Tag: M.W=150-200

Lu, Shi-Chao; Chang, Zhi-Xin; Xiao, Yu-Liang; Li, Hong-Shuang published the artcile< Regio- and Stereoselective Synthesis of 2-Hydroxymethyl-1,3-enynes by Rhodium-Catalyzed Decarboxylative C-C Coupling>, Name: 3-(4-Chlorophenyl)propiolic acid, the main research area is hydroxymethyl enyne preparation regioselective diastereoselective; propiolic acid propargyl alc decarboxylative coupling rhodium catalyst.

A regio- and stereoselective protocol for rhodium(I)-catalyzed decarboxylative C-C coupling between propiolic acids R1CCC(O)2H (R1 = CH3, C6H5, 1-benzothiophen-2-yl, etc.) and propargyl alcs. R2R3C(OH)CCR2 (R2R3 = -(CH2)4-, R4 = CH3; R2 = R3 = H, R4 = CH3; R2 = CH3, R3 = C6H5, R4 = H, etc.) has been achieved. This efficient catalytic approach could facilitate the preparation of a diversity of synthetically valuable 2-hydroxymethyl-1,3-enynes (Z)-R2R3C(OH)C(CCR1)=CHR4 with high Z-stereoselectivity. Notably, non-terminal alkynes were smoothly transformed into the target products that show intriguing synthetic utility.

Advanced Synthesis & Catalysis published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Name: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Krylov, Igor B.; Kompanets, Mykhailo O.; Novikova, Katerina V.; Opeida, Iosip O.; Kushch, Olga V.; Shelimov, Boris N.; Nikishin, Gennady I.; Levitsky, Dmitri O.; Terentev, Alexander O. published the artcile< Well-known mediators of selective oxidation with unknown electronic structure: Metal-free generation and EPR study of imide-N-oxyl radicals>, COA of Formula: C8H3ClO3, the main research area is mediator selective oxidation electronic structure imideNoxyl radical.

Nitroxyl radicals are widely used in chem., materials sciences, and biol. Imide-N-oxyl radicals are subclass of unique nitroxyl radicals that proved to be useful catalysts and mediators of selective oxidation and CH-functionalization. An efficient metal-free method was developed for the generation of imide-N-oxyl radicals from N-hydroxyimides at room temperature by the reaction with (diacetoxyiodo)benzene. The method allows for the production of high concentrations of free radicals and provides high resolution of their EPR spectra exhibiting the superhyperfine structure from benzene ring protons distant from the radical center. An anal. of the spectra shows that, regardless of the electronic effects of the substituents in the benzene ring, the superhyperfine coupling constant of an unpaired electron with the distant protons at positions 4 and 5 of the aromatic system is substantially greater than that with the protons at positions 3 and 6 that are closer to the N-oxyl radical center. This is indicative of an unusual character of the spin d. distribution of the unpaired electron in substituted phthalimide-N-oxyl radicals. Understanding of the nature of the electron d. distribution in imide-N-oxyl radicals may be useful for the development of com. mediators of oxidation based on N-hydroxyimides.

Journal of Physical Chemistry A published new progress about Electron spin density. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, COA of Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pan, Jin-Long; Liu, Tuan-Qing; Chen, Chao; Li, Quan-Zhe; Jiang, Wei; Ding, Tong-Mei; Yan, Zhi-Qiang; Zhu, Guo-Dong published the artcile< Rhodium(III)-catalysed cascade [3 + 2] annulation of N-aryloxyacetamides with 3-(hetero)arylpropiolic acids: synthesis of benzofuran-2(3H)-ones>, Application of C9H5ClO2, the main research area is benzofuranone preparation stereoselective regioselective fluorescence; aryloxyacetamide arylpropiolic acid annulation rhodium catalyst.

Herein, a cascade [3 + 2] annulation of N-aryloxyacetamides with 3-(hetero)arylpropiolic acids affording benzofuran-2(3H)-ones I (R = 7-CH3, 7-Cl, 6-CF3,etc.; Ar = C6H5, 4-MeC6H4, 3-FC6H4, etc.) via rhodium(III)-catalyzed redox-neutral C-H functionalization/isomerization/lactonization using an internal oxidative directing group O-NHAc was achieved. This catalytic system provides a regio- and stereoselective approach to synthesize (Z)-3-(amino(aryl)methylene)benzofuran-2(3H)-ones with exclusive Z configuration selectivity, acceptable yields and good functional group tolerance. Preliminary investigations on UV-visible and fluorescence behaviors reveal that the annulation products may be applied as a promising fluorescent probe for sensing metal cations, especially for cerium (Ce3+).

Organic & Biomolecular Chemistry published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-aryloxy). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Application of C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sitte, Nikolai A.; Bursch, Markus; Grimme, Stefan; Paradies, Jan published the artcile< Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation>, Electric Literature of 17082-09-6, the main research area is carboxylic amide hydrogen borane oxalyl chloride hydrogenation catalyst; amine tertiary preparation.

A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. D. functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (carboxylic amides). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fonte, Melanie; Fagundes, Natalia; Gomes, Ana; Ferraz, Ricardo; Prudencio, Cristina; Araujo, Maria Joao; Gomes, Paula; Teixeira, Catia published the artcile< Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials>, Application of C8H7ClO3, the main research area is diaminoacridine preparation antimalarial drug.

This is the first multi-step synthetic route, which has been developed towards N4,N9-disubstituted 4,9-diaminoacridines I. The target structures I are likely to reveal interesting biol. activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.

Tetrahedron Letters published new progress about Acridines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Min; Luo, Yanshu; Xu, Qianlan; Zhao, Yukun; Gong, Xiangnan; Xia, Yuanzhi; Hu, Lin published the artcile< A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles>, Formula: C8H3ClO3, the main research area is oxindole peroxide chiral phase transfer catalyst enantioselective annulation DFT; chiral spirooxindole oxacycle stereoselective preparation; annulation reaction; organocatalysis; oxygen heterocycles; peroxides; umpolung reaction.

A unified catalytic asym. (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Angewandte Chemie, International Edition published new progress about C-C bond formation. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Perry, Robert J.; Turner, S. Richard; Blevins, Richard W. published the artcile< Palladium-Catalyzed Formation of Poly(imide-amides). 2. Reactions with Chloroiodophthalimides and Diamines>, Application In Synthesis of 118-45-6, the main research area is palladium catalyst polymerization chlorophthalimide aromatic diamine; iodine catalyst preparation polyimide polyamide.

High-mol.-weight poly(imide-amides) can be readily formed by the Pd-mediated carbonylation and condensation reactions of activated chlorophthalimide monomers and aromatic diamines. The presence of iodide ion greatly accelerates the rate of reaction and increases the ultimate mol. weight of the polymer. Polymerizations proceed best using a protocol of high CO pressure (90 psig) for 2-4 h, followed by lower CO pressure (20 psi) in DMAc or NMP for 24-48 h at 100° using 0.3-3.0% PdCl2L2 (L = PPh3) as the catalyst with 2-6 equiv of PPh3/Pd and 0.3-1.0 equiv of an iodide/chloro group.

Macromolecules published new progress about Glass transition temperature. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gormemis, Ahmet E.; Ha, Tal Soo; Im, Isak; Jung, Kwan-Young; Lee, Ju Yeon; Park, Chul-Seung; Kim, Yong-Chul published the artcile< Benzofuroindole analogues as potent BKCa channel openers>, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate, the main research area is arylhydrazine benzofuranone condensation; arylhydrazone benzofuranone preparation Fischer cyclization acid catalyst; benzofuranone arylhydrazone preparation Fischer cyclization microwave irradiation acid catalyst; benzofuroindole preparation potassium channel opener; structure activity relationship benzofuroindole potassium channel opener.

New, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R1 = H, Br; R2 = H, CF3, OCH3, Cl; R3 = H, COOH, COOCH3, Cl, OCH3, CF3; R4 = H, Cl, F; R5 = H, Cl, CF3; R6 = H, Cl, F, CF3) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BKCa-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R1 = R4 = R5 = H; R2 = CF3; R3 = COOH, R6 = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.

ChemBioChem published new progress about Fischer indole synthesis. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Recommanded Product: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bai, Lu; Luo, Pan; Yang, Xudong; Xu, Jianquan; Kawaguchi, Daisuke; Zhang, Cuiyun; Yamada, Norifumi L.; Tanaka, Keiji; Zhang, Wei; Wang, Xinping published the artcile< Enhanced Glass Transition Temperature of Thin Polystyrene Films Having an Underneath Cross-Linked Layer>, COA of Formula: C9H9Cl, the main research area is ultrathin polystyrene film glass transition temperature chain mobility conformation.

Due to the importance of the interface in the segmental dynamics of supported macromol. ultrathin films, the glass transition temperature (Tg) of polystyrene (PS) ultrathin films upon solid substrates modified with a crosslinked PS (CLPS) layer has been investigated. The results showed that the Tg of the thin PS films on a silica surface with a ∼ 5 nm crosslinked layer increased with reducing film thickness. Meanwhile, the increase in Tg of the thin PS films became more pronounced with increasing crosslinking d. of the layer. For example, a 20 nm thick PS film supported on CLPS with 1.8 kDa of crosslinking degree exhibited an ∼35 K and ∼50 K increase in Tg compared to its bulk and that on neat SiO2 substrate, resp. Such a large Tg elevation for the ultrathin PS films was attributed to the interfacial aggregation states in which chains diffused through nanolevel voids formed in the crosslinked layer to the SiO2-Si surface. In such a situation, the chains were topol. constrained in the crosslinked layer with less mobility. These results offer us the opportunity to tailor interfacial effects by changing the degree of crosslinking, which has great potential application in many polymer nanocomposites.

ACS Macro Letters published new progress about Annealing. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Yanqing; Song, Gonghua; Qian, Xuhong published the artcile< Imidation of cyclic carboxylic anhydrides under microwave irradiation>, Category: chlorides-buliding-blocks, the main research area is cyclic carboxylic anhydride imidation microwave; imide preparation.

Efficient and facile conversion of cyclic carboxylic anhydrides to corresponding imides with formamide under microwave irradiation is described.

Synthetic Communications published new progress about Anhydrides Role: RCT (Reactant), RACT (Reactant or Reagent) (cyclic). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics