Tag: M.W=150-200

Miwa, Takuya published the artcileRhodium-Catalyzed Synthesis of Silicon-Bridged 1,2-Dialkenylbenzenes via 1,4-Rhodium Migration, COA of Formula: C7H8BClO2, the publication is Organic Letters (2019), 21(6), 1627-1631, database is CAplus and MEDLINE.

An efficient synthesis of 1,3-dialkylidene-2,3-dihydro-1H-benzo[c]siloles, a new type of Si-bridged π-conjugated compounds, was developed from a simple substrate combination of dialkynylsilanes and arylboronic acids under Rh catalysis through the use of 1,4-Rh migration. The reaction pathway was probed by D-labeling experiments, and the use of o-tolylboronic acids gave 6-membered silacycles via 1,5-Rh migration.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seelam, Mohan published the artcileAn efficient methodology for the synthesis of thioureas from amine mediated by a cobalt source, HPLC of Formula: 3696-23-9, the publication is Tetrahedron Letters (2016), 57(48), 5297-5300, database is CAplus.

The cheap, readily available and air stable cobalt catalyst was used as the desulfurization agent for the conversion of aniline to thioureas in one pot three step reaction under mild reaction conditions. The reactions are rapid and facile and accomplished at room temperature

Tetrahedron Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C17H20ClN3, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Chengjun published the artcileChemoselective Transfer Hydrogenation of Nitroarenes Catalyzed by Highly Dispersed, Supported Nickel Nanoparticles, Name: 3-Chloro-4-fluoronitrobenzene, the publication is ACS Catalysis (2015), 5(8), 4814-4818, database is CAplus.

A recyclable highly dispersed Ni/SiO₂ catalyst was prepared by at. layer deposition. Chemoselective reduction of nitroarenes was studied using the prepared Ni/SiO₂ as the catalyst and hydrazine hydrate as a hydrogen donor. Different kinds of nitroarenes were converted to the corresponding anilines with high yields. The high activity of the catalysts could be a result of the highly dispersed Ni nanoparticles.

ACS Catalysis published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shankar, Ravi published the artcileCatalytic oxidation of diorganosilanes to 1,1,3,3-tetraorganodisiloxanes with gold nanoparticle assembly at the water-chloroform interface, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is New Journal of Chemistry (2019), 43(2), 813-819, database is CAplus.

The formation of the spherical self-assembly of gold nanoparticles (AuNPs) of 200 ± 20 nm size at the water-chloroform interface is achieved by employing the cyclotetrasiloxane [RSCH₂CH₂SiMeO]₄ (R = CH₂CH₂OH) as the stabilizing ligand. The interfacially stabilized AuNPs act as a versatile catalyst for selective hydrolytic oxidation of only one of the Si-H bonds in secondary organosilanes, RR¹SiH₂ (R, R¹ = alkyl, aryl, and sila-alkyl), to afford the high yield synthesis of 1,1,3,3-tetraorganodisiloxanes, (HRR¹Si)₂O. The study unravels for the first time the role of the photothermal effect arising from the excitation of the surface plasmon resonance of the AuNPs under visible light irradiation in enhancing the catalytic activity at ambient temperature

New Journal of Chemistry published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C14H31NO2, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Kartikey published the artcileMetal- and Phenol-Free Synthesis of Biaryl Ethers: Access to Dibenzobistriazolo-1,4,7-oxadiazonines and Vancomycin-Like Glyco-Macrocycles as Antibacterial Agents, COA of Formula: C6H3ClFNO2, the publication is Journal of Organic Chemistry (2018), 83(24), 14882-14893, database is CAplus and MEDLINE.

An efficient synthesis of biaryl ethers, from electron-deficient aryl halides using NaH/DMSO under metal- and phenol-free conditions, has been achieved to access dibenzo-bistriazolo-1,4,7-oxadiazonines and vancomycin-like glyco-macrocycles. A 44-membered glyco-macrocycle showed promising activity against vancomycin-resistant Staphylococcus aureus (VRSA).

Journal of Organic Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H9N3O2S, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Karan published the artcileSynthesis, characterization and antimicrobial study of some novel fluorine based 2-aminothiazoles, Synthetic Route of 3696-23-9, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2014), 6(10), 429-433, 5 pp., database is CAplus.

The synthesis of some novel fluorine based 2-aminothiazoles I (R = 4-Cl, 4-CH₃, 4-NO₂, etc.; R¹ = 2,4-F₂C₆H₃, 3-O₂NC₆H₄, 4-H₃COC₆H₄, etc.), II (R² = Cl, CH₃, OCH₃) have been described by using hypervalent iodine [I(III)] mediated approach. The synthesized compounds I and II were screened for their anti-microbial activity. The results revealed that compounds I (R = 4-OCH₃, R¹ = 2,4-F₂C₆H₃; R = 2,4-Cl₂, R¹ = 2,4-F₂C₆H₃; R² = Cl; R² = CH₃; R² = OCH₃; R = 2,4-F₂, R¹ = 3-O₂NC₆H₄; R = 2,4-F₂, R² = C₆H₅) showed moderate to good antibacterial activity as compared with the standard drug chloramphenicol.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H8BFO2, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gupta, Atul published the artcileEvaluation of in-vivo anti-implantation and in-vitro anti-proliferative activities of substituted 3-phenyl-4-phenylvinyl benzopyranone derivatives, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Letters in Drug Design & Discovery (2009), 6(1), 46-50, database is CAplus.

A series of substituted 3-phenyl-4-phenylvinyl benzopyranone derivatives (11a-e) was evaluated for their anti-implantation activity in mature female Sprague-Dawley rat model. Compounds were further evaluated for anti-proliferative activity in human adenocarcinoma breast cancer cell line (MCF-7 cancer cell line). The tested compounds showed significant anti-proliferative activity with moderate anti-implantation activity. The inhibitory concentration (IC₅₀) values of most active compounds 11 (c-e) are 8.43 μM, 7.97 μM and 7.91 μM resp. and comparable to that of tamoxifen (5.10 μM), a well known antiestrogen used for treatment of breast cancer.

Letters in Drug Design & Discovery published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Shuai published the artcileDiscovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors, COA of Formula: C8H6ClF3, the publication is Chinese Chemical Letters (2020), 31(2), 418-422, database is CAplus.

Targeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degraders have been identified, some of which have advanced into clin. trials. In this work, a focused library of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4. WS-722 inactivated BRD4 (BD1/BD2), BRD2 (BD1/BD2) and BRD3 (BD1/BD2) broadly with the IC₅₀ values less than 5μmol/L. Besides, WS-722 inhibited growth of THP-1 cells with an IC₅₀ value of 3.86μmol/L. Like (+)-JQ1, WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability. Docking studies showed that WS-722 occupied the central acetyl-lysine (Kac) binding cavity and formed a hydrogen bond with Asn140. In THP-1 cells, WS-722 showed target engagement to BRD4. Cellular effects of WS-722 on THP-1 cells were also examined, showing that WS-722 could block c-MYC expression, induce G0/G1 phase arrest and p21 up-regulation, and promote differentiation of THP-1 cells. BRD4 inhibition by WS-722 resulted in cell apoptosis and up-regulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines. The [1,2,4]triazolo[1,5-a]pyrimidine is a new template for the development of new BRD4 inhibitors.

Chinese Chemical Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15ClN2, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Pengfei published the artcileMultipathways for the Synthesis of Fused Bicyclic 2-Aminothiazolyl Compounds Tuned by Ring Size, Product Details of C7H7ClN2S, the publication is Synlett (2014), 25(19), 2797-2801, database is CAplus.

A new methodol. for the synthesis of fused bicyclic 2-aminothiazolyl compounds was developed, using cyclocondensation of aromatic thioureas with α,β-epoxy cycloketones in alc. under microwave irradiation without any catalyst. The product distribution is related to the ring size of α,β-epoxy cycloketones. Mechanistic studies suggest that the reactions share analogous bicyclic dihydroxy intermediates but undergo different further reactions to give diverse products.

Synlett published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cheng, Hua published the artcileDiscovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III, Related Products of chlorides-buliding-blocks, the publication is New Journal of Chemistry (2015), 39(9), 7281-7292, database is CAplus.

Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc₁ or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc₁ were designed and synthesized by coupling diverse di-Ph ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, ¹H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC₅₀ values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the com. control amisulbrom whose IC₅₀ value is 93.0 μM. Further evaluation against the resp. SQR and cyt bc₁ indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc₁-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc₁, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL^-1. In particular, compounds (I) and (II) exhibited much better antibacterial activity than the com. control bismerthiazol in terms of their EC₅₀. Impressively, II has an EC₉₀ of 33.62 μg mL^-1, more than 10-fold higher than that of bismerthiazol.

New Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics