Tag: M.W=150-200

Jangid, D. K. published the artcileAn efficient synthesis of 2-aminobenzothiazole and its derivatives in ionic liquids, Related Products of chlorides-buliding-blocks, the publication is International Journal of Pharmaceutical Sciences and Research (2017), 8(7), 2960-2964, database is CAplus.

The synthesis of 2-aminobenzothiazole derivatives I [R = H, MeO; R¹ = Cl, NO₂; R² = NH₂, NHEt, N=CHPh] were carried out from substituted phenyl-thiourea which was synthesized by substituted aniline in ionic liquid (1-butyl-3-methylimidazolium)bisulfate ([BMIM]⁺ [HSO₄]^–), (1-butyl-3-methylimidazolium)tetrafluoroborate ([BMIM]⁺ [BF₄]^–) and (1-butyl-3-methylimidazolium)hexafluorophosphate ([BMIM]⁺ [PF₆]^–). Ionic lquids were green alternate of volatile organic solvents, beneficiary environmentally and economically. The reactivity, reaction rate and yield were enhanced by using ionic lquids and the products were recovered by simple filtration. The characterization of synthesized compounds was done by elemental and spectral anal.

International Journal of Pharmaceutical Sciences and Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Boshi published the artcileVerifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4′-pyridyl)carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors, Application of 2-Chloroisonicotinic acid, the publication is Bioorganic Chemistry (2021), 104702, database is CAplus and MEDLINE.

In the present study, the role of 3-hydroxy group of a series of epoxymorphinan derivatives I (R¹ = H, OH; R² = Cl, Br, CN, Me, OMe) in their binding affinity and selectivity profiles toward the opioid receptors (ORs) has been investigated. It was found that the 3-hydroxy group was crucial for the binding affinity of these derivatives for all three ORs due to the fact that all the analogs I (R¹ = OH) exhibited significantly higher binding affinities compared to their counterpart 3-dehydroxy ones I (R¹ = H). Meanwhile most compounds carrying the 3-hydroxy group possessed similar selectivity profiles for the kappa opioid receptor over the mu opioid receptor as their corresponding 3-dehydroxy derivatives The [³⁵S]-GTPγS functional assay results indicated that the 3-hydroxy group of these epoxymorphinan derivatives I was important for maintaining their potency on the ORs with various effects. Further mol. modeling studies helped comprehend the remarkably different binding affinity and functional profiles between compound I (R¹ = H, R² = CN)(NCP) and its 3-dehydroxy analog I (R¹ = OH, R² = CN).

Bioorganic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Application of 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jiabao published the artcileNickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates, Product Details of C7H6Cl2, the publication is Organic Chemistry Frontiers (2021), 8(12), 2944-2948, database is CAplus.

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance.

Organic Chemistry Frontiers published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H14N4, Product Details of C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Jiabao published the artcileNickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates, Product Details of C8H6ClF3, the publication is Organic Chemistry Frontiers (2021), 8(12), 2944-2948, database is CAplus.

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance.

Organic Chemistry Frontiers published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C3H9ClOS, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Blunden, Gerald published the artcileNMR spectra of betaines from marine algae, COA of Formula: C7H16ClNO2, the publication is Magnetic Resonance in Chemistry (1986), 24(11), 965-71, database is CAplus.

The ¹H and ¹³C NMR spectroscopic characteristics of a range of betaines (i.e. quaternary ammonium and tertiary sulfonium compounds), most of which are found in marine algae, are described. The spectral features are an important aid in the identification of these compounds In the ¹³C NMR spectra, some (¹⁴N, ¹³C) couplings are clearly observed The fast atom bombardment of some of these compounds are also described.

Magnetic Resonance in Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sabatini, Stefano published the artcileRe-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance, Synthetic Route of 4584-49-0, the publication is Journal of Medicinal Chemistry (2013), 56(12), 4975-4989, database is CAplus and MEDLINE.

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, biocides, and dyes, resulting in a multidrug resistant (MDR) phenotype. In this work, a series of 2-phenylquinoline derivatives was designed by means of ligand-based pharmacophore modeling in an attempt to identify improved S. aureus NorA efflux pump inhibitors (EPIs). Most of the 2-phenylquinoline derivatives displayed potent EPI activity against the norA overexpressing strain SA-1199B. The antibacterial activity of ciprofloxacin, when used in combination with some of the synthesized compounds, was completely restored in SA-1199B and SA-K2378, a strain overexpressing norA from a multicopy plasmid. Compounds I and II also showed potent synergistic activity with the ethidium bromide dye in a strain overexpressing the MepA MDR efflux pump.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileCopper-Catalyzed Monoorganylation of Trialkyl Borates with Functionalized Organozinc Pivalates, HPLC of Formula: 209919-30-2, the publication is ChemCatChem (2018), 10(19), 4253-4257, database is CAplus.

Organozinc pivalates, a recently developed air- and moisture-stable organozinc species, were found for the 1st time as excellent organometallic species in the monoorganylation of trialkyl borates whereby boronic acids were prepared in high yields. The significant advantage of organozinc pivalates over another previously employed organometallic reagents, e. g., organolithium reagents, Grignard reagents and organozinc halides, is that the generation of multiorganylation byproducts such as borinic acids and trialkylboranes were completely suppressed. Addnl., the in situ generated boronates could be directly arranged into Suzuki-Miyaura type cross-coupling reactions to produce biaryls in high yields.

ChemCatChem published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Couture, Axel published the artcileA convenient synthetic methodology for the elaboration of the pyrido[2,3-b]- or -[3,4-b]pyrazine and -[1,4]diazepine skeletons, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Synthesis (1991), 982-4, database is CAplus.

The condensation of the anion of (acylamino)chloropyridines I (X, Y = N, CH; R = H, Me; R¹ = H, Cl) with R²CHCl(CH₂)_nNMe₂·HCl gave efficiently tetrahydropyridopyrazines II (n = 1) and tetrahydropyridodiazepines II (n = 2).

Synthesis published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alepee, Nathalie published the artcileUsefulness of the EpiSkin reconstructed human epidermis model within Integrated Approaches on Testing and Assessment (IATA) for skin corrosion and irritation, Category: chlorides-buliding-blocks, the publication is Toxicology In Vitro (2019), 147-167, database is CAplus and MEDLINE.

Predictive capacity of the EpiSkin model was evaluated on 87 chems. using the Bottom-Up and the Top-Down testing approaches recommended within Integrated Approach on Testing and Assessment for the identification of both skin irritation and corrosion hazards. Classified (UN GHS Cat. 1 and Cat. 2) chems. were identified with a very high sensitivity (�4%) and the non-classified (UN GHS Cat. 3 and No Cat.) chems. with an appropriate specificity (70%). Very high sensitivities were obtained for the identification of Cat. 1 chems. (�8%), very high specificities for non-Cat. 1 chems. (93%), and accuracies of -95% for the identification of skin corrosives vs. non-corrosives by both approaches. Overall accuracies of 72% were found for predicting the single (sub)categories: non-classified, Cat. 2, Subcat. 1B/1C and Subcat. 1A. Results indicated the testing strategies to be more predictive than the individual assays on a conservative safety approach. Finally, no extreme misclassifications (no under-prediction of in vivo Subcat. 1A as non-Cat. 1, and no over-prediction of non-classified chem. as Subcat. 1A) occur. These findings, independently of the approach used, confirm the usefulness of the EpiSkin in vitro model for a safe prediction of the skin irritant and corrosive hazards of chems.

Toxicology In Vitro published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cannon, Joseph G. published the artcileVinyl ethers of choline and congeners, COA of Formula: C5H13Cl2N, the publication is Journal of Medicinal Chemistry (1976), 19(7), 934-7, database is CAplus and MEDLINE.

The vinyl ethers of choline and of its α- and β-methyl homologs were prepared to determine their cholinergic effects and to determine whether a separation of the dual physiol. activity (nicotinic and muscarinic) reported for the choline vinyl ether iodide [24586-04-7] could be achieved by this modification. A literature method of vinyl transetherification of amino alcs. was studied and modified. (±)-2-(Dimethylamino)-1-propyl vinyl ether methiodide [59309-74-9] was prepared by vinyl transetherification of 2-dimethylamino-1-propanol [15521-18-3]. However, when this procedure was attempted on 1-dimethylamino-2-propanol [108-16-7], only a 4% yield of the vinyl ether was obtained. (±)-1-(Dimethylamino)-2-propyl vinyl ether methiodide [59276-15-2] was prepared by Hofmann degradation of (±)-2,4-dimethylmorpholine methiodide [59229-59-3]. Two independent, unequivocal syntheses of the (±)-1-(dimethylamino)2-propyl ethyl ether methiodide [99159-81-6] have been accomplished. The 2 literature methods for synthesis of this compound were found to be equivocal, and therefore, the biol. data previously reported for this compound may not be valid. Structure activity relationships of the ethers with respect to nicotinic and muscarinic activities are discussed.

Journal of Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics