Tag: M.W=150-200

Yu, Wei published the artcileSynthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety, HPLC of Formula: 620-20-2, the publication is Research on Chemical Intermediates (2019), 45(12), 5989-6001, database is CAplus.

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring I (R = cyano, 3,4-dichlorophenyl, 2-chlorothiazol-5-yl, etc.) were designed and synthesized from Et acetoacetate and tri-Et orthoformate as starting materials via multi-step reactions. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C8H8O2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, Kazumi published the artcileIntermolecular methyl transfer on pyrolysis of carpronium chloride, HPLC of Formula: 6249-56-5, the publication is Organic Mass Spectrometry (1979), 14(2), 61-5, database is CAplus.

Me transfer occurring in the formation of Me₂N(CH₂)₃CO₂Me (I) by pyrolysis of Me₃N⁺(CH₂)₃CO₂R Cl^– (II; R = Me) was examined using pyrolysis gas chromatog.-mass spectrometry of I and II (R = H, Me, Et, CHMe₂) and D labeling studies. Characteristic mol. ion peaks in the mass spectra of I and its deuterated analogs indicated intermol. Me transfer during pyrolysis of II (R = Me) to form I in which the Me group in the methoxycarbonyl group is replaced by an Me from the Me₃N group. The mechanism presented involves the bimol. reaction between zwitterionic intermediates formed by ionic O-demethylation of II (R = Me).

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, Kazumi published the artcilePyrolysis reaction of carpronium chloride and its structurally related compounds. 1. Electronic and steric effects on the orientation of the pyrolysis reaction, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Organic Mass Spectrometry (1983), 18(1), 27-33, database is CAplus.

The pyrolysis reaction of carpronium chloride [MeO₂C(CH₂)₃N⁺Me₃ Cl^–] and the structurally related compounds RO₂C(CH₂)_nN⁺Me₃ Cl^– (n = 2, 4, R = Me, Et, CHMe₂; n = 3, R = H, Et, CHMe₂), were studied by gas chromatog.-mass spectroscopy. The reaction modes of these ammonium compounds are dependent on the number of skeletal methylene groups and on the length of the carbon chain of the ester group. These phenomena were interpreted in terms of electronic and steric contributions for the ionic elimination reaction. The electronic and steric effects on the orientation of the reaction were discussed on the basis of the at. population calculated by the CNDO/2 method.

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tzvetkova-Chevolleau, Tzvetelina published the artcileMicroscale adhesion patterns for the precise localization of amoeba, Name: Dichloro(hexyl)(methyl)silane, the publication is Microelectronic Engineering (2009), 86(4-6), 1485-1487, database is CAplus.

In order to get a better understanding of amoeba-substrate interactions in the processes of cellular adhesion and directional movement, we engineered glass surfaces with defined local adhesion characteristics at a micrometric scale. Amoeba (Dictyostelium discoideum) are capable to adhere to various surfaces independently on the presence of extracellular matrix proteins. This paper describes the strategy used to create selective adhesion patterns using an appropriate surface chem. and shows the first results of locally confined amoeba adhesion. The approach is based on the natural ability of Dictyostelium to adhere to various types of surfaces (hydrophilic and hydrophobic) and on its inability to spread on inert surfaces, such as the block copolymer of polyethylene glycol and polypropylene oxide, named Pluronic. We screened diverse alkylsilanes, such as methoxy, chloro and fluoro silanes for their capacity to anchor Pluronic F127 efficiently on a glass surface. Our results demonstrate that hexylmethyldichlorosilane (HMDCS) was the most appropriate silane for the deposition of Pluronic F127. A complex dependence between the physico-chem. of the silanes and the polyethylene glycol block copolymer attachment was observed Using this method, we succeed in scaling down the micro-fabrication of Pluronic-based adhesion patterns to the amoeba cell size (10 μm). This original Pluronic patterning method should prove useful as a tool for controlling cell adhesion and directional movement in amoeba.

Microelectronic Engineering published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C6H12Br2, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jia, Xiaojuan published the artcileSulfur-silicon bond activation catalyzed by Cl/Br ions: waste-free synthesis of unsymmetrical thioethers by replacing fluoride catalysis and fluorinated substrates in S_NAr reactions, Application of 2-Chloroisonicotinic acid, the publication is Green Chemistry (2014), 16(7), 3444-3449, database is CAplus.

In contrast to conventional activation of Nu-SiR₃ reagents by F ion attributed to the strong affinity of Si to F, S-Si activation can now be achieved using Cl/Br ions of TBAX as catalysts via formation of weaker X-Si bonds and Me₃Si-X. This led to a waste-free synthesis of unsym. thioethers via F-free S_NAr reactions of activated (hetero)aryl halides and RS-SiMe₃, with recovery of the useful Me₃Si-X reagent in high yields.

Green Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Application of 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xia, Yuehan published the artcileDiscovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists, Formula: C7H8BClO2, the publication is European Journal of Medicinal Chemistry (2021), 113013, database is CAplus and MEDLINE.

The retinoic acid receptor-related orphan receptor γt (RORγt) is an important nuclear receptor that regulates the differentiation of Th17 cells and production of interleukin 17(IL-17). RORγt agonists increase basal activity of RORγt and could provide a potential approach to cancer immunotherapy. Herein, hit compound I was identified as a weak RORγt agonist during inhouse library screening. Changes in LHS core of I led to the identification of tetrahydroquinoline compound II as a partial RORγt agonist (maximum act. = 39.3%). Detailed structure-activity relationship on substituent of the LHS core, amide linker and RHS arylsulfonyl moiety was explored and a novel series of tetrahydroquinolines and benzomorpholines was discovered as potent RORγt agonists. Tetrahydroquinoline compound III (EC₅₀ = 8.9 ± 0.4 nM, maximum act. = 104.5%) and benzomorpholine compound IV (EC₅₀ = 7.5 ± 0.6 nM, maximum act. = 105.8%) were representative compounds with high RORγt agonistic activity in dual FRET assay, and they showed good activity in cell-based Gal4 reporter gene assay and Th17 cell differentiation assay (104.5% activation at 300 nM of III; 59.4% activation at 300 nM of IV). The binding modes of III and IV as well as the two RORγt inverse agonists accidentally discovered were also discussed.

European Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C13H11NO, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Changchun published the artcileSynthesis, insecticidal evaluation and 3D-QASR of novel anthranilic diamides derivatives containing N-arylpyrrole as potential ryanodine receptor activators, Application In Synthesis of 350-30-1, the publication is Journal of Agricultural and Food Chemistry (2020), 68(35), 9319-9328, database is CAplus and MEDLINE.

The synthesis of novel anthranilic diamides derivatives I [R = HC, N, Cl-C; R⁴ = O₂N, F₃C, i-Pr, etc; R⁵ = Me, i-Pr] incorporating pyrrole moiety targeting at insect RyRs. The structures I were confirmed by ¹H NMR, ¹³C NMR, ¹⁹F NMR and HRMS. The preliminary bioassay results indicated that most of the title compounds I showed good to excellent insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). For oriental armyworm, I [R = N; R⁴ = H; R⁵ = Me] displayed the same level of larvicidal activity as the pos. control chlorantraniliprole, with the LC₅₀ value of 0.21 mg/L. For diamondback moth II [R⁵ = Me; X = Br], [R⁵ = i-Pr; X = Br], [R⁵ = Me; X = Cl] and [R⁵ = i-Pr; X = Cl] exhibited higher insecticidal activities than chlorantraniliprole. In particular, In had 50% larvicidal activity at 0.00001 mg/L. Calcium imaging technique was applied to study the effect of I [R = N; R⁴ = H; R⁵ = Me] and II [R⁵ = Me; X = Br, Cl] on the intracellular calcium ion concentration ([Ca²⁺]i) in central neurons isolated from oriental armyworm. The results indicated that the tested compoundsI and II, like chlorantraniliprole was activate the insect ryanodine receptors. Furthermore, comparative mol. field (CoMFA) anal. and d. functional theory (DFT) calculations were carried out to study the structure-activity relationship (SAR).

Journal of Agricultural and Food Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C14H20BClO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jianbo published the artcileEnantioselective construction of remote tertiary carbon-fluorine bonds, Product Details of C7H8BClO2, the publication is Nature Chemistry (2019), 11(8), 710-715, database is CAplus and MEDLINE.

The carbon-fluorine bond engenders distinctive physicochem. properties and significant changes to general reactivity. The development of catalytic, enantioselective methods to set stereocenters that contain a benzylic C-F bond is a rapidly evolving goal in synthetic chem. Although there have been notable advances that enable the construction of secondary stereocenters that contain both a C-F and a C-H bond on the same carbon, significantly fewer strategies are defined to access stereocenters that incorporate a tertiary C-F bond, especially those remote from pre-existing activating groups. Here we report a general method that establishes C-F tertiary benzylic stereocenters by forging a C-C bond via a Pd-catalyzed enantioselective Heck reaction of acyclic alkenyl fluorides with arylboronic acids. This method provides a platform to rapidly incorporate significant functionality about the benzylic tertiary fluoride by virtue of the diversity of both reaction partners, as well as the ability to install the stereocenters remotely from pre-existing functional groups.

Nature Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Product Details of C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, X. published the artcileCyclic Voltammetric Study of Electroreduction of Dichlorosilanes, COA of Formula: C7H16Cl2Si, the publication is Journal of the Electrochemical Society (2005), 152(8), E259-E264, database is CAplus.

The electroreduction of organo-substituted dichlorosilanes, Me₂SiCl₂, MeEtSiCl₂, MePrSiCl₂, MeHexSiCl₂, Me(c-Hex)SiCl₂, MePhSiCl₂, and Ph₂SiCl₂ in THF, is reported. A 2-step reduction scheme (E₁: RR’SiCl₂ ⇌ [RR’SiCl₂]^•- and E₂: [RR’SiCl₂]^•- ⇌ [RR’SiCl₂]^2-) is suggested in which the redox potentials E₁ and E₂ are separated by ∼110 mV. A simulation of the irreversible voltammograms indicates multiple pathways in producing silyl anion, among them the decomposition of dianion and/or the disproportionation of silyl anion radicals, which is further corroborated by low-temperature cyclic voltammetric measurements. Subsequently, silyl anion undergoes S_N2 nucleophilic attack on another chlorosilane mol. to form Si-Si bonds. Taft substituent constants were applied and proved effective in correlating the substituent effect on the reduction of dichlorosilanes. For dialkyl-substituted chlorosilanes, the Taft anal. of the polar contribution of substituents to the cathodic peak shift gives a pos. ρ^*∼2.4, which indicates an S_N2 nucleophilic reaction in the formation of silyl dianion intermediate. The steric effect of substituents, however, is largely responsible for the stability of the S_N2 transition state.

Journal of the Electrochemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C25H16O, COA of Formula: C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Qing published the artcileCopper-catalyzed enantioselective desymmetrization of prochiral tetrasubstituted siladiols: Access toward optically active silicon-stereogenic silylmethanols, Product Details of C7H16Cl2Si, the publication is Catalysis Communications (2020), 105950, database is CAplus.

A copper/pyridinebisoxazoline-catalyzed desymmetrization of prochiral 2-sila-1,3-propanediols with benzoyl chlorides has been described. The catalytic system allowed the construction of optically active silymethanol derivatives, e.g. I, containing a quaternary siliconstereogenic center in good to high yields and moderate to good enantiomeric excesses.

Catalysis Communications published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C8H10O3, Product Details of C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics