Tag: M.W=150-200

Gross, Carol J. published the artcileUptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea pig enterocytes, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Molecular Cell Research (1986), 886(3), 425-33, database is CAplus and MEDLINE.

Uptake and metabolism of D– and L– isomers of carnitine (I), and acetyl-L–I were studied in isolated guinea pig enterocytes. Uptake of the D– and L-isomers of I was temperature dependent. Uptake of L-[¹⁴C]I by jejunal cells was Na⁺ dependent since replacement by Li⁺, K⁺, or choline greatly reduced uptake. L– And D–I developed intracellular-to-extracellular concentration gradients for total I (free plus acetylated) of 2.7 and 1.4, resp. However, acetylation of L–I accounted almost entirely for the difference between uptake of L– and D–I. About 60% of the intracellular label was acetyl-L–I after 30 min, and the remainder was free L–I. No other products were observed D–I was not metabolized. Acetyl-L–I was deacetylated during or immediately after uptake into intestinal cells and a portion of this newly formed intracellular free I was apparently reacetylated. L– And D–I transport (after adjustment for metabolism and diffusion) was evaluated over a concentration range of 2-1000 μM. K_m Values of 6-7 μM and 5 μM were estimated for L– and D–I, resp. Ileal cell uptake was âˆ?/2 that found for jejunal cells, but the labeled intracellular acetyl-I-to-I ratios were similar for both cell populations. I transport by guinea pig enterocytes demonstrated characteristics of a carrier-mediated process since it was inhibited by D–I and trimethylaminobutyrate, as well as being temperature and concentration dependent. The process appeared to be facilitated diffusion rather than active transport since L–I did not develop a significant concentration gradient and was unaffected by ouabain or actinomycin A.

Biochimica et Biophysica Acta, Molecular Cell Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thoma, William J. published the artcileEffect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig, SDS of cas: 6249-56-5, the publication is Biochimica et Biophysica Acta, General Subjects (1984), 797(1), 136-9, database is CAplus and MEDLINE.

The effect of ascorbate  [50-81-7] deficiency on carnitine  [541-15-1] biosynthesis was investigated in young male guinea pigs. Liver and skeletal muscle carnitine levels were reduced in scorbutic animals. Heart and kidney concentrations remained unchanged. ¹⁴C-labeled 4-N-trimethylaminobutyrate  [407-64-7] was administered to controls, pair-fed, and scorbutic animals and distribution of isotope in compounds present in the liver after 30 min was determined Control and pair-fed animals converted trimethylaminobutyrate to carnitine faster than scorbutic animals. Injection of ascorbate with the [¹⁴C]trimethylaminobutyrate reversed the decline in trimethylaminobutyrate hydroxylase (EC 1.14.11.1) [56803-11-3] activity in scorbutic animals.

Biochimica et Biophysica Acta, General Subjects published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C9H5Cl2F3, SDS of cas: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Elssner, Thomas published the artcileIsolation, Identification, and Synthesis of γ-Butyrobetainyl-CoA and Crotonobetainyl-CoA, Compounds Involved in Carnitine Metabolism of E. coli, Product Details of C7H16ClNO2, the publication is Biochemistry (2000), 39(35), 10761-10769, database is CAplus and MEDLINE.

A still unknown low-mol.-mass cofactor essential for the activity of carnitine-metabolizing enzymes (e.g., L-carnitine dehydratase, crotonobetaine reductase) from E. coli has been purified to homogeneity from a cell-free extract of E. coli O44K74. The purity of the cofactor was confirmed by HPLC anal. Biosynthesis of the unknown compound was only observed when bacteria were cultivated anaerobically in the presence of L-carnitine or crotonobetaine. The determined properties, together with results obtained from UV-visible, ¹H NMR, and mass spectrometry, indicate that the compound in question is a new CoA derivative The esterified compound was suggested to be γ-butyrobetaine – a metabolite of carnitine metabolism of E. coli. Proof of structure was performed by chem. synthesis. Besides γ-butyrobetainyl-CoA, a second new CoA derivative, crotonobetainyl-CoA, was also chem. synthesized. Both CoA derivatives were purified and their structures confirmed using NMR and mass spectrometry. Comparisons of structural data and of the chem. properties of γ-butyrobetainyl-CoA, crotonobetainyl-CoA, and the isolated cofactor verified that the unknown compound is γ-butyrobetainyl-CoA. The phys. and chem. properties of γ-butyrobetainyl-CoA and crotonobetainyl-CoA are similar to known CoA derivatives

Biochemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Serrano, Jose S. published the artcileCompared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Methods and Findings in Experimental and Clinical Pharmacology (1983), 5(4), 251-4, database is CAplus and MEDLINE.

The effects of GABA  [56-12-2], its quaternary derivative N-trimethyl-GABA  [10329-41-6], and quinidine  [56-54-2] were studied in a model of ventricular automaticity induced in the isolated ventricle of the rat. GABA showed low antiautomatic activity. N-Trimethyl-GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacies of the latter 2 drugs at 5 × 10^-5 M were not significantly different. Thus, N-trimethyl-GABA has antiautomatic activity in this exptl. model similar to that of the classic antidysrhythmic drug quinidine.

Methods and Findings in Experimental and Clinical Pharmacology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C10H7NO3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ballari, Maria Sol published the artcileOne-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives, Category: chlorides-buliding-blocks, the publication is RSC Advances (2019), 9(50), 29405-29413, database is CAplus.

A series of 2-(benzylsulfonyl)benzothiazoles I [R = H, 4-F, 2-I, etc.; X = S] was synthesized by an environmentally friendly method, using water as reaction medium via one-pot and two-step procedure, starting from 2-mercaptobenzothiazole and benzyl halides. Few compounds of 2-(benzylsulfonyl)benzoxazoles I [X = O] were successfully synthesized via oxidation of 2-(benzoxazolyl)benzylsulfides. The potential fungicides were tested against a panel of phytopathogenic fungi, with many of them showing a significant improvement compared to the non-oxidized analogs and the com. antifungal Captan. The new derivatives I [R = 4-Me, 2-Cl; X = S] presented remarkable properties, being able to inhibit the growth of two resistant molds (A. fumigatus and A. ustus). Compounds I [R = 4-Me, 2-Cl; X = S] could be classified as broad-spectrum fungicides, emerging as possible candidates for the control of these molds, which had neg. impact in food production

RSC Advances published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosmalski, Tomasz published the artcileThe Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents, HPLC of Formula: 939-99-1, the publication is Molecules (2022), 27(4), 1374, database is CAplus and MEDLINE.

Chemotherapy is one of the most commonly used methods of cancer disease treatment. Due to the acquisition of drug resistance and the possibility of cancer recurrence, there is an urgent need to search for new mols. that would be more effective in destroying cancer cells. In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100-250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24-27), also reduced HeLa cell viability at similar concentrations but with lower efficiency. Further cytotoxicity evaluation confirmed the specific toxicity of (E)-acetophenone O-2-morpholinoethyl oxime (22) against A-549, Caco-2, and HeLa cancer cells, with an EC₅₀ around 7 μg/mL (30 μM). The most potent and specific compound was (E)-1-(benzothiophene-2-yl)ethanone O-4-methoxybenzyl oxime (27), which was selective for Caco-2 (with EC₅₀ 116 μg/mL) and HeLa (with EC₅₀ 28 μg/mL) cells. Considering the bioavailability parameters, the tested derivatives meet the criteria for good absorption and permeation. The presented results allow us to conclude that oxime ethers deserve more scientific attention and further research on their chemotherapeutic activity.

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haszeldine, Robert N. published the artcilePerfluoroalkyl derivatives of sulfur. Part XIX. Reaction of fluoroolefins with fluoride ion in the presence of dimethyl disulfide, and related reactions, Category: chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1178-82, database is CAplus.

F2C:CF2 reacted with CsF in the presence of MeS2Me to give 15% CF3CFRSMe (I; R = F), 77% MeSCF2CFRSMe (II; R = F), and 2% CF3CF2H, whereas F2C:CFCl gave 15% I (R = Cl), 56% II (R = Cl) and 13% of a mixture (III) of cis- and trans-MeSCF:CFR (R = Cl. Under similar conditions CF3CF:CF2 gave 38% I (R = CF3) and 12-21% III (R = CF3) together with olefin telomers. F2C:CF2 with CsF in the presence of Me2S gave only CF3CF2H. F2C:CFCl and CF3CF:CF2 reacted with NaSMe in Et2O at -196° to give 77 and 90% III, resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sumida, Yuto published the artcileBoron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M, Formula: C7H8BClO2, the publication is Organic Letters (2014), 16(23), 6240-6243, database is CAplus and MEDLINE.

An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki-Miyaura cross-coupling between o-borylphenols and aryl halides or triflates bearing a 1,8-diaminonaphthalene-protected o-boryl group is reported [e.g., I + II (dan = 1,8-diaminonaphthalene) â†?III (quant) using Pd(OAc)₂, CyJohnPhos as ligand and K₃PO₄ as base]. A short synthesis of defucogilvocarcin M (IV) was achieved using the proposed method in combination with several other boron-mediated transformations.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C18H24N6O6S4, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kinnear, A. M. published the artcileComposition of mustard gas made by the Levinstein process, HPLC of Formula: 1002-41-1, the publication is Journal of the Society of Chemical Industry, London, Transactions and Communications (1948), 107-10, database is CAplus.

cf. Fuson, et al., C.A. 41, 689g. A sample of Levinstein mustard gas was found to contain 61.4% S(CH₂CH₂Cl)₂ (I), m. 14.45°; 4.3% S₂(CH₂CH₂Cl)₂ (II), colorless liquid, m. 0.2°, b_0.3 90-2°; 17.4% S₃(CH₂CH₂Cl)₂ (III), m. 27°, b_0.3 110-12°; 10.7% S (free and combined with III); 6.2% tars and exptl. losses. I, II, and III were synthesized as follows: HOCH₂CH₂Cl and Na₂S₄ gave S(C₂H₄OH)₂, S₂(C₂H₄OH)₂, and S₃(C₂H₄OH)₂. These products and HCl gave I, II, and III, resp. On boiling with NaI in MeOH, II gave S₂(CH₂CH₂I)₂, m. 42°. II and PhONa in alc. gave S₂(CH₂CH₂OPh)₂, m. 96°. The labile polysulfide (IV) (S combined with III), upon boiling in Me₂CO formed S and III. IV was synthesized by heating 1 g. mol. III with 3 g. atoms rhombic S at 110° for several hrs. Since I or II do not form polysulfides on heating with S, it is thought that IV has a structure of the type (ClCH₂CH₂S)₂S→S→Sâ†?or(ClCH₂CH₂S)₂Sâ†?sub>S→Sâ†?/sub>→S→Sâ†?

Journal of the Society of Chemical Industry, London, Transactions and Communications published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pitts-McCoy, Anthony M. published the artcileGas-phase ion/ion chemistry as a probe for the presence of carboxylate groups in polypeptide cations, Product Details of C7H16ClNO2, the publication is Journal of the American Society for Mass Spectrometry (2019), 30(2), 329-338, database is CAplus and MEDLINE.

The reactivity of 1-hydroxybenzoyl triazole (HOBt) esters with the carboxylate functionality present in peptides is demonstrated in the gas phase with a doubly deprotonated dianion. The reaction forms an anhydride linkage at the carboxylate site. Upon ion trap collisional-induced dissociation (CID) of the modified peptide, the resulting spectrum shows a nominal loss of the mass of the reagent and a water mol. Analogous phenomenol. was also noted for model peptide cations that likely contain zwitterionic/salt-bridged motifs in reactions with a neg. charged HOBt ester. Control experiments indicate that a carboxylate group is the likely reactive site, rather than other possible nucleophilic sites present in the peptide. These observations suggest that HOBt ester chem. may be used as a chem. probe for the presence and location of carboxylate groups in net pos. charged polypeptide ions. As an illustration, deprotonated sulfobenzoyl HOBt was reacted with the [M+7H]⁷⁺ ion of ubiquitin. The ion was shown to react with the reagent and CID of the covalent reaction product yielded an abundant [M+6H-H₂O]⁶⁺ ion. Comparison of the CID product ion spectrum of this ion with that of the water loss product generated from CID of the unmodified [M+6H]⁶⁺ ion revealed the glutamic acid at residue 64 as a reactive site, suggesting that it is present in the deprotonated form.

Journal of the American Society for Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics