Tag: M.W=150-200

Product Details of 50-84-0. Recently I am researching about ANTITUMOR EVALUATION; PROTEIN-LEVELS; GINSENG; SEMISYNTHESIS; APOPTOSIS; CANCER, Saw an article supported by the National Key R&D Program of China [2017YFC1702302]; Technology Platform of Industrialization Chromatographic Preparation for Standard Extract of Traditional Chinese Medicine [2010ZX09401-304-105B]; Construction of R&D institute of state original new drugs at Benxi of Liaoning Province [2009ZX09301-012-105B]; Liaoning (FGW) Engineering Technology Research Center for industrial chromatographic preparation of natural innovative drugs materials [2017-1007]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Xiao, SN; Lin, Z; Wang, XD; Lu, JC; Zhao, YQ. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In this study, 13 panaxadiol (PD) derivatives were synthesized via reactions with aromatic compounds and amino acids. Following this, the cytotoxicity of these compounds was evaluated against four cancer cell lines (human hepatoma cells HepG-2, human lung cancer cells A549, human breast cancer cells MCF-7, and human colon cancer cells HCT-116) and one normal cell lines (human gastric epithelial cells GES-1). The results showed that the panaxadiol derivatives 3, 12, and 13 showed significant inhibition of cellular proliferation against cancer cells compared with PD, and the panaxadiol derivative 12 had the lowest IC50 value for A549 (IC50=18.91 +/- 1.03 mu m). For MCF-7 cells, most compounds exhibited good inhibition of cellular proliferation, and the panaxadiol derivative 13 showed the strongest inhibitory effect (IC50=8.62 +/- 0.23 mu m), which significantly increased the cytotoxicity of PD and was stronger than the positive control (mitomycin). For normal cells, all compounds exhibited low or no toxic effects; thus, these derivatives can be used to develop novel antiproliferative agents.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xiao, SN; Lin, Z; Wang, XD; Lu, JC; Zhao, YQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. I found the field of Engineering; Environmental Sciences & Ecology very interesting. Saw the article TiC doped palladium/nickel foam cathode for electrocatalytic hydrodechlorination of 2,4-DCBA: Enhanced electrical conductivity and reactive activity published in 2019, Reprint Addresses Xu, XH (corresponding author), Zhejiang Univ, Coll Environm & Resource Sci, Dept Environm Engn, Hangzhou 310058, Zhejiang, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

Titanium carbide (TiC) with excellent electrical conductivity, chemical and thermal stabilities has been recognized as one of the most promising electrocatalysts. A novel cathode, titanium carbide doped palladium/nickel foam (TiC-Pd/Ni foam), was synthesized via electroless deposition to improve the performance of Pd/Ni foam in electrocatlytic hydrodechlorination (ECH). TiC can be co-precipitated onto the surface of cathode during galvanic replacement reaction between Pd(II) solution and Ni foam. Both constant potential and constant current tests proved that TiC-Pd/Ni foam cathode performed remarkably higher activity for 2,4-dichlorobenzoic acid (2,4-DCBA) than Pd/Ni foam cathode, owing to the excellent conductivity of TiC and enhanced water dissociation over TiC-Pd/Ni foam cathode. Under the optimized reaction conditions of -0.85 V (vs Ag/AgCl), electrolyte of 10 mM and initial pH of 4, 99.8% of aqueous 2,4-DCBA (0.2 mM) was removed within 90 min. The removal process of the aqueous 2,4-DCBA obeyed first-order decay kinetic model. Over 86.3% of 2,4-DCBA can still be removed by TiC-Pd/Ni foam cathode in the fifth consecutive run within 120 min, which was much higher than that of Pd/Ni foam cathode (37.5%). Consequently, TiC-Pd/Ni foam cathode was a promising design for enhanced ECH activity and reduced operation cost.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Lou, ZM; Li, YZ; Zhou, JS; Yang, KL; Liu, YL; Baig, SA; Xu, XH or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ in [Dong, Lili; Shen, Shengqiang; Lu, Huizhe; Xu, Dongdong; Jin, Shuhui; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Appl Chem, Beijing, Peoples R China; [Chen, Wei; Yang, Qing] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China published Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations in 2019, Cited 36. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

The insect enzyme GH20 beta-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenee) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+ 2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human beta-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, K-i= 28.68 mu M; HsHexB, K-i > 100 mu M) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H4Cl2O2. In 2020 INT J ELECTROCHEM SC published article about ELECTROCHEMICAL DEGRADATION; PALLADIUM NANOPARTICLES; OXYGEN REDUCTION; FOAM ELECTRODES; HYDRODECHLORINATION; CARBON; CATHODE; MECHANISM; 2,4-DICHLOROPHENOL; DECHLORINATION in [Li, Ning; Song, Xiaozhe; Wang, Hui] Beijing Forestry Univ, Coll Environm Sci & Engn, Beijing 100083, Peoples R China in 2020, Cited 35. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Dual effects of cathodic dechlorination and oxidative decomposition of 2,4-dichlorobenzoic acid (2,4-DCBA) can be achieved using electrochemical reduction-oxidation technology. The removal efficiency was improved by optimizing the experimental conditions affecting electrode activity and contaminant degradation. The 2,4-DCBA removal efficiency reached 90.8% at a current density at 50 mA.cm(-2), initial pH of 5, and sodium sulfate concentration of 0.05 mol.L-1, with a 2,4-DCBA concentration of 20 mg.L-1. Furthermore, a good total organic carbon removal efficiency of 81.6% was achieved in the electrocatalytic reduction and oxidation process, with the present system retaining high stability after many experiment cycles. The reaction mechanism under different conditions is discussed, which provides new approaches to the degradation of chlorinated organic compounds.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Li, N; Song, XZ; Wang, H or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2-yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach WOS:000587914500029 published article about ACETYLCHOLINESTERASE; NOOTKATONE; PESTICIDES; DERIVATIVES; INHIBITORS in [Guo, Yong; Liu, Zhiyan; Hou, Enhua; Ma, Nannan; Fan, Jiangping; Jin, Cheng-Yun; Yang, Ruige] Zhengzhou Univ, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Henan, Peoples R China; [Jin, Cheng-Yun] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China in 2020, Cited 34. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Recommanded Product: 50-84-0

(+)-Nootkatone, a non-food bioactive natural bicyclic sesquiterpene ketone, is isolated from Chamaecyparis nootkatensis [D. Don] Spach as a renewable forest resource. In continuation of our effort to develop synthetic natural derived insecticides from non-food bioactive products, a small library of thirty N-(1,3- thiazol-2-yl) carboxamides fused (+)-nootkatone was prepared by molecular hybridization and characterized by H-1/C-13 NMR, HR-MS, and IR spectroscopy. Their insecticidal activities against Mythimna separata Walker and Plutella xylostella Linnaeus were evaluated. Compounds B6, B7, B9, B19-21 and B24 showed better insecticidal activity against M. separata than the botanical insecticide azadirachtin, and their LC50 values ranged from 0.55 -0.68 mg/mL. Particularly, compound B9 exhibited 1.87-fold more pronounced insecticidal activity against M. separata than azadirachtin. The insecticidal activity of B21 against P. xylostella was 1.37-fold of that of azadirachtin. Through acetylcholinesterase (AChE) inhibitory activity and molecular docking studies, AChE may be the insecticidal target of B9 against M. separata. In addition, three pronounced compounds B9, B21 and B24 exhibited low hemolytic and cytotoxic activities on normal mammalian cells. These findings will give insights into the further development of (+)-nootkatone derivatives as potentially synthetic natural derived insecticides for pest management.

Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Guo, Y; Liu, ZY; Hou, EH; Ma, NN; Fan, JP; Jin, CY; Yang, RG or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2019 PHOSPHORUS SULFUR published article about BACTERIAL LEAF-BLIGHT; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; 1,4-PENTADIEN-3-ONE DERIVATIVES; MOSAIC-VIRUS; DESIGN; INHIBITORS; 3D-QSAR; BETA in [Tang, Xu; Wang, Zhongbo; Zhong, Xinmin; Chen, Lijuan; He, Ming; Xue, Wei] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang, Guizhou, Peoples R China; [Wang, Xiaobin] Nanjing Agr Univ, Coll Sci, Nanjing, Jiangsu, Peoples R China in 2019, Cited 37. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 mu g/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 50-84-0. I found the field of Neurosciences & Neurology; Pediatrics; Surgery very interesting. Saw the article Cost comparison of surgical management of nonsagittal synostosis: traditional open versus endoscope-assisted techniques published in 2020, Reprint Addresses Patel, KB (corresponding author), Washington Univ, Sch Med, St Louis, MO 63110 USA.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

OBJECTIVE Management of craniosynostosis at an early age is important for mitigating the risk of abnormal cranial development, but treatment can result in significant expenses. Previous research has shown that endoscope-assisted craniectomy (EAC) is less costly than open cranial vault remodeling (CVR) for patients with sagittal synostosis. The aim of this study was to strengthen the existing body of healthcare cost research by elucidating the charges associated with open and endoscopic treatment for patients with nonsagittal synostosis. METHODS The authors performed a retrospective analysis of data obtained in 41 patients who underwent open CVR and 38 who underwent EAC with postoperative helmet therapy for nonsagittal, single-suture craniosynostosis (metopic, coronal, and lambdoid) between 2008 and 2018. All patients were < 1 year of age at the time of surgery and had a minimum 1 year of follow-up. Inpatient charges, physician fees, helmet charges, and outpatient clinic visits in the 1st year were analyzed. RESULTS The mean ages of the children treated with EAC and open CVR were 3.5 months and 8.7 months, respectively. Patients undergoing EAC with postoperative helmet therapy required more outpatient clinic visits in the 1st year than patients undergoing CVR (4 vs 2; p < 0.001). Overall, 13% of patients in the EAC group required 1 helmet, 30% required 2 helmets, 40% required 3 helmets, and 13% required 4 or more helmets; the mean total helmeting charges were $10,072. The total charges of treatment, including inpatient charges, physician fees, outpatient clinic visit costs, and helmet charges, were significantly lower for the EAC group than they were for the open CVR group ($50,840 vs $95,588; p < 0.001). CONCLUSIONS Despite the additional charges for postoperative helmet therapy and the more frequent outpatient visits, EAC is significantly less expensive than open CVR for patients with metopic, coronal, and lambdoid craniosynostosis. In conjunction with the existing literature on clinical outcomes and perioperative resource utilization, these data support EAC as a cost-minimizing treatment for eligible patients with nonsagittal synostosis. Recommanded Product: 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zubovic, E; Lapidus, JB; Skolnick, GB; Naidoo, SD; Smyth, MD; Patel, KB or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. In 2020 ACS MED CHEM LETT published article about 2,4-METHANOPROLINE in [Duffy, James; Laleu, Benoit] Med Malaria Venture, CH-1215 Geneva 15, Switzerland; [Cox, Brian; Zdorichenko, Victor; Bellanger, Corentin; Bishop, Stephen J.] Univ Sussex, Photodivers Ltd, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England; [Hurcum, Jessica] Univ Sussex, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England; [Booker-Milburn, Kevin, I; Elliott, Luke D.] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Booker-Milburn, Kevin, I; Robertson-Ralph, Michael] Univ Bristol, Sch Chem, Photodivers Ltd, Bristol BS8 1TS, Avon, England; [Swain, Christopher J.] Cambridge MedChem Consulting, Cambridge CB22 4RN, England; [Hallyburton, Irene; Anderson, Mark] Univ Dundee, Wellcome Ctr Antiinfect Res, Drug Discovery Unit, Dundee DD1 5EH, Scotland in 2020, Cited 18. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

We utilized synthetic photochemistry to generate novel sp 3 -rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-azabicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5 mu M range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.

HPLC of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Cox, B; Duffy, J; Zdorichenko, V; Bellanger, C; Hurcum, J; Laleu, B; Booker-Milburn, KI; Elliott, LD; Robertson-Ralph, M; Swain, CJ; Bishop, SJ; Hallyburton, I; Anderson, M or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. I found the field of Pharmacology & Pharmacy very interesting. Saw the article The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues published in 2021, Reprint Addresses Zoidis, G (corresponding author), Natl & Kapodistrian Univ Athens, Dept Pharm, Athens 15771, Greece.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

The significant antifungal activity of a series of novel 1,2,4-triazole derivatives against different strains ofCandida albicans,Candida kruseiandAspergillus fumigatus, compared to the commercial fungicides ketoconazole and itraconazole, is reported. Systemic mycosis and invasive fungal infections, whether from immunodeficiency or hospital-acquired infection, have been on an upward trend for several years. The 1,2,4-triazole ring substituted with other aromatic and heteroaromatic systems plays an important role in the field of antifungal drug discovery and development. Thus, an extensive series of 29 triazoles, substituted in different positions with a variety of aromatic rings, has been designed, synthesized, and evaluated for their fungicidal activity. Almost all the agents testedin vitroshowed high activity against all examined fungal strains. It is noteworthy that, in the case ofA. fumigatus, all the examined compounds achieved equal or higher antifungal activity than ketoconazole, but less activity than itraconazole. Among all the derivatives studied, the dichlorourea analogue and bromo-substituted triazole stand out as the most promising compounds. Quantitative structure-activity relationship (QSAR) models were built for a systematic structure-activity relationship (SAR) profile to explain and potentially explore the potency characteristics of 1,2,4-triazole analogues.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zoidis, G; Kritsi, E; Lecinska, P; Ivanov, M; Zoumpoulakis, P; Sokovic, M; Catto, M or concate me.. HPLC of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL EVALUATION; IN-VITRO; DOCKING; ANALOGS, Saw an article supported by the DBT, New DelhiDepartment of Biotechnology (DBT) India [BT/IN/Spain/39/SMl2017-18]; DST FIST, New DelhiDepartment of Science & Technology (India) [SR/FST/CSI-240/2012]; CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Application In Synthesis of 2,4-Dichlorobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 mu M. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC(90)s ranging from 3.73 to 4.00 mu M and one compound (6e) showed an IC90 of 40.32 mu M. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

Application In Synthesis of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics