Tag: M.W=150-200

Rilvin-Derrick, Eloise; Oram, Niall; Richardson, Jeffery published the artcile< An Efficient Palladium-Catalyzed Aminocarbonylation of Benzyl Chlorides>, Related Products of 611-19-8, the main research area is chloromethyl arene amine carbon monoxide palladium catalyst aminocarbonylation; arylacetamide preparation.

An improved procedure for the aminocarbonylation of benzyl chloride derivatives using carbon monoxide and either primary or secondary amines were developed. Studying the competing background alkylation reaction allowed the solvent and base to be selected for a simple catalyst screen, which in turn, enabled the discovery of a method for the preparation of 2-arylacetamides under mild conditions, with minimal side-products using an inexpensive phosphine ligand. This non-traditional optimization strategy allowed us to overcome the background alkylation, which was cited as justification for the development of more complex and less atom-economical approaches.

Synlett published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiangtao; Chen, Guofei; Fang, Xingzhong published the artcile< Synthesis and characterization of high performance poly(thioether imide)s via aromatic nucleophilic substitution reaction of isomeric AB-type monomers>, HPLC of Formula: 118-45-6, the main research area is polyimide polythioether synthesis property.

A series of isomeric poly(thioether imide)s (PTIs) containing thioether linkages were prepared by aromatic nucleophilic substitution reaction of isomeric N-(4-mercaptophenyl)-3-chlorophthalimide and/or N-(4-mercaptophenyl)-4-chlorophthalimide. The inherent viscosities of these polymers were in the range of 0.38-0.42 dL/g. The glass transition temperature increased with increasing the content of 3-substituted phthalimide unit in the polymer backbone. The 5 % weight loss temperatures of isomeric PTIs (a-e) were 506-531° in nitrogen and 509-536° in air, resp. The isomeric PTIs (b-d) films exhibited good mech. properties with tensile strength of about 90 MPa, elongation at break of more than 6.0 %, and tensile moduli of more than 2.2 GPa. The storage moduli of PTIs (b-d) almost completely maintained at about 2.0 GPa before reaching the corresponding glass transition temperatures It is noted that the min. melt viscosity of these polymers decreased with increasing the content of unsym. 3- and 4-substituted phthalimide unit.

Polymer Bulletin (Heidelberg, Germany) published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Das, Agnideep; Schleinitz, Jules; Karmazin, Lydia; Vincent, Bruno; Le Breton, Nolwenn; Rogez, Guillaume; Guenet, Aurelie; Choua, Sylvie; Grimaud, Laurence; Desage-El Murr, Marine published the artcile< A Single Bioinspired Hexameric Nickel Catechol-Alloxazine Catalyst Combines Metal and Radical Mechanisms for Alkene Hydrosilylation>, HPLC of Formula: 27841-33-4, the main research area is hexameric nickel catechol alloxazine complex preparation hydrosilylation alkene catalyst; crystal structure mol hexameric nickel catechol alloxazine complex preparation; radical mechanism alkene hydrosilylation hexanickel catechol alloxazine catalyst safety; alloxazine; chain walking; nickel catalysis; radical chemistry; redox-active ligands.

Mechanisms combining organic radicals and metallic intermediates hold strong potential in homogeneous catalysis. Such activation modes require careful optimization of two interconnected processes: one for the generation of radicals and one for their productive integration towards the final product. We report that a bioinspired polymetallic nickel complex can combine ligand- and metal-centered reactivities to perform fast hydrosilylation of alkenes under mild conditions through an unusual dual radical- and metal-based mechanism. This earth-abundant polymetallic complex incorporating a catechol-alloxazine motif as redox-active ligand operates at low catalyst loading (0.25 mol%) and generates silyl radicals and a nickel-hydride intermediate through a hydrogen atom transfer (HAT) step. Evidence of an isomerization sequence enabling terminal hydrosilylation of internal alkenes points towards the involvement of the nickel-hydride species in chain walking. This single catalyst promotes a hybrid pathway by combining synergistically ligand and metal participation in both inner- and outer- sphere processes.

Chemistry – A European Journal published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, HPLC of Formula: 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Taehyung; Ju, Changha; Park, Chanhyuk; Kang, Hyo published the artcile< Enhanced, parallel liquid crystal alignment based on polystyrene substituted with phthalimidoyl groups>, Application In Synthesis of 1592-20-7, the main research area is phthalimidoyl group polystyrene liquid crystal alignment.

A series of polystyrene (PS) polymers substituted with phthalimide (PPH#), where # is the degree of substitution, were synthesized via a polymer analogus reaction to investigate liquid crystal (LC) alignment behaviors of LC cells fabricated using PPH# films. The PPH# films exhibited higher optical transparency in the visible light region compared to a com. polyimide (PI) film. The transmittance of each PPH# film ranged from 91 to 93%, whereas that of PI was 80.5% at 550 nm. The LC cell fabricated with a pristine PS film showed planar LC alignment perpendicular with respect to the rubbing direction. The introduction of the phthalimide group to the side chain of PS diverted the LC alignment direction from perpendicular to parallel with respect to the rubbing direction. The LC cells fabricated with PPH# films exhibited planar LC alignment parallel with respect to the rubbing direction when the degree of substitution of phthalimidoyl moieties was >20 mol%. In addition, the long-term stability of the LC cell composed of pristine PS was very low. However, the long-term stability of the LC cells fabricated with the PPH# series was remarkably enhanced in addition to their UV stability. Therefore, this study contributes to the development of planar and parallel LC alignments on PS derivatives and can be used in the next-generation display industry for the production of flexible displays.

RSC Advances published new progress about Glass transition temperature. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Su, Shijun; Chen, Mei; Li, Qin; Wang, Yihui; Chen, Shuai; Sun, Nan; Xie, Chengwei; Huai, Ziyou; Huang, Yinjiu; Xue, Wei published the artcile< Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity>, Reference of 611-19-8, the main research area is quinazolinyl pentadieneone oxime ether preparation diastereoselective antitumor SAR drug; Anticancer; Oxime ether; Penta-1, 4-diene-3-one; Quinazoline; SMMC-7721 cells.

A series of novel penta-1,4-diene-3-one derivatives I [R = H, [(2,4-dichlorophenyl)methyl]oxidanyl, [(2-chlorophenyl)methyl]oxidanyl, [(4-chlorophenyl)methyl]oxidanyl, [(2-fluorophenyl)methyl]oxidanyl; R1 = thiophen-2-yl, pyridin-2-yl; R2 = H, [(2-fluorophenyl)methyl]oxidanyl, [(2,4-dichlorophenyl)methyl]oxidanyl, [(3-methylphenyl)methyl]oxidanyl, etc.; R3 = H, 6-Cl, 8-Me] containing quinazoline and oxime ether moieties were designed and synthesized. Their anticancer activities were evaluated by MTT assay, and the results showed that most compounds exhibited extremely inhibitory effects against hepatoma SMMC-7721 cells. In particular, compounds I [R = R3 = H; R1 = pyridin-2-yl; R2 = [(3-methylphenyl)methyl]oxidanyl] (II) and I [R = H; R1 = pyridin-2-yl; R2 = [(4-chlorophenyl)methyl]oxidanyl; R3 = 6-Cl] (III) displayed the more potent inhibitory activity with IC50 values of 0.64 and 0.63μM, which were better than that of gemcitabine (1.40μM). Further mechanism studies indicated that compounds II, III, I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = R3 = H] and I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = H; R3 = 6-Cl] could control the migration of SMMC-7721 cells effectively, and inhibit the proliferation of cancer cells by inhibiting the DNA replication. Western-blot results showed that compounds II and III induced irreversible apoptosis of SMMC-7721 cells by regulating the expression level of apoptose-related proteins. Those studies demonstrated that the penta-1,4-diene-3-one derivatives I containing quinazoline and oxime ether fragments merited further research as potential anticancer agents.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carmona, Maria; Rodriguez, Ricardo; Passarelli, Vincenzo; Carmona, Daniel published the artcile< Mechanism of the Alkylation of Indoles with Nitrostyrenes Catalyzed by Chiral-at-Metal Complexes>, Electric Literature of 5153-70-8, the main research area is alkylation indole nitrostyrene catalyzed chiral phosphinobenzyl pyridylmethyl amine rhodium; mol structure calculation phosphinobenzyl pyridylmethyl amine rhodium nitrostyrene complex.

Chiral-at-metal rhodium(III) complexes of the formula [Rh(κ4C,N,N’,P-L)A(Solv)][SbF6]n (Solv = A = MeCN, n = 2 (1); Solv = H2O, A = MeCN, n = 2 (2); Solv = MeCN, A = Cl, n = 1 (3); Solv = H2O, A = Cl, n = 1 (4)) catalyze the Friedel-Crafts reaction of trans-β-nitrostyrene and N-methyl-2-methylindole. Complex 4 reacts with trans-β-nitrostyrene, affording [RhCl(κ4C,N,N’,P-L)(trans-β-nitrostyrene)]+ (5). In the presence of N-methyl-2-methylindole, complex 5 reversibly gives a mixture of aci-nitro complexes 6 in high diastereoselectivity which, in turn, evolve to the FC adducts through 1,3-prototropy mediated by a water mol. On the basis of exptl. NMR studies and DFT calculations, a detailed mechanistic pathway for the alkylation reaction is proposed, including an explanation of the origin of the measured enantiomeric ratio.

Organometallics published new progress about Alkylation. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moon, Jihyeon; Seo, Kyutae; Kang, Hyo published the artcile< Vertical alignment of liquid crystals on comb-like renewable chavicol-modified polystyrene>, Formula: C9H9Cl, the main research area is vertical alignment liquid crystal chavicol polystyrene copolymer; alignment; chavicol; liquid crystal; phytochemical; renewable.

This study demonstrates liquid crystal (LC) alignment behaviors on the surface of phytochem.-based and renewable chavicol-modified polystyrene (PCHA#, # = 20, 40, 60, 80, and 100, where # represent the molar content of chavicol moiety in the side group) via polymer modification reactions. Generally, a LC cell fabricated with a polymer film containing a high molar content of the chavicol side group exhibited a vertical LC alignment property. There is a correlation between the vertical alignment of LC mols. and the polar surface energy value of the polymer films. Therefore, vertical LC alignment was observed when the polar surface energy values of these polymer films were smaller than about 1.3 mJ/m2, induced by the nonpolar chavicol moiety having long and bulky carbon groups. Aligning stability under harsh conditions such as UV irradiation of about 5 J/cm2 was observed in the LC cells fabricated from PCHA 100 film. Therefore, it was found that the plant-based chavicol-substituted polymer system can produce an eco-friendly and sustainable LC alignment layer for next-generation applications.

Polymers (Basel, Switzerland) published new progress about Contact angle (water, diiodomethane). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kalani, Komal; Chaturvedi, Vinita; Trivedi, Priyanka; Tondon, Sudeep; Srivastava, Santosh Kumar published the artcile< Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents>, Application of C9H7ClO, the main research area is Mycobacterium dihydroartemisinin antitubercular agent; Anti-tubercular activity; Dihydroartemisinin; Semi-synthetic derivatives; Synergistic effect Artemisia annua; Tuberculosis..

Chem. transformation of dihydroartemisinin for anti-tubercular lead optimization. Dihydroartemisinin, a metabolite of artemisinin was chem. converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37Rv virulent strain of Mycobacterium tuberculosis by agar-based proportion assay. Further, synergistic activity of 12-O-m-anisoyl dihydroartemisinin was also studied with the front-line anti-TB drugs, isoniazid and rifampicin. Results: The results showed that all the derivatives were active but out of eight, 12-O-m-anisoyl dihydroartemisinin and 12-O-p-anisoyl dihydroartemisinin were significantly active (MIC 25.0μg/mL). In synergistic activity evaluation, the 12-O-m-anisoyl dihydroartemisinin derivative showed reduction in MIC (by 1/8th, i.e. 3.12μg/mL and that of rifampicin by 1/4th, i.e. 0.05μg/mL) with the front-line anti-TB drug, rifampicin. The sumfractional inhibitory concentration (Σ FIC) was 0.375. These results suggested a synergistic effect of the 12-O-m-anisoyl dihydroartemisinin with rifampicin and established its base for the development of anti-tubercular agents from an in-expensive and non-toxic natural product. To the best of our knowledge this is the first ever report on the anti-tubercular potential of dihydroartemisinin and its derivatives

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Mycobacterium tuberculosis. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Giorgianni, Giuliana; Nori, Valeria; Baschieri, Andrea; Palombi, Laura; Carlone, Armando published the artcile< Organocatalyzed Michael addition to nitroalkenes via masked acetaldehyde>, Reference of 5153-70-8, the main research area is nitroaldehyde preparation enantioselective; acetaldehyde nitroalkene Michael addition organocatalyst.

A novel and safe reaction protocol for the enantioselective enamine-catalyzed addition of acetaldehyde to nitroalkenes R1CH=CHNO2 (R1 = Bu, 4-chloropheny, 2-phenylethyl, etc.) is presented; this protocol makes use of a safe acetaldehyde precursor to access important intermediates R/S-R1CH(CH2C(O)H)CH2NO2 to Active Pharmaceutical Ingredients (APIs), and allows the use of fewer equivalent of acetaldehyde and lower catalyst loadings. The reaction developed proved to be suitable to be performed on gram-scale and to produce key intermediates, such as (R)-5-methyl-3-(nitromethyl)hexanal for the synthesis of pharmacol. active compounds such as pregabalin.

Catalysts published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (nitro). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Reference of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blazejewski, Jean Claude; Dorme, Regine; Wakselman, Claude published the artcile< Chlorous acid oxidation of trifluoromethylphenols: cyclopentenolones by benzilic acid ring contraction>, Formula: C7H4ClF3O, the main research area is oxidation fluoromethylphenol chlorous acid; chlorohydroxyoxotrifluoromethylcyclopentenecarboxylic acid preparation decarboxylation; cyclopentenecarboxylic acid chloro hydroxy oxo fluoromethyl; cyclopentanedione chloro fluoromethyl.

HClO2 oxidation of 2- and 3-F3CC6H4OH initially gives isolable (trifluoromethyl)cyclopentenecarboxylic acid I, which decarboxylates upon heating to give 2-chloro-2-(trifluoromethyl)-1,3-cyclopentanedione.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Oxidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Formula: C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics