Tag: M.W=150-200

McConnell, Nicholas published the artcileSynthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity, Quality Control of 6313-54-8, the publication is ChemistrySelect (2017), 2(35), 11821-11825, database is CAplus and MEDLINE.

An efficient method was developed for the synthesis of benzimidazole dual-heterocycles, e.g., I and quinoxalinone dual-heterocycles, e.g., II utilizing robust post-Ugi cyclization starting from carboxylic acids, isocyanides, benzaldehydes and N-Boc-1,2-phenylenediamine including Ugi-deprotection-cyclization methodol. Through mol. modeling it was shown that the developed compounds I and II were capable of binding to MDMX by exploiting a deep non-polar groove and a deep hydrophobic pocket on the protein. Addnl., the synthesized compounds I and II showed micromolar activity against pancreatic cancer cell line, supporting the therapeutic utility of these compounds

ChemistrySelect published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kong, Deyu published the artcileOptimization of P2Y₁₂ Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, Synthetic Route of 939-99-1, the publication is Journal of Medicinal Chemistry (2019), 62(6), 3088-3106, database is CAplus and MEDLINE.

P2Y₁₂ antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y₁₂ antagonist AZD1283 (I), a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-Me group led to lactone analogs of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-Me substituent to the piperidinyl moiety. Compound II displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, II showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound II as a promising drug candidate.

Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Synthetic Route of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Narjes, Frank published the artcilePotent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design, COA of Formula: C7H5BClNO2, the publication is Journal of Medicinal Chemistry (2018), 61(17), 7796-7813, database is CAplus and MEDLINE.

Retinoic acid receptor related orphan receptor γt (RORγt), has been identified as the master regulator of T_H17-cell function and development, making it an attractive target for the treatment of autoimmune diseases by a small-mol. approach. Herein, we describe our investigations on a series of 4-aryl-thienyl acetamides, which were guided by insights from X-ray cocrystal structures. Efforts in targeting the cofactor-recruitment site from the 4-aryl group on the thiophene led to a series of potent binders with nanomolar activity in a primary human-T_H17-cell assay. The observation of a DMSO mol. binding in a subpocket outside the LBD inspired the introduction of an acetamide into the benzylic position of these compounds Hereby, a hydrogen-bond interaction of the introduced acetamide oxygen with the backbone amide of Glu379 was established. This greatly enhanced the cellular activity of previously weakly cell-active compounds The best compounds combined potent inhibition of IL-17 release with favorable PK in rodents, with compound 32 representing a promising starting point for future investigations.

Journal of Medicinal Chemistry published new progress about 915763-60-9. 915763-60-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (3-Chloro-5-cyanophenyl)boronic acid, and the molecular formula is C7H5BClNO2, COA of Formula: C7H5BClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matralis, Alexios N. published the artcileMolecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2018), 26(20), 5547-5554, database is CAplus and MEDLINE.

Lamin A contributes to the structure of nuclei in all mammalian cells and plays an important role in cell division and migration. Mature lamin A is derived from a farnesylated precursor protein, known as prelamin A, which undergoes posttranslational cleavage catalyzed by the zinc metalloprotease STE24 (ZPMSTE24). Accumulation of farnesylated prelamin A in the nuclear envelope compromises cell division, impairs mitosis and induces an increased expression of inflammatory gene products. ZMPSTE24 has been proposed as a potential therapeutic target in oncol. A library of peptidomimetic compounds were synthesized and screened for their ability to induce accumulation of prelamin A in cancer cells and block cell migration in pancreatic ductal adenocarcinoma cells. The results of this study suggest that inhibitors of lamin A maturation may interfere with cell migration, the biol. process required for cancer metastasis.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ye, Jiao published the artcileSynthesis and Cytotoxicity in Vitro of N-Aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine, Name: 1-(4-Chlorophenyl)thiourea, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2015), 62(7), 627-631, database is CAplus.

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines I [R = H, 4-Me, 2-F, etc.] were synthesized in a green way. H₂O₂-NaBr brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. Structures of the target compounds were confirmed by ¹H NMR and elemental anal. and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound I [R = 3-F₃C] was the most potent compound with the IC₅₀ values of 9μM against Hela cells and 15μM against Bel-7402 cells resp.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Yan-Xia published the artcileThe small auxin-up RNA OsSAUR45 affects auxin synthesis and transport in rice, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Plant Molecular Biology (2017), 94(1-2), 97-107, database is CAplus and MEDLINE.

Key message: This research is the first to demonstrate that OsSAUR45 is involved in plant growth though affecting auxin synthesis and transport by repressing OsYUCCA and OsPIN gene expression in rice. Abstract: Small auxin-up RNAs (SAURs) comprise a large multigene family and are rapidly activated as part of the primary auxin response in plants. However, little is known about the role of SAURs in plant growth and development, especially in monocots. Here, we report the biol. function of OsSAUR45 in the model plant rice (Oryza sativa). OsSAUR45 is expressed in a tissue-specific pattern and is localized to the cytoplasm. Rice lines overexpressing OsSAUR45 displayed pleiotropic developmental defects including reduced plant height and primary root length, fewer adventitious roots, narrower leaves, and reduced seed setting. Auxin levels and transport were reduced in the OsSAUR45 overexpression lines, potentially because of decreased expression of Flavin-binding monooxygenase family proteins (OsYUCCAs) and PIN-FORMED family proteins (OsPINs). Exogenous auxin application rapidly induced OsSAUR45 expression and partially restored the phenotype of rice lines overexpressing OsSAUR45. These results demonstrate that OsSAUR45 is involved in plant growth by affecting auxin synthesis and transport through the repression of OsYUCCA and OsPIN gene expression in rice.

Plant Molecular Biology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C12H16N2O2, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Che, Chao published the artcileStudies on Pyridine Derivatives. IX. Synthesis and Herbicidal Activities of N-(1-carbomethoxy)-ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] Amides, COA of Formula: C6H4ClNO2, the publication is Nongyaoxue Xuebao (2004), 6(3), 15-20, database is CAplus.

In order to investigate the structure-activity relationship and improve the activity of herbicidal lead compound 2-sec-butylamino-5-(2-chloropyrid-4-yl)-1,3,4-thiodiazole (BCPT), which was found in previous work on pyridine derivatives, a novel series of N-(1-carbomethoxy) ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] amides were synthesized and subjected to post-emergence herbicidal tests. All the compounds showed much weaker herbicidal activity than BCPT itself. The results suggested that BCPT might act to herbs in different way to amide herbicides.

Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Jing published the artcileLigand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Acta Pharmaceutica Sinica B (2021), 11(10), 3193-3205, database is CAplus and MEDLINE.

Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis and inflammation. Our group previously identified TAK-632 (5) as an effective necroptosis inhibitor by dual-targeting RIP1 and RIP3. In this study, using ligand-based substituent-anchoring design strategy, we focused on the benzothiazole ring to obtain a series of TAK-632 analogs showing significantly improving on the anti-necroptosis activity and RIP1 selectivity over RIP3. Among them, a conformational constrained fluorine-substituted derivative (25) exhibited 333-fold selectivity for RIP1 (K_d = 15 nmol/L) than RIP3 (K_d > 5000 nmol/L). This compound showed highly potent activity against cell necroptosis (EC₅₀ = 8 nmol/L) and systemic inflammatory response syndrome (SIRS) induced by TNF-α in vivo. Especially, it was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of UC. Taken together, the highly potent, selective, orally active anti-necroptosis inhibitor represents promising candidate for clin. treatment of UC.

Acta Pharmaceutica Sinica B published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H22OSi, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gao, Donghong Amy published the artcileSAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability, Quality Control of 6313-54-8, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(17), 5039-5043, database is CAplus and MEDLINE.

SAR studies to improve the selectivity and metabolic stability of a class of recently discovered MMP-13 inhibitors are reported. Improved selectivity was achieved by modifying interactions with the S1′ pocket. Metabolic stability was improved through reduction of inhibitor lipophilicity. This translated into lower in vivo clearance for the preferred compound

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gauthier, S. published the artcileThe effect of phase-transfer catalysts on polysilane formation, Quality Control of 14799-94-1, the publication is Macromolecules (1989), 22(5), 2213-18, database is CAplus.

Polysilanes are most often prepared by a Wurtz-type coupling of organodichlorosilanes with Na in refluxing PhMe. The addition of a catalytic amount of crown ether to the reaction mixture increases the rate of disappearance of the monomer with increasing crown ether concentration, suggesting that anionic species are involved in the polymerization mechanism. Higher yields of polymer relative to cyclic material were obtained, and the polymer displays a monomodal distribution. The presence of cryptand has similar effects although some degradation of the polymer upon continued refluxing of the reaction mixture was observed Degradation experiments on poly(n-hexylmethylsilane) with Na in refluxing PhMe showed that the polymer degraded to cyclics in a few minutes with cryptand but not with crown ether.

Macromolecules published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics