Tag: M.W=150-200

Diwakar, Kirti published the artcileFacile synthesis, molecular docking and toxicity studies of 4-Phenyl-3-phenylamino-4H-[1,2,4]thiadiazol-5-one analogs as GABA_A receptor agonists, Product Details of C7H7ClN2S, the publication is Medicinal Chemistry Research (2016), 25(11), 2631-2642, database is CAplus.

A series of thiadiazol-5-one derivatives I (Ar = 3,4-(Cl)₂C₆H₃, 4-FC₆H₄, 4-MeC₆H₄, etc.) were synthesized by a simple method and their structures were established by phys. and spectroscopic methods. Log P value and in vitro hydrolysis, in simulated gastric fluid and simulated intestinal fluid, of all the compounds were determined by standard methods. Synthesized 1,2,4-thiadiazolines were screened for their anticonvulsant activity against maximal electroshock method and isoniazid induced seizures and all the compounds showed good anticonvulsant activity. The compound I (Ar = 3,4-(Cl)₂C₆H₃) was found to be the most potent member of the series. Mol. docking studies of the synthesized compounds depicted their stable ligand-receptor complex conformation with the typical binding pocket of γ-aminobutyric acid A receptor protein. Compound I (Ar = 3,4-(Cl)₂C₆H₃) confined its effect in the mol. docking studies also by non-covalent interactions with Tyr 157, Phe 200 and Tyr 205, the key interacting residues of γ-aminobutyric acid A receptor protein 4COF. In silico absorption, distribution, metabolism and elimination performance of all the compounds also appear to favor anticonvulsant effect. “LAZAR” and “OSIRIS” property explorer predicted nontoxic, nonmutagenic, noncarcinogenic, etc. nature for all the compounds In conclusion, some γ-aminobutyric acid A receptor agonists have been synthesized in this study with promising drug-like properties, which merit further development.

Medicinal Chemistry Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Dong-Jun published the artcileDiscovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo, SDS of cas: 620-20-2, the publication is European Journal of Medicinal Chemistry (2020), 112153, database is CAplus and MEDLINE.

NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC₅₀ value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator.

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Kai published the artcileSynthesis of 2,2′-Dihalobiaryls via Cu-Catalyzed Halogenation of Cyclic Diaryliodonium Salts, Safety of 4-Chloro-2-methylphenylboronic acid, the publication is Organic Letters (2020), 22(23), 9356-9359, database is CAplus and MEDLINE.

We report an efficient method for the preparation of various 2,2′-dihalobiaryls from cyclic diaryliodonium salts. With cheap halogen sources as starting materials, a broad range of 2,2′-diiodobiaryls, 2-bromo-2′-iodobiaryls, and 2-chloro-2′-iodobiaryls were obtained under mild reaction conditions. More importantly, a chiral copper-bisoxazoline catalyst system was further developed for the preparation of axially chiral 2,2′-dihalobiaryls in excellent yields and enantioselectivities, which can serve as versatile precursors for the synthesis of various chiral ligands.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C22H18O2, Safety of 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wienhoefer, Gerrit published the artcileGeneral and Selective Iron-Catalyzed Transfer Hydrogenation of Nitroarenes without Base, Application In Synthesis of 350-30-1, the publication is Journal of the American Chemical Society (2011), 133(32), 12875-12879, database is CAplus and MEDLINE.

The first well-defined iron-based catalyst system for the reduction of nitroarenes to anilines has been developed applying formic acid as reducing agent. A broad range of substrates possessing other reducible functional groups were converted to the corresponding anilines in good to excellent yields at mild conditions with other function group untouched. Notably, the process constitutes a rare example of base-free transfer hydrogenations.

Journal of the American Chemical Society published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H8BNO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Salas-Reyes, V. published the artcileSynthesis and characterization of bis[(3-chloro-4-dodecyloxyphenyl)malondialdehyde] complexes of copper(II) and nickel(II), Synthetic Route of 33697-81-3, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (1996), 51(12), 1679-1682, database is CAplus.

Bis[(3-chloro-4-dodecyloxyphenyl)malondialdehyde] copper(II) and its nickel homolog were synthesized. The Cu complex shows a narrow (15°) nematic phase below its clearing temperature The Ni complex is polymeric in nature.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Synthetic Route of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Niggemyer, Allison published the artcileIsolation and characterization of a novel As(V)-reducing bacterium: implications for arsenic mobilization and the genus Desulfitobacterium, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Applied and Environmental Microbiology (2001), 67(12), 5568-5580, database is CAplus and MEDLINE.

Dissimilatory arsenate-reducing bacteria have been implicated in the mobilization of arsenic from arsenic-enriched sediments. An As(V)-reducing bacterium, designated strain GBFH, was isolated from arsenic-contaminated sediments of Lake Coeur d’Alene, Idaho. Strain GBFH couples the oxidation of formate to the reduction of As(V) when formate is supplied as the sole carbon source and electron donor. Addnl., strain GBFH is capable of reducing As(V), Fe(III), Se(VI), Mn(IV) and a variety of oxidized sulfur species. 16S ribosomal DNA sequence comparisons reveal that strain GBFH is closely related to Desulfitobacterium hafniense DCB-2^T and Desulfitobacterium frappieri PCP-1^T. Comparative physiol. demonstrates that D. hafniense and D. frappieri, known for reductively dechlorinating chlorophenols, are also capable of toxic metal or metalloid respiration. DNA-DNA hybridization and comparative physiol. studies suggest that D. hafniense, D. frappieri, and strain GBFH should be united into one species. The isolation of an Fe(III)- and As(V)-reducing bacterium from Lake Coeur d’Alene suggests a mechanism for arsenic mobilization in these contaminated sediments while the discovery of metal or metalloid respiration in the genus Desulfitobacterium has implications for environments cocontaminated with arsenious and chlorophenolic compounds

Applied and Environmental Microbiology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vilsmaier, Elmar published the artcileHaloalkyl thio ethers. II. Reaction of dichloroiodides with thio ethers, Synthetic Route of 1002-41-1, the publication is Justus Liebigs Annalen der Chemie (1971), 62-7, database is CAplus.

Reaction of alkyl thio ethers with 3-(dichloroiodo)pyridine (I) gave 69-72% (α-chloroalkyl) thio ethers. The mechanism of this reaction was investigated. Reaction of I with ethylene sulfide or thietane gave only (ClCH2CH2)2S2 and [Cl(CH2)3]2S2, resp.

Justus Liebigs Annalen der Chemie published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C19H14Cl2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Salvino, Joseph M. published the artcileNovel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(10), 2216-2220, database is CAplus and MEDLINE.

Prostate cancer is the most frequently diagnosed malignancy and the leading cause of cancer related death in men. First line therapy for disseminated disease relies on androgen deprivation, leveraging the addiction of these tumors on androgens for both growth and survival. Treatment typically involves antagonizing the androgen receptor (AR) or blocking the synthesis of androgens. Recurrence is common and within 2-3 years patients develop castration resistant tumors that become unresponsive to AR-axis targeted therapies. To provide a more effective treatment, the authors are utilizing an approach that targets a key scaffolding protein, Sigma1 (also known as sigma-1 receptor), a unique 26-kDa integral membrane protein that is critical in stabilizing the AR. Herein the authors report on a new series of Sigma1 compounds for lead optimization derived from a hybrid pharmacophore approach.

Bioorganic & Medicinal Chemistry Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zolnowska, Beata published the artcileN-(2-Arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amide derivatives as potential antimicrobial agents-synthesis and biological studies, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is International Journal of Molecular Sciences (2020), 21(1), 210, database is CAplus and MEDLINE.

A series of N-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amides I [R = Ph, 3-F₃CC₆H₄, 4–F₃CC₆H₄, 1-naphthyl, 2-naphthyl] and II was synthesized. The antimicrobial activity of compounds I and II was evaluated on Gram-pos., Gram-neg. bacteria and fungal species. Experiments took into account investigation of antibacterial activity against planktonic cells as well as biofilms. Compounds I and II showed high bacteriostatic activity against staphylococci, with the most active mols. I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] presenting low MIC values of 4-8μg/mL against reference methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains as well as clin. isolates. Compounds I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] also showed an ability to inhibit biofilms formed by MRSA and MSSA. The potential of I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] as antibiofilm agents was supported by cytotoxicity assays that indicated no cytotoxic effect either on normal cells of human keratinocytes or on human cancer cells, including cervical, colon, and breast cancer lines.

International Journal of Molecular Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H9NOS, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

van der Maaden, Koen published the artcileFluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK_a Determination of Self-Assembled Monolayers on Silicon Surfaces, Related Products of chlorides-buliding-blocks, the publication is Langmuir (2012), 28(7), 3403-3411, database is CAplus and MEDLINE.

Since the computer industry enables one to generate smaller and smaller structures, silicon surface chem. is becoming increasingly important for (bio-)anal. and biol. applications. For controlling the binding of charged biomacromols. such as DNA and proteins on modified silicon surfaces, the surface pK_a is an important factor. Here the authors present a fluorescent nanoparticle adhesion assay as a novel method to determine the surface pK_a of silicon surfaces modified with weak acids or bases. This method is based upon electrostatic interactions between the modified silicon surface and fluorescent nanoparticles with an opposite charge. Silicon slides were modified with 3-aminopropyltriethoxysilane (APTES) and were further derivatized with succinic anhydride. Layer thickness of these surfaces was determined by ellipsometry. After incubating the surfaces with an amine-reactive fluorescent dye, fluorescence microscopy revealed that the silicon surfaces were successfully modified with amine- and carboxyl-groups. Two surface pK_a values were found for APTES surfaces by the fluorescent nanoparticle adhesion assay. The 1st surface pK_a (6.55 ± 0.73) was comparable with the surface pK_a obtained by contact angle titration (7.3 ± 0.8), and the 2nd surface pK_a (9.94 ± 0.19) was only found by using the fluorescent nanoparticle adhesion assay. The surface pK_a of the carboxyl-modified surface by the fluorescent nanoparticle adhesion assay (4.37 ± 0.59) did not significantly differ from that found by contact angle titration (5.7 ± 1.4). In conclusion, the authors have developed a novel method to determine the surface pK_a of modified silicon surfaces: the fluorescent nanoparticle adhesion assay. This method may provide a useful tool for designing pH-dependent electrostatic protein and particle binding/release and to design surfaces with a pH-dependent surface charge for (bio-)anal. lab-on-a-chip devices or drug delivery purposes.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H28N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics