Tag: M.W=150-200

Jiang, Xiu-Juan; Tang, Hao; Li, Xiao-Yuan; Zang, Shuang-Quan; Hou, Hong-Wei; Mak, Thomas C. W. published the artcile< Two new isomerous fluorescent chemosensors for Al3+ based on photoinduced electron transfer>, Related Products of 118-45-6, the main research area is isomer fluorescent chemosensor aluminum photoinduced electron transfer; Al(3+); Fluorescent chemosensors; Isomerous; PET.

Two new isomerous PET fluorescent chemosensors (L and L’) for Al3+ were designed, synthesized and characterized. The two chemosensors exhibited fluorescence enhancement upon binding Al3+ in CH3CN by PET inhibition processes from both the sulfur and the nitrogen donors to anthracene. The job’s plot, Benesi-Hildebrand plot and 1H NMR titration experiments indicate that both chemosensors form a 1:1 complex with Al3+. The binding constants are (1.432 ± 0.186) × 105 and (1.427 ± 0.970) × 105, resp. Also, the lowest detection limit for Al3+ in CH3CN is 4.8 × 10-7 M and 2.2 × 10-7 M, resp.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Crystal structure. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lumma, William C. Jr.; Hartman, Richard D.; Saari, Walfred S.; Engelhardt, Edward L.; Lotti, Victor J.; Stone, Clement A. published the artcile< Piperazinylquinoxalines with central serotoninmimetic activity>, Recommanded Product: 5-Chloroquinoxalin-2-ol, the main research area is serotoninmimetic piperazinylquinoxaline; serotoninin reuptake blocking quinoxaline; piperazinylquinoxaline; quinoxaline piperazinyl.

The piperazinylquinoxalines I (R = H, Ac, Me; R1 = H, OH (and the related ketone), CO2H; R2, R3 = H, Cl, NH2, CF3, SPh, OMe, F, etc.; m, n = 0, 1) were prepared by various methods. I were tested for selectivity in regards to serotonin reuptake blocking and serotoninmimetic activity. In general, introduction of a 6-substituent into I enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted I and I (R1 = OH) had primary serotoninmimetic activity.

Journal of Medicinal Chemistry published new progress about 55687-19-9. 55687-19-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H5ClN2O, Recommanded Product: 5-Chloroquinoxalin-2-ol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Jialin; Zhang, Lina; Sun, Nannan; Hu, Deng; Shen, Qun; Mao, Fang; Gao, Qiang; Wei, Wei published the artcile< Facile and Rapid Preparation of Ag@ZIF-8 for Carboxylation of Terminal Alkynes with CO2 in Mild Conditions>, Computed Properties of 3240-10-6, the main research area is silver zeolitic imidazolate framework carboxylation catalyst terminal alkyne; CO; MOF; ZIF; carboxylation; catalysis.

Metal-organic frameworks (MOFs) are promising hosts for catalytic active sites due to their adjustable porosity and framework chem. Strategies to improve synergistic effects between the installed sites and the parent MOF are highly desired. A facile and rapid method for the preparation of xAg@ZIF-8 materials was reported. The materials were systematically characterized and used as catalysts for carboxylation of terminal alkynes via direct insertion of CO2 to the C(sp)-H bond (CTACO2). The integrity of the ZIF-8 structure could be retained upon Ag loading, but short-range crystalline ordering was modified. Two types Ag species could be installed, namely, highly dispersed Ag(I) in the backbone (AgHD) and aggregated Ag(0) nanoparticles on the outer surface (AgNP). The AgNP sites are highly effective for the activation of terminal alkynes due to its high accessibility, while the AgHD-modified ZIF-8 framework worked as a CO2 reservoir with enhanced affinity. Combination of these factors translated to high activity in the CTACO2 process, the measured turnover frequency and time yield are among the highest among most heterogeneous catalysts.

ACS Applied Materials & Interfaces published new progress about Adsorption. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Computed Properties of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sahin-Bolukbasi, Serap; Sahin, Neslihan; Tahir, Muhammad Nawaz; Arici, Cengiz; Cevik, Esranur; Gurbuz, Nevin; Ozdemir, Ismail; Cummings, Brian S. published the artcile< Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity>, SDS of cas: 611-19-8, the main research area is preparation crystal structure silver heterocyclic carbene complex; anticancer activity silver heterocyclic carbene complex.

The authors synthesized four novel unsym. substituted NHC ligands (1a-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental anal., FTIR, 1H NMR, and 13C NMR spectroscopy and X-ray crystallog. The mol. structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9-C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)°. The Ag-Cl and Ag-C single bond lengths are 2.3553(7) and 2.096(2) Å, resp. The C-Ag-Cl bond angle is 168.27(7)°. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)-NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)-NHC complex displaying IC50 <1 μM all time points. Further, the IC50s for Ag(I)-NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells. Inorganica Chimica Acta published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, SDS of cas: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Xu-Jun; Zhang, Wei; Zhao, Chi-Na; Wu, Qing-Lai; Li, Jun-Kai; Xu, Zhi-Hong published the artcile< Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives>, Synthetic Route of 611-19-8, the main research area is phenazine carboxylic triazole preparation SAR fungicidal; Derivatives; fungicidal activity; phenazine-1-carboxylic acid; synthesis; triazole.

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC6H4, 2-FC6H4, 2,4-Cl2C6H3, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC6H4, 4-iPrC6H4, 4-tBuC6H4, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] were promising fungicidal candidates, deserving further studies.

Journal of Asian Natural Products Research published new progress about Agrochemical fungicides. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Synthetic Route of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Huanfeng; Zhang, Hao; Xiong, Wenfang; Qi, Chaorong; Wu, Wanqing; Wang, Lu; Cheng, Ruixiang published the artcile< Iridium-Catalyzed Three-component Coupling Reaction of Carbon Dioxide, Amines, and Sulfoxonium Ylides>, Application of C9H7ClO, the main research area is carbon dioxide amine sulfoxonium ylide three component coupling iridium; aryl oxoalkyl carbamate preparation mol crystal structure; steroid oxoalkyl carbamate preparation antitumor; iridium three component coupling catalyst.

The first iridium-catalyzed three-component coupling reaction of carbon dioxide, amines, and sulfoxonium ylides has been developed, providing an efficient and straightforward method for the construction of a range of structurally diverse O-β-oxoalkyl carbamates, e.g., I (X-rays single crystal structure shown), in moderate to excellent yields. This novel protocol features the use of readily available substrates, wide substrate scope, and good functional group tolerance. Moreover, the phosgene-free strategy was successfully applied to the synthesis of a potential antitumor agent via a a three-step procedure starting from a steroid carboxylic acid.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andy H. published the artcile< High-Affinity Partial Agonist Imidazo[1,5-a]quinoxaline Amides, Carbamates, and Ureas at the γ-Aminobutyric Acid A/Benzodiazepine Receptor Complex>, Category: chlorides-buliding-blocks, the main research area is imidazoquinoxaline carbamate carboxamide preparation benzodiazepine receptor; anxiolytic imidazoquinoxaline carbamate carboxamide preparation; cyclopropyl oxadiazolyl imidazoquinoxalinecarboxamide preparation; urea imidazoquinoxaline preparation benzodiazepine receptor.

A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the γ-aminobutyric acid A/benzodiazepine receptor complex was developed. Compounds within this class have varying efficacies ranging from antagonists to full agonists. However, most analogs were found to be partial agonists as indicated by [35S]TBPS and Cl- current ratios. Many of these compounds were also effective in antagonizing metrazole-induced seizures in accordance with anticonvulsant and possible anxiolytic activity. Selected quinoxalines displayed limited benzodiazepine-type side effects such as ethanol potentiation and phys. dependence in animal models. An interesting analog was 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-N,N-dimethylimidazo[1,5-a]quinoxaline-5(4H)-carboxamide which has a partial agonist profile in vitro while possessing useful activity in animal models of anxiety such as the Vogel and Geller assays. In accordance with its partial agonist profile, 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-N,N-dimethylimidazo[1,5-a]quinoxaline-5(4H)-carboxamide was devoid of typical benzodiazepine side effects.

Journal of Medicinal Chemistry published new progress about Anxiolytics. 55687-19-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H5ClN2O, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Keivanloo, Ali; Lashkari, Saeed; Sepehri, Saghi; Bakherad, Mohammad; Abbaspour, Sima published the artcile< Ligand-assisted click reaction for the synthesis of new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione and evaluation of their antibacterial activities>, Formula: C7H6Cl2, the main research area is triazole diphenylimidazolidinedione preparation regioselective click reaction antibacterial activity.

The new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione I (R = 3-nitrophenyl, 2-chloro-4-nitrophenyl, 4-chloro-2-nitrophenyl, 4-chloro-3-nitrophenyl), II (R1 = 4-nitrophenyl, 4-chloro-3-nitrophenyl, 2-chloro-4-nitrophenyl) and III (X = H, 2-Cl, 4-Me) were successfully synthesized by copper-catalyzed click reaction in the presence of water-soluble ligand, sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate and copper salt. The click reaction of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione and 5,5-diphenyl-1,3-di(prop-2-yn-1-yl)imidazolidine-2,4-dione with aryl azides RN3 or sodium azide and benzyl chloride XC6H4CH2Cl in water produced new 1,2,3-triazoles linked-5,5-diphenylimidazolidine-2,4-dione. The 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate was used as ligand, which enhanced the reactions and reduced the quantity of the toxic copper salt. The in vitro antibacterial activities of the all synthesized compounds I, II and III were screened against the Gram-pos. and Gram-neg. bacteria, by the use of well diffusion method. The results showed that all compounds I, II and III were active against both M. luteus and P. aeruginosa bacteria.

Monatshefte fuer Chemie published new progress about Antibacterial agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti published the artcile< Asymmetric Michael Addition of Unactivated Ketones with β-Nitrostyrenes Mediated by Bifunctional L-Prolinamide Organocatalysts>, Quality Control of 5153-70-8, the main research area is nitrostyrene ketone orgnocatalyst diastereoselective Michael addition; nitrophenylethyl ketone preparation.

The catalytic activity of two types of L-prolinamide organocatalysts was investigated for asym. Michael addition reaction of cyclic/acyclic ketones with β-nitrostyrens. L-Prolinamides bearing amino groups as efficient catalyst as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having -NH2 group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various β-nitrostyrenes with ketones to afforded the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.

ChemistrySelect published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Quality Control of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaiser, Carl; Lester, Bruce M.; Zirkle, Charles L.; Burger, Alfred; Davis, Charles S.; Delia, Thomas J.; Zirngibl, Ludwig published the artcile< 2-Substituted cyclopropylamines. I. Derivatives and analogs of 2-phenylcyclopropylamine>, Application In Synthesis of 90940-40-2, the main research area is .

A series of derivatives (I, II) of 2-phenylcyclopropylamine and analogs, 2-arylcyclopropanecarboxhydrazides, -carboxamides, -methyl-amines, -carboxylic acids, esters, and chlorides has been prepared in order to study relationships between chem. structure and monoamine oxidase-inhibiting activity.

Journal of Medicinal & Pharmaceutical Chemistry published new progress about 90940-40-2. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Application In Synthesis of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics