Tag: M.W=150-200

Madhura, V. published the artcileA new route for the synthesis of 4-arylacetamido-2-aminothiazoles and their biological evaluation, Related Products of chlorides-buliding-blocks, the publication is Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences (2015), 70(7), 483-489, database is CAplus.

A series of 2-(2-amino-1,3-thiazol-4-yl)-N-phenylacetamides I [R = H, C₆H₅, 4-MeC₆H₄, etc.; R¹ = H, 2-Me, 3-Cl, 4-Cl] was synthesized in high yields via a single step reaction of ω-bromoacetoacetanilides and thiourea/phenyl thioureas. These synthesized thiazoles I were evaluated for their in vitro antibacterial, antifungal and antioxidant activities. In vitro antimicrobial evaluation of these compounds indicated their specificity towards Gram-pos. species such as S. aureus and E. faecalis. Among the tested compounds, thiazole derivatives I [R = 4-MeC₆H₄, R¹ = H; R = 3-ClC₆H₄, R¹ = H] exhibited the lowest min. inhibitory concentration values against S. aureus and E. faecalis whereas thiazole I [R = 4-MeC₆H₄; R¹ = 4-Cl] showed maximum antioxidant activity. The other compounds exhibited promising antimicrobial and moderate antioxidant activity.

Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Shuai-Bing published the artcileAntifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses, Product Details of C7H16ClNO2, the publication is Applied Microbiology and Biotechnology (2021), 105(20), 7871-7888, database is CAplus and MEDLINE.

Chem. control of fungal spoilage of postharvest cereal grains is an important strategy for the management of grain storage. Here, the potential antifungal activity of 1-nonanol, a main component of cereal volatiles, against Aspergillus flavus was studied. The growth of A. flavus was completely inhibited by 0.11 and 0.20 μL/mL 1-nonanol at vapor and liquid contact phases, resp. Metabolomic anal. identified 135 metabolites whose expression was significantly different between 1-nonanol-treated and untreated A. flavus. These metabolites were involved in the tricarboxylic acid cycle, amino acid biosynthesis, protein degradation and absorption, aminoacyl-tRNA biosynthesis, mineral absorption, and in interactions with ABC transporters. Biochem. validation confirmed the disruptive effect of 1-nonanol on A. flavus growth, as indicated by the leakage of intracellular electrolytes, decreased succinate dehydrogenase, mitochondrial dehydrogenase, and ATPase activity, and the accumulation of reactive oxygen species. We speculated that 1-nonanol could disrupt cell membrane integrity and mitochondrial function and might induce apoptosis of A. flavus mycelia. Simulated grain storage experiments showed that 1-nonanol vapor, at a concentration of 264 μL/L, completely inhibited A. flavus growth in wheat, corn, and paddy grain with an 18% moisture content. This study provides new insights into the antifungal mechanism of 1-nonanol against A. flavus, indicating that it has a promising potential as a bio-preservative to prevent fungal spoilage of postharvest grains. 1-Nonanol showed higher antifungal activity against A. flavus. · The antifungal mechanisms of 1-nonanol against A. flavus were revealed. · 1-Nonanol could damage cell membrane integrity and mitochondrial function.

Applied Microbiology and Biotechnology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C2H2N4O2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suryadevara, Praveen Kumar published the artcileDialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents, Computed Properties of 350-30-1, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(23), 6492-6499, database is CAplus and MEDLINE.

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound I as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound I is highly efficacious in the acute model of the disease. However, compound I has a high mol. weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC₅₀ <1 nM) against T. cruzi in culture. The halogenated derivatives II (where R² = Cl, R³ = Me or H; R² = F, R³ = H) display excellent activity against T. cruzi amastigotes, with reduced mol. weight and lipophilicity, and exhibit suitable physicochem. properties for an oral drug candidate.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C3H6F3N, Computed Properties of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Savel’eva, E. I. published the artcileStudy of the composition of gas emissions from bitumen-salt materials including mustard gas degradation products, Product Details of C4H8Cl2S2, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg) (1999), 72(9), 1501-1506, database is CAplus.

The method of steady-state vapor-phase anal. was used to investigate the composition of th gas emissions from the bitumen-salt materials, including products OK decontamination of mustard gas with mixture of monoethanolamine and ethylene glycol. Gas chromatog.-mass spectrometry were for analyzing the components. Homologous series of alkyldithianes and ethanolthiomopholines were noted in the gas emissions of the detoxication products of mustard gas with ethanolamine. All these compounds with the exception of 1,4-dithiane were characteristic of destruction of mustard gas. At the same time. 1.4-dithiane, the most stable product of transformation of mustard gas, may serve as an unusual indicator for ascertaining illegal use of the mustard gas.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Product Details of C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gupta, Atul published the artcileSynthesis of 3-phenyl-4-phenylvinylbenzopyranones and the corresponding 2,2-dimethylbenzopyrans with structural similarity to estradiol, as estrogen receptor ligands, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Medicinal Chemistry (2007), 3(5), 446-454, database is CAplus and MEDLINE.

7-Methoxy-3-phenyl-4-phenylvinylbenzopyran-2-ones I [R¹R² = oxo, R⁴ = (CH₂)₂R⁵, CH(Me)CH₂NMe₂, R⁵ = 1-pyrrolidinyl, 1-piperidinyl, NMe₂, NEt₂] and the corresponding 2,2-dimethylbenzopyrans I [R¹ = R² = Me] substituted with different alkylamino residues were synthesized. Except compound I [R¹R² = oxo, R⁴ = CH(Me)CH₂NMe₂], all compounds showed high levels of estrogen agonistic activity (>81 %) whereas, compounds I [R¹R² = oxo, R⁴ = (CH₂)₂R⁵, CH(Me)CH₂NMe₂, R⁵ = 1-piperidinyl, NMe₂, NEt₂] and I [R¹ = R² = Me, R⁴ = (CH₂)₂R⁵, R⁵ = 1-pyrrolidinyl] showed significant estrogen antagonistic activity (>20 %). X-Ray anal. of I [R¹R² = oxo, R⁴ = (CH₂)₂NEt₂] showed its structural resemblance to endogenous estrogen, 17β-estradiol. Estrogenic and anti-estrogenic activities of these derivatives demonstrate their estrogen receptor (ER) binding ability. The lack of hydroxyl groups at appropriate positions resulted in poor relative binding affinity (RBA).

Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Carmine, Graziano published the artcileSynthesis of functionalized imidazolidine-2-thiones via NHC/base-promoted aza-benzoin/aza-acetalization domino reactions, Name: 1-(4-Chlorophenyl)thiourea, the publication is Organic & Biomolecular Chemistry (2017), 15(41), 8788-8801, database is CAplus and MEDLINE.

A strategy for the synthesis of biol. relevant 5-hydroxy-imidazolidine-2-thione derivatives I [R¹ = i-Pr, 4-pyridinyl, 2-ClC₆H₄, etc.; R² = i-Pr, Ph, 2-FC₆H₄, 4-ClC₆H₄, 3-MeC₆H₄, 3-BrC₆H₄; R³ = cyclohexyl, Ph, 2-MeC₆H₄, 2-FC₆H₄, 4-ClC₆H₄; X = S] and imidazolidine-2-one I [R¹ = Ph; R² = 4-ClC₆H₄; R₃ = Bn; X = O] was presented. A novel class of α-sulfonylamines had been suitably prepared (46-81% yield) as precursors of formal benzylidenethiourea acceptors; these were generated in situ and intercepted by N-heterocyclic carbene (NHC)-activated aldehydes affording open-chain aza-benzoin-type adducts, which in turn underwent an intramol. aza-acetalization reaction in a one-pot fashion. A thiazolium salt/triethylamine couple proved to be the more effective system to trigger the domino sequence giving the target heterocycles in good yields (45-97%) and diastereoselectivities (up to 99 : 1 dr). The multigram scale synthesis and elaboration of a selected 5-hydroxy-imidazolidine-2-thione compound I [R¹ = 4-ClC₆H₄, R² = R³ = Ph] was also described.

Organic & Biomolecular Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Geetanjali, Y. published the artcileFurano compounds: synthesis of aroylbenzofurans, benzo[1,2-b:5,4-b’]difurans and their basic ethers, Product Details of C5H13Cl2N, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1985), 24B(11), 1129-32, database is CAplus.

Alkylaminoalkoxybenzofurans I (R = CH₂CH₂NR¹R², CHMeCH₂NMe₂, 3-piperidinopropyl; NR¹R² = NMe₂, NEt₂, pyrrolidino, piperidino, morpholino) have been synthesized by condensing I (R = H) with RCl.HCl in the presence of K₂CO₃ in dry Me₂CO. I (R = H) was obtained by refluxing 1,3-Ac₂C₆H₂(OH)₂-4,6 with BrCH₂Bz. Dibenzoylbenzo[1,2-b:5,4-b‘]difurans II (R³ = H, OMe, OH, OR) have also been synthesized. Condensation of BrCH₂Bz with 5-acetyl-6-hydroxy-2,3-diphenylbenzofuran results in 6-benzoyl-5-methyl-2,3-diphenylbenzo[1,2-b:5,4-b‘]difuran.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prasad, G. K. published the artcileSun light assisted photocatalytic decontamination of sulfur mustard using ZnO nanoparticles, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Molecular Catalysis A: Chemical (2011), 349(1-2), 55-62, database is CAplus.

Sunlight-assisted photocatalytic decontamination of sulfur mustard (HD) was studied using ZnO nanoparticles and the data were compared with those carried out in the presence of UVA and visible light radiation. In the presence of sunlight, 100% of HD was decomposed in 12 h. Whereas, in the presence of UVA light 90%, and in visible light 80% of HD was decomposed in 12 h. GC-MS data indicated the formation of thiodiglycol, hemisulfur mustard, divinyl sulfide, 2-chloro Et vinyl sulfide, etc., on the surface of ZnO nanoparticles in the case of dark and visible light irradiation experiments However, in sunlight and UVA light irradiation experiments, GC-MS data indicated the formation of HD sulfoxide, HD sulfone, 1,3-dithiane, 2-chloro ethanol, acetaldehyde, CO₂, etc. along with hydrolysis and elimination products. Under the illumination of visible light and in dark hydrolysis, elimination and surface complexation reactions contributed to decontamination of HD. Whereas, in the presence of sunlight and UVA light, photocatalytic reactions like C-S bond cleavage, oxidation of C, S atoms were observed to have contributed to decontamination of HD in addition to hydrolysis and elimination reactions.

Journal of Molecular Catalysis A: Chemical published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ahn, Ki Chang published the artcileDetection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay, Category: chlorides-buliding-blocks, the publication is Environmental Science & Technology (2016), 50(7), 3754-3761, database is CAplus and MEDLINE.

A sensitive, competitive ELISA for the detection of the antimicrobial triclosan (TCS) was developed. Novel immunizing haptens were synthesized by derivatizing at the 4-Cl position of the TCS mol. Compounds derived from substitutions at 4′-Cl and that replaced the 2′-OH with a Cl atom were designed as unique coating antigen haptens. Polyclonal rabbit antisera were screened against the coating antigen library to identify combinations of immunoreagents resulting in the most sensitive assays. The most sensitive assay identified was one utilizing antiserum number 1155 and a heterologous competitive hapten, where the 2′-OH group was substituted with a Cl atom. An IC₅₀ value and the detection range for TCS in assay buffer were 1.19 and 0.21-6.71 μg/L, resp. The assay was selective for TCS, providing low cross-reactivity (<5%) to the major metabolites of TCS and to brominated di-Ph ether-47. A 2nd assay using a competitive hapten containing Br instead of Cl substitutions was broadly selective for both brominated and chlorinated diphenylethers. Using the most sensitive assay combination, we measured TCS concentrations in water following dilution Biosolid samples were analyzed following the dilution of a simple solvent extract The immunoassay results were similar to those determined by LC-MS/MS. This immunoassay can be used as a rapid and convenient tool to screen for human and environmental exposure.

Environmental Science & Technology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Darroudi, Mahdieh published the artcileSynthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI-Fe₃O₄@SiO₂ (TMS-EDTA), COA of Formula: C7H7ClN2S, the publication is Applied Organometallic Chemistry (2020), 34(12), e5962, database is CAplus.

In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives I and II was designed as tyrosinase inhibitors. The compounds I and II were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives I and II was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe₃O₄@SiO₂ core-shell (CuI/Fe₃O₄@SiO₂(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET anal. The excellent catalytic performance in ethanol with high surface area (351.7 m²g^-1) and short reaction time for diverse functional groups (120-200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions were the advantageous of this work. Moreover,the nanocatalyst was used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives I [X=Y=Z = H, X=Y = H; Z = Br, X = 4-N; Y = H; Z = 2-Cl and X = 4-N; Y = H; 3,4-di-Cl] showed promising tyrosinase inhibitory activity with IC₅₀ values in the range of 5.90-9.81μM. The compounds I and II were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC₅₀ = 18.36μM).

Applied Organometallic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, COA of Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics