Tag: M.W=150-200

Zhang, Xiao published the artcileDesign, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues, Category: chlorides-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2021), 69(10), 3005-3014, database is CAplus and MEDLINE.

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogs of IPPA08 by converting the pyridyl moiety of IPPA08 into Ph groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound (I) at 0.75 mg/L lowered the LC₅₀ value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC₅₀ value was observed for IPPA08. The results of bee toxicity test showed that compound I display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a Ph ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Journal of Agricultural and Food Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C11H13N3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiao published the artcileDesign, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Agricultural and Food Chemistry (2021), 69(10), 3005-3014, database is CAplus and MEDLINE.

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogs of IPPA08 by converting the pyridyl moiety of IPPA08 into Ph groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound (I) at 0.75 mg/L lowered the LC₅₀ value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC₅₀ value was observed for IPPA08. The results of bee toxicity test showed that compound I display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a Ph ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Journal of Agricultural and Food Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H17Br, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Rongxiang published the artcileCobalt-catalyzed decarboxylative oxyalkylation of styrenes with α-cyanoacid: Access to γ-ketonitriles, Related Products of chlorides-buliding-blocks, the publication is Tetrahedron Letters (2022), 153807, database is CAplus.

A cobalt-catalyzed decarboxylative oxyalkylation of styrenes ArCH=CH₂ (Ar = 3,4-dimethoxyphenyl, 2-naphthyl, 4-cyanophenyl, etc.) and (E)-prop-1-en-1-ylbenzene with α-cyanoacid has been established, leading to a variety of γ-ketonitriles ArC(O)CH₂CH₂CN and 3-methyl-4-oxo-4-phenylbutanenitrile in moderate yields. An α-Cyanoacid was applied as the nitrile sources. This methodol. was distinguished by operational simplicity, easily available starting materials and good functionality tolerance.

Tetrahedron Letters published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gao, Sai-nan published the artcileExperimental study on activated carbon adsorption for treating effluents from oil-field wastewater treatment facilities, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Huanjing Kexue Yu Jishu (2010), 33(12), 56-61, 65, database is CAplus.

An on-site pilot experiment was conducted, which involved application of granular activated carbon (GAC) adsorption to advanced treatment of the effluent from an oil-field wastewater treatment facility equipped with separation-coagulation-filtration plus biol. hydrolytic acidification-oxidation process. The experiment included both static adsorption using a shaker and dynamic adsorption operated in a plexiglass column. Based on the continuous run, this paper put forward the adsorption design data for engineering application. Besides, GC-MS was used to verify the removals by adsorption of halo-hydrocarbons, heterocyclic compounds and carboxylic acid derivatives It was also found that major compounds in the treated effluent were large mol. organic acids, which were identified as non-polar hydrophobic organic compounds through the anal. of organic conceptual diagram.

Huanjing Kexue Yu Jishu published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Lian-Fang published the artcileSyntheses of methadone and 5-nitrofurfural, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bulletin of the Institute of Chemistry, Academia Sinica (1980), 13-17, database is CAplus.

EtCOCPh₂CH₂CHMeNMe₂ (I), was prepared from ClCH₂CHMeOH (II) in 4 steps. Thus, amination of II with Me₂NH and subsequent SOCl₂ chlorination gave Me₂NCH₂CHClMe, which condensed with Ph₂CHCN in aqueous NaOH to give Ph₂C(CN)CH₂CHMeNMe₂. Reaction of the latter with EtMgBr and subsequent hydrolysis gave I. Nitration of furfural by HNO₃-H₂SO₄ in Ac₂O gave 2-(diacetoxymethyl)-5-nitrofuran, which was treated with 73% H₂SO₄ to give 5-nitrofurfural, an intermediate in the preparation of furazolidone.

Bulletin of the Institute of Chemistry, Academia Sinica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bao, Ting published the artcileSynthesis and structure of lateral halogenated V-shaped liquid crystal molecules based on a 1,7-naphthalene central core and alkylthio tails, Synthetic Route of 350-30-1, the publication is Liquid Crystals (2014), 41(12), 1687-1695, database is CAplus.

A series of small angle bent-core (V-shaped) mesogens carrying 1,7-naphthalene as a central core linked with lateral halogenated (chlorinated or fluorinated) Schiff-base side wings and alkylthio terminal tails of variable carbon number (n = 12, 16) was synthesized in order to reduce the transition temperature and improve the phase stability of bent-core liquid crystal mols. Differential scanning calorimetry (DSC), polarising optical microscopy (POM), small-angle X-ray scattering system (SAXS) and two-dimensional X-ray diffractometer were applied to ascertain the mesomorphic structure and phase transition temperatures of the compounds The results confirm that all the mols. show thermotropic liquid crystalline behavior and exhibit hexagonal columnar phase (Colh) in a certain temperature range. Compared with the homologous compounds without lateral halogen, the cleaning point temperature of lateral halogenated V-shaped compounds generally decrease and the Colh phase ranges are more extensive. The influence of lateral chlorine on the cleaning point temperature is more obvious, as well as the effect of lateral fluorine on the range of Colh phase.

Liquid Crystals published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Synthetic Route of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Sheng published the artcileNi-Catalyzed Reductive Arylacylation of Alkenes toward Carbonyl-Containing Oxindoles, Computed Properties of 939-99-1, the publication is Organic Letters (2019), 21(18), 7498-7503, database is CAplus and MEDLINE.

Using iso-Bu chloroformate as a carbon monoxide equivalent, N-(bromoaryl) α-substituted acrylamides such as I underwent reductive arylacylation reactions with alkyl iodides such as iodocyclohexane or benzylic chlorides in the presence of NiBr₂(DME), and 4,4′-dimethyl-2,2′-bipyridine using manganese or zinc as reductant in 1:1 DMA:THF to yield oxoalkyl oxindoles such as II. The mechanism was studied using an alkyl iodide susceptible to radical cyclization and stoichiometric reaction of a oxindolylmethyl nickel complex; a mechanism involving reaction of alkyl radicals with nickel complexes is proposed. Reaction using a nonracemic octahydrobinaphthyl phosphoramidate ligand yielded product in 8% yield and 50% ee.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C22H32O2, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhan, Bei-Bei published the artcileSynthesis of Axially Chiral Biaryl-2-amines by Pd^II-Catalyzed Free-Amine-Directed Atroposelective C-H Olefination, Computed Properties of 209919-30-2, the publication is Angewandte Chemie, International Edition (2020), 59(9), 3568-3572, database is CAplus and MEDLINE.

A simple and ubiquitously present group, free amine, is used as a directing group to synthesize axially chiral biaryl compounds by Pd^II-catalyzed atroposelective C-H olefination. A broad range of axially chiral biaryl-2-amines can be obtained in good yields with high enantioselectivities (up to 97% ee). Chiral spiro phosphoric acid (SPA) proved to be an efficient ligand and the loading could be reduced to 1 mol % without erosion of enantiocontrol in gram-scale synthesis. The resulting axially chiral biaryl-2-amines also provide a platform for the synthesis of a set of chiral ligands.

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C24H29N5O3, Computed Properties of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Huarong published the artcileA novel and green method for the synthesis of 4-thiazolidinones with 2-chloroacetamide and thioureas, HPLC of Formula: 3696-23-9, the publication is Youji Huaxue (2014), 34(4), 761-766, database is CAplus.

A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the substituted thioureas and 2-chloroacetamide in the ionic liquids This method offers several advantages such as high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.

Youji Huaxue published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C3H6O2, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Pei-Yi published the artcileRational Optimization and Action Mechanism of Novel Imidazole (or Imidazolium)-Labeled 1,3,4-Oxadiazole Thioethers as Promising Antibacterial Agents against Plant Bacterial Diseases, Safety of 3-Chlorobenzylchloride, the publication is Journal of Agricultural and Food Chemistry (2019), 67(13), 3535-3545, database is CAplus and MEDLINE.

The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery and development of new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating the crucially bioactive scaffolds of the imidazole motif and 1,3,4-oxadiazole skeleton in a single mol. architecture. Subsequently, a superior antibacterial compound A₆ was gradually discovered possessing excellent competence against plant pathogens Xanthomonas oryzae pv oryzae and Xanthomonas axonopodis pv citri with EC₅₀ values of 0.734 and 1.79 μg/mL, resp. These values were better than those of com. agents bismerthiazol (92.6 μg/mL) and thiodiazole copper (77.0 μg/mL). Further modifying the imidazole moiety into the imidazolium scaffold led to the discovery of an array of potent antibacterial compounds providing the corresponding min. EC₅₀ values of 0.295 and 0.607 μg/mL against the two strains. Moreover, a plausible action mechanism for attacking pathogens was proposed based on the concentration dependence of SEM, transmission electron microscopy, and fluorescence microscopy images. Given the simple mol. structures, easy synthetic procedure, and highly efficient bioactivity, imidazole (or imidazolium)-labeled 1,3,4-oxadiazole thioethers can be further explored and developed as promising indicators for the development of com. drugs.

Journal of Agricultural and Food Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C18H35NO, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics