Tag: M.W=150-200

Liu, Dengyue published the artcileFirst Discovery of Novel Pyrido[1,2-a]pyrimidinone Mesoionic Compounds as Antibacterial Agents, HPLC of Formula: 939-99-1, the publication is Journal of Agricultural and Food Chemistry (2019), 67(43), 11860-11866, database is CAplus and MEDLINE.

Plant bacterial diseases cause tremendous decreases in crop yield and quality, and there is a lack of highly effective and low-risk antibacterial agents. A series of novel pyrido[1,2-a]pyrimidinone mesoionic compounds containing vanillin moieties were synthesized, and the application of these mesoionic compounds as plant antibacterial agents was reported here for the first time. The bioassay results revealed that the mesoionic compounds had good antibacterial activity. Of these compounds, compound (I) showed excellent in vitro activity against Xanthomonas oryzae pv. oryzae, with an EC₅₀ value of 1.1μg/mL, which was substantially better than that of bismerthiazol (92.7μg/mL) and thiodiazole copper (105.4μg/mL). Moreover, greenhouse condition trials indicated that the protective and curative activities of compound I against rice bacterial leaf blight were 75.12% and 72.04%, resp., which were better than those of bismerthiazol (62.24% and 50.83%, resp.) and thiodiazole copper (53.35% and 65.04%, resp.). These results provide a basis for the application of mesoionic vanillin moieties as new antibacterial agents.

Journal of Agricultural and Food Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nan, Xiang published the artcileDesign, synthesis and biological evaluation of novel N-sulfonylamidine-based derivatives as c-Met inhibitors via Cu-catalyzed three-component reaction, Synthetic Route of 939-99-1, the publication is European Journal of Medicinal Chemistry (2020), 112470, database is CAplus and MEDLINE.

A series of new N-sulfonylamidine derivatives were designed, synthesized via Cu-catalyzed multicomponent reaction (MCR) as the key step, and evaluated for their in vitro biol. activities against c-Met kinase and four cancer cell lines (A549, HT-29, MKN-45 and MDA-MB-231). Most of the target compounds showed moderate to significant potency at enzyme and cell-based assay. The preliminary SAR studies demonstrated that compound I (c-Met IC₅₀ = 2.89 nM) was the most promising compound compared with the pos. foretinib, which exhibited the remarkable antiproliferative activities, with IC₅₀ values ranging from 0.28 to 0.72μM. Mechanistic studies of compound I showed the anticancer activity was closely related to the blocking phosphorylation of c-Met, leading to cell cycle arresting at G2/M phase and apoptosis of A549 cells by a concentration-dependent manner. The promising compound I was further identified as a relatively selective inhibitor of c-Met kinase, which also possessed an acceptable safety profile and favorable pharmacokinetic properties in BALB/c mouse. The favorable drug-likeness of I suggested that N-sulfonylamidines may be used as a promising scaffold for antitumor drug development. Addnl., the docking study and mol. dynamics simulations of I revealed a common mode of interaction with the binding site of c-Met. These pos. results indicated that I is a potential anti-cancer candidate for clin. trials, and deserves further development as a selective c-Met inhibitor.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Synthetic Route of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qin, Yaoguo published the artcileDesign, synthesis and biological activity of novel aphid alarm pheromone analogues containing isonicotinic acid, Name: 2-Chloroisonicotinic acid, the publication is Gaodeng Xuexiao Huaxue Xuebao (2016), 37(11), 1977-1986, database is CAplus.

A series of new aphid alarm pheromone [(E)-β-farnesene, EBF] analogs containing isonicotinic acid was designed based on the principles of connecting sub-structure and bioisosterism. With EBF as a lead compound, 20 EBF analogs were prepared via four steps starting from geraniol. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. The preliminary bioassay suggested that all the analogs showed repellent and aphicidal activities against Myzus persicae (Sulzer). Among them, compounds 7d, 8f and 8n showed good repellent activity with the repellent rate of 62.6%, 62.0% and 61.0% resp.; and the analogs 8a, 8b and 8d exhibited better aphicidal mortality of 73.6%, 81.1% and 70.2% than lead EBF. The primary structure-activity relationship (SAR) anal. indicated that introducing of ester group was favorable to repellent activity while introducing amide was conducive to aphicidal activity. Moreover, N-substituted carbon chain length, number of branched chain as well as aromaticity played roles in repellent activity. This study provides useful clues for further development of novel aphid control agent.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hou, Xuehui published the artcileDesign, synthesis and bioactivities evaluation of novel quinazoline analogs containing oxazole units, Application In Synthesis of 350-30-1, the publication is Chinese Journal of Chemistry (2014), 32(6), 538-544, database is CAplus.

Novel quinazoline derivatives I (R = PhOCH₂, Me), which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, were synthesized and their biol. activities evaluated for anti-proliferative activities and EGFR inhibitory potency. Enantiomer (R)-I (R = PhOCH₂) demonstrated the most potent inhibitory activity (IC₅₀=0.95 μmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further studies.

Chinese Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jin, Kunfeng published the artcileFacile Access to Solid-State Carbon Dots with High Luminescence Efficiency and Excellent Formability via Cellulose Derivative Coatings, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(15), 5937-5945, database is CAplus.

Carbon dots (CDs), which are one kind of novel fluorescent materials, exhibit benign biocompatibility, high photobleaching resistance, and easy processing; thus, they have attracted a lot of attention. However, the intrinsic self-aggregation of nanoscale-sized CDs leads to fluorescence quenching, thereby limiting their application in the solid state. In this work, we demonstrate an effective and universal method to obtain solid-state CDs with high luminescence efficiency and excellent formability. Taking advantage of the charged surfaces of most CDs, we utilize two types of eco-friendly cellulose derivatives with pos. or neg. charges to surround the CDs via electrostatic attractions. As a result, the particles of CDs have been isolated and their aggregation-induced quenching phenomenon has been inhibited. The obtained CDs@cellulose derivative powders show bright fluorescence and have a high fluorescence quantum yield (QY); for example, the QY of blue-emitting powder reaches up to 71.5%. Such a simple strategy is available for various CDs. More significantly, the excellent processability and formability of cellulose derivatives enable CDs@cellulose derivatives to be easily processed into films, coatings, and printing inks, providing a huge potential in eco-friendly solid-emitting devices and light-stable anticounterfeiting labels. CDs-based solid fluorescent materials were fabricated by constructing a shell layer with charged cellulose chains via electrostatic attractions.

ACS Sustainable Chemistry & Engineering published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Schutter, Joris W. published the artcileNovel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase, Safety of 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5781-5786, database is CAplus and MEDLINE.

A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Safety of 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Ming-bo published the artcileSynthesis and structure-activity relationship of novel tetrahydrobenzo[d]thiazole as androgen receptor modulator, Related Products of chlorides-buliding-blocks, the publication is Zhongguo Shengwu Huaxue Yu Fenzi Shengwu Xuebao (2018), 34(9), 962-971, database is CAplus.

Prostate cancer is one of the most commonly diagnosed cancer in men, and androgen receptor (AR) is an important target for the treatment of prostate cancer. For many reasons, existing AR antagonists fail to treat prostate cancer after long-term use. Therefore, the development of novel AR antagonists is still of great significance. A series of tetrahydrobenzo[d]thiazole compounds were synthesized by condensation reaction of α,β-epoxycyclohexanones and appropriate substituted thioureas 8, which were obtained from the corresponding anilines 7. Their antiandrogenic activities were tested using an yeast two-hybrid (Y2H) system, and several compounds exhibited androgen receptor (AR) antagonistic behavior equal or stronger than that of flutamide (IC₅₀ ≤ 2.48 mmol/L). Further cell viability assay demonstrated that some active compounds effectively inhibited the proliferation of androgen-sensitive LNCaP cells values with IC₅₀ values of 17.1-41.4 mmol/L. Mol. docking study provide a possible model of ligand receptor interactions, which was consistent with the initial structure-activity relationship (SAR) studies. Taken together, tetrahydrobenzo[d]thiazoles act as effective AR modulators may represent promising leads for further development of novel and improved AR antagonists.

Zhongguo Shengwu Huaxue Yu Fenzi Shengwu Xuebao published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, HPLC of Formula: 620-20-2, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, Formula: C8H6ClF3, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Surnin, V. A. published the artcileAminoalkylation of hydrazine by 2-halopropylamine hydrohalides, SDS of cas: 4584-49-0, the publication is Zhurnal Organicheskoi Khimii (1983), 19(11), 2288-94, database is CAplus.

MeCHXCH₂NRR¹.HX¹ (I; X = OH; R = H, R¹ = H, Me, Me₃C, Ph; R = R¹ = Me; X¹ = Br) reacted with PBr₃ or SOCl₂ to give 6 corresponding I (X = X¹ = Br, Cl) (II) in 31-90% yield. II reacted with N₂H₄.H₂O in MeOH to give mixtures of 5 corresponding H₂NNHCHMeCH₂NRR¹ (III) and RR¹NCHMeCH₂NHNH₂ (IV) with the latter predominating, indicating an aziridinium salt intermediate. All 10 III and IV condensed with 1 equivalent Me₂CO in C₆H₆ to give the corresponding Me₂C:NNHCHMeCH₂NRR¹ and RR¹NCHMeCH₂NHN:CMe₂, resp. Treating III (R = R¹ = H) and IV (R = R¹ = H) with excess refluxing Me₂CO containing potash gave 40% iminoimidazolidines V (Z = CHMeCH₂, CH₂CHMe).

Zhurnal Organicheskoi Khimii published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H10Cl3O3P, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics