Tag: M.W=150-200

Klages, Uwe published the artcileDegradation of 4-chlorophenylacetic acid by a Pseudomonas species, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Bacteriology (1981), 146(1), 64-8, database is CAplus and MEDLINE.

Pseudomonas Strain CBS3 utilized 4-chlorophenylacetic acid as the sole source of C and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid was an intermediate that was further metabolized by the meta cleavage pathway. Furthermore, 3 isomers of chlorohydroxyphenylacetic acid, 2 of them identified as 3-chloro-4-hydroxyphenylacetic acid and 4-chloro-3-hydroxyphenylacetic acid, were isolated from the culture medium. 4-Hydroxyphenylacetic acid was catabolized in a different manner by the glutathione-dependent homogentisate pathway. Degradation enzymes of both of these pathways were inducible.

Journal of Bacteriology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ioannidou, Heraklidia A. published the artcileThree-Step Synthesis of Ethyl Canthinone-1-carboxylates from Ethyl 4-Bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-Catalyzed Suzuki-Miyaura Coupling and a Cu-Catalyzed Amidation Reaction, COA of Formula: C7H8BClO2, the publication is Journal of Organic Chemistry (2011), 76(12), 5113-5122, database is CAplus and MEDLINE.

Et canthin-6-one-1-carboxylate (I) and nine analogs were prepared from readily prepared Et 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a three-step non-classical approach that focused on construction of the central pyrrole (ring B) using Pd-catalyzed Suzuki-Miyaura coupling followed by Cu-catalyzed C-N coupling. Furthermore, treatment of I with NaOH in DCM/MeOH (9:1) gave the canthin-6-one-1-carboxylic acid in high yield. All compounds are fully characterized.

Journal of Organic Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boehm, Philip published the artcilePalladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange, Synthetic Route of 6313-54-8, the publication is Angewandte Chemie, International Edition (2021), 60(31), 17211-17217, database is CAplus and MEDLINE.

An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution.

Angewandte Chemie, International Edition published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vishnumurthy, Kodumuru published the artcileNovel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling, Recommanded Product: 4-Chloro-2-hydroxyphenylboronic acid, the publication is Journal of Combinatorial Chemistry (2010), 12(5), 664-669, database is CAplus and MEDLINE.

Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

Journal of Combinatorial Chemistry published new progress about 1238196-66-1. 1238196-66-1 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-hydroxyphenylboronic acid, and the molecular formula is C9H4F6O, Recommanded Product: 4-Chloro-2-hydroxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sambaiah, M. published the artcileTandem Schiff-Base Formation/Heterocyclization: An Approach to the Synthesis of Fused Pyrazolo-Pyrimidine/Isoxazolo-Pyrimidine Hybrids, Related Products of chlorides-buliding-blocks, the publication is Synlett (2019), 30(5), 586-592, database is CAplus.

A new synthesis of pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines was described. Key steps in the synthesis involve Stille coupling of 4,6-dichloro-2-phenyl-pyrimidine with tributyl(1-ethoxyvinyl)stannane and tandem Schiff-base formation/heterocyclization of 2,6-di-aryl-5-fluoro-4-acetylpyrimidine with hydrazines or hydroxylamine to give pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines, resp. The position of the fluoro group in the pyrimidine ring is important for the success of heterocyclization reaction.

Synlett published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Badolato, Mariateresa published the artcileTriazolopyrimidinium salts: discovery of a new class of agents for cancer therapy, Recommanded Product: 3-Chlorobenzylchloride, the publication is Future Medicinal Chemistry (2020), 12(5), 387-402, database is CAplus and MEDLINE.

Aim: The [1,2,4]triazolo[1,5-a]pyrimidine core is highly privileged in medicinal chem. due to its versatile pharmacol. activity profile. Recently, the search for novel anticancer agents has focused on [1,2,4]triazolo[1,5-a]pyrimidine derivatives Results: Our hit functionalization has led to the discovery of new [1,2,4]triazolo[1,5-a]pyrimidinium salts with potential anticancer activity. Among a small library of mols., compound 9 significantly inhibits cancer cell growth in a panel of in vitro models. Mol. docking studies and preliminary binding assay have displayed that 9 could directly bind the Src homol. 2 (SH2) domain of STAT3 protein. Conclusion: Compound 9 is a novel promising lead compound that motivates addnl. evaluation of [1,2,4]triazolo[1,5-a]pyrimidinium salts as novel potential chemotherapeutics.

Future Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferla, Salvatore published the artcileRational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein, HPLC of Formula: 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2020), 28(8), 115401, database is CAplus and MEDLINE.

Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract diseases in infants and young children, with potentially serious and fatal consequences associated with severe infections. Despite extensive research efforts invested in the identification of therapeutic measures, no vaccine is currently available, while treatment options are limited to ribavirin and palivizumab, which both present significant limitations. While clin. and pre-clin. candidates mainly target the viral fusion protein, the nucleocapsid protein or the viral polymerase, our focus has been the identification of new antiviral compounds targeting the viral M2-1 protein, thanks to the presence of a zinc-ejecting group in their chem. structure. Starting from an anti-RSV hit we had previously identified with an in silico structure-based approach, we have designed, synthesized and evaluated a new series of dithiocarbamate analogs, with which we have explored the antiviral activity of this scaffold. The findings presented in this work may provide the basis for the identification of a new antiviral lead to treat RSV infections.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gou, Fei-Hu published the artcileNickel-catalyzed cross-coupling of amino-acid-derived alkylzinc reagents with alkyl bromides/chlorides: Access to diverse unnatural amino acids, Product Details of C7H4ClF3, the publication is Organic Letters (2022), 24(1), 240-244, database is CAplus and MEDLINE.

Unnatural α-amino acids are important synthetic targets in the field of peptide science. Herein we report an efficient, versatile, and straightforward strategy for the synthesis of homophenylalanine derivatives via the nickel-catalyzed Csp³-Csp³ cross-coupling of (fluoro)benzyl bromides/chlorides with natural α-amino-acid-derived alkylzinc reagents. The current protocol features the advantages of a low-cost nickel catalyst system, synthetic convenience, and the tolerance of rich functionality and stereochem.

Organic Letters published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Product Details of C7H4ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie published the artcileSynthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry Research (2019), 28(7), 959-973, database is CAplus.

Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-pos. bacterial strains (including multidrug-resistant clin. isolates) and Gram-neg. bacterial strains, with min. inhibitory concentration (MIC) values in the range of 2-64 μg/mL. Compounds 3a, 5a, and 7l showed significant inhibitory activity against the Gram-pos. bacterial strain Staphylococcus aureus RN 4220, the Gram-neg. bacterial strain Escherichia coli 1924, and four multidrug-resistant Gram-pos. bacterial strains, with MIC values of 2 and 4 μg/mL. In anti-inflammatory tests, most of the compounds exhibited potent activity, in particular compound 3a displayed the most potent activity with 81.61% inhibition after i.p. administration, which was more potent than ursolic acid and the reference drugs (ibuprofen and indomethacin). The cytotoxic activity of compound 3a was assessed in HeLa, Hep3B, and A549 cells.

Medicinal Chemistry Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C21H26BF4NO, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Shuai published the artcileDiscovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112630, database is CAplus and MEDLINE.

A novel series of [1,2,4]triazolo[1,5-a]pyrimidine-based compoundsI [R¹ = benzyl, 4-fluorobenzyl, 4-chlorobenzyl, etc.; R² = Me, Et, Ph; R³ = H, Me] and II [R⁴ = Ph, (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl), (4-(3-(5-bromo-2-pyridyl)prop-2-enoyl)phenyl), etc.] were synthesized and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl), (4-(3-(5-bromo-2-pyridyl)prop-2-enoyl)phenyl)] inhibited gastric cancer cells at micromolar level. Compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] against gastric cancer cell. To our surprising, ROS level was increased by compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] in MGC-803 cells. Taken together, compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound II [R⁴ = (4-(3-(6-bromo-2-pyridyl)prop-2-enoyl)phenyl)] may support further development of lead compounds for gastric cancer therapy via mitochondria pathway.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C6H12F3NO5S, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics