Tag: M.W=150-200

Boudjouk, Philip published the artcileHydrosilylation catalyzed by activated nickel, Computed Properties of 14799-94-1, the publication is Journal of the Chemical Society, Chemical Communications (1991), 1424-5, database is CAplus.

Activated nickel, prepared by lithium reduction of nickel iodide under sonication, efficiently catalyzes the hydrosilylation of 1-hexene, styrene, vinyl Bu ether and acrylonitrile under mild conditions. Thus, 1-hexene gave 94% Cl₃Si(CH₂)₅Me with Cl₃SiH.

Journal of the Chemical Society, Chemical Communications published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Computed Properties of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kang, Seung-Hyun published the artcilePhosphonium Chloride-Catalyzed Dehydrochlorinative Coupling Reactions of Alkyl Halides with Hydridochlorosilanes, Name: Dichloro(hexyl)(methyl)silane, the publication is Organometallics (2003), 22(3), 529-534, database is CAplus.

The dehydrochlorinative Si-C coupling reactions of various primary and secondary alkyl chlorides with hydridochlorosilanes in the presence of tetrabutylphosphonium chloride as catalyst gave the coupling products with elimination of HCl as a gas. For example, RCl (R = CH₂C₆H₄X-p; X = H, Cl, F, Me, MeO), when coupled with HSiCl₃ in the presence of catalytic amounts of phosphonium salts [Bu₄Y]Z (Y = P, N; Z = Cl, Br, I) gave RSiCl₃ (R = same as above) in 80-96% yields. Coupling reactions of activated alkyl chlorides such as benzyl chlorides proceeded at 130°, while unactivated organic chlorides such as silylalkyl chlorides and secondary alkyl chlorides required higher reaction temperatures of 150 or 170° and longer reaction times. Primary alkyl chlorides reacted with trichlorosilane (1) to give coupling products in good to excellent yields, but secondary alkyl chlorides reacted at a slower rate and gave lower yields of products. Coupling reactions with methyldichlorosilane instead of 1 proceeded at slower rates and gave lower yields of products.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.

N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄, 4-F₃CC₆H₄, 4-t-BuC₆H₄, 4-Cl-3-F₃CC₆H₃, 4-Br-3-F₃CC₆H₃, 3,4-Cl₂C₆H₃, 3,5-Cl₂C₆H₃, 4-Br-2-MeC₆H₃, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC₆H₄, 2-R¹-6-R²-4-R³C₆H₂, 3-Cl-4-R⁴OC₆H₃; R¹, R² = H, F; R³ = Ph, 3-MeOC₆H₄; R⁴ = Ph, PhCH₂, 2-Cl-6-FC₆H₃CH₂) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C5H10Cl3O3P, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.

N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄, 4-F₃CC₆H₄, 4-t-BuC₆H₄, 4-Cl-3-F₃CC₆H₃, 4-Br-3-F₃CC₆H₃, 3,4-Cl₂C₆H₃, 3,5-Cl₂C₆H₃, 4-Br-2-MeC₆H₃, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC₆H₄, 2-R¹-6-R²-4-R³C₆H₂, 3-Cl-4-R⁴OC₆H₃; R¹, R² = H, F; R³ = Ph, 3-MeOC₆H₄; R⁴ = Ph, PhCH₂, 2-Cl-6-FC₆H₃CH₂) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.

Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C13H16O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binderup, E. published the artcileChlorosulfates as reagents in the synthesis of carboxylic acid esters under phase-transfer conditions, SDS of cas: 90906-61-9, the publication is Synthetic Communications (1984), 14(9), 857-64, database is CAplus.

Chlorosulfates ClSO₃R (R = CH₂Cl, Me, CHMeCl, Bu, Et) and (ClSO₃)₂CH₂ were used to esterify several carboxylic acids, i.e., penicillanic acid derivatives, BzOH, and alkanoic acids. Thus, penicillanic acid sulfone was converted to the chloromethyl ester by treatment with ClSO₃CH₂Cl in H₂O-CH₂Cl₂ in the presence of NaHCO₃ and Bu₄N⁺HSO₄^–.

Synthetic Communications published new progress about 90906-61-9. 90906-61-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1-Chloroethyl sulfochloridate, and the molecular formula is C2H4Cl2O3S, SDS of cas: 90906-61-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Peng-Fei published the artcileDiscovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold, Safety of 2-Chloro-4-methylphenylboronic acid, the publication is Chinese Chemical Letters (2014), 25(5), 673-676, database is CAplus.

Dipeptidyl peptidase IV (DPP4) inhibitors were proven in the treatment of type 2 diabetes. A series of novel indole compounds was synthesized that selectively inhibit the activity of DPP4 over dipeptidyl peptidase 9 DPP9 (>200 fold). It was further co-crystallized DPP4 with indole sulfonamide to confirm a proposed binding mode. Good metabolic stability of the indole compounds represented another pos. attribute for further development.

Chinese Chemical Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C9H10N2O, Safety of 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gross, Raymond S. published the artcileDesign and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists, Computed Properties of 145349-62-8, the publication is Journal of Medicinal Chemistry (2005), 48(18), 5780-5793, database is CAplus and MEDLINE.

Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochem. properties, new tricyclic CRF₁ antagonists were designed, synthesized, and tested for biol. activity. As a result of studies aimed at establishing a relationship between structure and CRF₁ binding affinity, NBI 35965 [i.e., (7S)-6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene (I)] was identified as a high-affinity antagonist with a pK_i value of 8.5. I proved to be a functional CRF₁ antagonist with pIC₅₀ values of 7.1 and 6.9 in the in vitro CRF-stimulated cAMP accumulation and ACTH production assays, resp., and I also reduced CRF or stress induced ACTH production in vivo.

Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gross, Raymond S. published the artcileDesign and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists, HPLC of Formula: 209919-30-2, the publication is Journal of Medicinal Chemistry (2005), 48(18), 5780-5793, database is CAplus and MEDLINE.

Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochem. properties, new tricyclic CRF₁ antagonists were designed, synthesized, and tested for biol. activity. As a result of studies aimed at establishing a relationship between structure and CRF₁ binding affinity, NBI 35965 [i.e., (7S)-6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene (I)] was identified as a high-affinity antagonist with a pK_i value of 8.5. I proved to be a functional CRF₁ antagonist with pIC₅₀ values of 7.1 and 6.9 in the in vitro CRF-stimulated cAMP accumulation and ACTH production assays, resp., and I also reduced CRF or stress induced ACTH production in vivo.

Journal of Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pontillo, Joseph published the artcileSynthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor, Computed Properties of 854778-30-6, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(19), 4363-4366, database is CAplus and MEDLINE.

Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds One compound was identified as potent gonadotropin-releasing hormone receptor antagonist from this series.

Bioorganic & Medicinal Chemistry Letters published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BClO3, Computed Properties of 854778-30-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Liren published the artcile5-Aryluracils as potent GnRH antagonists – Characterization of atropisomers, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(11), 3344-3349, database is CAplus and MEDLINE.

Optimization of a series of uracils bearing a 2-fluoro- or 2-chloro-3-methoxyphenyl group at the 5-position resulted in compounds such as I (R = Me, X = CF₃, Y = F, Cl) with subnanomolar binding affinity at the human GnRH receptor. While the 2-fluoro-3-methoxyphenyl compound I (R = X = Y = Me) was characterized as a mixture of interchangeable atropisomers, the diastereoisomers of 2-chloro-3-methoxyphenyl analogs were separated It was found that the aR-atropisomer was much more potent than the aS-isomer based on the X-ray crystal structure of I (R = CH₂OH, X = CF₃, Y = Cl).

Bioorganic & Medicinal Chemistry Letters published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C14H31NO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics