Tag: M.W=150-200

Wang, Wei published the artcilePalladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters, Computed Properties of 939-99-1, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2541-2545, database is CAplus.

A convenient procedure for the synthesis of thioesters RCH₂C(O)SR¹ (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R¹ = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH₂Cl with sulfonyl chlorides R¹S(O)₂Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)₆ exhibited dual roles as both a solid CO surrogate and reductant here.

Advanced Synthesis & Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C7H8BClO2, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Xing-wei published the artcileLead/rare earth-free green-light-emitting crystal of molecular-based hybrid compound: (C₅H₁₃ClN)₂[MnCl₄] with large crystal size, COA of Formula: C5H13Cl2N, the publication is Wuji Huaxue Xuebao (2018), 34(2), 283-288, database is CAplus.

Reaction of MnCl₂ and 2-dimethylaminoisopropyl chloride hydrochloride afforded one novel mol.-based material, (C₅H₁₃ClN)₂[MnCl₄] (1). And it is interesting to note that 1 exhibits intense greenish fluorescent emission (520 nm) at room temperature and relatively high thermal stability (stable up to 450 K). Moreover, structure and spectra analyses reveal that its excellent optical property can be attributed to the ⁴T₁ (G) → ⁶A₁ electronic transition of Mn²⁺ in [MnX₄]^2- tetrahedron.

Wuji Huaxue Xuebao published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Kewang published the artcileAdsorption of Cu²⁺ by modified chitosan microspheres and its application in homocoupling of arylboronic acid, Synthetic Route of 145349-62-8, the publication is Arabian Journal of Chemistry (2022), 15(10), 104170, database is CAplus.

The modified chitosan microspheres were first prepared by emulsification and investigated the performance of the chitosan adsorbent for the adsorption of copper ions. The catalytic performance of chitosan-supported copper microspheres in the self-coupling of arylboronic acids using 4-methoxybenzene as the model substrate was evaluated, while exploring a wide range of substrates including aryl boronic acid derivatives and heterocyclic arylboronic acids, including aldehyde, nitro, and aldehyde groups. The exptl. results show that good to excellent yields (55%-95%) of the desired dimer products were obtained under mild conditions at room temperature and in air, and the catalytic material could be reused up to five times with no significant decrease in catalytic activity.

Arabian Journal of Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C15H24S, Synthetic Route of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nevalainen, Vesa published the artcileStudies on the preparation of dihydro-1,4-oxathiines. Computer-assisted evaluation of the results of retrosynthetic analysis verified by synthetic experiments and by-product analyses. Synthetic pathways involving α-sulfenylated ketones and 1,3-oxathiolanes of α-halo and α-hydroxy ketones, COA of Formula: C4H8Cl2S2, the publication is Acta Chemica Scandinavica (1990), 44(6), 591-602, database is CAplus.

The preparation of 2- and 2,3-substituted 5,6-dihydro-1,4-oxathiines (I, R = Me or Ph, R¹ = H, Me, CO₂H, CO₂Me, CO₂Et, or CONHPh) was studied by computer simulation and by experiment Three major synthetic pathways, involving 2-(1-hydroxyalkyl)-1,3-oxathiolanes, 2-(1-haloalkyl)-1,3-oxathiolanes, 2-hydroxyethylthiomethyl ketones, methanesulfonates of 2-hydroxyethylthiomethyl ketones and 2-chloroethylthiomethyl ketones as intermediates, were evaluated, by running the program CAMEO, and by experiment The results of the two approaches were compared and the major byproducts of the reactions were identified by GLC/MS.

Acta Chemica Scandinavica published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nevalainen, Vesa published the artcileStudies on the formation of dihydro-1,4-oxathiines by halogenation of 1,3-oxathiolanes, Computed Properties of 1002-41-1, the publication is Journal of Chemical Research, Synopses (1988), 182-3, database is CAplus.

Dihydro-1,4-oxathiins I (R, R¹ = Me, H; Et, H; Ph, H; Me, Ph; CO₂Me, H; Me, CO₂Me; Me, CONHPh) were prepared in 6-45% yields by the halogenation of the resp. 1,3-oxathiolanes II (R, R¹ = Me, H; Me, Me; Ph, H; Me, Ph; CO₂Me, H; Me, CO₂Me; Me, CONHPh) with SOCl₂. Several byproducts were formed.

Journal of Chemical Research, Synopses published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Computed Properties of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brzozowski, Zdzislaw published the artcileDerivatives of 2-mercaptobenzenesulfonamide. XIII. Syntheses and some pharmacological properties of 1-[4-chloro-2-(dialkylaminoalkylthio)-5-methylbenzenesulfonyl]-2-imidazolidinone hydrochlorides, COA of Formula: C5H13Cl2N, the publication is Acta Poloniae Pharmaceutica (1993), 50(4-5), 359-64, database is CAplus and MEDLINE.

In the search for new antiarrhythmic agents, 3-[(4-chloro-2-mercapto-5-methylphenyl)sulfonyl]imidazolidinone I (R = H) was treated with dialkylaminoalkyl chloride hydrochlorides in Me₂CHONa-Me₂CHOH to yield I (R = Me₂NCH₂CHMe, Me₂NCMe₂CH₂, and R¹CH₂CH₂; R¹ = Pr₂N, Bu₂N, (C₆H₁₁)₂N, piperidinyl, 2,6-dimethylpiperidinyl, morpholinyl, and piperazinyl). Data for LD₅₀ and activity against acinitine- and BaCl₂-induced arrhythmia in rats are presented for I hydrochlorides.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nongmaithem, Sapana published the artcileEnhanced Polar Auxin Transport in Tomato Polycotyledon Mutant Seems to be Related to Glutathione Levels, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Plant Growth Regulation (2021), 40(2), 761-773, database is CAplus.

Glutathione-dependent root growth in Arabidopsis is linked to polar auxin transport (PAT). Arabidopsis mutants with reduced glutathione (GSH) levels also show reduced PAT. To gain an insight into the relationship between PAT and GSH level, we analyzed tomato polycotyledon mutant, pct1-2, which has enhanced PAT. Microarray anal. of gene expression in pct1-2 mutant revealed underexpression of several genes related to glutamate and glutathione metabolism In consonance with microarray anal., enzymic as well as in vivo assay revealed higher glutathione levels in the early phase of pct1-2 seedling growth than WT. The inhibition of auxin transport by 2,3,5-triiodobenzoic acid (TIBA) reduced both GSH level and PIN1 expression in pct1-2 root tips. The reduction of in vivo GSH accumulation in pct1-2 root tips by buthionine sulfoximine (BSO) stimulated elongation of the short root of pct1-2 mutant akin to TIBA. The rescue of the short root phenotype of the pct1-2 mutant was restricted to TIBA and BSO. The other auxin transport inhibitors 1-N-naphthylphthalamic acid (NPA), 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid (BUM), 3-chloro-4-hydroxyphenylacetic acid (CHPAA), brefeldin and gravacin inhibited root elongation in both WT and pct1-2 mutant. Our results indicate a relationship between PAT and GSH levels in tomato akin to Arabidopsis. Our work also highlights that TIBA rescues the short root phenotype of the pct1-2 mutant by acting on a PAT component distinct from the site of action of other PAT inhibitors.

Journal of Plant Growth Regulation published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Doobary, Sayad published the artcileIntramolecular Alkene Fluoroarylation of Phenolic Ethers enabled by Electrochemically Generated Iodane, COA of Formula: C8H7ClO3, the publication is Journal of Organic Chemistry (2021), 86(22), 16095-16103, database is CAplus and MEDLINE.

Herein, synthesis of 3-fluorinated chromanes from allylic phenol ethers was described. Oxidant-free approach takes advantage of an electrochem. generation of a hypervalent iodine species, difluoro-λ³-tolyl iodane, which mediates the alkene fluoroarylation. High yields and selectivity for this transformation are achieved for electron poor substrates. The redox chem. has been characterized for the electrochem. generation of the iodane in the presence of fluoride, and insights into the mechanism are given. The transformation has been demonstrated on larger gram scales, which represents the potential broader utility of the process.

Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gaglione, Maria published the artcileTuning RNA Interference by Enhancing siRNA/PAZ Recognition, Quality Control of 33697-81-3, the publication is ACS Medicinal Chemistry Letters (2013), 4(1), 75-78, database is CAplus and MEDLINE.

Chem. modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theor. data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.

ACS Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kapoor, Jitander K. published the artcileSelective Synthesis of 3-(α,α-Dibromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one as an Excellent Precursor for the Synthesis of 2-Substituted 4-(4-Hydroxy-6-methyl-2H-2-oxopyran-3-yl)thiazoles as Antimicrobial and Antifungal Agents, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Journal of Heterocyclic Chemistry (2018), 55(4), 899-906, database is CAplus.

A selective synthesis of 3-(α,α-dibromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one has been achieved by bromination of DHA using CuBr₂/CHCl₃-EtOAc. The reaction of the above compound with different thioureas/thiomides/thiosemicarbazide offers a convenient and efficient method for the syntheses of 2-substituted 4-(4-hydroxy-6-methyl-2H-2-oxopyran-3-yl)thiazoles I (R = C₆H₅NH, 4-MeC₆H₄NH, 4-ClC₆H₄NH, etc.). These thiazoles were evaluated for their antimicrobial and antifungal activity.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics