Tag: M.W=150-200

Lourenco, Nuno M. T. published the artcileIonic Acylating Agents for the Enzymatic Resolution of sec-Alcohols in Ionic Liquids, Related Products of chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2010), 6938-6943, S6938/1-S6938/52, database is CAplus.

Potential acylating agents containing pendant ionic groups have been screened for the enzymic kinetic resolution of rac-secondary alcs. in ionic liquids with CAL-B as biocatalyst. This study has allowed the identification of the 1-methyl-3-alkylimidazolium cation attached to a carboxylate group through a C₁₀-alkyl chain as an efficient acylating agent for this transformation. This strategy was applied to the resolution of 2-hydroxycyclohexanecarbonitrile in which the 1R,2S enantiomer was isolated in 35 % ee (73 % yield) and the 1S,2R enantiomer in 97 % ee (23 % yield).

European Journal of Organic Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Onofrio, Jennifer published the artcileAn Efficient and Versatile Solid-Phase Synthesis of 5′- and 3′-Conjugated Oligonucleotides, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Organic Letters (2005), 7(22), 4927-4930, database is CAplus and MEDLINE.

An easy and efficient solid-phase strategy to obtain 5′- and 3′-oligonucleotide conjugates in highly pure form has been developed. Ad hoc derivatized solid supports, to which the first nucleoside unit can be attached through a phosphate linkage, have been exploited both in a pre- and post-DNA assembly conjugation approach. A number of 5′- or 3′- oligonucleotide conjugates, incorporating a variety of labels covalently linked through a phosphodiester or a phosphoramidate bond, have been synthesized and characterized.

Organic Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boyd, G. S. published the artcileThe interrelations and effects of iodothyronines and cholesterol on the myocardium of the rat, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Atherosclerosis Research (1961), 470-88, database is CAplus and MEDLINE.

3,3′,5-Triiodo-L-thyronine (T₃) was administered to adult male rats at 50 γ/day. Serum cholesterol, O consumption, heart rate, and histology of the heart were studied in these animals. The hyperthyroid state in the rat was accompanied by an increase in O consumption, heart rate, and cardiac hypertrophy. Many of the hearts from hyperthyroid rats exhibited degenerative lesions of the cardiac muscle characterized by focal necrosis and fibrosis. The effect of varying the diet on the metabolic and histol. responses was studied. The inclusion of cholesterol and olive oil in the diet appeared to protect the animal against T₃-induced myocardial lesions. The time-course of these lesions with respect to the cardiac hypertrophy suggests that the effects may be causally related. The lesions can be produced by a wide variety of iodothyronines related to T₃, provided the dosage of the analog is adjusted to produce an approx. equivalent cardiac hypertrophy.

Journal of Atherosclerosis Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stadler, Marco published the artcileDesign, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA_A) Receptor Modulators, Category: chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(1), 317-341, database is CAplus and MEDLINE.

Subunit-selective modulation of γ-aminobutyric acid type A receptors (GABA_AR) is considered to exert fewer side effects compared to unselective clin. used drugs. Here, the β2/3 subunit-selective GABA_AR modulators valerenic acid (VA) and loreclezole (LOR) guided the synthesis of novel subunit-selective ligands with simplified structures. We studied their effects on GABA_ARs expressed in Xenopus laevis oocytes using two-microelectrode voltage clamp technique. Five compounds showed significantly more efficacious modulation of GABA-evoked currents than VA and LOR with retained potency and selectivity. Compound 18 [(E)-2-Cyano-3-(2,4-dichlorophenyl)but-2-enamide] induced the highest maximal modulation of GABA-induced chloride currents (E_max: 3114 ± 242%), while 12 [(Z)-3-(2,4-dichlorophenyl)but-2-enenitrile] displayed the highest potency (EC₅₀: 13 ± 2 μM). Furthermore, in hippocampal neurons 12 facilitated phasic and tonic GABAergic inhibition, and in vivo studies revealed significantly more potent protection against pentylenetetrazole (PTZ)-induced seizures compared to VA and LOR. Collectively, compound 12 constitutes a novel, simplified, and subunit-selective GABA_AR modulator with low-dose anticonvulsant activity.

Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C10H10O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galons, Herve published the artcileA convenient procedure for the synthesis of phenothiazine drugs, Related Products of chlorides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1985), 33(11), 5108-9, database is CAplus.

Alkylation of phenothiazines to prepare chloropromazine and analogous compounds was achieved by solid-liquid phase-transfer catalysis in the presence of Aliquat 336 in the absence of any organic solvent. This simple procedure is easy and rapid.

Chemical & Pharmaceutical Bulletin published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Luca, Laura published the artcileSynthesis and biochemical evaluation of 5-(pyridin-4-yl)-3-(alkylsulfanyl)-4H-1,2,4-triazol-4-amine-based inhibitors of tyrosinase from Agaricus bisporus, Name: 3-Chlorobenzylchloride, the publication is ARKIVOC (Gainesville, FL, United States) (2022), 156-166, database is CAplus.

A series of small mols. able to inhibit diphenolase activity of tyrosinase from Agaricus bisporus. The designed compounds I [n = 1,2; R = H, 4-Me, 2,4-F etc.] were readily synthesized by S-alkylation and the synthesized compounds I were tested through biochem. screening, thus provided structure-affinity relationships for this class of comp. I . In addition, docking simulations suggested the binding mode within the catalytic site of the targeted enzyme.

ARKIVOC (Gainesville, FL, United States) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Name: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Taylor, Scott D. published the artcileSynthesis of Methylene- and Difluoromethylenephosphonate Analogs of Uridine-4-phosphate and 3-Deazauridine-4-phosphate, COA of Formula: C6H4ClNO2, the publication is Journal of Organic Chemistry (2006), 71(25), 9420-9430, database is CAplus and MEDLINE.

Cytidine triphosphate synthetase (CTPS) catalyzes the formation of cytidine triphosphate from glutamine, uridine-5′-triphosphate (UTP), and adenosine-5′-triphosphate. Inhibitors of CTPS are of interest because of their potential as therapeutic agents. One approach to potent enzyme inhibitors is to use analogs of high energy intermediates formed during the reaction. The CTPS reaction proceeds via the high energy intermediate UTP-4-phosphate (UTP-4-P). Four novel analogs of uridine-4-phosphate, e.g. I, and 3-deazauridine-4-phosphate (3-deazaU-4-P) were synthesized in which the labile phosphate ester oxygen was replaced with a methylene and difluoromethylene group. The methylene analog of uridine-4-phosphate, was prepared by a reaction of the sodium salt of tert-Bu diethylphosphonoacetate with protected, 4-O-activated uridine followed by acetate deprotection and decarboxylation. It was found that this compound undergoes relatively facile dephosphonylation presumably via a metaphosphate intermediate. The difluoromethylene derivative, was prepared by electrophilic fluorination of protected uridine-4-phosphate. This compound was stable and did not undergo dephosphonylation. Synthesis of the methylene analog of 3-deazaU-4-P, was achieved by ribosylation of protected 4-(phosphonomethyl)-2-hydroxypyridine. Electrophilic fluorination was also employed in the preparation of protected 4-(phosphonodifluoromethyl)-2-hydroxypyridine which was used as the key building block in the synthesis of difluoro derivative These compounds represent the first examples of a nucleoside in which the base has been chem. modified with a methylene or difluoromethylenephosphonate group.

Journal of Organic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C20H40O2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajaiah, Honnappa published the artcileMechanochemical solid-state synthesis of 2-aminothiazoles, quinoxalines and benzoylbenzofurans from ketones by one-pot sequential acid- and base-mediated reactions, Computed Properties of 3696-23-9, the publication is Organic & Biomolecular Chemistry (2016), 14(17), 4129-4135, database is CAplus and MEDLINE.

Mechanochem. solid-state synthesis of 2-aminothiazoles, 2-hydrazinylthiazoles, quinoxalines and benzoylbenzofurans via one-pot sequential α-chlorination of ketones followed by base-mediated condensations with thiourea/thiosemicarbazides, o-phenylenediamine and salicylaldehyde resp. under ball-milling conditions was described. Chlorination of ketones proceeded with atom-economical trichloroisocyanuric acid reagent in the presence of p-TSA under ball-milling conditions to give α-chloroketones which was then further used without isolation. The viability of one-pot sequential acid- and base-mediated reactions in the solid state under ball-milling conditions was thus demonstrated.

Organic & Biomolecular Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sahoo, Prangya Rani published the artcileOxidation of phenylthioureas by cetyltrimethylammonium permanganate: a kinetic study, Formula: C7H7ClN2S, the publication is Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry (2014), 53A(2), 174-178, database is CAplus.

Phenylthioureas have been subjected to oxidation in acetonitrile medium in neutral condition to investigate the oxidation behavior of cetyltrimethylammonium permanganate on multifunctional groups. The oxidation product in each reaction is found to be the corresponding phenylurea. The rate of reaction is dependent on [CTAP], [phenylthiourea], [surfactant] and reaction temperature A Michaelis-Menten type kinetics is observed with respect to the substrate. A reaction mechanism involving the formation of a cyclic intermediate in the slow step is proposed for the oxidation reaction.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tripathi, P. N. published the artcileToxicological study of nitrobenzene derivatives against tetrahymena pyriformis using topological parameters, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Chemical and Pharmaceutical Research (2014), 6(5), 848-854, 7 pp., database is CAplus.

Eight topol. descriptors namely molar refractivity, solvent accessible surface area (SASA), shape index (order-1), shape index (order-2), shape index (order-3), valence connectivity index (order-0), valence connectivity index (order-1) and valence connectivity index (order-2) of fifty four nitrobenzene derivatives have been calculated with the help of CAChe Pro of Fujitsu software. Observed toxicities of all compounds are in terms of -log (IGC50), mM, which is the inverse logarithm of the concentration causing 50% growth inhibition of Tetrahymena pyriformis after 40 h. These eight descriptors have been used in developing QSTR models with the help of multi linear regression (MLR) anal. The quality of regression has been adjudged by correlation coefficient, cross validation coefficient and statistical parameters like standard error, standard error of estimate, degrees of freedom etc. The QSTR model developed from descriptors molar refractivity, solvent accessible surface area, shape index (order-1) and valence connectivity index (order-2) have very high predictive power and can be used to find out the toxicity of any new derivative of nitrobenzene. Reliable QSTR model has been obtained from single descriptor shape index (order-1) which is also present in all best four QSTR models. Therefore, shape index (order-1) appears an important descriptor for the toxicol. study of nitrobenzene derivatives

Journal of Chemical and Pharmaceutical Research published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C20H32B2O4, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics