comonomers. In all cases a high level of divinylbenzene leads to resins with high surface area, ∼500 m² g^-1, as determined from a BET treatment of N₂ sorption data. The functional group content of each group of four resins was varied from 5-25%. All resins were aminated to generate benzyltrimethylethylenediamine ligands on the polymer matrix, and then each was loaded with Pt(II) using KPtCl₄. The anal. data confirmed the formation of ligand PtCl₂ mol. complexes. Each of the resin immobilized Pt complexes has been assessed for catalytic activity in the room temperature, solventless, hydrosilylation of oct-1-ene using methyldichlorosilane, and a comparison made with soluble Speier’s catalyst under identical conditions. Though less active than the soluble catalyst the activity of all the polymer catalysts is good, and of practical value, the activity being higher than we have previously reported in the case of supports with lower surface area. Furthermore while Speier’s catalyst induces significant levels of oct-1-ene isomerization, isomerization in the case of the polymer catalysts is much lower, and indeed can be all but eliminated by appropriate washing. Extensive catalyst leaching and recycling studies have been carried out, with the best catalysts showing retention of useful activity after 10 cycles. Careful control experiments have provided strong circumstantial evidence that the isomerization that does arise with the polymer catalysts can be attributed to a component of leached soluble Pt species. Overall the most active and stable polymer catalyst has the highest surface area (∼550 m² g^-1) of those studied, along with the lowest ligand and Pt contents (each ∼0.25 mmol g^-1). The surface area dependence confirms our earlier view that maximum accessibility to potential metal complex catalytic sites is vital in these systems, and the metal complex loading dependence suggests that generating discrete isolated ligand PtCl₂ species provides optimal use of the loaded Pt.

Journal of the Chemical Society, Perkin Transactions 1 published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Drake, Robert published the artcileHigh surface area polystyrene resin-supported Pt alkene hydrosilylation catalysts: ultimate performance and sting in the tail’, Computed Properties of 14799-93-0, the publication is Reactive & Functional Polymers (2004), 65-75, database is CAplus.

Two vinylbenzyl chloride (VBC)-based resins were prepared by suspension polymerization with a VBC feed in each of 5 vol%. A high level of divinylbenzene (DVB) was employed with toluene as a porogen to produce high surface areas (>600 m² g^-1) in the resins. Each resin was aminated using N,N,N’-trimethylethylenediamine and Pt loaded onto each. The so formed resin catalysts were evaluated in the hydrosilylation of oct-1-ene using methyldichlorosilane at room temperature, and in the absence of solvent. Extensive recycling and Pt leaching studies were carried out and the most active, selective and stable catalyst identified. Heterogeneous species with an overall performance superior to that a soluble K₂PtCl₆ were produced. The results also confirm that hydrosilylation is catalyzed by immobilized Pt complexes and that any concurrent alkene isomerization is due to leached soluble Pt species. Anal. of spent resin catalyst from multiple recycling experiments has shown the presence of chem. bonded oligosiloxane arising from hydrosilylation of pendent unreacted vinyl groups in the resin followed by hydrolysis and condensation when exposed to atm. moisture. This fouling of the resin is however not a problem while the resin catalysts are being recycled.

Reactive & Functional Polymers published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Computed Properties of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Golubev, A. S. published the artcileSynthesis of 3-fluoromethyl-2,1-benzisoxazoles, Related Products of chlorides-buliding-blocks, the publication is Russian Chemical Bulletin (2014), 63(10), 2264-2270, database is CAplus.

A convenient synthetic method to access hitherto unknown 3-(trifluoromethyl)- and 3-(difluoromethyl)-2,1-benzisoxazoles by a reaction of sodium azide with 1-(2-halophenyl)-2,2,2-trifluoroethanone derivatives or 1-(2-halophenyl)-2,2-difluoroethanone derivatives was developed. 3-Fluoromethyl-2,1-benzisoxazoles are versatile precursors for o-(fluoroacetyl)aniline derivatives The synthesis of the target compounds was achieved by a reaction of sodium azide with 2,2,2-trifluoro-1-(2-fluorophenyl)ethanone 1-(2-chlorophenyl)-2,2,2-trifluoroethanone 1-(2,5-dichlorophenyl)-2,2,2-trifluoroethanone, 1-(5-bromo-2-fluorophenyl)-2,2,2-trifluoroethanone, 1-(2,5-dichlorophenyl)-2,2-difluoroethanone and 1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone. The formation of [2-(azido)phenyl]alkanone derivatives was postulated which underwent a cyclization reaction. The tilte compounds thus formed included 5-bromo-3-(trifluoromethyl)-1,2-benzisoxazole and similar compounds Ring-opening products included 1-(2-aminophenyl)-2,2,2-trifluoroethanone (aniline ketone, anthranil).

Russian Chemical Bulletin published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shankar, Ravi published the artcileCatalytic oxidation of diorganosilanes to 1,1,3,3-tetraorganodisiloxanes with gold nanoparticle assembly at the water-chloroform interface, Related Products of chlorides-buliding-blocks, the publication is New Journal of Chemistry (2019), 43(2), 813-819, database is CAplus.

The formation of the spherical self-assembly of gold nanoparticles (AuNPs) of 200 ± 20 nm size at the water-chloroform interface is achieved by employing the cyclotetrasiloxane [RSCH₂CH₂SiMeO]₄ (R = CH₂CH₂OH) as the stabilizing ligand. The interfacially stabilized AuNPs act as a versatile catalyst for selective hydrolytic oxidation of only one of the Si-H bonds in secondary organosilanes, RR¹SiH₂ (R, R¹ = alkyl, aryl, and sila-alkyl), to afford the high yield synthesis of 1,1,3,3-tetraorganodisiloxanes, (HRR¹Si)₂O. The study unravels for the first time the role of the photothermal effect arising from the excitation of the surface plasmon resonance of the AuNPs under visible light irradiation in enhancing the catalytic activity at ambient temperature

New Journal of Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C8H6ClN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akapo, S. O. published the artcileThe production of stable, uniform reverse phases for liquid chromatography by oligomeric synthesis, Related Products of chlorides-buliding-blocks, the publication is Journal of Liquid Chromatography (1991), 14(2), 217-36, database is CAplus.

The use of oligomeric synthesis for the preparation of reverse phases by a fluidized bed technique is described. Reverse phases comprising 1-10 oligomers were synthesized and the phys. and chromatog. properties of each phase examined The nature of the interactions were investigated by measuring the excess free enthalpies of absorption of a homologous series of aromatic hydrocarbons and aromatic esters from retention measurements taken at different temperatures It is shown that a reverse phase comprising ≥5 oligomers behaves as a true dispersive phase, has consistent and predictable retentive properties, and is far more stable to acid conditions than the normal type reverse phase.

Journal of Liquid Chromatography published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Purohit, Priyank published the artcileC-O Bond Activation by Nickel-Palladium Hetero-Bimetallic Nanoparticles for Suzuki-Miyaura Reaction of Bioactive Heterocycle-Tethered Sterically Hindered Aryl Carbonates, Category: chlorides-buliding-blocks, the publication is ACS Catalysis (2017), 7(4), 2452-2457, database is CAplus.

Ni-Pd binary nanoclusters are reported for the activation of the C-O bond for Suzuki-Miyaura cross-coupling of bioactive heterocycle-tethered sterically hindered aryl carbonates with aryl boronic acids. The reaction does not take place in the presence of either the Pd or Ni salts/complexes or the individual Pd or Ni nanoparticles, indicating ensembling cooperativity between the Pd and Ni nanoparticles in activating the C-O bond.

ACS Catalysis published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics