Tag: M.W=150-200

Hagemann, Justin P. published the artcileDesigner ligands. Part 4. Synthesis of acyclic and macrocyclic platinum group metal-specific ligands, Quality Control of 1002-41-1, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), 341-348, database is CAplus.

Synthetic pathways to a range of novel, polydentate, sulfur-containing, mono-amide ligands, e.g. mercaptoacetanilides I (R = H, MeO), designed to coordinate platinum group metals, have been developed. Access to the tetradentate systems was facilitated by the extensive use of disulfide linkages as a protection strategy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Quality Control of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Patel, Daksha published the artcileThe cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomaterials (2010), 32(4), 1167-1176, database is CAplus and MEDLINE.

A new class of nanoparticle-based dual-modality positron emission tomog./magnetic resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a superparamagnetic iron oxide (SPIO) or manganese oxide core coated with 3,4-dihydroxy-D,L-phenylalanine (dl-DOPA). The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to DOPA termini. The DOTA modified nanoparticles allow chelation of copper for PET imaging. These surface functionalized nanoparticle-based probes have been characterized by various anal. techniques. The cell-labeling efficacy, cytotoxicity and relaxivity of these nanoparticles have been evaluated and compared with the same properties of one of the most commonly utilized MRI contrast agents, Feridex. Evidently, this new nanoparticle has a great potential for use in cell tracking with MRI and PET in the absence of transfecting agent. It is noteworthy that there is a sharp increase in r₂ relaxivity of these nanoparticles on coordination with Cu²⁺ ions. Thus these iron oxide nanoparticles can also be explored as the smart magnetic resonance (MR) sensor for the detection of micromolar changes in copper concentration for neurodegenerative diseases such as Alzheimer’s disease, Menkes and Wilson’s diseases, amyotrophic lateral sclerosis and prion diseases.

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nadaf, Afra Quasar A. published the artcileSynthesis, characterization, crystal structure and hirshfeld surface analysis of alkyl substituted N,4-diphenyl thiazole-2-amine., Computed Properties of 3696-23-9, the publication is Chemical Data Collections (2019), 100297, database is CAplus.

The present work describes the synthesis of alkyl substituted N,4-di-Ph thiazole-2-amines (I) and (II) through a three step pathway. Further, the structures were confirmed by single crystal X-ray diffraction studies which revealed that compound I crystallizes in triclinic system with P-1 space group whereas compound II crystallizes as monoclinic with P2₁/c space group. The asym. unit consists of only one mol. in both the structures. The study of torsional angles of compound I and compound II indicated that S1 and C4 are cis to each other whereas N2 and C4 are trans. A detailed anal. of intermol. hydrogen bonding interactions has been performed. Also their C-H···π and π···π stacking interactions have been explored using Hirshfeld surface anal. and their 2D fingerprint plots. The most significant contributions in both the compounds are due to H···H interactions which also account for their stability.

Chemical Data Collections published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Puwen published the artcile7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2008), 16(13), 6589-6600, database is CAplus and MEDLINE.

Novel 7-aryl benzo[1,4]oxazepin-2-ones were synthesized and evaluated as non-steroidal progesterone receptor (PR) modulators. The structure activity relationship of 7-aryl benzo[1,4]oxazepinones was examined using the T47D cell alk. phosphatase assay. A number of 7-aryl benzo[1,4]oxazepinones such as 10j and 10v demonstrated good in vitro potency (IC₅₀ of 10-30 nM) and selectivity (over 100-fold) at PR over other steroidal receptors such as glucocorticoid and androgen receptors (GR and AR). Several 7-aryl benzo[1,4]oxazepinones were active in the rat uterine decidualization model. In this in vivo model, compounds 10j (I) and 10u (II) were active at 3 mg/kg when dosed orally.

Bioorganic & Medicinal Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C20H18BrN3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, V. published the artcileHeterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2006), 41(9), 1048-1058, database is CAplus and MEDLINE.

Triazolo[3,4-b]thiadiazoles I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are prepared in three steps from the hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) and the carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) via aminomercaptotriazoles II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); the antiinflammatory, analgesic, antibacterial, and antifungal activities of I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are determined Base-mediated condensation of hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carbon disulfide followed by condensation of the potassium arylcarbonylhydrazinocarbodithioate with hydrazine hydrate provides II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); condensation of II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) in phosphorus oxychloride provides I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂). The activities of the prepared compounds are lower than those of the standard agents used.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileSynthesis, characterization and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, Quality Control of 6313-54-8, the publication is E-Journal of Chemistry (2007), 4(3), 320-342, database is CAplus.

4-Amino-5-aryl, or heteroaryl, substituted-3-mercapto-1,2,4-triazoles were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. These compounds were then reacted with various aromaticand hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles, e.g., I, and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles resp. Elemental anal., IR, ¹H NMR and mass spectral data was elucidated for the structures of all newly synthesized compounds Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

E-Journal of Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileStudies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2007), 42(6), 823-840, database is CAplus and MEDLINE.

Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole, e.g., I (R = H, Me or Ph), and their dihydro analogs were synthesized from hetero aromatic acids and hetero aromatic aldehydes, resp., by microwave-assisted and conventional methods. Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Emami, Leila published the artcileNovel N-substituted isatin-ampyrone Schiff bases as a new class of antiproliferative agents: Design, synthesis, molecular modeling and in vitro cytotoxic activity, COA of Formula: C7H6Cl2, the publication is Journal of Heterocyclic Chemistry (2022), 59(7), 1144-1159, database is CAplus.

Thirteen novel isatin-ampyrone Schiff bases derivatives such as I [X = H, Cl; R = H, 3-F, 4-OMe, etc.] were synthesized by the reaction of isatins and benzyl halides followed by condensation with ampyrone. In vitro cytotoxic activity of these new Schiff bases against three human tumor cell lines (MCF-7, A549, and SCOV3) as well as normal breast cell line (MCF-10A) were evaluated by MTT assay. Structure-activity relationship of the tested compounds revealed that chlorine group at C-5 position of the isatin ring significantly increased the cytotoxic activity. This study generally led to introduce a highly active mol. I [X = Cl; R = 3-Cl] with IC₅₀ values of 5.12, 25.5, and 12.9μM, on MCF-7, A549, and SCOV3, resp. Furthermore, mol. docking studies of the synthesized compounds were also done to investigate their binding modes to toward VEGFR-2 and JNK3-MAP kinase as the main targets for isatin-containing anticancer agents. Binding free energy values of the compounds showed pos. correlation with their cytotoxic activities. To confirm the docking results, mol. docking simulations of potent compound I [X = Cl; R = 3-Cl] against VEGFR-2 and JNK3 MAP kinase were also performed. According to the cytotoxic results and in silico ADMET predictions together, I [X = Cl; R = 3-Cl] could be considered as a potent candidate for the future anticancer studies.

Journal of Heterocyclic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kuramochi, Takahiro published the artcileDiscovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2005), 13(12), 4022-4036, database is CAplus and MEDLINE.

Ca²⁺ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca²⁺ overload, because NCX inhibitors can directly inhibit the influx of Ca²⁺ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives We have discovered a novel NCX inhibitor (I) with an IC₅₀ value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P 450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of I are discussed.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, Jyothi N. published the artcileSolvent free microwave-assisted synthesis of some novel pyrimidinones/thiones and their biological studies, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Chemica Sinica (2016), 7(3), 38-42, database is CAplus.

Pyrimidinone derivatives I [R = H; X = O; R¹ = CH₃, C₂H₅] and pyrimidinethione derivatives I [R = H, C₆H₅, 4-MeOC₆H₄, 4-MeC₆H₄, etc.; X = S; R¹ = C₂H₅] were synthesized via reaction of 1-phenyl-3-methyl-5-chloro-pyrazole-4-aldehyde, Et acetoacetate/methyl acetoacetate and urea/thiourea/thiourea derivatives under conventional heating as well as microwave irradiation All the newly synthesized compounds were screened for their antibacterial and antifungal activities. The antimicrobial study revealed that pyrimidinone compound I [R = H; X = O; R¹ = C₂H₅] and pyrimidinethione compounds I [ R = 4-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; X = S; R¹ = C₂H₅] showed excellent antibacterial and antifungal activities against all the tested organisms.

Chemica Sinica published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics