Tag: M.W=150-200

Bourquin, J. P. published the artcileSyntheses in the phenothiazine family. II. N-Substituted phenothiazinethiol derivatives, Formula: C5H13Cl2N, the publication is Helvetica Chimica Acta (1958), 1072-108, database is CAplus.

cf. C.A. 52, 18423d. 2-(N-Methyl-2-pyrrolidyl)ethanol (31.0 g.) in 200 ml. CHCl₃ treated with HCl 10 min. at 10°, 59.0 g. SOCl₂ added, after 2 hrs. at 70° the mixture concentrated, treated with 160 ml. 3N NaOH, extracted with Et₂O, and the dried extracts distilled gave 90% 2-(N-methyl-2-pyrrolidyl)-1-chloroethane (I), b₁₁ 65-6°; picrate, m. 133-5° (EtOH). BuNHMe (60.9 g.) and 54.6 g. Br(CH₂)₃Cl in boiling Et₂O 24 hrs. gave 68% BuMeN(CH₂)₃Cl, b₁₃ 71-2°; picrate, m. 94-6° (EtOH). BrCH₂CHMeCH₂Cl (68.6 g.), 36.0 g. Me₂NH, and 20 ml. C₆H₆ heated in an autoclave at 110° 7 hrs., 100 ml. H₂O and 320 ml. 10% HCl added, and the mixture extracted with 250 ml. Et₂O and 140 ml. 30% NaOH gave 68% Me₂NCH₂CHMeCH₂Cl, b₁₁ 35-6°. To 50.0 g. N-methylpiperazine in 150 ml. MeOH was added 37.7 g. propylene oxide, the mixture boiled 3 hrs., and distilled giving 70% N-methyl-N’-(2-hydroxypropyl)piperazine (II), b₁₁ 91-3°. II (50.7 g.) in 250 ml. C₆H₆ saturated with HCl, 78.2 g. SOCl₂ added, the mixture refluxed 5 hrs. then concentrated, 100 ml. H₂O and 120 ml. 30% NaOH added, the mixture extracted with 600 ml. C₆H₆, and the extract distilled gave 60% N-methyl-N’-(2-chloropropyl)piperazine, b₁₁ 87-9°; di-HCl salt, m. 233-5° (EtOH). N-Methylpiperazine (46.8 g.) and 40 g. BrCH₂CHMeCH₂Cl in 120 ml. refluxing Et₂O 24 hrs. gave 30% N-methyl-N’-(3-chloro-2-methylpropyl)piperazine, b₁₁ 99-100°; di-HCl salt, m. 234-6° (MeOH). Similarly, 233 g. N-benzylpiperazine and 104 g. Br(CH₂)₃Cl in 370 ml. Et₂O 48 hrs. gave 75% N-benzyl-N’-(3-chloropropyl)piperazine, b_0.01 132-6°; di-HCl salt, m. 249-51° (absolute EtOH). 2-(Methylthio)phenothiazine (III) (16.65 g.), 3.18 g. NaNH₂, and 100 ml. absolute xylene refluxed 3 hrs., 10.0 g. I in 10 ml. absolute xylene added during 1.5 hrs., after refluxing 3 hrs. and cooling 5 g. NH₄Cl and 150 ml. H₂O added, the xylene layer extracted with 115 ml. 15% tartaric acid, 35 ml. concentrated NaOH added, and the freed base extracted with 100 ml. C₆H₆ gave 85% 10-[2-(N-methyl-2-pyrrolidyl)ethyl]-2-(methylthio)phenothiazine, b_0.008 209°; tartrate, sintered 70°, m. 115°. Similarly prepared were the following 10-[2-(N-methyl-2-pyrrolidyl)ethyl]-2-(alkylthio)phenothiazines (alkyl groups given): Et, b_0.01 213° (tartrate-0.5-H₂O, sintered 65°, m. 90°); iso-Pr, b_0.008 217° (tartrate-0.5H₂O, sintered 70°, m. 90°); Bu, b_0.01 225° (tartrate-0.5H₂O, sintered 60°, m. 75°). 10-[2-(N-Methyl-2-piperidyl)ethyl]-2-(alkylthio)phenothiazines (alkyl groups given): Et (IV) [80% from 18.89 g. 2-(ethylthio)phenothiazine (V) and 14.7 g. 2-(N-methyl-2-piperidyl)-1-chloroethane], b_0.008, m. 57-9° (iso-PrOH) (tartrate, sintered 70°, decompose 135°); Pr, b_0.01 247° (tartrate, sintered 70°, decompose 120°); iso-Pr, b_0.05 223°, m. 73-5° (tartrate, sintered 70°, decompose 120°); Bu, b_0.005 227°; iso-Bu, b_0.003 215°; sec-Bu, b_0.007 215°; n-hexyl, b_0.015 235°; PhCH₂ (VI), b_0.01 246° (tartrate-0.5-H₂O, sintered 75°, m. 105°). 10-(N-Methyl-3-piperidylmethyl)-2-alkylphenothiazines (alkyl groups given): Me [60% from 50.0 g. III and 33.8 g. N-methyl-3-(chloromethyl)piperidine], b_0.01 207° [HCl salt, sintered 110°, decompose 124-6° (Me₂CO); tartrate-0.5H₂O, sintered 75°, decompose 140° (EtOAc); oxalate, decompose 182-4° (absolute EtOH)]; Et, b_0.01 222° (tartrate, sintered 75°, m. 140°); Pr, b_0.01 225°, sintered 85°, m. 145°; iso-Pr, b_0.01 216° (tartrate-0.5H₂O, sintered 75°, decompose 140°); Bu, b_0.01 223° (tartrate, sintered 80°, decompose 100°); iso-Bu, b_0.005 207° (tartrate-0.5H₂O, sintered 85°, m. 120°); sec-Bu, b_0.005 206°, tartrate-0.5H₂O, sintered 80°, m. 110°); PhCH₂, b_0.007 236° (tartrate-H₂O, sintered 90°, m. 120°). 10-(3-Dimethylaminopropyl)-2-(alkylthio)phenothiazines (alkyl group given): Et (80-5% from 20.0 g. V and 11.3 g. Me₂N(CH₂)₃Cl), b_0.008 200° [tartrate, sintered 110°, m. 117-9° (absolute EtOH)]; Pr, b_0.02 227° (tartrate-0.5H₂O, sintered 55°, decompose 90°); iso-Pr, b_0.01 198° (tartrate-0.5H₂O, sintered 60°, decompose 90°; oxalate, decompose 206-8°); Bu, b_0.005 202°; iso-Bu, b_0.004 195°; sec-Bu, b_0.006 189°; PhCH₂, b_0.01 224° (tartrate, sintered 65°, m. 85°). 10-Dialkylaminoalkyl-2-(methylthio)phenothiazines (dialkylaminoalkyl groups given): Me₂NCH₂CH₂ (85% from 50.0 g. III and 22.0 g. Me₂NCH₂CH₂Cl), b_0.01 195-6°, m. 72-4° (iso-PrOH) [HCl salt, m. 175-7° (absolute EtOH)]; Et₂NCH₂CH₂, b_0.01 198° (HCl salt, m. 160-2°); Et₂NCHMeCH₂, b_0.01 182° (HCl salt, sintered 194°, m. 202-4°); 2-(N-pyrrolidyl)ethyl, b_0.01 219-21°, m. 73-5° (HCl salt, m. 170-2°); 2-(N-methyl-N’-piperazyl)ethyl, b_0.02 228-30°, m. 85-7° (di-HCl salt, decompose 243-5°); 3-(N-piperidyl)propyl, b_0.05 235-7° (tartrate, sintered 65°, decompose 100°; methobromide, sintered 165°, m. 178-80°); 3-(N-benzyl-N’-piperazyl)propyl, m. 82-4° (di-HCl salt, sintered 225°, decompose 236-8°); 3-(N-morpholyl)propyl, b_0.03 240-2°, m. 100-2° (HCl salt, sintered 146°, m. 152-4°); 2-(N-pyrrolidyl)propyl, b_0.015 204° (HCl salt, m. 177-9°); 2-(N-methyl-N’-piperazyl)propyl, b_0.01 211° (di-HCl salt-0.5H₂O, sintered 210°, m. 224-6°). 10-Dialkylaminoalkyl-2-(isopropylthio)phenothiazines: Me₂NCH₂CH₂, b_0.015 189° (HCl salt, m. 182-4°); Et₂NCH₂CH₂, b_0.01 187° (HCl salt, m. 162-4°);

Helvetica Chimica Acta published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spinnato, Davide published the artcileA Photochemical Organocatalytic Strategy for the α-Alkylation of Ketones by using Radicals, Formula: C8H6ClF3, the publication is Angewandte Chemie, International Edition (2020), 59(24), 9485-9490, database is CAplus and MEDLINE.

Reported herein is a visible-light-mediated radical approach to the α-alkylation of ketones. This method exploits the ability of a nucleophilic organocatalyst to generate radicals upon S_N2-based activation of alkyl halides and blue light irradiation The resulting open-shell intermediates are then intercepted by weakly nucleophilic silyl enol ethers, which would be unable to directly attack the alkyl halides through a traditional two-electron path. The mild reaction conditions allowed functionalization of the α position of ketones with functional groups that are not compatible with classical anionic strategies. In addition, the redox-neutral nature of this process makes it compatible with a cinchona-based primary amine catalyst, which was used to develop a rare example of enantioselective organocatalytic radical α-alkylation of ketones. Thus, e.g., treatment of acetophenone O-TBS silyl enol ether with chloroacetonitrile afforded I (91%) in presence of dithiocarbonyl catalyst II using blue LED irradiation and TFA or TBAF workup.

Angewandte Chemie, International Edition published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C9H10O3S, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Su, Helen C. F. published the artcileSynthesis of possible cancer chemotherapeutic compounds based on enzyme approach. III. 1,2,3-Oxadithiolane 2-oxide, Product Details of C4H8Cl2S2, the publication is Journal of Organic Chemistry (1961), 4993-5, database is CAplus.

1,2,3-Oxadithiolane 2-oxide (I) was prepared from mercaptoethanol (II) and SOCl₂ in CHCl₃. The 5-Me derivative (III) was prepared by this method. Attempted preparation of the 5-Ph derivative under the same conditions led only to 2,5-diphenyl-p-dithiane (IV). Treatment of I with K₂CO₃ gave CO₂, SO₂, and ethylene sulfide. Bromination of I with Br yielded bis(2-bromoethyl) disulfide (V) and with N-bromosuccinimide, yielded N-(2-bromoethylthio)succinimide (VI). II (156 g.) in 150 ml. CHCl₃ and 262 g. SOCl₂ added dropwise into 200 ml. CHCl₃ at room temperature and stirred 5 hrs. gave 176 g. I, b₃ 77-9°, n²⁰_D 1.5771, 22.3% 2-chloro-2′-mercaptodiethyl sulfide, b₄ 91-4°, n²⁰_D 1.5653, 1.5% p-dithiane, flakes, m. 111-12°, and a residual paste which, treated with hot concentrated H₂SO₄-HNO₃, gave a gray sponge. Isopropenyl acetate (20 g.) treated dropwise with 16.7 g. thiolacetic acid and the mixture heated 2 hrs. gave 74% 1-acetoxythioisopropyl acetate (VII), b_0.65-0.70 56.5-8.0°, n³³_D 1.4635. VII refluxed with 1% MeOH-HCl for 7 hrs. and evaporated gave 2-hydroxypropyl mercaptan, b_46-7 75-9°, n³⁰_D 1.4818. III, prepared in 3 hrs. at 28-30° by the same method used for I, b_1.7-2.1 72-85°, m. 39-9.5°; distillation of the residue gave a dark liquid, b_1.6-2.1 82-120°. Attempted redistillation of this product led to severe decomposition Styrene oxide (36 g.) added in 5 hrs. to 30 g. Ba(OH)₂ in 75% alc. saturated with H₂S below 30°, H₂S passed in for 1 hr. longer and the mixture saturated with CO₂ and extracted gave 76.8% 1-phenyl-2-mercaptoethanol (VIII), b_3.7-4.1 124.5-7.0°, n²⁷_D 1.5803. VIII (31.5 g.) and 35.7 g. SOCl₂ added simultaneously to CHCl₃ at 25-30°, stirred 5 hrs., evaporated, and the liquid treated with C in CHCl₃, concentrated, and triturated with Et₂O gave IV, flakes, m. 212-14°. The solvent filtrate further concentrated gave rhombic crystals of S, m. 113-15°. Equimolar amounts of I and K₂CO₃ heated to the point where gas was evolved gave almost quant. yields of CO₂ and SO₂ and 2.3 ml. ethylene sulfide, b. 55-6°, n²⁰_D 1.4821. I (12.4 g.) was added dropwise to a preheated flask at 270°/130-5 mm. and the products distilled to give S and unchanged I, H₂O and a rubbery substance, and a mixture of SO₂, H₂O, and more rubbery product. I (12.4 g.) in 100 ml. CCl₄ treated at -5° with 16 g. Br in 20 ml. CCl₄, and the mixture stirred 5 hrs. at room temperature and distilled gave 4.5 g. V, b_0.5-.055 103-6°, n¹⁹_D 1.6190. N-Bromosuccinimide (17.8 g.) added portionwise to 12.4 g. I in 100 ml. CCl₄ at 15-20° and the mixture heated 6 hrs. at 25-30° gave 8 g. VI, m. 89-90.5°. The liquid was evaporated to give a small amount of V. I (28.3 g.) containing 0.1 g. Bz₂O₂ treated at -5° with Cl, stirred 3 hrs. at 0°, then overnight at room temperature, and distilled gave 63% V. I (12.4 g.) and 13.4 g. N-chlorosuccinimide refluxed 8 hrs. in 100 ml. CCl₄ gave succinimide. The CCl₄ solution afforded some I and 1.5 g. bis(2-chloroethyl) disulfide, b_0.8 80-7°, n²⁰_D 1.5634. III treated with Br in CCl₄ as above gave bis(g-bromopropyl) disulfide, b_0.8 113-14°, n²²_D 1.5805. Infrared spectra were given for the above compounds

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C8H5F3O2S, Product Details of C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ishikawa, Tomoyasu published the artcileDesign and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2011), 54(23), 8030-8050, database is CAplus and MEDLINE.

Dual inhibitors of human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) have been investigated for breast, lung, gastric, prostate, and other cancers; one, lapatinib, is currently approved for breast cancer. To develop novel HER2/EGFR dual kinase inhibitors, we designed and synthesized pyrrolo[3,2-d]pyrimidine derivatives, e.g. I, capable of fitting into the receptors’ ATP binding site. Among the prepared compounds, I showed potent HER2 and EGFR (HER1) inhibitory activities as well as tumor growth inhibitory activity. The X-ray cocrystal structures of I with both HER2 and EGFR demonstrated that I interacts with the expected residues in their resp. ATP pockets. Furthermore, reflecting its good oral bioavailability, I exhibited potent in vivo efficacy in HER2-overexpressing tumor xenograft models. On the basis of these findings, we report I (TAK-285) as a promising candidate for clin. development as a novel HER2/EGFR dual kinase inhibitor.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Yuta published the artcileDiscovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore, Formula: C6H4ClNO2, the publication is Journal of Medicinal Chemistry (2022), 65(5), 4270-4290, database is CAplus and MEDLINE.

Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher’s disease and has been suggested as a potential target for treating Parkinson’s disease. Herein, authors report the discovery of novel brain-penetrant GCS inhibitors. Assessment of the structure-activity relationship revealed a unique pharmacophore in this series. The lipophilic ortho-substituent of aromatic ring A and the appropriate directionality of aromatic ring B were key for potency. Optimization of the absorption, distribution, metabolism, elimination, toxicity (ADMETox) profile resulted in the discovery of T-036, a potent GCS inhibitor in vivo. Pharmacophore-based scaffold hopping was performed to mitigate safety concerns associated with I. The ring opening of I resulted in another potent GCS inhibitor with a lower toxicol. risk, II, which reduced glucosylceramide in a dose-dependent manner in the plasma and cortex of mice. Finally, authors discuss the structural aspects of the compounds that impart a unique inhibition mode and lower the cardiovascular risk.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C19H14Cl2, Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dabholkar, Vijay V. published the artcileMicrowave assisted synthesis of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones, Category: chlorides-buliding-blocks, the publication is Heterocyclic Letters (2015), 5(3), 419-423, database is CAplus.

A series of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones and 5H-2(substituted)phenylimino-5-phenylthiazole-4-ones was synthesized by interaction of ethyl-2-bromo-2-phenylethanoate with urea and thiourea under microwave condition resp. The technique consumes less time and gaves excellent yields. These compounds were also synthesized by conventional method. Structure of compounds were elucidated on the basis of spectral and laboratorial techniques. Further, the compound were scanned for their biol. activities.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Krymov, Stepan K. published the artcileSynthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold, Product Details of C8H6ClF3, the publication is European Journal of Medicinal Chemistry (2022), 113997, database is CAplus and MEDLINE.

Carbonic anhydrase IX is a promising target for the search for new antitumor compounds with improved properties. Using the mol. hybridization approach, on the basis of structures of a selective carbonic anhydrase IX inhibitor 3 and an activator of apoptosis 2 (1), a series of 1-substituted isatin-5-sulfonamides I [R = benzyl, 2-fluorobenzyl, 3-fluorobenzyl, etc.] were designed and synthesized. The study of the inhibitory activity of isatin-5-sulfonamides showed the ability to inhibit I, II, IX, XII isoforms at nano- and micromolar concentrations Docking of compounds 1-(3,5-Difluorobenzyl)-2,3-dioxoindoline-5-sulfonamide and 1-(2,4-Dichlorobenzyl)-2,3-dioxoindoline-5-sulfonamide into the active site of II and IX carbonic anhydrase isoforms showed the coordination of sulfonamidate anions with zinc cations, as well as a number of addnl. hydrophobic interactions. The trifluoromethylthio derivative2,3-Dioxo-1-(4-((trifluoromethyl)thio)benzyl)indoline-5-sulfonamide suppressed the growth of tumor cells at low micromolar concentrations, maintaining activity on resistant lines and under hypoxic conditions. Immunoblotting of MCF7 cells treated with the 2,3-Dioxo-1-(4-((trifluoromethyl)thio)benzyl)indoline-5-sulfonamide revealed its antiestrogenic activity and ability to activate apoptosis in tumor cells.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jones, Richard T. published the artcileChromatography of human hemoglobin. Factors influencing chromatography and differentiation of similar hemoglobins, Related Products of chlorides-buliding-blocks, the publication is Journal of Chromatography (1963), 421-31, database is CAplus and MEDLINE.

The method of Allen, et al. (CA 52, 10344d) and its modifications for hemoglobin (I) determination are reviewed. The methods are affected by temperature, pH, and ionic concentration of developers, state of equilibrium of the Amberlite IRC-50, amount of I, and oxidation state of the heme in the I applied. By the use of a radioactive tracer technique, differences in the chromatographic behavior of I S and I D and of the ferrihemoglobin cyanide and oxyhemoglobin forms of I F were demonstrated.

Journal of Chromatography published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Markushyna, Yevheniia published the artcileChromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst, Quality Control of 939-99-1, the publication is Angewandte Chemie, International Edition (2021), 60(37), 20543-20550, database is CAplus and MEDLINE.

Among external stimuli used to promote a chem. reaction, photocatalysis possesses a unique one-light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryl disulfides at green to red light (e.g., S-Ph thioacetate → benzenesulfonyl chloride (93%) under blue light irradiation using HCl in water/MeCN and O₂ as electron acceptor). A combination of the neg. charged polyanion, highly pos. potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Angewandte Chemie, International Edition published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bazzi, Sakna published the artcileElectrogenerated Sm(II)-Catalyzed CO₂ Activation for Carboxylation of Benzyl Halides, Quality Control of 939-99-1, the publication is Organic Letters (2019), 21(24), 10033-10037, database is CAplus and MEDLINE.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO₂. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp³)-halide activation pathway.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics