Tag: M.W=150-200

Vaz, Frédéric M published the artcileCarnitine biosynthesis in mammals., Application In Synthesis of 6249-56-5, the publication is The Biochemical journal (2002), 361(Pt 3), 417-29, database is MEDLINE.

Carnitine is indispensable for energy metabolism, since it enables activated fatty acids to enter the mitochondria, where they are broken down via beta-oxidation. Carnitine is probably present in all animal species, and in numerous micro-organisms and plants. In mammals, carnitine homoeostasis is maintained by endogenous synthesis, absorption from dietary sources and efficient tubular reabsorption by the kidney. This review aims to cover the current knowledge of the enzymological, molecular, metabolic and regulatory aspects of mammalian carnitine biosynthesis, with an emphasis on the human and rat.

The Biochemical journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C6H4ClNO2, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Yun published the artcileDiscovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2019), 62(13), 6083-6101, database is CAplus and MEDLINE.

Starting from our previously developed c-KIT kinase inhibitor CHMFL-KIT-8140, through a type II kinase inhibitor binding element hybrid design approach, we discovered a novel c-KIT kinase inhibitor compound 18 (CHMFL-KIT-64), which is potent against c-KIT wt and a broad spectrum of drug-resistant mutants with improved bioavailability. 18 exhibits single-digit nM potency against c-KIT kinase and c-KIT T670I mutants in the biochem. assay and displays great potencies against most of the gain-of-function mutations in the juxtamembrane domain, drug-resistant mutations in the ATP binding pocket (except V654A), and activation loops (except D816V). In addition, 18 exhibits a good in vivo pharmacokinetic (PK) profile in different species including mice, rats, and dogs. It also displays good in vivo antitumor efficacy in the c-KIT T670I, D820G, and Y823D mutant-mediated mice models as well as in the c-KIT wt patient primary cells which are known to be imatinib-resistant. The potent activity against a broad spectrum of clin. important c-KIT mutants combining the good in vivo PK/pharmacodynamic properties of 18 indicates that it might be a new potential therapeutic candidate for gastrointestinal stromal tumors.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C7H15NO, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mei, Lei published the artcileHalogen Bonded Three-Dimensional Uranyl-Organic Compounds with Unprecedented Halogen-Halogen Interactions and Structure Diversity upon Variation of Halogen Substitution, Name: 2-Chloroisonicotinic acid, the publication is Crystal Growth & Design (2015), 15(3), 1395-1406, database is CAplus.

Actinide-based metal-organic materials have drawn much attention due to their intriguing 5f bonding properties and promising applications in nuclear fuels and other fields. Introduction of weak interactions, such as halogen bonds, into actinide-organic hybrid materials will provide them with more flexibility and dynamics. The first case of halogen bonded three-dimensional (3D) uranyl-organic supramol. frameworks with regular nanoscale channels has been obtained from multifunctional halogen-substituted isonicotinic acids. Distinct from conventional halogen bonded uranyl-organic frameworks, the supramol. networks obtained here consist of three-component cocrystals and have been assemblied by intensive supramol. networks to obtain an extended 3D geometry. Moreover, secondary “X₃” and “X₆” halogen-halogen interactions resulting from the driving forces of primary hydrogen bonds have been found and analyzed by quantum chem. calculation, indicating their feature of weak bonding and special geometry. It is notable that this unprecedented type of “X₆” synthon, especially for “Br₆“, represents a new pattern of halogen-halogen interaction. When halogen substitution of the organic precursor is changed, another type of halogen bonded and hydrogen bonded 3D uranyl-organic framework with two-dimensional layered networks and crosslinking agents formed in situ was acquired. Finally, reversible transformation of 3D uranyl-organic supramol. frameworks is available through loss and regain of water involving in hydrogen bonding networks and thus affords them structural dynamics.

Crystal Growth & Design published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Qianli published the artcileSyntheses and characterization of organostannoxanes derived from 2-chloroisonicotinic acid: Tetranuclear and hexanuclear, HPLC of Formula: 6313-54-8, the publication is Polyhedron (2015), 361-368, database is CAplus.

Three types of ladder-like organostannoxanes, [(Me₂Sn)₂(μ₃-O)L₂]₂ (1), [(n-Bu₂Sn)₂(μ₃-O)(μ-OH)L]₂ (2), [(Ph₂Sn)₂(μ₃-O)(μ-OH)L]₂ (3), [(Bz₂Sn)₂(μ₃-O)(μ-OH)L]₂ (4) and [(Me₂Sn)₂(μ₃-O)(μ-OSnMe₃)L]₂ (5) (LH = 2-chloroisonicotinic acid), have been synthesized by the treatment of 2-chloroisonicotinic acid and the corresponding diorganotin(IV) dichloride or trimethyltin(IV) chloride with sodium ethoxide in methanol. All of the complexes have been fully characterized by elemental anal. and FT-IR, NMR (¹H, ¹³C, and ¹¹⁹Sn) spectroscopy, and particularly for 1, 2, 4 and 5, by x-ray crystallog. The structural analyses of 1, 2 and 4 reveal them to be tetranuclear, possessing two different ladder-like structures. Complexes 5 is also a ladder-like structure, but the essential difference from 1 to 4 is that complex 5 is a hexanuclear complex containing mixed tri- and dimethyltin units, where the central tetranuclear Sn₄O₄ motif is bridged by two μ-OSn(Me)₃ groups. A series of O-H···O, O-H···N and C-H···Cl intermol. hydrogen bonds in these complexes play an important function in the supramol. aggregation, and 2D network structures are formed by these interactions.

Polyhedron published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, HPLC of Formula: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yan, Dingyuan published the artcileA selenium-catalysed para-amination of phenols, SDS of cas: 145349-62-8, the publication is Nature Communications (2018), 9(1), 1-9, database is CAplus and MEDLINE.

Se-catalyzed para-amination of phenols was reported while, in contrast, the reactions with sulfur donors were stoichiometric. A catalytic amount of phenylselenyl bromide smoothly converts N-aryloxyacetamides to N-acetyl p-aminophenols. When the para position was substituted (for example, with tyrosine), the dearomatization occurred and 4,4-disubstituted cyclodienone products were obtained. A combination of exptl. and computational studies was conducted and suggested the weaker Se-N bond plays a key role in the completion of the catalytic cycle. Our method extends the selenium-catalyzed processes to the functionalization of aromatic compounds Finally, the mild nature of the para-amination reaction was demonstrated by generating an AIEgen 2-(2′-hydroxyphenyl)benzothiazole (HBT) product in a fluorogenic fashion in a PBS buffer.

Nature Communications published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Xufeng published the artcileMixed Alkyl/Aryl Diphos Ligands for Iron-Catalyzed Negishi and Kumada Cross Coupling Towards the Synthesis of Diarylmethane, SDS of cas: 939-99-1, the publication is ChemCatChem (2021), 13(24), 5134-5140, database is CAplus.

Mixed alkyl/aryl diphos ligands have been prepared and their application in iron-catalyzed cross coupling of benzylic chlorides with diaryl zinc (Negishi) or aryl Grignard reagents (Kumada) towards the synthesis of diarylmethane has been evaluated. The iron-diphos catalytic system exhibited the enhanced activity and selectivity in the two coupling reactions. The electron-rich mixed PPh₂/PCy₂ ligands outperformed their sym. PPh₂ congeners, and led to decreased homocoupling byproduct formation. It indicates that the electronic effect of the ligands plays an important role in the catalytic performance. The Fe catalyst bearing an electron-rich PCy₂ substituent and a sterically demanding tert-Bu on ethene backbone exhibited the best catalytic performance and good functional group tolerance in the two cross coupling reactions.

ChemCatChem published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Jinyi published the artcileDensity, viscosity, and saturated vapour pressure of 3-chloro-4-fluoronitrobenzene and 3-chloro-2-fluoronitrobenzene, HPLC of Formula: 350-30-1, the publication is Journal of Chemical Thermodynamics (2021), 106337, database is CAplus.

D. and viscosity data of pure 3-chloro-4-fluoronitrobenzene and 3-chloro-2-fluoronitrobenzene were obtained in temperature range from 318.15 K to 348.15 K at the local atm. pressure of 99.7 kPa. The value of corresponding saturated vapor pressure of two isomers were determined in the temperature range of 409 K to 517 K. The relationship between temperature and d. can be well correlated by the linear equation. The viscosity data was well described by the Litovitz, Ghatee, VFT, and Andrade equations, and the calculated value by the VFT equation is consistent with the measured data. Both the Antoine and Riedel equations can accurately describe the relationship between saturated vapor pressure and temperature of 3-chloro-4-fluoronitrobenzene and 3-chloro-2-fluoronitrobenzene, which can meet the requirements for chem. design. In addition, the thermal expansion coefficient was determined based on the d. data, and the molar vaporisation enthalpy of two isomers was evaluated using the Clausius-Clapeyron equation.

Journal of Chemical Thermodynamics published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, HPLC of Formula: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brovko, V. S. published the artcileHydrosilylation of unsaturated compounds in the presence of thiourea complexes of platinum(II) and palladium(II), Related Products of chlorides-buliding-blocks, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1987), 60(11), 2554-6, database is CAplus.

Treating 1-hexene or PhCCH with MeSiHCl₂ in the presence of the title catalysts, e.g., [Pt(NH₂CSNH₂)₄][BPh₄]₂ (I), cis-[Pt(PhNCSNHR)₂]Cl₂ (II, R = α-pyridyl), [Pd(PhNHCSNHPh)₄]²⁺ (bound on ion-exchange resin KRS-20P), gave BuCH₂CH₂SiCl₂Me or E-PhCH:CHSiCl₂Me, resp., with nearly 100% selectivity and 90-100% yields with I or II as catalysts.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Carcache, David A. published the artcileOptimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2018), 61(15), 6724-6735, database is CAplus and MEDLINE.

The transcription factor RORγt is an attractive drug-target due to its role in the differentiation of IL-17 producing Th17 cells that play a critical role in the etiopathol. of several autoimmune diseases. Identification of starting points for RORγt inverse agonists with good properties has been a challenge. We report the identification of a fragment hit and its conversion into a potent inverse agonist through fragment optimization, growing and merging efforts. Further anal. of the binding mode revealed that inverse agonism was achieved by an unusual mechanism. In contrast to other reported inverse agonists, there is no direct interaction or displacement of helix 12 observed in the crystal structure. Nevertheless, compound 9 proved to be efficacious in a delayed-type hypersensitivity (DTH) inflammation model in rats.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Borovska, Jirina published the artcileAccess of inhibitory neurosteroids to the NMDA receptor, Category: chlorides-buliding-blocks, the publication is British Journal of Pharmacology (2012), 166(3), 1069-1083, database is CAplus and MEDLINE.

Background and Purpose: NMDA receptors are glutamatergic ionotropic receptors involved in excitatory neurotransmission, synaptic plasticity and excitotoxic cell death. Many allosteric modulators can influence the activity of these receptors pos. or neg., with behavioral consequences. 20-Oxo-5β-pregnan-3α-yl sulfate (pregnanolone sulfate; PA-6) is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective. The authors tested the hypothesis that the interaction of PA-6 with the plasma membrane is critical for its inhibitory effect at NMDA receptors. Exptl. Approach: Electrophysiol. recordings and live microscopy were performed on heterologous HEK293 cells expressing GluN1/GluN2B receptors and cultured rat hippocampal neurons. Key Results: The authors’ experiments showed that the kinetics of the steroid inhibition were slow and not typical of drug-receptor interaction in an aqueous solution In addition, the recovery from steroid inhibition was accelerated by β- and γ-cyclodextrin. Values of IC₅₀ assessed for novel synthetic C3 analogs of PA-6 differed by more than 30-fold and were pos. correlated with the lipophilicity of the PA-6 analogs. Finally, the onset of inhibition induced by C3 analogs of PA-6 ranged from use-dependent to use-independent. The onset and offset of cell staining by fluorescent analogs of PA-6 were slower than those of steroid-induced inhibition of current responses mediated by NMDA receptors. Conclusion and Implications: The authors conclude that steroid accumulation in the plasma membrane is the route by which it accesses a binding site on the NMDA receptor. Thus, the authors’ results provide a possible structural framework for pharmacol. targeting the transmembrane domains of the receptor.

British Journal of Pharmacology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics