Tag: M.W=150-200

Bretschneider, Leonore published the artcileCationically modified 6-deoxy-6-azido cellulose as a water-soluble and reactive biopolymer derivative, Product Details of C7H16ClNO2, the publication is Polymer Bulletin (Heidelberg, Germany) (2015), 72(3), 473-485, database is CAplus.

Cellulose p-toluenesulfonic acid ester was obtained by conversion of cellulose with p-toluenesulfonic acid chloride and triethylamine in N,N-dimethylacetamide/LiCl solution Further reaction with sodium azide afforded the corresponding 6-deoxy-6-azido cellulose with almost complete displacement of the sulfonate groups. Conversion of 6-deoxy-6-azido cellulose with carboxypropyltrimethylammonium chloride in the presence of N,N’-carbonyldiimidazole yielded 6-deoxy-6-azido cellulose-2,3-O-[4-(N,N,N-trimethylammonium)]butyrate chloride with the degree of substitution of cationic groups up to 0.24. Alternatively, conversion of 6-deoxy-6-azido cellulose with 4-bromobutyltrimethylammonium bromide in the presence of sodium hydroxide in 2-propanol slurry afforded 6-deoxy-6-azido-2,3-O-(4-trimethylammonium)butyl cellulose bromide with a DS of cationic groups up to 0.30. The resulting products are water soluble provided that the content of cationic groups is sufficiently high. Etherification was found to influence the d.p. much more than esterification. Utilization of DMSO and sodium hydride caused predominant polymer degradation

Polymer Bulletin (Heidelberg, Germany) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Xiaohui published the artcilePhenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(19), 6218-6223, database is CAplus and MEDLINE.

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cardoso, David S. P. published the artcileAlkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells, HPLC of Formula: 620-20-2, the publication is European Journal of Medicinal Chemistry (2021), 112985, database is CAplus and MEDLINE.

Aiming at generating a series of monoterpene indole alkaloids with enhanced multidrug resistance (MDR) reversing activity in cancer, two major epimeric alkaloids isolated from Tabernaemontana elegans, tabernaemontanine and dregamine, were derivatized by alkylation of the indole nitrogen. Twenty-six new derivatives were prepared by reaction with different aliphatic and aromatic halides, whose structures were elucidated mainly by NMR, including 2D NMR experiments Their MDR reversal ability was evaluated through a functional assay, using as models resistant human colon adenocarcinoma and human ABCB1-gene transfected L5178Y mouse lymphoma cells, overexpressing P-glycoprotein (P-gp), by flow cytometry. A considerable increase of activity was found for most of the derivatives, being the strongest P-gp inhibitors those sharing N-phenethyl moieties, displaying outstanding inhibitory activity, associated with weak cytotoxicity. Chemosensitivity assays were also performed in a model of combination chemotherapy in the same cell lines, by studying the in vitro interactions between the compounds and the antineoplastic drug doxorubicin. Most of the compounds have shown strong synergistic interactions with doxorubicin, highlighting their potential as MDR reversers. QSAR models were also explored for insights on drug-receptor interaction, and it was found that lipophilicity and bulkiness features were associated with inhibitory activity, although linear correlations were not observed

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Martyanov, Igor N. published the artcilePhotocatalytic Oxidation of Gaseous 2-Chloroethyl Ethyl Sulfide over TiO₂, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Environmental Science and Technology (2003), 37(15), 3448-3453, database is CAplus and MEDLINE.

Photocatalytic oxidation of gaseous 2-chloroethyl Et sulfide (2-CEES) over TiO₂ illuminated with UV light and maintained at 25° or 80° in air has been investigated. 2-CEES was found to suffer progressive oxidation to yield ethylene, chloroethylene, ethanol, acetaldehyde, chloroacetaldehyde, di-Et disulfide, 2-chloroethyl Et disulfide, and bis(2-chloroethyl) disulfide as the main primary intermediates, and water, carbon dioxide, sulfur dioxide, surface sulfate ions, and hydrogen chloride as the final products. Trace concentrations of gaseous 2-chloroethanol, ethanesulfonyl chloride, Et thioacetate, and considerable amounts of acetic acid, crotonaldehyde, Me acetate, and Me formate were also detected in the gas phase during the photooxidation conducted at 80°. An increase in temperature from 25° to 80° accelerates formation of gaseous ethanol, acetaldehyde, chloroacetaldehyde, di-Et disulfide, 2-chloroethyl Et disulfide, and bis(2-chloroethyl) disulfide but suppresses ethylene and chloroethylene production at initial stages of the process. Some aspects of the possible reaction mechanism leading to this wide array of intermediates and final products are discussed.

Environmental Science and Technology published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Markus, Astrid published the artcileMicrobial degradation of 4-chlorophenylacetic acid. Chemical synthesis of 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy- and 4-chloro-2-hydroxyphenylacetic acid, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie (1982), 363(4), 431-7, database is CAplus and MEDLINE.

Pseudomonas CBS 3 converts 4-chlorophenylacetic acid partly into 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy-, and 4-chloro-2-hydroxyphenylacetic acid by the action of monooxygenases. However, these compounds are not intermediates in the degradation of 4-chlorophenylacetic acid. Pseudomonas CBS 3 cannot grow with 3-chloro-4-hydroxy- and 4-chloro-3-hydroxyphenylacetic acid as sole C sources. 4-Chloro-2-hydroxyphenylacetic acid is slowly degraded, forming 4-chloro-2,3-dihydroxyphenylacetic acid. The actual degradation of 4-chlorophenylacetic acid seems to be initiated by the attack of a dioxygenase. The syntheses of 4-chloro-3-hydroxyphenylacetic acid and of 4-chloro-2-hydroxyphenylacetic acid are described.

Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hoerner, Sebastian published the artcileNanoscale Biodegradable Organic-Inorganic Hybrids for Efficient Cell Penetration and Drug Delivery, Computed Properties of 6249-56-5, the publication is Angewandte Chemie, International Edition (2016), 55(47), 14842-14846, database is CAplus and MEDLINE.

We report a comprehensive study on novel, highly efficient, and biodegradable hybrid mol. transporters. To this end, we designed a series of cell-penetrating, cube-octameric silsesquioxanes (COSS), and investigated cellular uptake by confocal microscopy and flow cytometry. A COSS with dense spatial arrangement of guanidinium groups displayed fast uptake kinetics and cell permeation at nanomolar concentrations in living HeLa cells. Efficient uptake was also observed in bacteria, yeasts, and archaea. The COSS-based carrier was significantly more potent than cell-penetrating peptides (CPPs) and displayed low toxicity. It efficiently delivered a covalently attached cytotoxic drug, doxorubicin, to living tumor cells. As the uptake of fluorescently labeled carrier remained in the presence of serum, the system could be considered particularly attractive for the in vivo delivery of therapeutics.

Angewandte Chemie, International Edition published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kaneyasu, Tomoko published the artcileAuxin response, but not its polar transport, plays a role in hydrotropism of Arabidopsis roots, Category: chlorides-buliding-blocks, the publication is Journal of Experimental Botany (2007), 58(5), 1143-1150, database is CAplus and MEDLINE.

Plants are sessile in nature, and need to detect and respond to many environmental cues in order to regulate their growth and orientation. Indeed, plants sense numerous environmental cues and respond via appropriate tropisms, and it is widely accepted that auxin plays an important role in these responses. Recent analyses using Arabidopsis have emphasized the importance of polar auxin transport and differential auxin responses to gravitropism. Even so, the involvement of auxin in hydrotropism remains unclear. To clarify whether or not auxin is involved in the hydrotropic response, Arabidopsis seedlings were treated with inhibitors of auxin influx (3-chloro-4-hydroxyphenylacetic acid), efflux (1-naphthylphthalemic acid and 2,3,5-triiodobenzoic acid), and response (p-chlorophenoxyisobutylacetic acid), and their effects were examined on both hydrotropic and gravitropic responses. In agreement with previous reports, gravitropism was inhibited by all the chems. tested. By contrast, only an inhibitor of the auxin response (p-chlorophenoxyisobutylacetic acid) reduced hydrotropism, whereas inhibitors for influx or efflux of auxin had no effect. These results suggest that auxin response, apart from its polar transport, plays a definite role in hydrotropic response, and will evoke a new concept for the auxin-mediated regulation of tropisms.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sareen, V. published the artcileSynthesis of some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines, Quality Control of 3696-23-9, the publication is Heterocyclic Letters (2014), 4(1), 115-118, 4 pp., database is CAplus.

Some new 2-(4-nitroanilino)-4-(4-carboxyanilino)-6-(substituted thioureido)-1,3,5-triazines I (R = C₆H₅, 4-FC₆H₄, 4-ClC₆H₄, etc.) have been prepared by reacting 2,4,6-trichloro-1,3,5-triazine with nucleophilic reagents, 4-nitroaniline, 4-carboxyaniline and different substituted thioureas.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Quality Control of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Attimarad, Mahesh Veerabhadra published the artcileMicrowave assisted synthesis, pharmacological activities, and molecular docking studies of ethyl 2-[2-substituted-4-(thiophenyl) thiazolyl] acetates, Application In Synthesis of 3696-23-9, the publication is Iranian Journal of Pharmaceutical Research (2017), 16(4), 1379-1395, database is CAplus.

Two series of Et 2-[2-anilino-4-(2-thienyl)thiazol-5-yl]acetates I [R = 3-MeC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄, etc.] and Et 2-[2-(2-benzylidenehydrazino)-4-(2-thienyl)thiazol-5-yl]acetates II [R¹ = 2-HOC₆H₄, 4-ClC₆H₄, 4-Me₂NC₆H₄] were synthesized and screened for their anti-inflammatory, analgesic and antioxidant activities. In-vivo test results showed that the compounds I [R¹ = 4-FC₆H₄, 4-ClC₆H₄, 3-Cl-4-FC₆H₃, 2,4-Cl₂C₆H₃, 4-BrC₆H₄] exhibited good anti-inflammatory and analgesic activities, similar to that of indomethacin and aspirin, resp. Compounds II showed better anti-oxidant activity than compounds I when compared to ascorbic acid. Further, a mol. docking study was performed to predict the possible binding modes on cyclooxygenase-1 (COX-1) and COX-2 for compounds I and II. Good correlation was observed between the anti-inflammatory activity of the compounds I and II and the results of the binding modes in COX-2.

Iranian Journal of Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Balinge, Kamlesh Rudreshwar published the artcileFacile access to polymer supported zinc-salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium, Application In Synthesis of 3696-23-9, the publication is Research on Chemical Intermediates (2018), 44(3), 2075-2097, database is CAplus.

The synthesis of polymer supported zinc-salen complex (PS-Zn-salen) is described. The mononuclear zinc(II)-salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform IR spectrophotometry (FT-IR), thermogravimetric anal., SEM, surface area and pore size distribution by Brunauer-Emmett-Teller. The synthesized PS-Zn-salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, resp. In spite of conventional heterogeneous catalysts, current PS-Zn-salen complex shows thermal stability up to 280 °C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn-salen is negligible, which was confirmed by AAS and hot filtration test.

Research on Chemical Intermediates published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics