Tag: M.W=150-200

Dai, Ali published the artcileA 1,3,4-Oxadiazole Contained Sesquiterpene Derivatives: Synthesis and Microbiocidal Activity for Plant Disease, Category: chlorides-buliding-blocks, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2022), 854274, database is CAplus and MEDLINE.

A series of 1,3,4-oxadiazole contained sesquiterpene derivatives were synthesized, and the activity of the target compounds against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac), and tobacco mosaic virus (TMV) were evaluated. The biol. activity results showed that the EC₅₀ values of compounds H4, H8, H11, H12, H14, H16, and H19 for Xac inhibitory activity were 33.3, 42.7, 56.1, 74.5, 37.8, 43.8, and 38.4 μg/mL, resp. Compounds H4, H8, H15, H19, H22, and H23 had inhibitory effects on Xoo, with EC₅₀ values of 51.0, 43.3, 43.4, 50.5, 74.6, and 51.4 μg/mL, resp. In particular, the curative and protective activities of compound H8 against Xoo in vivo were 51.9 and 49.3%, resp. In addition, the EC₅₀ values of the inactivation activity of compounds H4, H5, H9, H10, and H16 against TMV were 69.6, 58.9, 69.4, 43.9, and 60.5 μg/mL, resp. The results of mol. docking indicated that compound H10 exhibited a strong affinity for TMV-coat protein, with a binding energy of -8.88 kcal/mol. It may inhibit the self-assembly and replication of TMV particles and have an anti-TMV effect, which supports its potential usefulness as an antiviral agent.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gu, Huifen published the artcileSeparation and identification of mustard gas compounds in diesel fuel, Category: chlorides-buliding-blocks, the publication is Fenxi Ceshi Xuebao (1995), 14(3), 6-9, database is CAplus.

Separation and identification of mustard and mustard disulfide in diesel fuel and aromatic compound mixtures are presented. Samples were prepurified by column chromatog. using hexane as eluate, and interfering matrixes were removed. Pure compounds were obtained with thin-layer chromatog. by developing the TLC plate twice in hexane and identified with gas chromatog.-mass spectrometry and NMR spectrometry.

Fenxi Ceshi Xuebao published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

An, Shaoyu published the artcileMetal-Free Synthesis of Selenodihydronaphthalenes by Selenoxide-Mediated Electrophilic Cyclization of Alkynes, SDS of cas: 620-20-2, the publication is European Journal of Organic Chemistry (2021), 2021(21), 3059-3070, database is CAplus.

A transition-metal-free, selenium mediated electrophilic cyclization reaction was realized through a one-pot procedure between simple alkynes and triflic anhydride-activated selenoxides to give selenium containing dihydronaphthalene products. This method gave good to very high yields for all products, including selenium-substituted phenanthrene, dihydroquinoline, 2H-chromene, and coumarin, which can be further transformed to other functionalized compounds

European Journal of Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Jianping published the artcileIridium-Catalyzed Synthesis of Diaryl Ethers by Means of Chemoselective C-F Bond Activation and the Formation of B-F Bonds, Category: chlorides-buliding-blocks, the publication is Chemistry – An Asian Journal (2015), 10(2), 468-473, database is CAplus and MEDLINE.

Transition-metal-catalyzed C-F activation, in comparison with C-H activation, is more difficult to achieve and therefore less fully understood, mainly because carbon-fluorine bonds are the strongest known single bonds to carbon and have been very difficult to cleave. Transition-metal complexes are often more effective at cleaving stronger bonds, such as C(sp²)-X vs. C(sp³)-X. Here, the iridium-catalyzed C-F activation of fluorarenes was achieved through the use of bis(pinacolato)diboron with the formation of the B-F bond and self-coupling. This strategy provides a convenient method with which to convert fluoride aromatic compounds into sym. diaryl ether compounds Moreover, the chemoselective products of the C-F bond cleavage were obtained at high yields with the C-Br and C-Cl bonds remaining.

Chemistry – An Asian Journal published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Shuai published the artcileDevelopment of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction, HPLC of Formula: 939-99-1, the publication is Journal of Medicinal Chemistry (2019), 62(5), 2772-2797, database is CAplus and MEDLINE.

The cullin-RING ubiquitin ligases (CRLs) are responsible for about 20% of cellular protein degradation and regulate diverse cellular processes, and the dysfunction of CRLs is implicated in human diseases. Targeting the CRLs has become an emerging strategy for the treatment of human diseases. Herein, we describe the discovery of a hit compound from our inhouse library and further structure-based optimizations, which have enabled the identification of new triazolo[1,5-a]pyrimidine-based inhibitors targeting the DCN1-UBC12 interaction. Compound WS-383 blocks the DCN1-UBC12 interaction (IC₅₀ = 11 nM) reversibly and shows selectivity over selected kinases. WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells. WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27, and NRF2. Collectively, targeting the DCN1-UBC12 interaction would be a viable strategy for selective neddylation inhibition of Cul3/1 and may be of therapeutic potential for disease treatment in which Cul3/1 is dysregulated.

Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C15H16O3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Jingyi published the artcile^99mTc-Labeled Polyethylenimine-Entrapped Gold Nanoparticles with pH-Responsive Charge Conversion Property for Enhanced Dual Mode SPECT/CT Imaging of Cancer Cells, Application In Synthesis of 6249-56-5, the publication is Langmuir (2019), 35(41), 13405-13412, database is CAplus and MEDLINE.

Development of tumor dual mode contrast agents is still a great challenge due to the relative low accumulation at tumor site, which result in the poor imaging efficiency. In this study, we constructed functional technetium-99m (^99mTc) labeled polyethylenimine (PEI)-entrapped gold nanoparticles (Au PENs) with pH-responsive charge conversion property for enhanced single photon emission computed tomog. (SPECT)/computed tomog. (CT) dual mode imaging of cancer cells. PEI with amine functional groups (PEI.NH₂) was successively modified with monomethyl ether and carboxyl functionalized polyethylene glycol (mPEG-COOH), maleimide and succinimidyl valerate functionalized PEG (MAL-PEG-SVA), diethylenetriaminepentaacetic dianhydride (DTPA), and fluorescein isothiocyanate (FI), and used to entrapped gold nanoparticles inside, followed by conjugation with the alkoxyphenyl acylsulfonamide (APAS) through the PEG maleimide, acetylation of the PEI leftover surface amines and ^99mTc labeling. The created nanosystem with the mean Au core diameter of 3.3 nm and with a narrow size distribution displays an excellent colloidal stability and desired cytocompatibility in the investigated Au concentration range. Due to the fact that the attached APAS moieties are responsive to pH, the functionalized Au PENs with a neutral surface charge can switch to be pos. charged under slightly acidic pH condition, which could improve the cellular uptake by cancer cells. With these properties, the developed functionalized Au PENs could achieve enhanced dual mode SPECT/CT imaging of cancer cells in vitro. The constructed PEI-based nanodevices may be adopted as an excellent dual mode contrast agent for SPECT/CT imaging of cancer cells of different types.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4H6O3, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Qian published the artcileMetal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides, Computed Properties of 620-20-2, the publication is Tetrahedron Letters (2020), 61(7), 151492, database is CAplus.

An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I₂O₅ and DBU via direct oxidative coupling was described. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation

Tetrahedron Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Dingzhong published the artcileFeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones, COA of Formula: C6H3ClFNO2, the publication is ChemistryOpen (2022), 11(5), e202200023, database is CAplus and MEDLINE.

An efficient hydrazine substitution of p-nitro-aryl fluorides viz., 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 2-fluoro-5-nitroaniline, etc. with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. These hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups such as 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 1-bromo-2,4-difluoro-5-nitrobenzene, etc. proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups such as 2-fluoro-5-nitroaniline, 1-fluoro-2-methyl-4-nitrobenzene, 2-bromo-4-fluoro-1-nitrobenzene, etc. also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines viz., (2-chloro-4-nitrophenyl)hydrazine, (3-fluoro-4-nitrophenyl)hydrazine, (2-bromo-4-nitrophenyl)hydrazine, (2,3-difluoro-4-nitrophenyl)hydrazine, (2-chloro-3-fluoro-4-nitrophenyl)hydrazine, some phthalazinones I (R = H, 4-hydroxyphenyl; R¹ = 2-Cl, 2-Br, 3-F, 2-Cl-3-F, 2,3-F₂), interesting as potential structures for pharmaceuticals, have been successfully synthesized in high yields.

ChemistryOpen published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morano, Cain published the artcileMultiple Isotopic Labels for Quantitative Mass Spectrometry, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Analytical Chemistry (Washington, DC, United States) (2008), 80(23), 9298-9309, database is CAplus and MEDLINE.

Quant. mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammonium butyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light form without deuterium). In the present report, two addnl. forms containing three and six deuteriums have been synthesized and tested. These addnl. isotopic tags perform identically to the previously reported tags; peptides labeled with the new TMAB reagents coelute from reversed-phase HPLC columns with peptides labeled with the lighter and heavier TMAB reagents. Altogether, these four tags allow for multivariate anal. in a single liquid chromatog./mass spectrometry anal., with each isotopically tagged peptide differing in mass by 3 Da per tag incorporated. The synthetic scheme is described in simple terms so that a biochemist without specific training in organic chem. can perform the synthesis. The interpretation of tandem mass spectrometry data for the TMAB-labeled peptides is also described in more detail. The addnl. TMAB isotopic reagents described here, together with the addnl. description of the synthesis and anal., should allow these labels to be more widely used for proteomics and peptidomics analyses.

Analytical Chemistry (Washington, DC, United States) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Ming-Lu published the artcileSwitchable, Reagent-Controlled C(sp³)-H Selective Iodination and Acetoxylation of 8-Methylquinolines, Computed Properties of 209919-30-2, the publication is Journal of Organic Chemistry (2022), 87(9), 5730-5743, database is CAplus and MEDLINE.

An efficient Pd-catalyzed C(sp³)-H selective iodination of 8-methylquinolines I (R = H, Ph, 4-chlorophenyl; R¹ = H, Cl, Ph, etc.; R² = H, F, Cl, Br; R³ = H, Cl, Br, I) is reported herein for the first time. Because of the versatility of organic iodides, the method offers a facile access to various C8-substituted quinolines II. By slightly switching the reaction conditions, an efficient C(sp³)-H acetoxylation of 8-methylquinolines I has also been enabled. Both approaches feature mild reaction conditions, good tolerance of functional groups, and a broad substrate scope.

Journal of Organic Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H6N2O2S, Computed Properties of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics