Tag: M.W=150-200

Yang, Zaibo published the artcileDesign, synthesis, and biological evaluation of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties as active insecticidal agents, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Chemical Papers (2020), 74(5), 1621-1632, database is CAplus.

To discover and develop novel active mols., in this study, a series of novel pyrethrin derivatives containing 1,3,4-oxadiazole and thioether moieties were I [R = Ph, 5-chloro-thienyl, 2-fluorophenyl, etc.] designed and synthesized. Bioassay results revealed that some of the target compounds I possessed good insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), resp., which were even better than those of the com. insecticidal agents chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. The results favored this rational design intention and provide a new class of small-mol. inhibitors available for the development of active insecticidal agents targeting P. xylostella, V. aphids, and E. vitis.

Chemical Papers published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H5ClO4S, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Li-Miao published the artcilePalladium Catalyzed Aminocarbonylation of Benzylic Ammonium Triflates with Nitroarenes: Synthesis of Phenylacetamides, COA of Formula: C6H3ClFNO2, the publication is Advanced Synthesis & Catalysis (2021), 363(8), 2061-2065, database is CAplus.

A palladium catalyzed reductive aminocarbonylation of benzylic ammonium triflates with nitroarenes for the synthesis of phenylacetamides was developed. Using Pd(acac)₂/DPPF catalyst system, a range of different substituted phenylacetamides were prepared in moderate to good yields from benzylic ammonium triflates and nitroarenes through Csp³-N bond cleavage. A variety of alkyl, aryl, and halide substituents on both substrates was used, and many useful functional groups were tolerated.

Advanced Synthesis & Catalysis published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C11H21BF4N2O2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jianping published the artcileSynthesis and herbicidal activity of α-benzylcyclododecanone oxime esters, Synthetic Route of 6313-54-8, the publication is Nongyaoxue Xuebao (2008), 10(2), 161-165, database is CAplus.

Several α-(benzyl)cyclododecanone oxime esters were synthesized by a reaction of α-(benzyl)cyclododecanone oxime with carboxylic acid derivatives Product structures were determined by NMR, elemental anal., IR. A preliminary bioassay indicated that one compound possessed an an inhibition rate 72.70% and 54.98% against Digitaria sanguinalis and 85.04% and 81.91% against Abutilon theophrasti at a concentration of 100 and 1 mg/L. The IC₅₀ value for Digitaria sanguinalis and IC₉₀ value for Abutilon theophrasti of that compound was was 0.49 and 1.90 mg/L, resp.

Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yan, Yu-Hang published the artcileStructure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors, Category: chlorides-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2022), 113965, database is CAplus and MEDLINE.

X-ray structure-guided optimization of 1H-imidazole-2-carboxylic acid (ICA) derivatives, I [R¹ = cyclopropyl, 4-pyridylmethyl, 2-(1-methyltetrazol-5-yl)sulfanylethyl, etc.; R² = R³ = Me, cyclopropyl, Ph, etc.] was reported by considering how to engage with the active-site flexible loops and improve penetration into Gram-neg. bacteria. Structure-activity relationship studies revealed the importance of appropriate substituents at ICA 1-position to achieve potent inhibition to class B1 MBLs, particularly the Verona Integron-encoded MBLs (VIMs), mainly by involving ingenious interactions with the flexible active site loops as observed by crystallog. analyses. Of the tested ICA inhibitors, I [R¹ = 4-pyridylmethyl, R² = R³ = H] displayed potent synergistic antibacterial activity with meropenem against engineered Escherichia coli strains and even intractable clin. isolated Pseudomonas aeruginosa producing VIM-2 MBL. The morphol. and internal structural changes of bacterial cells after treatment further demonstrated that I [R¹ = 4-pyridylmethyl, R² = R³ = H] crossed the outer membrane and reversed the activity of meropenem. Moreover, I [R¹ = 4-pyridylmethyl, R² = R³ = H] showed good pharmacokinetic and safety profile in vivo, which could be a potential candidate for combating VIM-mediated Gram-neg. carbapenem resistance.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C3H6O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Ke published the artcileSynthesis and in vitro cytotoxic activities of sorafenib derivatives, Quality Control of 33697-81-3, the publication is Chinese Chemical Letters (2014), 25(5), 702-704, database is CAplus.

A series of novel sorafenib derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC₅₀ = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, one of the compounds demonstrated significant inhibitory activity against A549, ACHN, and MDA-MB-231 cell lines with IC₅₀ values of 1.29, 1.99, 3.11 μmol/L, resp.

Chinese Chemical Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C21H24O8, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jing-Bo published the artcileSynthesis, insecticidal evaluation and 3D-QSAR study of novel anthranilic diamide derivatives as potential ryanodine receptor modulators, Formula: C6H3ClFNO2, the publication is Pest Management Science (2019), 75(4), 1034-1044, database is CAplus and MEDLINE.

BACKGROUND : Anthranilic diamide insecticides control lepidopteran pests through selectively binding and activating insect ryanodine receptors. In order to search for potential insecticides targeting the ryanodine receptors, a series of anthranilic diamide analogs including trifluoromethyl, nitro, or chloro groups were designed and synthesized by the principle of bioisosterism and structural optimization. RESULTS : Insecticidal data indicated that some compounds displayed good activity against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). In particular, the larvicidal activity of 6p against P. xylostella was 95% at 0.01 mg L^-1, equivalent to chlorantraniliprole (85%, 0.01 mg L^-1). The comparative mol. similarity index anal. model obtained indicated that hydrogen bond acceptor and electron-withdrawing groups in the R’₃ group are favorable for insecticidal activity against M. separata, which is consistent with the structure-activity relationships. Moreover, the calcium imaging experiment indicated, like chlorantraniliprole, that 6h and 6p are interacting with the ryanodine receptor. CONCLUSION : Introducing trifluoromethyl, nitro, or chloro groups to a specific position in the N-phenylpyrazole could improve or maintain the activity against M. separata and P. xylostella. 6h and 6p could be used as potential lead compounds for ryanodine receptor modulators.Μ.

Pest Management Science published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Wen-xiao published the artcileA study on preparing 3-chloro-4-fluoroaniline by hydrogenation, Formula: C6H3ClFNO2, the publication is Ranliao Yu Ranse (2014), 51(6), 35-39, database is CAplus.

The compound 3-chloro-4-fluoro aniline synthesized from 3-chloro-4-fluoride nitrobenzene with catalyst Pt-Cu-S/C by low-pressure hydrogenation was studied. The performances of the catalyst for hydrogenation of 3-chloro-4-fluoro nitrobenzene were investigated, and probed into the main factors influencing the hydrogenation. Experiments showed that the catalyst has high catalytic activity and selectivity. In conditions of mass fraction of Pt in the catalyst 1%, mass fraction of Cu in the catalyst 0.1%, the mass fraction of S in the catalyst 0.03%, catalyst amount 0.5% (in weight of nitro compound), the amount of solvent 2 mL ethanol/1 g nitro compounds, the reaction temperature 80°C, pressure 1.5 MPa, yield of 3-chloro-4-fluoro aniline was 98%, purity more than 99.5%.

Ranliao Yu Ranse published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Chen published the artcileElusive Metal-Free Primary Amination of Arylboronic Acids: Synthetic Studies and Mechanism by Density Functional Theory, Related Products of chlorides-buliding-blocks, the publication is Journal of the American Chemical Society (2012), 134(44), 18253-18256, database is CAplus and MEDLINE.

Herein the authors disclose the first metal-free synthesis of primary aromatic amines from arylboronic acids, a reaction that has eluded synthetic chemists for decades. This remarkable transformation affords structurally diverse primary arylamines in good chem. yields, including a variety of halogenated primary anilines that often cannot be prepared via transition-metal-catalyzed amination. The reaction is operationally simple, requires only a slight excess of aminating agent [O-(2,4-dinitrophenyl)hydroxylamine], proceeds under neutral or basic conditions, and, importantly, can be scaled up to provide multigram quantities of primary anilines. D. functional calculations reveal that the most likely mechanism involves a facile 1,2-aryl migration, and that the presence of an ortho nitro group in the aminating agent plays a critical role in lowering the free energy barrier of the 1,2-aryl migration step.

Journal of the American Chemical Society published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C14H10N2O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Yulong published the artcileDesign, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties, Name: 3-Chlorobenzylchloride, the publication is Chemistry & Biodiversity (2022), 19(3), e202100839, database is CAplus and MEDLINE.

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, resp. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the com. procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 vs. 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.

Chemistry & Biodiversity published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C65H82N2O18S2, Name: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Yulong published the artcileDesign, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties, HPLC of Formula: 939-99-1, the publication is Chemistry & Biodiversity (2022), 19(3), e202100839, database is CAplus and MEDLINE.

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, resp. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the com. procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 vs. 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.

Chemistry & Biodiversity published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C10H18BNO2, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics