Tag: M.W=150-200

Haga, Yuji published the artcileDiscovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist, Synthetic Route of 6313-54-8, the publication is Bioorganic & Medicinal Chemistry (2009), 17(19), 6971-6982, database is CAplus and MEDLINE.

A series of trans-3-oxospiro[(aza)isobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide derivatives were synthesized to identify potent NPY Y5 receptor antagonists. Of the compounds, 21j (I)showed high Y5 binding affinity, metabolic stability and brain and cerebrospinal fluid (CSF) penetration, and low susceptibility to P-glycoprotein transporters. Oral administration of 21j significantly inhibited the Y5 agonist-induced food intake in rats with a min. ED of 1 mg/kg. This compound was selected for proof-of-concept studies in human clin. trials.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Creber, K. A. M. published the artcileAn investigation into the use of ionizing radiation for the destruction of sulphur mustard, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Radioanalytical and Nuclear Chemistry (2009), 282(2), 597-600, database is CAplus.

Chem. warfare agents have been stockpiled for almost a decade and their destruction has become an environmental issue that will continue to require attention for many years. There are hundreds of thousands of tons yet to be destroyed, and the current chem. or incineration techniques are not without problems. While many researchers are seeking better chem. techniques, we decided to try ionizing radiation to destroy sulfur mustard with the goal of producing non-toxic products. We irradiated a variety of sulfur mustard samples by both a mixed field source (β, γ and neutrons) and a pure gamma source. The mixed field irradiation of wet sulfur mustard for long irradiation times was the most successful at destroying the chem. agent.

Journal of Radioanalytical and Nuclear Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Veeresham, A. published the artcileGas chromatography/mass spectrometry analysis of reaction products of sulfur mustards with phenol, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is European Journal of Mass Spectrometry (2020), 26(3), 213-224, database is CAplus and MEDLINE.

Screening of chems. related to chem. weapons convention including their all possible degrdation and reaction products in environmental samples is important in the organization for prohibition of chem. weapons verification process. Sulfur mustards, commonly known as blistering agents, are included in schedule 1 chems. of chem. weapons convention. Because of the presence of chlorine atoms in sulfur mustards, they are highly reactive and prone to react with other organic mols. such as phenols to produce corresponding reaction products. In this study, the reaction products of the sulfur mustards with phenol (compounds 1-7) were studied by gas chromatog./mass spectrometry under electron ionization and chem. ionization conditions. The EI spectra of 1-7 displayed mol. ion and characteristic fragments that provided structure information. The methane or isobutane CI spectra showed M^+., [M + H]⁺, and [M – H]⁺ ions including reagent specific adduct ions. The CI spectra also showed other adduct ions formed by association of analyte mols. with its most abundant fragment ion. The gas chromatog./retention index values were also calculated, which support unambiguous identification of targeted mols. in suspected environmental samples. The method was demonstrated for detection of the targeted mols. spiked in soil samples.

European Journal of Mass Spectrometry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C7H7IN2O, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Parmar, Tejasvi H. published the artcileSynthesis of novel drug-like small molecules library based on 1H-benzo[d]imidazole, Quality Control of 915763-60-9, the publication is Australian Journal of Chemistry (2022), 75(4), 276-284, database is CAplus.

A series of novel ‘drug-like’ small mols. based on 1H-benzo[d]imidazole derivatives bearing furan-2-yl, 4-piperidine and 5-aryl/aminoaryl substitutions were designed and synthesized. The key intermediate tert-butyl-4-(5-bromo-2-(furan-2-yl)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate was synthesized via sequential reaction starting from 4-bromo-1-fluoro-2-nitrobenzene. The 5-aryl-substituted mol. library was generated via Suzuki-Miyaura coupling of the key intermediate with various boronic acids while Buchwald coupling with various anilines generated the second mol. library of tert-butyl-4-(2-(furan-2-yl)-5-(arylamino)-1H -benzo[d]imidazol-1-yl)piperidine-1-carboxylates. The structures of all the newly synthesized compounds were confirmed by spectral anal. The optimized procedure gives easy access to two new mol. libraries of 1H-benzo[d]imidazoles with operational simplicity and good yield.

Australian Journal of Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C7H5BClNO2, Quality Control of 915763-60-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mohammadhosseini, Negar published the artcileSynthesis and biological evaluation of novel benzyl piperazine derivatives of 5-(5-nitroaryl)-1,3,4-thiadiazoles as anti-Helicobacter pylori agents, Name: 2,4,5-Trifluorobenzyl chloride, the publication is Daru, Journal of Pharmaceutical Sciences (2013), 66/1-66/8, 8 pp., database is CAplus and MEDLINE.

A series of 1-(substituted benzyl)-4-(5-(5-nitroheteroaryl-2-yl)-1,3,4-thiadiazol-2-yl) piperazine derivatives I [X = O, S; R= 3-MeO, 2-O₂N, 2,5-(Cl)₂, 2,4,5-(F)₃, etc.] were synthesized. The synthesized compounds I were evaluated against three metronidazole-resistant isolates of Helicobacter pylori using disk diffusion bioassay test. The results of SAR study indicated that the potency and anti-H. pylori activity profile of synthesized derivatives was mainly attributed to the substituted nitroaryl moiety at the C-5 position of 1,3,4-thiadiazole ring. Compound I [X = O; R = 3-MeO] was found to be the most potent.

Daru, Journal of Pharmaceutical Sciences published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Name: 2,4,5-Trifluorobenzyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nandi, Sudipta published the artcileUrea transporter and its specific and nonspecific inhibitors: State of the art and pharmacological perspective, Application of 1-(4-Chlorophenyl)thiourea, the publication is European Journal of Pharmacology (2021), 174508, database is CAplus and MEDLINE.

Hypertension is a major concern for a wide array of patients. The traditional drugs are commonly referred as ′water pills′ and these mols. have been successful in alleviating hypertension. However, this comes at the high expense of precious electrolytes in our body. To dissipate this major adverse effect, the urea transporter inhibitors play especially important roles in maintaining the fluid balance by maintaining the concentration of urea in the inner medullary collecting duct. The purpose of this communication is to provide insights into the structural feature of these target proteins and inhibition of both urea transporter types A (UT-A) and B (UT-B) selectively and non-selectively with a special focus on the UT-A inhibitors as they are the primary target for diuresis. It was observed that a wide class of drugs such as thiourea analogs, 2,7-disubstituted fluorenones can inhibit both the protein non-selectively whereas 8-hydroxyquinoline, aminothiazolone, 1,3,5-triazine, triazolothienopyrimidine, thienoquinoline, arylthiazole, γ-sultambenzosulfonamide and 1,2,4-triazoloquinoxaline classes of compounds inhibit UT-A. The goal of this study is to highlight the important aspects that may be useful to understanding the perspectives of urea transporter inhibitors in rational drug discovery.

European Journal of Pharmacology published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cardenas, Mariel M. published the artcileCatalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines via S_NAr, Computed Properties of 145349-62-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(78), 10087-10090, database is CAplus and MEDLINE.

Herein authors report the catalytic atroposelective syntheses of pharmaceutically relevant 3-arylquinolines via the nucleophilic aromatic substitution (SNAr) of thiophenols into 3-aryl-2-fluoroquinolines mediated by catalytic amounts of Cinchona alkaloid-derived ureas. These reactions displayed a spectrum of dynamic kinetic resolution (DKR) and kinetic resolution (KR) characters depending upon the stereochem. stability of the starting material. Low barrier substrates proceeded via DKR while higher barrier substrates proceeded via KR. On the other hand, substrates with intermediate stabilities displayed hallmarks of both DKR and KR. Finally, authors also show that they can functionalize the atropisomerically enriched quinolines into pharmaceutically privileged scaffolds with minimal observed racemization.

Chemical Communications (Cambridge, United Kingdom) published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bagherzadeh, Nastaran published the artcileGreen and efficient synthesis of thioureas, ureas, primary O-thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2021), 45(26), 11852-11858, database is CAplus.

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(II) chloride [ChCl][SnCl₂]₂ with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalita, Pranjal published the artcileKIT-5 Supported Copper (II) Oxide Mesoporous Materials: An Efficient Catalyst for Regioselective Synthesis of 1,4- Disubstituted-1H-1,2,3-Triazoles in Water, HPLC of Formula: 620-20-2, the publication is Polycyclic Aromatic Compounds, database is CAplus.

We have synthesized copper-incorporated KIT-5 mesoporous materials which were characterized thoroughly by powder x-ray diffraction, N₂-sorption, UV-Vis, HR-SEM & EDS and HR-TEM techniques. The low angle PXRD with theta values of 0.609, 0.660, 0.704 and 0.746 confirmed the mesoporosity of the synthesized materials. In addition, the materials showed type-IV isotherms which are spherical in morphol. and fringes with pores of materials supporting the formation of mesoporous materials. The catalytic activity of synthesized materials was also investigated. We have used our materials as catalyst for the synthesis of 1,2,3-triazole derivatives via three component reaction of alkyl/aryl halide, terminal alkynes and sodium azide in water as a solvent. The desired triazole products were obtained in very good yields. This study indicates the importance of Cu element, solid support with uniformity of metal nanoparticles over the materials. The recyclability study with PXRD data of the catalyst confirmed the existence of the mesoporosity of the catalyst after the reaction and the yield decreased marginally from 98 to 91% over three cycles. This reaction has broad substrate scope and is compatible for aliphatic, aromatic, allyl substrates giving high yield of triazole products.

Polycyclic Aromatic Compounds published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sarmah, N. K. published the artcileSynthesis and antimicrobial evaluation of a novel series of some s-triazine moiety, Related Products of chlorides-buliding-blocks, the publication is Journal of Applicable Chemistry (Lumami, India) (2014), 3(5), 1936-1944, 9 pp., database is CAplus.

Some new 2-[N-(3,4,5-trimethoxybenzylidino)(benzoylhydrazinoyl)-amino-4-yl]-4-(4-cyclohexylamino)-6-(arylthioureido)-1,3,5-triazines I (R = 2-OMe, 2-Me, 2-Cl, etc.) were synthesized and evaluated for their in vitro antimicrobial activity against gram pos. and gram neg. strains using micro dilution procedure. Synthesized compounds proved to be effective with MIC (mg ml^-1), among them I (R = 4-OMe, 2-O₂N, 2,4-di-O₂N, R = 2-Cl-4-O₂N) showed excellent activity against a panel of microorganisms.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics