Tag: M.W=150-200

Gauthier, Sylvie published the artcileMechanistic studies of polysilane polymerization, Synthetic Route of 14799-94-1, the publication is Advances in Chemistry Series (1990), 299-307, database is CAplus.

The mechanisms and kinetics of condensation polymerization of dialkyldichlorosilanes were studied. The reactivities of the monomers were different under either concurrent or consecutive monomer addition Block copolymers were formed by sequential addition of monomers to polymer systems. Relative rates of monomer consumption were MePhSiCl₂ > hexylmethyldichlorosilane > Me₂SiCl₂ >> vinylmethyldichlorosilane; relative rates of monomer consumption during copolymerization were in a different order. General schemes were suggested for the reaction pathways, but the kinetics of the reaction were very complex; a kinetic scheme could not be derived.

Advances in Chemistry Series published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Synthetic Route of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jichao published the artcileHexamethyldisilazane Lithium (LiHMDS)-Promoted Hydroboration of Alkynes and Alkenes with Pinacolborane, Application of 4-Chloro-3-fluorostyrene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Lithium-promoted hydroboration of alkynes and alkenes using com. available hexamethyldisilazane lithium as a precatalyst and HBpin as a hydride source has been developed. This method will be appealing for organic synthesis because of its remarkable substrate tolerance and good yields. Mechanistic studies revealed that the hydroboration proceeds through the in situ-formed BH₃ species, which acts to drive the turnover of the hydroboration of alkynes and alkenes.

Journal of Organic Chemistry published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Application of 4-Chloro-3-fluorostyrene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jing, Lanlan published the artcileIdentification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries, Safety of 3-Chlorobenzylchloride, the publication is European Journal of Medicinal Chemistry (2019), 111696, database is CAplus and MEDLINE.

Cell division cycle 25 (Cdc25) protein phosphatases play key roles in the transition between the cell cycle phases and their association with various cancers has been widely proven, which makes them ideal targets for anti-cancer treatment. Though several Cdc25 inhibitors have been developed, most of them displayed low activity and poor subtype selectivity. Therefore, it is extremely important to discover novel small mol. inhibitors with potent activities and significant selectivity for Cdc25 subtypes, not only served as drugs to treat cancer but also to probe its mechanism in transitions. In this study, miniaturized parallel click chem. synthesis via CuAAC reaction followed by in situ biol. screening were used to discover selective Cdc25 inhibitors. The bioassay results showed that compound M2N12 proved to be the most potent Cdc25 inhibitor, which also act as a highly selective Cdc25C inhibitor and was about 9-fold potent than that of NSC 663284. Moreover, M2N12 showed remarkable anti-growth activity against the KB-VIN cell line, equivalent to that of PXL and NSC 663284. An all-atom mol. dynamics (MD) simulation approach was further employed to probe the significant selectivity of M2N12 for Cdc25C relative to its structural homologs Cdc25A and Cdc25B. Overall, above results make M2N12 a promising lead compound for further investigation and structural modification.

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Zhou published the artcileDesign and synthesis of a novel isoxazole derivative, Application In Synthesis of 350-30-1, the publication is Xuzhou Yixueyuan Xuebao (2011), 31(11), 728-730, database is CAplus.

To design and develop a new method for the synthesis of a novel isoxazole derivative I which may had potential bactericidal activity, the product was synthesized with six steps in gram scales using benzaldehyde, 4-fluoro-3-chloronitrobenzene et al as starting materials. The structure of the product was confirmed by ¹H NMR, HRMS and IR spectra. A mild route to synthesize an isoxazole derivative with 35% total yield was reported.

Xuzhou Yixueyuan Xuebao published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C7H10O4, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Cheng published the artcileDiscovery of cytochrome bc₁ complex inhibitors inspired by the natural product karrikinolide, Safety of 2-Chloro-4-methylphenylboronic acid, the publication is RSC Advances (2016), 6(100), 97580-97586, database is CAplus.

The cytochrome bc₁ complex (cyt bc₁ or complex III) is a promising target of numerous antibiotics and fungicides. With an aim to indentify new lead structures for the bc₁ complex, a series of novel inhibitors were discovered from the natural product karrikinolide for the first time. Extensive screening results suggested variable inhibitory activities of these compounds against succinate-cytochrome reductase [SCR, a mixture of respiratory complex II (SQR) and complex III (the bc₁ complex)], implying the essential role of a 4-substituted Ph group for the high potency. Exceptionally, compound 12g showed excellent inhibition potency having an IC₅₀ value in the sub-micromolar range, demonstrating its higher potency than the com. control amisulbrom by over two orders of magnitude. Further experiments inferred that these newly prepared compounds mainly target the bc₁ complex. Seemingly, this work has presented a new lead scaffold for further development of bc₁ complex inhibitors.

RSC Advances published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Safety of 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Yi published the artcileElectrochemical Sulfoxidation of Thiols and Alkyl Halides, Quality Control of 939-99-1, the publication is Journal of Organic Chemistry (2022), 87(10), 6942-6950, database is CAplus and MEDLINE.

A green and efficient electrochem. sulfoxidation via the use of readily available materials, i.e., thiols and alkyl halides was reported. The simple operation, mild conditions and broad substrate scope render this protocol potentially applicable for the preparation of diverse synthetically significant sulfoxides RSOCH₂R¹ [R = i-Pr, 4-FC₆H₄, 4-ClC₆H₄, etc.; R¹ = (CH₂)₂CH₃, Ph, 3-MeOC₆H₄, etc.].

Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C21H24O8, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lei, Ying-jie published the artcileUltrasound assisted synthesis and antibacterial activity of 4-(coumarin-3-yl)-2-arylaminothiazoles, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2018), 40(6), 518-522, 588, database is CAplus.

In this work, 3-(2-bromoacetyl)-2H-chromen-2-ones prepared from 3-acetyl coumarins with tetrabutylammonium tribromide on bromination were used as the raw material. An efficient approach toward the synthesis of 4-(coumarin-3-yl)-2-arylaminothiazoles was carried out by the reaction of the starting compounds with certain Ph thioureas in presence of PEG-400 under ultrasound irradiation at a frequency of 40 kHz in 20âˆ?0 min, with a yield of 81.6%âˆ?3.0%. The structures of target compounds were confirmed by IR, ¹HNMR, ¹³CNMR, MS and elemental anal. Preliminary bioassay results showed that some of them have certain antibacterial activities against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. This method is operationally simple and environmentally benign and the solvent could be reused for several times.

Huaxue Shiji published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bhhatarai, Barun published the artcileEvaluation of TOPKAT, Toxtree, and Derek Nexus in Silico Models for Ocular Irritation and Development of a Knowledge-Based Framework To Improve the Prediction of Severe Irritation, Formula: C6H3ClFNO2, the publication is Chemical Research in Toxicology (2016), 29(5), 810-822, database is CAplus and MEDLINE.

Assessment of ocular irritation is an essential component of any risk assessment. A number of (Q)SARs and expert systems have been developed and are described in the literature. Here, the authors focus on three in silico models (TOPKAT, BfR rulebase implemented in Toxtree, and Derek Nexus) and evaluate their performance using 1644 inhouse and 123 European Center for Toxicol. and Ecotoxicol. of Chems. (ECETOC) compounds with existing in vivo ocular irritation classification data. Overall, the in silico models performed poorly. The best consensus predictions of severe ocular irritants were 52 and 65% for the inhouse and ECETOC compounds, resp. The prediction performance was improved by designing a knowledge-based chem. profiling framework that incorporated physicochem. properties and electrophilic reactivity mechanisms. The utility of the framework was assessed by applying it to the same test sets and three addnl. publicly available in vitro irritation data sets. The prediction of severe ocular irritants was improved to 73-77% if compounds were filtered on the basis of AlogP_MR (hydrophobicity with molar refractivity). The predictivity increased to 74-80% for compounds capable of preferentially undergoing hard electrophilic reactions, such as Schiff base formation and acylation. This research highlights the need for reliable ocular irritation models to be developed that take into account mechanisms of action and individual structural classes. It also demonstrates the value of profiling compounds with respect to their chem. reactivity and physicochem. properties that, in combination with existing models, results in better predictions for severe irritants.

Chemical Research in Toxicology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nasim, Muhammad Jawad published the artcilePronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria, SDS of cas: 620-20-2, the publication is New Journal of Chemistry (2019), 43(15), 6021-6031, database is CAplus.

Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC₅₀ = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance.

New Journal of Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mazurek, M. published the artcileCapillary gas chromatography-atomic emission spectroscopy-mass spectrometry analysis of sulfur mustard and transformation products in a block recovered from the Baltic Sea, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Chromatography A (2001), 919(1), 133-145, database is CAplus and MEDLINE.

A block of yperite recovered from the Baltic Sea was analyzed by gas chromatog. coupled with at. emission spectrometry and mass spectrometry. In the samples of the block �0 compounds were detected, out of which 30 were identified. The identification of the compounds was performed using the element chromatograms of the studied compounds, and the data obtained by mass spectrometric detection. Thiodiglycol was not found among the compounds in the studied block. The calculations of the contents of S mustard and some products in the block were performed by an external calibration method using bis(2-chloroethyl) sulfide as the standard A satisfactory precision of elements determinations was obtained (RSD 4.4-14.3%).

Journal of Chromatography A published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics