Tag: M.W=150-200

Wang, Lujie published the artcileDurable antimicrobial cotton fabric fabricated by carboxymethyl chitosan and quaternary ammonium salts, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Cellulose (Dordrecht, Netherlands) (2021), 28(9), 5867-5879, database is CAplus.

In this article, carboxymethyl chitosan (CMC) and (3-carboxypropyl) trimethylammonium chloride (CPTC) were used as raw materials to prepare an antibacterial cotton fabric with excellent laundering durability. CMC was first anchored to the surface of cotton fiber via esterification between the carboxyl groups of CMC and the hydroxyl groups of the cellulose mols. on the cotton fiber surface, and then the CPTC was linked to the CMC chains via amidation to the amino groups of the grafted CMC chains. The antibacterial tests showed that the bacteriostatic reduction rate (BR) of the finished cotton fabric against S. aureus and E. coli was above 99.9%, and the BR value of modified cotton fabric remained above 99.9% even after 120 laundering cycles. The results of cytotoxicity, vapor transmissibility, and tensile strength of the fabric samples, as well as the evaluation of water absorption and flexibility show that the modified cotton fabrics are safe and comfortable.

Cellulose (Dordrecht, Netherlands) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C16H18Br2ClN3O3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cheng, Wei-Chieh published the artcileRapid modifications of N-substitution in imino-sugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease, Product Details of C8H7ClO3, the publication is Bioorganic & Medicinal Chemistry (2013), 21(17), 5021-5028, database is CAplus and MEDLINE.

The rapid discovery of β-glucocerebrosidase (GCase) inhibitors and pharmacol. chaperones for Gaucher disease is described. The N-aminobutyl DNJ-based iminosugar was synthesized and conjugating with a variety of carboxylic acids to generate a N-diversely substituted iminosugar-based library. Several members of this library were found to be nanomolar-range inhibitors of GCase; the inhibition constant K_i of the most potent was found to be 71 nM. Although these new mols. showed reasonable chaperoning activity (1.5- to 1.9-fold) in the N370S fibroblast of Gaucher patient-derived cell line, this was accompanies by a concomitant decrease in the cellular α-glucosidase activity, which might limit their further therapeutic potential. Next, newly developed N-substituents were assembled with pyrrolidine-based scaffolds to generate new mols. for further evaluation. The new 2,5-dideoxy-2,5-imino-D-mannitol (DMDP)-based iminosugar 22 was found to exhibit a satisfactory chaperoning activity to enhance GCase activity by 2.2-fold in Gaucher N370S cell line, without impairment of cellular α-glucosidase activity.

Bioorganic & Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Forster, Michael published the artcileImproved Multigram Route to a Tricyclic Key Intermediate for Dibenzosuberone-Based p38 Inhibitors via an Optimized Early-Stage Heck Coupling, Application In Synthesis of 620-20-2, the publication is Organic Process Research & Development (2021), 25(8), 1831-1840, database is CAplus.

The p38α MAP kinase has been a heavily investigated target in the last two decades. The structural class of dibenzosuberone-based p38 inhibitors, exemplified by the promising candidate skepinone-L, was already successfully validated in several in vivo models of inflammatory as well as oncol. indications. The increasing demand of key intermediates and final compounds caused by the ongoing development of this inhibitor class urged the conception of an optimized route for the preparation of the core dibenzosuberone scaffold in multigram quantities. Rerouting of the initial discovery route resulted in an almost 4-fold increase of overall yield to 46%, the elimination of chromatog. purification, and the substitution of two critical reaction steps, which hindered a feasible scale-up. The key modification was the introduction and optimization of an early-stage Heck coupling based on Buchwald precatalysts allowing consistently high yields (ca. 90%) at multigram scales with a favorably low Pd loading of 0.1 mol %. This newly developed synthetic access to the dibenzosuberone intermediate 2-chloro-7-hydroxy-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one is capable of ensuring the supply of skepinone-L and other candidates during further development.

Organic Process Research & Development published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sorribes, Ivan published the artcileChemoselective Transfer Hydrogenation to Nitroarenes Mediated by Cubane-Type Mo₃S₄ Cluster Catalysts, SDS of cas: 350-30-1, the publication is Angewandte Chemie, International Edition (2012), 51(31), 7794-7798, S7794/1-S7794/4, database is CAplus and MEDLINE.

Cubane-type Mo₃S₄ cluster compounds catalyzed transfer hydrogenation to nitro arenes or nitro heteroarenes to give aromatic amines. E.g., in presence of formic acid and NEt₃ as the reducing agent, [Mo₃S₄H₃(dmpe)₂]BPh₄ catalyzed the transfer hydrogenation of 4-O₂NC₆H₄NH₂ to give 90% p-phenylenediamine.

Angewandte Chemie, International Edition published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C7H6Cl2O, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lochmueller, C. H. published the artcileQuantitative photoacoustic spectroscopy of chemically-modified silica surfaces, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Analytica Chimica Acta (1980), 118(1), 101-8, database is CAplus.

The degree of surface coverage on chem.-modified silica gel was determined by using photoacoustic spectroscopy. Vibrational overtones in the near IR were employed for the examination of modified materials containing bonded aliphatic, aromatic, and aminoalkyl functions. A linear relation between photoacoustic signal amplitude and C or N content of the chem.-modified surface was obtained.

Analytica Chimica Acta published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Zhen published the artcileA tautomeric ligand enables directed C-H hydroxylation with molecular oxygen, Computed Properties of 6313-54-8, the publication is Science (Washington, DC, United States) (2021), 372(6549), 1452-1457, database is CAplus and MEDLINE.

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. IR, x-ray, and computational anal. support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

Science (Washington, DC, United States) published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Zhen published the artcileA tautomeric ligand enables directed C-H hydroxylation with molecular oxygen, Computed Properties of 939-99-1, the publication is Science (Washington, DC, United States) (2021), 372(6549), 1452-1457, database is CAplus and MEDLINE.

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. IR, x-ray, and computational anal. support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

Science (Washington, DC, United States) published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Limin published the artcileDesign, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives, HPLC of Formula: 620-20-2, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128268, database is CAplus and MEDLINE.

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC₅₀ = 2.27 μM), which was better than the pos. control 5-FU (IC₅₀ = 9.37 μM). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Limin published the artcileDesign, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128268, database is CAplus and MEDLINE.

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC₅₀ = 2.27 μM), which was better than the pos. control 5-FU (IC₅₀ = 9.37 μM). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davis, Rohan A. published the artcileThe isolation and synthesis of 3-chloro-4-hydroxyphenylacetamide produced by a plant-associated microfungus of the genus Xylaria, Category: chlorides-buliding-blocks, the publication is Tetrahedron Letters (2005), 46(6), 919-921, database is CAplus.

Chem. investigations of the fermentation broth from the microfungus Xylaria sp. have afforded the new natural product 3-chloro-4-hydroxyphenylacetamide (I) and the previously reported fungal metabolite 3-chloro-4-hydroxyphenylacetic acid (II). This letter reports the isolation and full spectroscopic characterization of I and II by NMR, UV, IR and MS data. The crystal structure and 1-pot synthesis of I are also reported.

Tetrahedron Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics